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1. 发明授权

US5015374A Closure cap for dialyzers 失效
标题翻译：透析器盖帽
公开(公告)号：US5015374A
公开(公告)日：1991-05-14
申请号：US386284
申请日：1989-07-27
申请人： Bernd Mathieu , Michael Rinck , Jurgen Schnur , Dieter Selzer , Wolfram Weber
发明人： Bernd Mathieu , Michael Rinck , Jurgen Schnur , Dieter Selzer , Wolfram Weber
IPC分类号： A61M1/16 , A61M1/18 , A61M39/20 , B01D61/30 , B01D63/00 , B01D65/02
CPC分类号： B01D61/30 , B01D65/022 , A61M1/168 , A61M39/20 , B01D2321/16 , Y10S285/921
摘要： The invention relates to a closure cap (1) for dialyzers which is suitable for a so-called in-line sterilization. For this purpose the closure cap (1) comprises two cap parts (2, 3) of which the first cap part (2) is adapted to be mounted on a dialyzer flange (4) while the second cap part (3) is arranged movably in a receiving compartment (5) of the first cap part (2) between an open position and a closure position. In an open position passage of a sterilization medium is possible so that all the parts, sealing and guide surfaces can be reliably sterilized. In the closure position the second cap part (3) is pushed into a sealing position within the first cap part (2) so that contamination of the dialyzer after removal from the sterilization apparatus can be prevented with certainty.
摘要翻译：本发明涉及一种用于透析器的封闭盖（1），其适用于所谓的在线灭菌。为此，封闭盖（1）包括两个帽部分（2,3），第一帽部分（2）适于安装在透析器凸缘（4）上，而第二帽部分（3）可移动地布置在第一盖部分（2）的接收隔间（5）中处于打开位置和关闭位置之间。在灭菌介质的打开位置通道中，可以使所有的部件，密封和引导表面都可靠地消毒。在封闭位置，第二帽部分（3）被推入第一帽部分（2）内的密封位置，从而可以确定地防止从灭菌装置移除之后透析器的污染。

2. 发明授权

US4774415A Device for sterilization of a hose coupling device in the connected condition 失效
标题翻译：在连接状态下对软管接头装置进行灭菌的装置
公开(公告)号：US4774415A
公开(公告)日：1988-09-27
申请号：US4502
申请日：1987-01-20
申请人： Hubert Biegel , Wolfram Weber , Arthur Meisberger , Bernd Mathiew , Wolfram Weber , Arthur Meisberger , Bernd Mathieu
发明人： Hubert Biegel , Wolfram Weber , Arthur Meisberger , Bernd Mathiew , Wolfram Weber , Arthur Meisberger , Bernd Mathieu
IPC分类号： A61L2/08 , A61M39/18 , A61L2/10 , G21K5/04 , H01J37/20
CPC分类号： A61M39/18 , A61L2/08
摘要： The device in accordance with the invention for the sterilization of a hose coupling device (in its connected condition) of dialysis apparatus, comprises an opening housing into which the coupling device is placed. The coupling device is subjected to infrared radiation from heating elements in the housing whose heating effect is monitored and automatically controlled by a temperature probe arranged under the coupling device in the housing. Since the temperature probe is designed to have such an infrared absorption characteristic that the temperature increase rate of the probe is substantially the same as that of the coupling device, one may be certain that the coupling device will have reached the desired temperature (which is detected at the temperature probe) with only a slight delay if any. At the same time there is the advantage that the interior of the coupling device is heated to substantially above the minimum necessary sterilization temperature.
摘要翻译：根据本发明的用于灭菌透析设备的软管联接装置（在其连接状态）的装置包括开口壳体，联接装置放置在该开口壳体中。耦合装置受到壳体中加热元件的红外辐射的影响，其加热效应被监测，并由设置在壳体中的耦合装置下方的温度探针自动控制。由于温度探针被设计成具有这样的红外吸收特性，使得探头的温度升高速率基本上与耦合装置的温度升高速率相同，所以可以确定耦合装置将达到所需的温度（被检测到）在温度探头）只有轻微的延迟（如果有的话）。同时具有将耦合装置的内部加热到基本上高于最低必需灭菌温度的优点。

