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1. 发明授权

US07551967B1 Implantable medical leads and devices having carbon nanotube-based anti-electrostatic coatings and methods for making such leads and devices 有权
标题翻译：具有碳纳米管的防静电涂层的植入式医疗引线和器件以及用于制造这种引线和器件的方法
公开(公告)号：US07551967B1
公开(公告)日：2009-06-23
申请号：US11133921
申请日：2005-05-19
申请人： Annapurna Karicherla , Buehl E. Truex , Sheldon Williams
发明人： Annapurna Karicherla , Buehl E. Truex , Sheldon Williams
IPC分类号： A61N1/39
CPC分类号： A61N1/056 , A61N1/0563 , A61N1/3752 , Y10T29/49117 , Y10T428/31551 , Y10T428/31938
摘要： An implantable medical lead for transmitting electrical signals between an implantable medical device and selected body tissue comprises a lead body having a distal end portion, a proximal end and an electrically insulating, elongated housing connecting the distal end portion and the proximal end. The proximal end of the lead body carries an electrical connector assembly adapted to be electrically connected to the implantable medical device and the distal end portion of the lead body carries at least one electrode electrically coupled to a terminal contact on the connector assembly. The lead comprises at least one surface susceptible during use of the lead to the accumulation of electrostatic charges, the at least one surface having a coating comprising carbon nanotubes.
摘要翻译：用于在可植入医疗装置和所选择的身体组织之间传输电信号的可植入医疗引线包括具有连接远端部分和近端的远端部分，近端和电绝缘的细长壳体的引线体。引线体的近端携带适于电连接到可植入医疗装置的电连接器组件，并且引线体的远端部分承载电连接到连接器组件上的端子触点的至少一个电极。所述引线包括至少一个表面，所述表面在使用所述引线时易于积聚静电电荷，所述至少一个表面具有包含碳纳米管的涂层。

2. 发明申请

US20090249617A1 METHOD FOR MAKING IMPLANTABLE MEDICAL DEVICES HAVING CARBON NANOTUBE-BASED ANTI-ELECTROSTATIC COATINGS 审中-公开
标题翻译：制备具有碳纳米管基抗静电涂层的可植入医疗器械的方法
公开(公告)号：US20090249617A1
公开(公告)日：2009-10-08
申请号：US12466975
申请日：2009-05-15
申请人： Annapurna Karicherla , Buehl E. Truex , Sheldon Williams
发明人： Annapurna Karicherla , Buehl E. Truex , Sheldon Williams
IPC分类号： H01R43/00 , B32B9/00 , B32B27/40 , B32B27/06 , B32B27/32
CPC分类号： A61N1/056 , A61N1/0563 , A61N1/3752 , Y10T29/49117 , Y10T428/31551 , Y10T428/31938
摘要： A method of fabricating an implantable medical device having a receptacle adapted to receive a connector assembly attached to a proximal end of an implantable lead. A distal end portion of the implantable lead carries at least one electrode electrically connected with a terminal contact on the connector assembly. The receptacle contains at least one internal insulative sealing surface. An anti-static coating comprising carbon nanotubes is applied to the at least one internal insulative sealing surface.
摘要翻译：一种制造可植入医疗装置的方法，其具有适于容纳连接到可植入引线的近端的连接器组件的插座。可植入引线的远端部分承载与连接器组件上的端子触点电连接的至少一个电极。容器包含至少一个内部绝缘密封表面。将包含碳纳米管的防静电涂层施加到至少一个内部绝缘密封表面。

