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1. 发明授权

US08810237B2 Relative angle detection device, rotation angle detection device, relative angle detection method, and rotation angle detection method 有权
标题翻译：相对角度检测装置，旋转角度检测装置，相对角度检测方法和旋转角度检测方法
公开(公告)号：US08810237B2
公开(公告)日：2014-08-19
申请号：US13512555
申请日：2010-06-30
申请人： Hiroyuki Muto , Kiyokazu Okado , Tsukasa Suzuki
发明人： Hiroyuki Muto , Kiyokazu Okado , Tsukasa Suzuki
IPC分类号： G01B7/14
CPC分类号： G01D5/04 , G01D5/145
摘要： Disclosed is a relative angle detection device for detecting a relative angle between a first rotary shaft and a second rotary shaft, the relative angle detection device being provided with a first magnetic field sensing unit which outputs a value according to a magnetic field of a magnet, a second magnetic field sensing unit which outputs a value according to the magnetic field of the magnet and outputs a value different from the output value of the first magnetic field sensing unit even if being placed in the same magnetic field as that of the first magnetic field sensing unit, a correction unit which corrects one output value out of the output value of the first magnetic field sensing unit and the output value of the second magnetic field sensing unit in accordance with an amplitude ratio between magnetic field components orthogonal to each other in the magnetic field of the magnet, and a computing unit which computes the relative angle between the first rotary shaft and the second rotary shaft on the basis of the one output value corrected by the correction unit and the other output value different from the one output value. Consequently, a technique capable of detecting the relative rotation angle with high accuracy is provided even if magnitudes of amplitudes of magnetic field components orthogonal to each other in the magnetically sensitive surface of the magnetic field sensing unit are different from each other.
摘要翻译：公开了一种相对角度检测装置，用于检测第一旋转轴和第二旋转轴之间的相对角度，该相对角度检测装置设置有第一磁场感测单元，其输出根据磁体的磁场的值，第二磁场感测单元，其输出与磁体的磁场相对应的值，即使与第一磁场的磁场相同，也输出与第一磁场检测单元的输出值不同的值检测单元，校正单元，其根据第一磁场感测单元的输出值中的一个输出值和第二磁场感测单元的输出值，根据在第二磁场感测单元中彼此正交的磁场分量之间的振幅比磁体的磁场以及计算第一旋转轴与第二旋转轴之间的相对角度的计算单元基于由校正单元校正的一个输出值和与一个输出值不同的另一个输出值的旋转轴。因此，即使在磁场感测单元的磁敏感表面中彼此正交的磁场分量的幅度的大小彼此不同，也能够提供能够高精度地检测相对旋转角度的技术。

2. 发明申请

US20130330345A1 MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII 有权
标题翻译：具有替代功能的多特异性抗原结合分子对血液凝血因子VIII的功能
公开(公告)号：US20130330345A1
公开(公告)日：2013-12-12
申请号：US13885421
申请日：2011-11-17
申请人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
发明人： Tomoyuki Igawa , Zenjiro Sampei , Tetsuo Kojima , Tetsuhiro Soeda , Atsushi Muto , Takehisa Kitazawa , Yukiko Nishida , Chifumi Imai , Tsukasa Suzuki , Kazutaka Yoshihashi
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , C07K16/36 , C07K2317/31 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/94
摘要： Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
摘要翻译：各种双特异性抗体特异性结合血液凝固因子IX /活化血液凝固因子IX和血液凝固因子X，并功能取代血液凝固因子VIII的辅因子功能，即促进凝血因子X活化的功能活化血液凝固因子IX。从这些抗体中，成功发现了具有高功能取代凝血因子VIII活性的多特异性抗原结合分子。

3. 发明申请

US20090297503A1 Blood Coagulation Factor VIII Activation-Enhancing Antibodies 有权
标题翻译：血液凝固因子VIII激活增强抗体
公开(公告)号：US20090297503A1
公开(公告)日：2009-12-03
申请号：US12395909
申请日：2009-03-02
申请人： Masahiro Takeyama , Keiji Nogami , Midori Shima , Tsukasa Suzuki
发明人： Masahiro Takeyama , Keiji Nogami , Midori Shima , Tsukasa Suzuki
IPC分类号： A61K39/395 , C07K16/00 , A61P7/00
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： For the first time, the present invention provides antibodies that enhance the generation of activated blood coagulation factor VIII. The antibodies enhance the cleavage of blood coagulation factor VIII at the Arg of position 372 and suppress the cleavage at the Arg of position 336 by recognizing and binding to the A2 domain of blood coagulation Factor VIII. Such antibodies are expected to be useful in preventing or treating diseases that develop or progress due to decrease or loss of the blood coagulation factor VIII activity, for example, hemophilia A, acquired hemophilia, and von Willebrand's disease.
摘要翻译：本发明首次提供增强活化凝血因子VIII产生的抗体。抗体增强了位置372的Arg处的凝血因子VIII的切割，并通过识别和结合凝血因子VIII的A2结构域来抑制位置336的Arg的切割。预期这样的抗体可用于预防或治疗由于凝血因子VIII活性降低或丧失而发展或进展的疾病，例如血友病A，获得性血友病和血管性血友病。

