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1. 发明授权

US4079127A Thymosin alpha 1 失效
标题翻译：胸腺素α1
公开(公告)号：US4079127A
公开(公告)日：1978-03-14
申请号：US766638
申请日：1977-02-08
申请人： Allan L. Goldstein , Teresa L. K. Low , Chun-Yen Lai , Su-Sun Wang
发明人： Allan L. Goldstein , Teresa L. K. Low , Chun-Yen Lai , Su-Sun Wang
IPC分类号： A61K38/00 , C07K14/575 , A61K37/00 , C07C103/52
CPC分类号： C07K14/57581 , A61K38/00 , Y10S930/18
摘要： The amino acid sequence of a biologically active polypeptide hormone isolated from calf thymus termed thymosin .alpha..sub.1 has been determined. Thymosin .alpha..sub.1 is a heat stable acidic molecule composed of 28 amino acid residues. This peptide is one of several present in thymosin fraction 5 which participate in the regulation, differentiation and function of thymic dependent lymphocytes (T cells).
摘要翻译：已经确定了从称为胸腺素α1的小牛胸腺分离的生物活性多肽激素的氨基酸序列。胸腺素α1是由28个氨基酸残基组成的热稳定酸性分子。该肽是参与胸腺依赖淋巴细胞（T细胞）的调节，分化和功能的胸腺素组分5中存在的几种之一。

2. 发明授权

US4543340A Radioimmunoassay of thymosin .beta..sub.4 失效
标题翻译：胸腺素β4的放射免疫测定
公开(公告)号：US4543340A
公开(公告)日：1985-09-24
申请号：US482384
申请日：1983-04-07
申请人： Allan L. Goldstein , Teresa L. K. Low , John McClure , Paul H. Naylor
发明人： Allan L. Goldstein , Teresa L. K. Low , John McClure , Paul H. Naylor
IPC分类号： G01N33/53 , A61K38/22 , A61K39/385 , A61K51/00 , C07K14/00 , C07K14/435 , C07K16/00 , C07K19/00 , G01N33/534 , G01N33/74 , A61K39/00
CPC分类号： G01N33/74 , Y10S436/804 , Y10S436/815 , Y10S930/18
摘要： A radioimmunoassay for the polypeptide thymic hormone thymosin .beta..sub.4 is described. The assay employs a radiolabelled Tyr-C13-thymosin .beta..sub.4 -analogue as probe and a thymosin .beta..sub.4 antibody.
摘要翻译：描述了多肽胸腺激素胸腺素β4的放射免疫测定。该测定采用放射性标记的Tyr-C13-胸腺素β4-类似物作为探针和胸腺素β4抗体。

3. 发明授权

US4297276A Thymosin beta 3 and beta 4 失效
标题翻译：胸腺素β3和β4
公开(公告)号：US4297276A
公开(公告)日：1981-10-27
申请号：US159430
申请日：1980-06-16
申请人： Allan L. Goldstein , Teresa L. K. Low
发明人： Allan L. Goldstein , Teresa L. K. Low
IPC分类号： A61K38/00 , C07K14/575 , C07C103/52 , A61K37/00
CPC分类号： C07K14/57581 , A61K38/00 , Y10S930/18
摘要： Two related polypeptides, thymosin .beta..sub.3 and thymosin .beta..sub.4, have been isolated from Thymosin fraction 5. These peptides have been characterized and sequenced. Thymosin .beta..sub.3 has 50 amino acid residues while thymosin .beta..sub.4 has 43 amino acid residues corresponding identically to the amino terminal 43 amino acids of thymosin .beta..sub.3. The compounds have useful biological activity as evidenced by their ability to induce terminal deoxynucleotidyl transferase (TdT) positive cells in T-cell populations. The invention described herein was made in part in the course of work under a grant or award from the Department of Health, Education and Welfare.
摘要翻译：已经从胸腺素级分5中分离了两种相关多肽，胸腺素β3和胸腺素β4。这些肽已被表征和测序。胸腺素β3具有50个氨基酸残基，而胸腺素β4具有与胸腺素β3的氨基末端43个氨基酸相同的43个氨基酸残基。化合物具有有益的生物学活性，其诱导末端脱氧核苷酸转移酶（TdT） T细胞群体中的阳性细胞。本文描述的发明部分是在卫生，教育和福利部的授予或奖励下的工作过程中进行的。

