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1. 发明授权

US08000790B2 Device for adjusting the sensitivity level of an implantable medical device 有权
标题翻译：用于调节植入式医疗装置的灵敏度水平的装置
公开(公告)号：US08000790B2
公开(公告)日：2011-08-16
申请号：US10576178
申请日：2003-10-27
申请人： Anders Björling , Nils Holmström , Karin Järverud , Martin Obel
发明人： Anders Björling , Nils Holmström , Karin Järverud , Martin Obel
IPC分类号： A61N1/00 , A61B5/04
CPC分类号： A61N1/3704 , A61B5/0452 , A61N1/368
摘要： An implantable cardiac stimulation device has an atrial detector that detects atrial events of a patient's heart, and a memory in which sequences of IEGM signals are stored, having a predetermined length, and an analyzing unit that analyzes the sequences to determine if the stored sequences contain atrial events having a lower amplitude than the current sensitivity setting of the atrial detector. A control unit is connected to the atrial detector to adjust the sensitivity setting thereof to a threshold that is determined based on the aforementioned analysis of the IEGM signals.
摘要翻译：可植入心脏刺激装置具有心房检测器，其检测患者心脏的心房事件，以及存储具有预定长度的IEGM信号序列的存储器，以及分析单元，其分析序列以确定所存储的序列是否包含心房事件的振幅低于心房检测器的当前灵敏度设置。控制单元连接到心房检测器以将其灵敏度设置调整到基于上述对IEGM信号的分析确定的阈值。

2. 发明授权

US07228172B2 Bi-ventricular pacer, system and method 有权
标题翻译：双心室起搏器，系统及方法
公开(公告)号：US07228172B2
公开(公告)日：2007-06-05
申请号：US10734767
申请日：2003-12-13
申请人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
发明人： Karin Järverud , Nils Holmström , Anders Björling , Asa Uhrenius , Sven-Erik Hedberg , Göran Budgifvars , Hans Strandberg
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3684 , A61N1/3712
摘要： An implantable bi-ventricular heart stimulating device and system, suitable for treating congestive heart failure, have a control circuit with first and second pacing circuits and first and second sensing circuits. The device operates with time cycles corresponding to normal heart cycles. The control circuit determines: (a) whether a signal typical of an evoked response to a pacing pulse delivered by the first pacing circuit is sensed within a first time interval and (b) whether a signal typical for an R-wave transferred from the second ventricle, or from some other part of the heart, to the first ventricle is detected within a first time window. The operation of the device depends on whether the conditions (a) and (b) are fulfilled.
摘要翻译：适用于治疗充血性心力衰竭的可植入式双心室心脏刺激装置和系统具有具有第一和第二起搏电路和第一和第二感测电路的控制电路。该装置以对应于正常心脏周期的时间周期运行。控制电路确定：（a）在第一时间间隔内是否感测到由第一起搏电路传送的起搏脉冲的典型诱发响应的信号，以及（b）是否从第二时间间隔传送的R波的典型信号在第一时间窗口内检测到心室或心脏的其他部分到第一脑室。设备的操作取决于条件（a）和（b）是否得到满足。

3. 发明授权

US07979125B2 Implantable biventricular heart stimulating device and method for performing a capture threshold search 有权
标题翻译：可植入的双心室心脏刺激装置和执行捕获阈值搜索的方法
公开(公告)号：US07979125B2
公开(公告)日：2011-07-12
申请号：US12090157
申请日：2005-10-31
申请人： Anders Björling , Nils Holmström , Karin Järverud
发明人： Anders Björling , Nils Holmström , Karin Järverud
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3712
摘要： In an implantable biventricular heart stimulating device, and a biventricular heart stimulating method, wherein operation takes place normally with a time VV between a pacing pulse delivered, or inhibited, by a first ventricular pacing circuit and a pacing pulse delivered, or inhibited, by a second ventricular pacing circuit, and wherein a time VVcts is determined that is to be used instead of VV during a capture threshold search.
摘要翻译：在可植入的双心室心脏刺激装置和双心室心脏刺激方法中，其中手术通常由第一心室起搏电路递送或抑制的起搏脉冲与通过一个或多个第一心室起搏电路递送或抑制的起搏脉冲之间的时间VV进行第二心室起搏电路，并且其中在捕获阈值搜索期间确定要用于代替VV的时间VVcts。