4. 发明授权

US5147515A Method for forming ceramic films by anode-spark discharge 失效
标题翻译：通过阳极喷射形成陶瓷膜的方法
公开(公告)号：US5147515A
公开(公告)日：1992-09-15
申请号：US573703
申请日：1990-08-28
申请人： Haruo Hanagata , Tsukasa Suzuki , Kazuo Yanagida , Hidesato Igarashi
发明人： Haruo Hanagata , Tsukasa Suzuki , Kazuo Yanagida , Hidesato Igarashi
IPC分类号： C25D9/06
CPC分类号： C25D13/02
摘要： A method for forming a ceramics film on the surface of a substrate comprises performing spark discharge in an electrolytic bath, wherein the electrolytic bath comprises an aqueous solution of a water-soluble or colloidal silicate and/or an oxyacid salt to which ceramics fine particles and/or specific fine particles are dispersed and the spark discharge is carried out in the electrolytic bath while ensuring the suspended state of the ceramics particles and/or the specific fine particles in the electrolytic bath. The method makes it possible to effectively form, on the surface of a metal substrate, ceramics films having a variety of color tones as well as excellent insulating properties and hardness. Moreover, it further makes it possible to effectively form a composite ceramics film having excellent wear resistance on the surface of a metal substrate.
摘要翻译：在基板表面上形成陶瓷膜的方法包括在电解槽中进行火花放电，其中所述电解槽包括水溶性或胶态硅酸盐和/或含氧酸盐的水溶液，陶瓷细颗粒和 /或特定的细颗粒分散，并且在电解浴中进行火花放电，同时确保电解浴中的陶瓷颗粒和/或特定细颗粒的悬浮状态。该方法可以在金属基材的表面上有效地形成具有各种色调的陶瓷膜以及优异的绝缘性能和硬度。此外，还可以有效地形成在金属基板的表面上具有优异的耐磨性的复合陶瓷膜。

5. 发明申请

US20140248282A1 NOVEL ANTI-DDR1 ANTIBODY HAVING ANTI-TUMOR ACTIVITY 有权
标题翻译：具有抗肿瘤活性的新型抗DDR1抗体
公开(公告)号：US20140248282A1
公开(公告)日：2014-09-04
申请号：US14240057
申请日：2012-08-23
申请人： Mei Ono , Yuji Sano , Tsukasa Suzuki
发明人： Mei Ono , Yuji Sano , Tsukasa Suzuki
IPC分类号： C07K16/40 , A61K39/395 , A61K47/48
CPC分类号： C07K16/40 , A61K39/3955 , A61K2039/505 , C07K16/2851 , C07K16/3023 , C07K2317/34 , C07K2317/76 , C07K2317/77
摘要： As a result of producing anti-DDR1 antibodies and conducting extensive studies on the antitumor activity thereof, antibodies that bind to the stalk domain in the amino acid sequence of human DDR1 were found to have a potent activity even when used alone compared to antibodies that bind to other domains. It was also found that the antibodies have one or more activities selected from the group consisting of: (i) an activity to suppress cell proliferation, (ii) an activity to inhibit cell migration, (iii) an activity to inhibit phosphorylation of DDR1 in cells, (iv) an activity to be taken up into cells, (v) an activity to decrease the expression level of DDR1 in cells, and (vi) an activity to decrease the expression level of TGF-β in cells.
摘要翻译：作为产生抗DDR1抗体并对其抗肿瘤活性进行广泛研究的结果，发现结合人DDR1的氨基酸序列中的茎结构域的抗体即使在单独使用时与具有结合力的抗体相比也具有有效活性到其他域。还发现抗体具有选自以下的一种或多种活性：（i）抑制细胞增殖的活性，（ii）抑制细胞迁移的活性，（iii）抑制DDR1磷酸化的活性细胞，（iv）被摄入细胞的活性，（v）降低细胞中DDR1表达水平的活性，和（vi）降低TGF-β1的表达水平的活性; 在细胞中。

