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    • 6. 发明申请
    • PROCESS FOR PRODUCING BOTH BIOBASED SUCCINIC ACID AND 2,5-FURANDICARBOXYLIC ACID
    • 生产双酚化酸和2,5-呋喃糖基酸的方法
    • US20140343305A1
    • 2014-11-20
    • US14239822
    • 2012-08-28
    • Bala SubramaniamXiaobin ZuoDaryle H. BuschPadmesh Venkitasubramaniam
    • Bala SubramaniamXiaobin ZuoDaryle H. BuschPadmesh Venkitasubramaniam
    • C07D307/68C07C51/245
    • C07D307/68C07C51/245C07D307/46C07C55/10
    • A process is provided for carrying out an oxidation on a feed including levulinic acid and/or a levulinic acid oxidation precursor to succinic acid, one or more furanic oxidation precursors of 2,5-furandicarboxylic acid and a catalytically effective combination of cobalt, manganese, and bromide components for catalyzing the oxidation of the levulinic acid component and of the one or more furanic oxidation precursors to produce both succinic acid and 2,5-furandicarboxylic acid products, which process comprises supplying the feed to a reactor vessel, supplying an oxidant, reacting the levulinic acid component and the one or more furanic oxidation precursors with the oxidant to produce both succinic acid and 2,5-furandicarboxylic acid (FDCA) and then recovering the succinic acid and FDCA products. A crude dehydration product from the dehydration of fructose, glucose or both, including 5-hydroxymethylfurfural, can be directly oxidized by the process to produce 2,5-furandicarboxylic acid and succinic acid.
    • 提供了一种方法,用于在包含乙酰丙酸和/或乙酰丙酸氧化前体的进料上进行氧化,所述前体包含琥珀酸,一种或多种2,5-呋喃二羧酸的呋喃氧化前体和催化有效的钴,锰, 以及用于催化乙酰丙酸组分和一种或多种呋喃氧化前体的氧化以产生琥珀酸和2,5-呋喃二羧酸产物的溴化物组分,该方法包括将进料供应到反应器容器中,供应氧化剂, 使乙酰丙酸组分和一种或多种呋喃氧化前体与氧化剂反应以产生琥珀酸和2,5-呋喃二羧酸(FDCA),然后回收琥珀酸和FDCA产物。 由脱水果糖,葡萄糖或两者(包括5-羟甲基糠醛)的粗脱水产物可直接氧化,生成2,5-呋喃二羧酸和琥珀酸。
    • 7. 发明授权
    • Polyol hydrogenolysis by in-situ generated hydrogen
    • 多元醇氢解由原位产生的氢气
    • US08415511B2
    • 2013-04-09
    • US12796245
    • 2010-06-08
    • Raghunath V. ChaudhariDebdut S. RoyBala Subramaniam
    • Raghunath V. ChaudhariDebdut S. RoyBala Subramaniam
    • C07C29/60B01J23/42B01J23/46B01J31/02
    • B01J23/462B01J21/04B01J21/18B01J23/6567B01J35/0006C07C29/60C07C31/205
    • A catalyst composition/system can include: a platinum catalyst metal (Pt) and/or rhenium catalyst metal (Re) on a first support; and a ruthenium catalyst metal (Ru) and/or rhenium catalyst metal (Re) on a second support or a platinum catalyst metal (Pt) and a ruthenium catalyst metal (Ru) and/or a rhenium catalyst metal (Re) on the same support. The Pt:Ru, Re:Pt and/or Re:Ru weight ratio can be between about 1:4 and about 4:1. The support can be alumina, carbon, silica, a zeolite, TiO2, ZrO2 or another suitable material. The first and second support can be on the same support structure or on different support structures. In one option, the first and second supports can be positioned such that the Pt and/or Re are capable of catalyzing a dehydrogenation and/or reforming reaction that produces hydrogen and the Ru and/or Re are capable of catalyzing a hydrogenolysis reaction.
    • 催化剂组合物/体系可以包括:在第一载体上的铂催化剂金属(Pt)和/或铼催化剂金属(Re); 以及在第二载体上的铂催化剂金属(Pt)和钌催化剂金属(Ru)和/或铼催化剂金属(Re)上的钌催化剂金属(Ru)和/或铼催化剂金属(Re) 支持。 Pt:Ru,Re:Pt和/或Re:Ru重量比可以在约1:4至约4:1之间。 载体可以是氧化铝,碳,二氧化硅,沸石,TiO 2,ZrO 2或其它合适的材料。 第一和第二支撑件可以在相同的支撑结构上或不同的支撑结构上。 在一个选择中,第一和第二载体可以被定位成使得Pt和/或Re能够催化产生氢的脱氢和/或重整反应,并且Ru和/或Re能够催化氢解反应。
    • 9. 发明授权
    • Method for precipitation of small medicament particles into use containers
    • 将小药物颗粒沉淀到使用容器中的方法
    • US07744923B2
    • 2010-06-29
    • US11870554
    • 2007-10-11
    • Roger A. RajewskiBala SubramaniamFenghui Niu
    • Roger A. RajewskiBala SubramaniamFenghui Niu
    • A61K9/14
    • A61K9/1688B01J2/02B01J2/04B01J2/18
    • Commercially feasible methods for lyophobic precipitation of liquid-dispersed or dissolved material (e.g., medicaments) are provided wherein a plurality of individual, open containers (22) each containing a quantity (84) of a solution or dispersion are treated within a common pressurizable chamber (12). In this process, desired near-supercritical or supercritical temperature and pressure conditions are established for a selected antisolvent gas such as carbon dioxide, and an ultrasonic device (14) is actuated to generate high energy ultrasonic waves in the chamber (12). This leads to intense mixing of the antisolvent with the liquid solution or dispersion within the containers (22), with consequent solvent removal and material precipitation.
    • 提供了用于液体分散或溶解的材料(例如药物)的疏液沉淀的商业上可行的方法,其中每个含有(84)溶液或分散体的多个单独的开放容器(22)在共同的可加压室 (12)。 在这个过程中,为所选择的反溶剂气体例如二氧化碳建立了所需的近临界或超临界温度和压力条件,并且致动超声波装置(14)以在腔室(12)中产生高能超声波。 这导致反溶剂与容器(22)内的液体溶液或分散体的强烈混合,随后进行溶剂去除和材料沉淀。