4. 发明授权

US07181279B2 Implantable heart stimulating device, system and method 有权
标题翻译：植入式心脏刺激装置，系统及方法
公开(公告)号：US07181279B2
公开(公告)日：2007-02-20
申请号：US10781171
申请日：2004-02-18
申请人： Anders Björling , Nils Holmström , Karin Järverud
发明人： Anders Björling , Nils Holmström , Karin Järverud
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/3684
摘要： An implantable bi-ventricular heart stimulating device and system operate, within a time cycle, to deliver pacing pulses with both a first and a second pacing circuit with a first time delay between these pacing pulses. The device employs a criterion with which a signal typical for a premature ventricular contraction is detected. The device also operates with a second time delay and/or with a third time delay, and, if a predefined pacing rule is fulfilled, to deliver a pacing pulse with the second time delay or said third time delay. The risk for arrhythmia in connection with a PVC is reduced.
摘要翻译：一种可植入的双心室心脏刺激装置和系统在一个时间周期内操作，以便在这些起搏脉冲之间具有第一和第二起搏电路与第一时间延迟之间输送起搏脉冲。该装置采用标准，通过该标准可以检测出早期心室收缩的典型信号。该装置还以第二时间延迟和/或第三时间延迟进行操作，并且如果满足预定的起搏规则，则以第二时间延迟或所述第三时间延迟递送起搏脉冲。与PVC相关的心律失常风险降低。

5. 发明授权

US07089058B2 Multi-chamber pacing system 失效
标题翻译：多室起搏系统
公开(公告)号：US07089058B2
公开(公告)日：2006-08-08
申请号：US10813776
申请日：2004-03-31
申请人： Sven-Erik Hedberg , Anders Björling , Nils Holmström , Karin Järverud
发明人： Sven-Erik Hedberg , Anders Björling , Nils Holmström , Karin Järverud
IPC分类号： A61N1/368
CPC分类号： A61N1/3702 , A61N1/3684
摘要： A multi-chamber pacing system has a pulse generator for successively delivering pacing pulses to chambers of a patient's heart. Evoked response detectors having blanking intervals following the delivery of pacing pulses include sensing elements for sensing IEGM-signals from each of the heart chambers and an integrating unit that integrates the IEGM-signal within evoked response detection time windows after delivery of pacing pulses for detecting evoked response. The evoked response detection time window for a heart chamber contain at least one blanking interval resulting from delivery of a pacing pulse to another chamber and each of the sensed IEGM signals having a generally known morphology. An integral reconstructing unit reconstructs the time integral of the IEGM signal from one of the heart chambers in the blanking interval following delivery of a pacing pulse to another heart chamber.
摘要翻译：多室起搏系统具有脉冲发生器，用于连续地向患者心脏的腔室输送起搏脉冲。在递送起搏脉冲之后具有消隐间隔的诱发响应检测器包括用于感测来自每个心室的IEGM信号的感测元件和在递送用于检测诱发的起搏脉冲之后的诱发响应检测时间窗口内积分IEGM信号的积分单元响应。心室的诱发反应检测时间窗口包含至少一个消隐间隔，其由将起搏脉冲递送到另一个腔室而产生，每个感测的IEGM信号具有通常已知的形态。整体重建单元在将起搏脉冲递送到另一个心室之后的消隐间隔中的一个心室重建IEGM信号的时间积分。