4. 发明授权

US4395404A Synthetic thymosin .beta..sub.3 and .beta..sub.4 analogues 失效
标题翻译：合成胸腺素β3和β4类似物
公开(公告)号：US4395404A
公开(公告)日：1983-07-26
申请号：US378463
申请日：1982-05-14
申请人： Teresa L. K. Low , Allan L. Goldstein
发明人： Teresa L. K. Low , Allan L. Goldstein
IPC分类号： C07K5/00 , A61K38/00 , A61K38/22 , A61P37/04 , C07K5/083 , C07K5/103 , C07K7/04 , C07K14/575 , A61K37/00 , C07C103/52
CPC分类号： C07K5/1005 , C07K14/57581 , C07K5/0806 , A61K38/00 , Y10S530/837 , Y10S930/18
摘要： Novel peptides representing fragments of thymosin .beta..sub.3 and .beta..sub.4 have been synthesized and are active agents affecting regulation, differentiation and function of thymus dependent lymphocytes and macrophages.
摘要翻译：已经合成了代表胸腺素β3和β4片段的新肽，并且是影响胸腺依赖性淋巴细胞和巨噬细胞的调节，分化和功能的活性剂。

5. 发明授权

US5702707A Diagnostic method and test kit for the serological detection of the AIDS virus 失效
标题翻译：用于艾滋病病毒血清学检测的诊断方法和检测试剂盒
公开(公告)号：US5702707A
公开(公告)日：1997-12-30
申请号：US476555
申请日：1995-06-07
申请人： Allan L. Goldstein , Su Sun Wang
发明人： Allan L. Goldstein , Su Sun Wang
IPC分类号： A61K39/00 , C07K14/16 , C07K16/10 , C07K16/26 , A61K39/12 , A61K39/21 , C07K1/00
CPC分类号： C07K14/005 , C07K16/1054 , C07K16/26 , A61K39/00 , C07K2317/34 , C12N2740/16222 , Y10S435/974 , Y10S435/975 , Y10S530/806 , Y10S530/807 , Y10S530/826 , Y10S930/221
摘要： A peptide of up to about 40 amino acids including the core sequence inclusive of amino acids at positions 92-109 of the p17 gag core protein of HIV-1, such as, Ile-Y.sub.1 -Y.sub.2 -Lys-Asp-Thr-Lys-Glu-Ala-Leu-Y.sub.3 -Lys-Ile-Glu-Glu-Glu-Gln-Asn wherein Y.sub.1 is Asp or Glu, Y.sub.2 is Val or Ile, and Y.sub.3 is Glu or Asp, is effective in inhibiting replication of the HIV virus and provides the basis for a vaccine for treatment or prevention of AIDS.
摘要翻译：包括高达约40个氨基酸的肽，包括核心序列，其包括HIV-1的p17 gag核心蛋白的第92-109位的氨基酸，例如Ile-Y1-Y2-Lys-Asp-Thr-Lys- Glu-Ala-Leu-Y3-Lys-Ile-Glu-Glu-Glu-Gln-Asn，其中Y1是Asp或Glu，Y2是Val或Ile，Y3是Glu或Asp，有效抑制HIV病毒的复制并为艾滋病治疗或预防疫苗提供依据。

6. 发明授权

US5665536A Diagnastic method and test kit for the serological detection of the AIDS virus 失效
标题翻译：艾滋病病毒血清学检测的诊断方法和检测试剂盒
公开(公告)号：US5665536A
公开(公告)日：1997-09-09
申请号：US476647
申请日：1995-06-07
申请人： Allan L. Goldstein , Su-Sun Wang
发明人： Allan L. Goldstein , Su-Sun Wang
IPC分类号： A61K39/00 , C07K14/16 , C07K16/10 , C07K16/26 , C12Q1/70
CPC分类号： C07K14/005 , C07K16/1054 , C07K16/26 , A61K39/00 , C07K2317/34 , C12N2740/16222 , Y10S435/974 , Y10S435/975 , Y10S530/806 , Y10S530/807 , Y10S530/826 , Y10S930/221
摘要： Vaccines effective in the inhibition of infection caused by the family of retroviruses, HTLV-III, Human T-Cell Leukemia Virus, LAV, Lymphadenopathy-associated virus, ARV-2, AIDS-Related Virus, (AIDS and AIDS-Related Complex) have been developed from an antisera prepared against thymosin .alpha..sub.1 (T.alpha..sub.1), a thymic hormone, as well as from antisera to synthetic peptide fragments of T.alpha..sub.1 and antisera to synthetic peptide fragments inclusive of amino acid positions 92-109 of the p17 gag core protein of HTLV-III, LAV and ARV-2. In this 18 amino acid primary sequence there is a 44 to 50% homology between the gag protein and T.alpha..sub.1. Immunoglobulin (IgG)-enriched preparations of the T.alpha..sub.1 antisera have enhanced activity in blocking vital replication. A diagnostic test capable of directly detecting the presence of HTLV-III, LAV, ARV-2 and related retroviruses associated with AIDS and ARC is also described.
摘要翻译：有效抑制由逆转录酶家族HTLV-III，人类T细胞白血病病毒，LAV，淋巴结病毒相关病毒，ARV-2，AIDS相关病毒（AIDS和AIDS相关复合物）引起的感染的疫苗有由抗胸腺素α1（Tα1），胸腺激素制备的抗血清以及来自抗血清的Tα1和抗血清的合成肽片段与合成肽片段（包括p17的氨基酸位置92-109）开发 HTLV-III，LAV和ARV-2的gag核心蛋白。在这个18个氨基酸的一级序列中，gag蛋白和Tα1之间存在44-50％的同源性.Tα1抗血清的免疫球蛋白（IgG）富含的制剂具有增强的阻断重要复制的活性。还描述了能够直接检测与AIDS和ARC相关的HTLV-III，LAV，ARV-2和相关逆转录病毒的存在的诊断测试。

