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1. 发明授权

US11857970B2 Cell culture vessel 有权
公开(公告)号：US11857970B2
公开(公告)日：2024-01-02
申请号：US16628474
申请日：2018-07-13
申请人： CORNING INCORPORATED
发明人： William Joseph Lacey , Gregory Roger Martin , Ana Maria del Pilar Pardo , Allison Jean Tanner
IPC分类号： B01L3/00 , C12M1/00 , C12M1/24
CPC分类号： B01L3/5085 , C12M23/08 , C12M23/38 , B01L2300/0858
摘要： A cell culture vessel has a wall and cell culture surface having a plurality of microcavities for culturing cells in three-dimensional conformation, referred to as “spheroids”. The inner surface of the wall and the cell culture surface define a cell culture chamber of the vessel. The wall is attached to the cell culture surface in a way that does not provide flat surfaces on or around the cell culture surface so that the vessel provides an environment suitable for the production of a homogeneous population of three-dimensional cell clusters, or spheroids.

2. 发明公开

US20230357688A1 CULTURE VESSELS CONTAINING 3D CELL CULTURE SUBSTRATES WITH DIFFUSION STRUCTURES 审中-公开
公开(公告)号：US20230357688A1
公开(公告)日：2023-11-09
申请号：US18028403
申请日：2021-09-29
申请人： CORNING INCORPORATED
发明人： Feng Li , Gregory Roger Martin
IPC分类号： C12M1/32 , C12M1/12 , C12M3/00
CPC分类号： C12M23/12 , C12M25/14 , C12M25/10 , C12M21/08
摘要： A cell culture device comprises a multi-well cell culture plate comprising a plurality of wells, each well comprising a top, a bottom, and a sidewall disposed between the top and the bottom and having an interior surface comprising an ultra-low attachment surface. A plurality of scaffolds are disposed within wells of the multi-well cell culture plate, each scaffold comprising a cell-adherent surface. In some embodiments, the scaffold comprises a fiber scaffold. In some embodiments, the scaffold comprises an artificial vascular scaffold. In some embodiments, cell culture devices comprise a plurality of hydrogel scaffolds disposed in a multi-well cell culture plate, the plurality of hydrogel scaffolds comprising hydrogel fibers of differing lengths, wherein opposite ends of a hydrogel fiber are disposed in different wells within the multi-well cell culture plate to create interconnected wells.

3. 发明授权

US11661574B2 Fluidic devices including microplates with interconnected wells 有权
公开(公告)号：US11661574B2
公开(公告)日：2023-05-30
申请号：US16630024
申请日：2018-07-13
申请人： CORNING INCORPORATED
发明人： Gregory Roger Martin , Allison Jean Tanner
IPC分类号： C12M1/32 , B01L3/00 , C12M1/00 , C12M1/12
CPC分类号： C12M23/12 , B01L3/50273 , C12M23/38 , C12M25/04 , B01L2200/027 , B01L2300/0864 , B01L2300/123 , B01L2400/0475
摘要： A fluidic device for culturing cells includes a microplate and plate lid. The microplate includes multiple wells and channels, the channels extending between the wells such that the channels interconnect the wells. The plate lid releasably engages the microplate to thereby enclose the wells and the channels. The wells include a culture surface such that a cell culture medium received therein is deposited over the culture surface. At least one channel that extends between adjacent ones of the wells is spaced from the culture surfaces of the adjacent wells defining a gap between the at least one channel and the culture surfaces of the adjacent wells for collection of the cell culture medium.

4. 发明公开

US20230151320A1 OPTICAL CELL CULTURE MONITORING AND ANALYTE MEASURING SYSTEM 审中-公开
公开(公告)号：US20230151320A1
公开(公告)日：2023-05-18
申请号：US18099597
申请日：2023-01-20
申请人： CORNING INCORPORATED
发明人： Scott Robertson Bickham , Ming-Jun Li , Gregory Roger Martin , Robert Raymond Raczkowski , Horst Schreiber , Todd Michael Upton
IPC分类号： C12M1/00 , C12M1/26 , C12M1/36 , G01N21/65
CPC分类号： C12M41/14 , C12M33/04 , C12M41/48 , C12M43/00 , G01N21/65 , C12M37/06
摘要： Methods, systems, and devices for non-invasive measurement of cell cultures are described that provide for remote monitoring of cell status. The system includes a cell culture vessel, at least one monitoring layer, at least one measurement device, and a communication component. The cell culture vessel may include at least one cell culture chamber configured for cell growth and for closed-system operation. The monitoring layer is external to the at least one cell culture chamber. In some cases, the communication component is configured to transmit data from the monitoring layer to a remote location.