6. 发明授权

US07069076B2 Multi-chamber pacing system 失效
标题翻译：多室起搏系统
公开(公告)号：US07069076B2
公开(公告)日：2006-06-27
申请号：US10761707
申请日：2004-01-21
申请人： Sven Erik Hedberg , Karin Järverud , Nils Holmström , Anders Björling
发明人： Sven Erik Hedberg , Karin Järverud , Nils Holmström , Anders Björling
IPC分类号： A61N1/36
CPC分类号： A61N1/3702 , A61N1/3684
摘要： A multi-chamber pacing system has a pulse generator for successively delivering pacing pulses to chambers of a patient's heart, and IEGM signal detectors, having blanking intervals following the delivery of pacing pulses, including sensing circuits for sensing IEGM-signals from each of the heart chambers. Each of said sensed IEGM signals has a generally known morphology. A signal-reconstructing unit reconstructs the IEGM signal from one of the heart chambers in the blanking interval following delivery of a pacing pulse to another heart chamber.
摘要翻译：多室起搏系统具有脉冲发生器，用于连续地向患者心脏的腔室输送起搏脉冲，以及IEGM信号检测器，其具有递送起搏脉冲之后的消隐间隔，包括用于感测来自每个心脏的IEGM信号的感测电路房间。所述感测的IEGM信号中的每一个具有通常已知的形态。信号重建单元在将起搏脉冲递送到另一个心室之后的消隐间隔中的一个心室重建IEGM信号。

7. 发明申请

US20100099994A1 IMPLANTABLE HEART ANALYZING DEVICE, SYSTEM AND METHOD 审中-公开
标题翻译：可植入心脏分析装置，系统和方法
公开(公告)号：US20100099994A1
公开(公告)日：2010-04-22
申请号：US12528160
申请日：2007-02-28
申请人： Nils Holmström , Andreas Blomqvist , Berit Larsson , Karin Järverud , Sven-Erik Hedberg
发明人： Nils Holmström , Andreas Blomqvist , Berit Larsson , Karin Järverud , Sven-Erik Hedberg
IPC分类号： A61B5/02
CPC分类号： A61B5/1107 , A61B5/0051 , A61B5/4519 , A61B5/6869 , A61N1/36578
摘要： An implantable heart analyzing device has a housing and a control circuit located within said housing. The control circuit generates an output signal adapted to actuate an activator, which is able to make a wall of the heart deflect or vibrate. The control circuit also communicates with a sensor, which can be identical with the activator, with which the movement of the heart wall can be sensed. The control circuit executes a procedure that involves the generation of an output signal and sensing a corresponding sensor signal, and to be able to derive information concerning the tension of the heart wall. An implantable heart analyzing includes the aforementioned heart analyzing device, as well as the activator and the sensor. The heart analyzing device and the system implement a method that results in generation of the aforementioned information concerning the tension of the heart wall.
摘要翻译：可植入心脏分析装置具有壳体和位于所述壳体内的控制电路。控制电路产生适于致动激活器的输出信号，其能够使心脏的壁发生偏转或振动。控制电路还与传感器通信，传感器可以与激活器相同，通过该传感器可以感测心脏壁的移动。控制电路执行涉及生成输出信号并感测相应的传感器信号的过程，并且能够得出关于心壁的张力的信息。可植入心脏分析包括上述心脏分析装置，以及活化剂和传感器。心脏分析装置和系统实施导致产生上述关于心脏壁张力的信息的方法。

8. 发明申请

US20100041970A1 IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：可植入医疗器械
公开(公告)号：US20100041970A1
公开(公告)日：2010-02-18
申请号：US12532186
申请日：2007-11-27
申请人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
发明人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindkvist , Urban Lönn , Nils Holmström
IPC分类号： A61B5/1459
CPC分类号： A61N1/3702 , A61B5/14542 , A61B5/1459 , A61N1/056 , A61N1/36557
摘要： An implantable medical device has an oxygen sensor adapted to measure the level of oxygen in oxygenized blood, and to generate an oxygen measurement signal in dependence of the level of oxygen. The oxygen sensor is adapted to perform measurements inside the heart, of blood entering the left atrium of a patient's heart. The obtained oxygen measurement signal is compared to a predetermined threshold level and an indication signal is generated in dependence of the comparison. The, indication signal is indicative of the lung functionality of the patient.
摘要翻译：可植入医疗装置具有适于测量氧合血液中的氧气水平的氧传感器，并且根据氧气水平产生氧测量信号。氧传感器适于在心脏内进行血液进入患者心脏左心房的血液。将获得的氧测量信号与预定阈值电平进行比较，并根据比较产生指示信号。该指示信号表示患者的肺功能。