7. 发明授权

US4339427A Radioimmunoassay of thymosin.alpha. 失效
标题翻译：胸腺素α的放射免疫测定
公开(公告)号：US4339427A
公开(公告)日：1982-07-13
申请号：US139944
申请日：1980-04-14
申请人： Allan L. Goldstein , John E. McClure , Su-Sun Wang
发明人： Allan L. Goldstein , John E. McClure , Su-Sun Wang
IPC分类号： G01N33/53 , C07K14/00 , C07K14/575 , G01N33/74 , G01N33/56 , A61K43/00 , C07G7/00
CPC分类号： G01N33/74 , Y10S530/835 , Y10S530/837 , Y10S930/18
摘要： An improved radioimmunoassay for the polypeptidic thymic hormone thymosin.alpha..sub.1 is described. The assay employs a radiolabelled [Tyr.sup.1 ]-thymosin.alpha..sub.1 or [Tyr.sup.1 ]-desacetylthymosin.alpha..sub.1 as probe and an affinity purified thymosin.alpha..sub.1 antibody of improved selectivity.
摘要翻译：描述了用于多肽胸腺激素胸腺素α1的改进的放射免疫测定。该测定采用放射性标记的[Tyr1] - 胸腺素α1或[Tyr1] - 乙酰胸腺素α1作为探针和亲和纯化的胸腺素α1抗体，其提高了选择性。

8. 发明授权

US07268118B2 Thymosin β4 compositions 有权
标题翻译：胸腺素β4组合物
公开(公告)号：US07268118B2
公开(公告)日：2007-09-11
申请号：US10853505
申请日：2004-05-26
申请人： Hynda K. Kleinman , Allan L. Goldstein , Katherine M. Malinda , Gabriel Sosne
发明人： Hynda K. Kleinman , Allan L. Goldstein , Katherine M. Malinda , Gabriel Sosne
IPC分类号： A61K38/00 , A61K38/24
CPC分类号： A61K38/2292 , A61K9/0048 , A61K38/08 , A61K38/1841 , A61K45/06 , Y10S930/18 , A61K2300/00
摘要： A composition with a polypeptide including amino acid sequence LKKTET [SEQ ID NO:1] or a conservative variant thereof, the composition further including a carrier for application to a surface of a body.
摘要翻译：具有包含氨基酸序列LKKTET [SEQ ID NO：1]或其保守变体的多肽的组合物，该组合物还包含用于施用于身体表面的载体。