5. 发明申请

US20230007854A1 CONNECTED ECOSYSTEM FOR LABORATORY ENVIRONMENT 有权
公开(公告)号：US20230007854A1
公开(公告)日：2023-01-12
申请号：US17780352
申请日：2020-11-09
申请人： CORNING INCORPORATED
发明人： John Wilfred Coddaire , Maryanne De Chambeau , James Thomas Eickmann , Paula Mary Flaherty , Anthony Glenn Frutos , Vasiliy Nikolaevich Goral , Angela Langer Julien , Marshall Jay Kosovsky , Brent Ravaughn Lanterman , Gregory Roger Martin , Christie Leigh McCarthy , John Forrest Roush , John Shyu , Tora Ann-Beatrice Eline Sirkka , Allison Jean Tanner , Kimberly Ann Titus , Todd Michael Upton , Timothy James Wood
IPC分类号： B01L1/00 , G06F3/16 , G06F21/32 , G06F3/01 , G06T7/00
摘要： A connected ecosystem for a laboratory environment comprises an electronic lab notebook, and instrumented biosafety cabinet, and one or more sensing vessels containing cell cultures. The electronic lab notebook interfaces with the instrumented biosafety cabinet to provide instructions, guidance, and monitoring of a user during the set up of the experimental protocol and to receive commands from the user via one of several input modalities. After the experimental protocol has been set up in the instrumented biosafety cabinet, cell cultures may be moved to an incubator where the connected ecosystem may provide automatic monitoring of the cultures. The automatic monitoring is provided by sensors integrated into cell culture vessels and supplemented by images of the cell cultures captured by a camera. The user may be informed of deviations from expected results detected based on the automatic monitoring.

6. 发明申请

US20220400667A1 CRYOPRESERVATION DEVICES 有权
公开(公告)号：US20220400667A1
公开(公告)日：2022-12-22
申请号：US17896697
申请日：2022-08-26
申请人： CORNING INCORPORATED
发明人： John Wilfred Coddaire , William Joseph Lacey , Gregory Roger Martin , Michael Kurt Schaefer , Paul Michael Szlosek , Allison Jean Tanner
IPC分类号： A01N1/02 , B65D83/00 , C12M1/00 , B01L3/00
摘要： Vial assemblies comprising a tubular body and a flexible bottom or flexible liner are described herein, wherein the flexible bottom or liner is configured to compress at least partially upon the application of force. Methods for storing and removing frozen samples from such vial assemblies are also described herein.

7. 发明申请

US20220195366A1 CELL CULTURE INSERT 有权
公开(公告)号：US20220195366A1
公开(公告)日：2022-06-23
申请号：US17691511
申请日：2022-03-10
申请人： CORNING INCORPORATED
发明人： Gregory Roger Martin , Allison Jean Tanner
IPC分类号： C12M1/12 , C12M3/00
摘要： A cell culture insert for use in culturing cells to promote the formation of spheroids and methods of using these spheroid-promoting cell culture inserts. The cell culture insert includes a porous membrane and one or more sidewalls that are non-adherent to cells and cause the cells in the insert to associate with each other and form spheroids.