3. 发明授权

US07200437B1 Tissue contact for satellite cardiac pacemaker 有权
标题翻译：卫星心脏起搏器的组织接触
公开(公告)号：US07200437B1
公开(公告)日：2007-04-03
申请号：US10964910
申请日：2004-10-13
申请人： Yelena Nabutovsky , Sheldon Williams , Mark W. Kroll , Buehl E. Truex , Rodney J. Hawkins , Adam Klonecke , Anders Bjorling , John W. Poore
发明人： Yelena Nabutovsky , Sheldon Williams , Mark W. Kroll , Buehl E. Truex , Rodney J. Hawkins , Adam Klonecke , Anders Bjorling , John W. Poore
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/0587 , A61N1/375 , Y10S128/903
摘要： An implantable cardiac system has a master pacing unit and a remote satellite pacing unit. The master pacing unit is electrically coupled to a right side of a patient's heart via a lead assembly. The satellite pacing unit is a leadless device mounted on the left side of the patient's heart and is wirelessly controlled by the master pacing unit. The satellite pacing unit is affixed to the heart by one or more mounting members. The base of the satellite unit case has a gel-like material which facilitates adhesion of the pacing unit to the heart tissue. The gel-like material promotes tissue growth to hold the pacing unit in place on the heart. The gel-like material may be composed of polyvinlpyrrolidone and may contain a steroid, such as dimethyl sulfoxide (DMSO), or dexamethazone sodium phosphate.
摘要翻译：可植入心脏系统具有主起搏单元和远程卫星起搏单元。主起搏单元通过引线组件电耦合到患者心脏的右侧。卫星起搏单元是安装在患者心脏左侧的无引线装置，由主起搏器无线控制。卫星起搏单元通过一个或多个安装构件固定在心脏上。卫星单元壳体的基部具有促进起搏单元粘附到心脏组织的凝胶状材料。凝胶状材料促进组织生长以将起搏单元保持在心脏上的适当位置。凝胶状材料可以由聚乙烯吡咯烷酮组成并且可以含有类固醇，例如二甲基亚砜（DMSO）或地塞米松磷酸钠。

4. 发明授权

US07389134B1 Trans-septal intra-cardiac lead system 失效
标题翻译：跨隔间心脏引导系统
公开(公告)号：US07389134B1
公开(公告)日：2008-06-17
申请号：US11053374
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/04 , A61B5/02
CPC分类号： A61B5/0215 , A61B5/042
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.
摘要翻译：公开了一种通过患者心脏中的隔膜测量压力的装置和方法。插入心脏右侧的导线穿过隔膜，以进入心脏的左侧。引线包括将引线固定到一个或两个隔膜壁的附接结构。附接结构可以包括接合隔膜的一侧或多侧的至少一个突出的齿，膜，可充气气囊，渐开线螺旋或J-引线。引线还包括一个或多个用于测量心脏左侧的心脏压力和根据需要的心脏的右侧的传感器。

5. 发明授权

US07448999B1 Trans-septal intra-cardiac lead system 有权
公开(公告)号：US07448999B1
公开(公告)日：2008-11-11
申请号：US11053468
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/02
CPC分类号： A61B5/02158 , A61B5/0422 , A61B5/6852 , A61B5/6853 , A61B5/6855 , A61B5/6857 , A61B5/6858 , A61B5/6859 , A61N1/057 , A61N1/0587
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

6. 发明授权

US07450999B1 Trans-septal intra-cardiac lead system 有权
公开(公告)号：US07450999B1
公开(公告)日：2008-11-11
申请号：US11053566
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61N1/378
CPC分类号： A61N1/057 , A61B5/02152 , A61B5/02158 , A61B5/6853 , A61B5/6857 , A61B5/6882
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

7. 发明授权

US07340288B1 Trans-septal intra-cardiac lead system 失效
公开(公告)号：US07340288B1
公开(公告)日：2008-03-04
申请号：US11053493
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61B5/04
CPC分类号： A61B5/0215 , A61N1/3627 , A61N1/36514 , A61N2001/0585
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.

8. 发明授权

US07274965B1 Trans-septal intra-cardiac lead system 失效
标题翻译：跨隔间心脏引导系统
公开(公告)号：US07274965B1
公开(公告)日：2007-09-25
申请号：US11053373
申请日：2005-02-07
申请人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
发明人： Annapurna Karicherla , Kevin L. Morgan , Gene A. Bornzin , Sheldon Williams
IPC分类号： A61N1/00
CPC分类号： A61N1/00
摘要： An apparatus for and method of measuring pressure through a septum in a patient's heart is disclosed. A lead inserted into the right side of a heart is routed through the septum to gain access to the left side of the heart. The lead includes an attachment structure that secures the lead to one or both of the septal walls. The attachment structure may include at least one protruding tine, membrane, inflatable balloon, involuted spiral or J-lead that engage one or more sides of the septum. The lead also includes one or more sensors for measuring cardiac pressure on the left side of the heart and, as necessary, the right side of the heart.
摘要翻译：公开了一种通过患者心脏中的隔膜测量压力的装置和方法。插入心脏右侧的导线穿过隔膜，以进入心脏的左侧。引线包括将引线固定到一个或两个隔膜壁的附接结构。附接结构可以包括接合隔膜的一侧或多侧的至少一个突出的齿，膜，可充气气囊，渐开线螺旋或J-引线。引线还包括一个或多个用于测量心脏左侧的心脏压力和根据需要的心脏的右侧的传感器。