9. 发明授权

US08716215B2 Method of treating or preventing tissue deterioration, injury or damage due to a neuro-, muscular- or neuro-muscular-degenerative disease, or restore tissue adversely affected by said disease 有权
标题翻译：治疗或预防由于神经，肌肉或神经 - 肌肉退行性疾病引起的组织退化，损伤或损伤或恢复由所述疾病不利影响的组织的方法
公开(公告)号：US08716215B2
公开(公告)日：2014-05-06
申请号：US11813264
申请日：2006-01-13
申请人： Allan L. Goldstein , Jack Finkelstein, Jr.
发明人： Allan L. Goldstein , Jack Finkelstein, Jr.
IPC分类号： A61K38/00 , A61K39/395 , A61P3/04 , A61P25/00 , C07K14/47
CPC分类号： G01N33/5058 , A61K38/08 , A61K38/1774 , A61K38/1841 , A61K38/19 , A61K38/191 , A61K38/193 , A61K38/20 , A61K38/2013 , A61K38/2026 , A61K38/204 , A61K38/2053 , A61K38/2066 , A61K38/208 , A61K38/2086 , A61K38/217 , A61K38/2292 , G01N33/5061
摘要： A method of treatment for treating, preventing, inhibiting or reducing tissue deterioration, injury or damage due to a neuro-, muscular- or neuro-muscular-degenerative disease, or for restoring tissue adversely affected by said disease, in a subject, includes administering to a subject in need of such treatment an effective amount of a composition including a peptide agent including amino acid sequence LKKTET or LKKTNT, a conservative variant thereof, or a peptide agent that stimulates production of an LKKTET or LKKTNT peptide, or a conservative variant thereof, in the tissue.
摘要翻译：一种治疗用于治疗，预防，抑制或减少由于神经，肌肉或神经 - 肌肉退行性疾病或恢复受到所述疾病不利影响的组织的组织退化，损伤或损伤的治疗方法，包括施用对于需要这种治疗的受试者，有效量的包含包含氨基酸序列LKKTET或LKKTNT的肽试剂，其保守变体或刺激LKKTET或LKKTNT肽的产生的肽试剂的组合物或其保守变体，在组织。

10. 发明授权

US08399412B2 Method of treating or preventing tissue deterioration, injury or damage due to periodontal disease or disease of oral mucosa, and/or downregulating NF-kappabeta or supressing NF-kappabeta-mediated actions 有权
标题翻译：治疗或预防由牙周病或口腔粘膜疾病引起的组织退化，损伤或损伤和/或下调NF-κB或抑制NF-κB介导的作用的方法
公开(公告)号：US08399412B2
公开(公告)日：2013-03-19
申请号：US12444331
申请日：2007-10-05
申请人： Gabriel Sosne , Michelle Wheater , Allan L. Goldstein
发明人： Gabriel Sosne , Michelle Wheater , Allan L. Goldstein
IPC分类号： A61K38/17
CPC分类号： A61K38/08 , A61K8/64 , A61K38/2292 , A61Q11/00
摘要： A method of treatment for treating, at least partly preventing, inhibiting or reducing tissue deterioration, injury or damage due to a periodontal disease or disease of oral mucosa, or for restoring tissue adversely affected by the disease, in a subject, and/or for downregulating NF-kappaB or suppressing NF-kappaB mediated action in a body, organ, tissue or cell, includes administering to a subject, body, organ, tissue or cell an effective amount of a composition including a peptide agent including at least one of Thymosin beta 4 (Tβ4), an isoform of Tβ4, an N-terminal fragment of Tβ4, a C-terminal fragment of Tβ4, Tβ4 sulfoxide, an LKKTET peptide or conservative variant thereof, an LKKTNT peptide or conservative variant thereof, a KLKKTET peptide or conservative variant thereof, an LKKTETQ peptide or conservative variant thereof, Tβ4ala, Tβ9, Tβ10, Tβ11, Tβ12, Tβ13, Tβ14, Tβ15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, depactin, DnaseI, vilin, fragmin, severin, capping protein, β-actinin, acumentin, an actin-sequestering peptide, an actin binding peptide, an actin-mobilizing peptide, an actin polymerization-modulating peptide, or a stimulating agent that stimulates production of an effective amount of the peptide agent in the subject, body, organ, tissue or cell.
摘要翻译：一种治疗方法，用于治疗，至少部分地预防，抑制或减少由于牙周疾病或口腔粘膜疾病引起的组织退化，损伤或损伤，或用于恢复患者受到不良影响的组织，和/或用于在身体，器官，组织或细胞中下调NF-κB或抑制NF-κB介导的作用，包括向受试者，身体，器官，组织或细胞施用有效量的组合物，所述组合物包括包含至少一种胸腺素的肽试剂 β4（T＆bgr; 4），T＆bgr的同种型; 4，T＆bgr的N末端片段; 4，T＆bgr; 4，T＆bgr; 4亚砜的C末端片段，LKKTET肽或其保守变体，LKKTNT 肽或其保守变体，KLKKTET肽或其保守变体，LKKTETQ肽或其保守变体，T＆bgr; 4ala，T＆bgr; 9，T＆bgr; 10，T＆bgr; 11，T＆bgr; 12，T＆bgr; 13，T＆bgr; T＆Bgr; 15，凝溶胶蛋白，维生素D结合蛋白（DBP），profilin，cof 肌动蛋白结合肽，肌动蛋白动员肽，肌动蛋白聚合调节肽或刺激剂，肌动蛋白结合肽，肌动蛋白动员肽，肌动蛋白聚合调节肽，其刺激受试者，身体，器官，组织或细胞中有效量的肽试剂的产生。

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