9. 发明授权

US08755874B2 Implantable medical device and method for classifying arrhythmia events 有权
标题翻译：植入式医疗器械和心律失常事件分类方法
公开(公告)号：US08755874B2
公开(公告)日：2014-06-17
申请号：US12989581
申请日：2008-05-07
申请人： Anders Björling , Rupinder Bharmi , Michael Broomé , Karin Järverud
发明人： Anders Björling , Rupinder Bharmi , Michael Broomé , Karin Järverud
IPC分类号： A61B5/04
CPC分类号： A61B5/0464 , A61B5/0809 , A61B5/7264 , A61N1/3622 , A61N1/36585 , A61N1/395 , A61N1/3987
摘要： In an implantable medical device such as an implantable cardiac defibrillator, and a method for classifying arrhythmia events, IEGM signals are analyzed to detect an arrhythmia event and a respiratory pattern of the patient is sensed. At least one respiratory parameter reflecting characteristics of the respiratory pattern of the patient is determined based on the sensed respiratory pattern and a respiratory measure corresponding to a change of a rate of change of the at least one respiratory parameter is calculated. The detected arrhythmia event is classified based on the respiratory measure and the IEGM signals, wherein arrhythmia events that satisfy at least a first criterion is classified as an arrhythmia event requiring therapy.
摘要翻译：在诸如可植入心脏除颤器的可植入医疗装置和用于分类心律失常事件的方法中，分析IEGM信号以检测心律失常事件并感测患者的呼吸模式。基于感测到的呼吸模式来确定反映患者呼吸模式特征的至少一个呼吸参数，并且计算与至少一个呼吸参数的变化率的变化相对应的呼吸测量。基于呼吸测量和IEGM信号对所检测到的心律失常事件进行分类，其中满足至少第一标准的心律失常事件被分类为需要治疗的心律失常事件。

10. 发明授权

US08738120B2 Implantable medical device and method comprising means for detecting and classifying an arrhythmia 有权
标题翻译：可植入医疗装置和方法包括用于检测和分类心律失常的装置
公开(公告)号：US08738120B2
公开(公告)日：2014-05-27
申请号：US13696261
申请日：2010-05-12
申请人： Anders Björling , Malin Hollmark , Tomas Svensson , Stefan Hjelm , Kjell Norén , Karin Järverud
发明人： Anders Björling , Malin Hollmark , Tomas Svensson , Stefan Hjelm , Kjell Norén , Karin Järverud
IPC分类号： A61B5/0468
CPC分类号： A61N1/3621 , A61N1/3622 , A61N1/36521 , A61N1/3704 , A61N1/3962
摘要： An implantable medical device (100) is configured for generating a cardiogenic impedance signal representative of the cardiogenic impedance of at least a portion of a heart (10) of a subject (20) during at least a portion of cardiac cycle. A moment processor (132) calculates a moment parameter value based on the cardiogenic impedance signal. The moment parameter is representative of a weighted sum of impedance amplitudes within a time window centered at defined time instance within the cardiac cycle. The weights of the impedance amplitudes are further dependent on the length in time between the defined time instance and the point of time of the associated impedance amplitude. The moment parameter is of high diagnostic value and is employed by an arrhythmia classifier (132) in order to classify a detected arrhythmia of the heart (10), such as discriminate between hemodynamically stable or unstable arrhythmias and/or supraventricular or ventricular tachycardia.
摘要翻译：可植入医疗装置（100）被配置为在心脏周期的至少一部分期间产生代表受试者（20）的心脏（10）的至少一部分的心源阻抗的心源性阻抗信号。时刻处理器（132）基于心源阻抗信号计算力矩参数值。力矩参数代表以心动周期内规定时间范围为中心的时间窗内的阻抗振幅加权和。阻抗幅度的权重进一步取决于所定义的时间实例和相关联的阻抗幅度的时间点之间的时间长度。时刻参数具有很高的诊断价值，并被心律失常分类器（132）采用，以便将检测到的心脏（10）的心律失常进行分类，例如区分血流动力学稳定或不稳定的心律失常和/或室上或室性心动过速。

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