3. 发明授权

US5445593A Method and apparatus for the continuous conditioning of a cell suspension 失效
标题翻译：用于连续调节细胞悬浮液的方法和装置
公开(公告)号：US5445593A
公开(公告)日：1995-08-29
申请号：US93491
申请日：1993-07-16
申请人： Wolfgang Biesel , Bernd Mathieu , Wolfram Weber
发明人： Wolfgang Biesel , Bernd Mathieu , Wolfram Weber
IPC分类号： B04B5/00 , A61M1/02 , A61M1/36 , B04B5/04 , C12N5/08 , B04B7/08
CPC分类号： A61M1/3693 , A61M1/3692 , A61M1/3696 , B04B5/0442 , A61M2202/0429 , B04B2005/045 , Y10T436/25375
摘要： A method and apparatus for the continuous conditioning of a cell suspension, more particularly whole blood, in order to obtain an erythrocyte concentrate which is returned to the patient by autotransfusion. In accordance with the invention there are three treatment stages, that is to say sedimentation of the cell suspension, the addition of washing solution to the cell concentrate and renewed sedimentation and separation of the washing solution.
摘要翻译：用于连续调节细胞悬浮液，特别是全血的方法和装置，以获得通过自体输血返回给患者的红细胞浓缩物。根据本发明，有三个处理阶段，即细胞悬浮液的沉淀，向细胞浓缩物中加入洗涤溶液和更新洗涤溶液的沉降和分离。

4. 发明授权

US4789473A Filter for obtaining plasma or plasma water 失效
标题翻译：用于获得等离子体或等离子体水的过滤器
公开(公告)号：US4789473A
公开(公告)日：1988-12-06
申请号：US1815
申请日：1987-01-08
申请人： Bernd Mathieu , Wolfram Weber , Wolfgang Schulz
发明人： Bernd Mathieu , Wolfram Weber , Wolfgang Schulz
IPC分类号： A61M1/02 , A61M1/18 , B01D63/02 , B29C41/04 , B29C70/84 , B01D13/01
CPC分类号： B01D63/022 , B01D63/02 , B29C41/045 , B29C70/845
摘要： A filter comprising a filter housing with an interior within which between two closure members filter membranes in the form of hollow fibers are disposed. Between the hollow fibers a free flow space remains to which are connected two connecting pieces disposed inclined on the housing. Through said connecting pieces blood is supplied to the interior so that a filtration from the outside to the inside into the hollow fibers is possible. This and the arrangement of the connecting pieces gives an extremely favourable flow approach to the hollow fibers so that the blood flow is hardly influenced in its velocity and flow behaviour because in addition to the cross-section of the free flow space is adapted to the cross section of the blood supply line. For making such a filter at least two filters are arranged parallel and spaced apart in a plane, the support surface for the filters being rotatably mounted and the axis of rotation not intersecting any of the two longitudinal axes of the filters. During the rotation and supplying of the casting or sealing compound for the closure members through end-face supply means into the interior inclined faces are formed which in their angle correspond to the angle (.alpha., .beta.) of the connecting pieces.
摘要翻译：一种过滤器，其包括具有内部的过滤器壳体，其中在两个封闭构件之间过滤中空纤维形式的膜。在中空纤维之间，剩余的自由流动空间连接到倾斜于壳体上的两个连接件。通过所述连接件将血液供应到内部，使得可以从外部到内部过滤到中空纤维中。这和连接件的布置给出了对中空纤维非常有利的流动方式，使得血流在其速度和流动行为几乎不受影响，因为除了自由流动空间的横截面适应于十字供血线段。为了制造这样的过滤器，至少两个过滤器在平面上平行并间隔布置，用于过滤器的支撑表面可旋转地安装，并且旋转轴线不与过滤器的两个纵向轴线中的任一个相交。在通过端面供给装置旋转和供给用于封闭构件的铸造或密封化合物的过程中，形成倾斜面，其倾斜角度对应于连接件的角度（α，β）。