8. 发明申请

US20180264460A1 UNITARY SEROLOGICAL PIPETTE AND METHODS OF PRODUCING THE SAME 审中-公开
公开(公告)号：US20180264460A1
公开(公告)日：2018-09-20
申请号：US15986323
申请日：2018-05-22
申请人： Corning Incorporated
发明人： John Claude Cadotte, JR. , Gregory Roger Martin , Michael Kurt Schaefer , James Mark Seymour
IPC分类号： B01L3/02
CPC分类号： B01L3/021 , B01L2200/12 , B01L2300/0681 , B01L2300/0838 , B01L2300/0858 , B01L2300/12 , B01L2300/16 , B29C49/04 , B29D23/001 , B29K2023/12 , B29K2025/06
摘要： A pipette may comprise a length, a longitudinal axis, and an inner curved surface enclosing a space. The pipette may have a tip region having a tip thickness. The tip region may be connected to a body region having a body thickness. The tip thickness may be greater than the body thickness. The body region may be connected to a mouth region having a mouth thickness. The mouth thickness may be greater than the body thickness. The inner curved surface may not contain bumps or ridges either between the tip region and the body region or between the body region and the mouth region. The pipette may be formed by blow molding or vacuum forming.

9. 发明申请

US20160186113A1 CELL CULTURE APPARATUS FOR CO-CULTURE OF CELLS 审中-公开
标题翻译：细胞培养细胞培养装置
公开(公告)号：US20160186113A1
公开(公告)日：2016-06-30
申请号：US15063040
申请日：2016-03-07
申请人： Corning Incorporated
发明人： Allison Jean Tanner , Gregory Roger Martin
IPC分类号： C12M1/04 , C12M1/00
CPC分类号： C12M23/24 , C12M23/34 , C12M23/38 , C12M23/40 , C12M29/04 , C12M35/08
摘要： A multilayered cell culture apparatus for the co-culturing of at least two cell types is disclosed. The cell co-culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s). The body of the apparatus has imparted therein gas permeable membranes in combination with tracheal spaces that will allow the free flow of gases between some cell culture chambers and the external environment. In addition, some cell culture chambers may have limited access to air creating relatively lower oxygen content cell culture chambers. The size of the apparatus, and location of an optional neck section, allows for its manipulation by standard automated assay equipment, further making the apparatus amenable to high throughput applications.
摘要翻译：公开了用于共培养至少两种细胞类型的多层细胞培养装置。细胞共培养装置被定义为具有与气管空间组合的多个细胞培养室的整体结构。该装置的主体在其中赋予气体可渗透的膜与气管空间的组合，这将允许气体在一些细胞培养室和外部环境之间自由流动。此外，一些细胞培养室可能有限制地进入空气，产生相对较低的含氧细胞培养室。设备的尺寸和可选的颈部的位置允许其通过标准自动化测定设备的操作，进一步使得该设备适合于高通量应用。

10. 发明申请

US20150048085A1 VESSELS AND METHODS FOR CRYOPRESERVATION 审中-公开
标题翻译：用于CRYOPRESERVATION的血管和方法
公开(公告)号：US20150048085A1
公开(公告)日：2015-02-19
申请号：US14081326
申请日：2013-11-15
申请人： CORNING INCORPORATED
发明人： Jessica Monique Brown , Nicholas Michael Illsley , Gregory Roger Martin , Ana Maria del Pilar Pardo , Allison Jean Tanner
IPC分类号： A01N1/02
CPC分类号： A01N1/0284 , A01N1/0242 , A01N1/0263 , A01N1/0268 , A01N1/0273 , A61J1/05 , A61J1/1412 , A61J1/16 , A61M5/145 , A61M5/2425 , C12M23/48 , C12M33/04 , C12M45/22
摘要： An article including, either: a frame having an interior cavity, and a flexible liner situated within the interior cavity; or a deformable frame having an interior cavity, as defined herein. Either frame can receive a sample, such as liquid having suspended live cells, and cooling freezes the sample to a solid sample. The solid sample can be readily ejected from the article having either a frame with the flexible liner, or the deformable frame, without extensive thawing. The solid sample can be rapidly displaced from the article by the methods and apparatus disclosed herein.
摘要翻译：一种制品，包括：具有内部空腔的框架和位于所述内部空腔内的柔性衬里; 或具有如本文所定义的内腔的可变形框架。任一框架可以接收样品，例如具有悬浮活细胞的液体，并且冷却将样品冻结成固体样品。固体样品可以容易地从具有柔性衬垫的框架或可变形框架的制品中排出，而无需大量解冻。通过本文公开的方法和装置，固体样品可以快速地从制品中移位。

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