9. 发明授权

US07418868B1 Pressure sensor and method of fabricating such a module 有权
标题翻译：压力传感器及其制造方法
公开(公告)号：US07418868B1
公开(公告)日：2008-09-02
申请号：US11359952
申请日：2006-02-21
申请人： Annapurna Karicherla , Sheldon Williams , Gene A. Bornzin , John W. Poore , Dion F. Davis
发明人： Annapurna Karicherla , Sheldon Williams , Gene A. Bornzin , John W. Poore , Dion F. Davis
IPC分类号： G01L7/00
CPC分类号： G01L19/142 , G01L19/0046 , G01L19/0061 , G01L19/0645
摘要： A body fluid pressure sensor module according to the invention comprises a housing having a first end and a second end and enclosing a pressure sensor. The pressure sensor is electrically coupled to a plurality of electrical conductors extending into the housing through a feedthrough disposed within, and hermetically sealing, the first end of the housing. The housing defines a chamber disposed between the feedthrough and the second end of the housing. The chamber contains a material in communication with the pressure sensor, the material being capable of transmitting pressure variations to the pressure sensor. The plurality of electrical conductors have ends within the housing, and the pressure sensor is mounted on the end of at least one of the conductors. Also disclosed are medical leads incorporating the pressure sensor module, and methods for fabricating the modules. The pressure sensor module is compact, and particularly so where cable conductors are utilized and the sensor is directly mounted on at least one of the cable conductors. The compactness of a pressure sensor module pursuant to the invention facilitates its incorporation into a small diameter, flexible medical lead enhancing its placement within a patient's body, for example, within the left atrium of the heart.
摘要翻译：根据本发明的体液压力传感器模块包括具有第一端和第二端并且包围压力传感器的壳体。压力传感器电耦合到通过设置在壳体的第一端内并且密封地密封壳体中的馈通部延伸到壳体中的多个电导体。壳体限定设置在馈通和壳体的第二端之间的室。该室包含与压力传感器连通的材料，该材料能够将压力变化传递到压力传感器。多个电导体具有在壳体内的端部，并且压力传感器安装在至少一个导体的端部上。还公开了结合压力传感器模块的医疗引线以及用于制造模块的方法。压力传感器模块是紧凑的，特别是在使用电缆导体并且传感器直接安装在至少一个电缆导体上的情况下。根据本发明的压力传感器模块的紧凑性便于其结合到小直径的柔性医疗引线中，从而增强其在患者身体内的放置，例如在心脏的左心房内。

10. 发明授权

US08406902B2 Intrapericardial lead with precurved distal end portion 有权
标题翻译：具有前端远端部分的心包内引线
公开(公告)号：US08406902B2
公开(公告)日：2013-03-26
申请号：US13005448
申请日：2011-01-12
申请人： Kevin L. Morgan , Steven R. Conger , Anna Barlow , Stuart Rosenberg , Wenbo Hou , Michael Yang , Sheldon Williams
发明人： Kevin L. Morgan , Steven R. Conger , Anna Barlow , Stuart Rosenberg , Wenbo Hou , Michael Yang , Sheldon Williams
IPC分类号： A61N1/05
CPC分类号： A61N1/059 , A61N1/057 , A61N1/0587 , A61N2001/058
摘要： The intrapericardial lead includes a lead body having a proximal portion and a flexible, pre-curved distal end portion. The distal end portion carries at least one electrode assembly containing an electrode adapted to engage pericardial tissue. The distal end portion further carries a pre-curved flexible wire member having ends attached to spaced apart points along the distal end portion of the lead body, the flexible wire member having a normally expanded state wherein an intermediate portion of the wire member is spaced apart from the distal end portion, and a generally straightened state wherein the wire member and the distal end portion are disposed in a more parallel, adjacent relationship so as to present a small frontal area to facilitate delivery into the pericardial space. The wire member re-expands to its normal state after delivery into the pericardial space to anchor the distal end portion of the lead body relative to the pericardial tissue.
摘要翻译：心包内引线包括具有近端部分和柔性的预弯曲的远端部分的引线体。远端部分携带至少一个电极组件，其包含适于接合心包组织的电极。远端部分还承载预弯曲的柔性线构件，其具有沿着引线本体的远端部附接到间隔开的点的端部，柔性线构件具有正常膨胀状态，其中线构件的中间部分间隔开以及大致直线状态，其中所述线构件和所述远端部分布置成更平行的相邻关系，以便呈现小的前部区域以便于输送到心包空间中。导线部件在输送到心包空间之后再膨胀至正常状态，以相对于心包组织锚固引线主体的远端部分。

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