5. 发明授权

US5268144A Method for sterilizing a medical unit 失效
标题翻译：对医疗单元进行消毒的方法
公开(公告)号：US5268144A
公开(公告)日：1993-12-07
申请号：US921907
申请日：1992-07-29
申请人： Klaus Heilmann , Bernd Mathieu , Michael Rink , Wolfram Weber
发明人： Klaus Heilmann , Bernd Mathieu , Michael Rink , Wolfram Weber
IPC分类号： A61L2/04 , A61L2/18 , A61M1/16 , B01D65/02 , A61L2/06 , A61L2/16
CPC分类号： A61L2/18 , A61L2/04 , B01D65/022 , A61M1/169 , B01D2321/08 , B01D2321/162
摘要： This invention relates to a method for sterilizing a medical unit having at least two connections for a fluid flow pathway where a sterilizing medium flows through the medical unit.Medical units of this type are e.g. medical filters, in particular dialyzers. A high degree of sterility is here required. This is accomplished through the steps of:(a) inserting the medical unit into a system under pressure-tight coupling of the at least two connections to a feed conduit and discharge conduit of the system under atmospheric conditions;(b) passing the sterilizing medium from the system through the medical unit for a given period of time;(c) closing the at least two connections in the coupled state and in a germproof manner, without the same being opened, on completion of the sterilization operation; and(d) removing said medical unit from said system as a sterile medical unit with closed connections.All steps, including the removal of the medical unit, are therefore carried out in a system where the sterility obtained is constantly maintained. This "inline sterilization" guarantees a high degree of sterility of the medical units treated.
摘要翻译：本发明涉及一种消毒医疗单元的方法，该医疗单元具有至少两个用于流体通路的连接，其中消毒介质流过医疗单元。这种类型的医疗单位是例如。医疗过滤器，特别是透析器。这里需要高度的无菌性。这通过以下步骤来实现：（a）在大气条件下，将至少两个连接压力联接到系统的进料管道和排出管道，将医疗单元插入系统中; （b）将灭菌介质从系统通过医疗单位一段给定的时间; （c）在所述灭菌操作完成时，在所述连接状态下并以无菌方式封闭所述至少两个连接件而不相同地打开; 和（d）将所述医疗单元从所述系统中移除为具有封闭连接的无菌医疗单元。因此，所有步骤，包括移除医疗单元，都是在不断得到不育的系统中进行的。这种“在线灭菌”保证所治疗的医疗单位的高度的无菌性。

6. 发明授权

US4564342A Peristaltically operating roller pump and pump rotor therefor 失效
标题翻译：蠕动式辊式泵和泵式转子
公开(公告)号：US4564342A
公开(公告)日：1986-01-14
申请号：US633804
申请日：1984-07-24
申请人： Wolfram Weber , Hans-Jurgen Neumann , Artur Meisberger , Bernd Mathieu
发明人： Wolfram Weber , Hans-Jurgen Neumann , Artur Meisberger , Bernd Mathieu
IPC分类号： F04B43/12 , F04B45/08
CPC分类号： F04B43/1276
摘要： A peristaltically operating roller pump, in particular a hose pump for medical technology, comprises a pump bed (25) whose bearing wall (28) in the exit region (31) has a curvature which is in the same sense as the circular path (33a) of a roller (33) mounted on a pump rotor (1) and which has a radius of curvature which is constant with respect to the circular path (33a) or gradually increases in the direction of rotation of the roller (33). The pump rotor (1) comprises a gear connection so that a constrained radial movement of a roller is converted to a corresponding follow-up movement of the other rollers or roller. By this combination of pump bed and pump rotor pressure peaks and fluctuations of the flow rate are effectively prevented.
摘要翻译：蠕动式操作辊式泵，特别是用于医疗技术的软管泵，包括泵床（25），其在出口区域（31）中的轴承壁（28）具有与圆形路径（33a）相同的曲率），其安装在泵转子（1）上并且具有相对于圆形路径（33a）恒定的曲率半径或者在辊（33）的旋转方向上逐渐增加。泵转子（1）包括齿轮连接，使得辊的受限的径向运动被转换成其它辊或辊的相应的跟随运动。通过泵床和泵转子的这种组合压力峰值和流量的波动被有效地防止。

7. 发明授权

US5147613A Apparatus for sterilizing a medical unit 失效
标题翻译：消毒医疗单位的设备
公开(公告)号：US5147613A
公开(公告)日：1992-09-15
申请号：US608560
申请日：1990-11-02
申请人： Klaus Heilmann , Bernd Mathieu , Michael Rink , Wolfram Weber
发明人： Klaus Heilmann , Bernd Mathieu , Michael Rink , Wolfram Weber
IPC分类号： A61L2/16 , A61L2/04 , A61L2/18 , A61L2/24 , A61M1/14 , A61M1/16 , B01D65/02
CPC分类号： A61L2/04 , A61L2/18 , B01D65/022 , A61M1/169 , B01D2321/08
摘要： This invention relates to an apparatus for carrying out a method for sterilizing a medical unit comprising at least two connections for a fluid flow pathway where a sterilizing medium flows through the unit.Medical units of this type are e.g. medical filters, in particular dialyzers. A high degree of sterility is here required. This is accomplished through the steps of:(a) inserting the unit into a system under pressure-tight coupling of the two connections to a feed conduit and discharge conduit of the system under atmospheric conditions;(b) passing the sterilizing medium from the system through the unit for a give period;(c) closing the two connections in the coupled state and in a germproof manner, without the same being opened, on completion of the sterilization operation; and(d) removing said unit from said system as a sterile unit with closed connections.All steps, including the removal of the unit, are therefore carried out in a system where the sterility obtained is constantly maintained. This "inline sterilization" guarantees a high degree of sterility of the medical units treated.
摘要翻译：本发明涉及一种用于实施用于消毒医疗单元的方法的设备，该医疗单元包括用于消毒介质流过该单元的流体流动路径的至少两个连接。这种类型的医疗单位是例如。医疗过滤器，特别是透析器。这里需要高度的无菌性。这是通过以下步骤完成的：（a）在大气条件下，将两个连接件与进料管道和系统的排放管道进行压力密封联接，将设备插入系统; （b）将灭菌介质从系统通过设备供给期; （c）在灭菌操作完成时，以连接状态和无菌方式封闭两个连接，而不打开; 和（d）将所述单元从所述系统中移除为具有封闭连接的无菌单元。因此，所有步骤，包括去除单位，都是在不断获得不育的系统中进行的。这种“在线灭菌”保证所治疗的医疗单位的高度的无菌性。

8. 发明授权

US4540397A Centrifugal apparatus 失效
标题翻译：离心机
公开(公告)号：US4540397A
公开(公告)日：1985-09-10
申请号：US553297
申请日：1983-11-18
申请人： Houshang Lolachi , Bernd Mathieu , Wolfram Weber
发明人： Houshang Lolachi , Bernd Mathieu , Wolfram Weber
IPC分类号： B04B5/00 , B04B5/04 , B04B9/08 , B04B11/00
CPC分类号： B04B5/0442 , B04B9/08
摘要： A centrifugal apparatus, in particular a flow-through centrifugal apparatus for processing biological fluids in continuous fluid communication, has a flexible tube securely fixed to a rotatably processing chamber and a stationary terminal coaxially above said processing chamber, and being formed in a loop around the outer periphery of said processing chamber so as, in operation, to orbit said loop around said processing chamber at half the rotational speed thereof to avoid twisting or drilling of said tube. To guide said loop of tube in its orbital movement, a rotating frame is provided also rotating at half the speed of the processing chamber. The drive trains for said processing chamber and said rotating frame, respectively, each comprise an individual drive shaft each drivingly connected separate from the other to a drive motor. This avoids any necessity of reversal of rotational direction in the drive trains and allows for a compact and simple construction with a minimum of rotating masses.
摘要翻译：离心装置，特别是用于处理连续流体连通的生物流体的流通式离心装置，具有可挠地固定在可旋转的处理室和固定的端子上的柔性管，同轴地位于所述处理室的上方，所述处理室的外周，以便在操作中以围绕所述处理室的一半转速绕所述环绕轨道，以避免所述管的扭转或钻孔。为了引导管道在其轨道运动中的所述环路，旋转框架也以处理室的一半的速度旋转。分别用于所述处理室和所述旋转框架的传动系列各自包括单独的驱动轴，每个驱动轴彼此分开地相互连接到驱动马达。这样就避免了驱动系中旋转方向反转的任何必要性，并允许以最小的旋转质量块进行紧凑且简单的结构。

9. 发明授权

US4551147A Apparatus for running off liquids from sealed vessels 失效
标题翻译：用于从密封容器中排出液体的装置
公开(公告)号：US4551147A
公开(公告)日：1985-11-05
申请号：US462442
申请日：1983-01-31
申请人： Bernd Mathieu , Wolfram Weber
发明人： Bernd Mathieu , Wolfram Weber
IPC分类号： A61M5/162 , A61M5/14
CPC分类号： A61M5/162 , A61M2005/1623
摘要： A universal infusion apparatus for use with sterile, sealed bottles of infusion liquid has a hydrophobic filter for stopping possible loss of liquid through the air duct, that is used for letting air into the vessel to take the place of the liquid run off therefrom. The air filter is furthermore used for stopping bacteria from the outside air being taken up into the vessel. For decreasing the degree of vacuum necessary for starting operation of the filter when there is liquid on the inside face of it so that there is no danger of the bottle collapsing, there is an air trap or storage space in which air will be kept when liquid makes its way through the air duct. Air may then be let off from the trap through an air pipe, which comes to an end a very small distance from the inside face of the filter so that only a very small degree of vacuum is needed for moving air as a bubble out of the pipe against the inner side of the filter which is then primed and will let air through at a lower degree of vacuum than would otherwise be the case.
摘要翻译：用于无菌，密封的输液的瓶子的通用输注设备具有疏水过滤器，用于通过空气管道阻止可能的液体损失，用于使空气进入容器以取代液体从其中排出。此外，空气过滤器用于阻止外部空气中的细菌被吸入容器中。为了降低过滤器的内表面上的液体开始运转所需的真空度，使得没有瓶子塌陷的危险，存在一个空气阱或储存空间，在液体穿过风道。然后空气可以通过空气管从陷阱中排出，空气管从过滤器的内表面到达非常小的距离，使得仅需非常小程度的真空才能将气体作为气泡移出管道抵靠过滤器的内侧，然后将其过滤，并使空气以比其他情况更低的真空度通过。

10. 发明授权

US4545744A Peristaltically operating roller pump 失效
标题翻译：蠕动式滚筒泵
公开(公告)号：US4545744A
公开(公告)日：1985-10-08
申请号：US633798
申请日：1984-07-24
申请人： Wolfram Weber , Hans-Jurgen Neumann , Artur Meisberger , Bernd Mathieu
发明人： Wolfram Weber , Hans-Jurgen Neumann , Artur Meisberger , Bernd Mathieu
IPC分类号： F04C5/00 , A61M5/142 , F04B43/12 , F04B45/08
CPC分类号： F04B43/1253 , F04B43/1276
摘要： A roller pump (1) comprises a stator member (2) in which a pump bed (3) is formed with specific geometry. In the interior of the pump bed (3) a rotor (6) is rotatably mounted. A pump hose (10) can be inserted into the pump bed (3), said hose being curved in loop-like manner and its two ends being combined in immediate vicinity to each other in a connecting piece (11). The connecting piece (11) can be fixed in location in the stator member (2), the arrangement in the stator member (2) being uniquely defined by cooperation of a location tongue (23) and a location slot (22). Interchanging of the pressure-side and suction-side connection is thus impossible. A holding-down member (24) arranged on the rotor (6) permits automatic insertion and ejection of the pump hose (10) or hose system (9).
摘要翻译：滚子泵（1）包括定子构件（2），其中形成具有特定几何形状的泵床（3）。在泵床（3）的内部，转子（6）可旋转地安装。泵软管（10）可以插入泵床（3）中，所述软管以环状方式弯曲，其两端在连接件（11）中彼此紧密组合。连接件（11）可以固定在定子构件（2）中的位置，定子构件（2）中的布置通过定位舌片（23）和定位槽（22）的配合而唯一地限定。因此，压力侧和吸入侧连接的互换是不可能的。布置在转子（6）上的压紧构件（24）允许泵软管（10）或软管系统（9）的自动插入和弹出。

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