6. 发明申请

US20120256619A1 RELATIVE ANGLE DETECTION DEVICE, ROTATION ANGLE DETECTION DEVICE, RELATIVE ANGLE DETECTION METHOD, AND ROTATION ANGLE DETECTION METHOD 有权
标题翻译：相对角度检测装置，旋转角度检测装置，相对角度检测方法和旋转角度检测方法
公开(公告)号：US20120256619A1
公开(公告)日：2012-10-11
申请号：US13512555
申请日：2010-06-30
申请人： Hiroyuki Muto , Kiyokazu Okado , Tsukasa Suzuki
发明人： Hiroyuki Muto , Kiyokazu Okado , Tsukasa Suzuki
IPC分类号： G01B7/30
CPC分类号： G01D5/04 , G01D5/145
摘要： Disclosed is a relative angle detection device for detecting a relative angle between a first rotary shaft and a second rotary shaft, the relative angle detection device being provided with a first magnetic field sensing unit which outputs a value according to a magnetic field of a magnet, a second magnetic field sensing unit which outputs a value according to the magnetic field of the magnet and outputs a value different from the output value of the first magnetic field sensing unit even if being placed in the same magnetic field as that of the first magnetic field sensing unit, a correction unit which corrects one output value out of the output value of the first magnetic field sensing unit and the output value of the second magnetic field sensing unit in accordance with an amplitude ratio between magnetic field components orthogonal to each other in the magnetic field of the magnet, and a computing unit which computes the relative angle between the first rotary shaft and the second rotary shaft on the basis of the one output value corrected by the correction unit and the other output value different from the one output value. Consequently, a technique capable of detecting the relative rotation angle with high accuracy is provided even if magnitudes of amplitudes of magnetic field components orthogonal to each other in the magnetically sensitive surface of the magnetic field sensing unit are different from each other.
摘要翻译：公开了一种相对角度检测装置，用于检测第一旋转轴和第二旋转轴之间的相对角度，该相对角度检测装置设置有第一磁场感测单元，其输出根据磁体的磁场的值，第二磁场感测单元，其输出与磁体的磁场相对应的值，即使与第一磁场的磁场相同，也输出与第一磁场检测单元的输出值不同的值检测单元，校正单元，其根据第一磁场感测单元的输出值中的一个输出值和第二磁场感测单元的输出值，根据在第二磁场感测单元中彼此正交的磁场分量之间的振幅比磁体的磁场以及计算第一旋转轴与第二旋转轴之间的相对角度的计算单元基于由校正单元校正的一个输出值和与一个输出值不同的另一个输出值的旋转轴。因此，即使在磁场感测单元的磁敏感表面中彼此正交的磁场分量的幅度的大小彼此不同，也能够提供能够高精度地检测相对旋转角度的技术。

7. 发明授权

US08252287B2 Blood coagulation factor VIII activation-enhancing antibodies 有权
标题翻译：血液凝固因子VIII激活增强抗体
公开(公告)号：US08252287B2
公开(公告)日：2012-08-28
申请号：US12395909
申请日：2009-03-02
申请人： Masahiro Takeyama , Keiji Nogami , Midori Shima , Tsukasa Suzuki
发明人： Masahiro Takeyama , Keiji Nogami , Midori Shima , Tsukasa Suzuki
IPC分类号： A61K39/395
CPC分类号： C07K16/36 , A61K2039/505 , C07K2317/56 , C07K2317/565
摘要： For the first time, the present invention provides antibodies that enhance the generation of activated blood coagulation factor VIII. The antibodies enhance the cleavage of blood coagulation factor VIII at the Arg of position 372 and suppress the cleavage at the Arg of position 336 by recognizing and binding to the A2 domain of blood coagulation Factor VIII. Such antibodies are expected to be useful in preventing or treating diseases that develop or progress due to decrease or loss of the blood coagulation factor VIII activity, for example, hemophilia A, acquired hemophilia, and von Willebrand's disease.
摘要翻译：本发明首次提供增强活化凝血因子VIII产生的抗体。抗体增强了位置372的Arg处的凝血因子VIII的切割，并通过识别和结合凝血因子VIII的A2结构域来抑制位置336的Arg的切割。预期这样的抗体可用于预防或治疗由于凝血因子VIII活性降低或丧失而发展或进展的疾病，例如血友病A，获得性血友病和血管性血友病。

8. 发明授权

US09175091B2 Monoclonal antibody capable of binding to anexelekto, and use thereof 有权
标题翻译：能够结合细胞毒素的单克隆抗体及其用途
公开(公告)号：US09175091B2
公开(公告)日：2015-11-03
申请号：US12742947
申请日：2008-11-14
申请人： Takehisa Kitazawa , Tsukasa Suzuki , Shigehisa Nagahashi , Hajime Miyamoto
发明人： Takehisa Kitazawa , Tsukasa Suzuki , Shigehisa Nagahashi , Hajime Miyamoto
IPC分类号： C07K16/00 , C07K16/32 , C07K16/40 , A61K39/00
CPC分类号： C07K16/32 , A01K2267/0331 , A61K2039/505 , C07K16/40 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2319/30
摘要： The present inventors have succeeded in producing anti-AXL antibodies with specific functions. The present inventors also discovered that the antibodies have an angiogenesis-suppressive effect and an antitumor effect, and thereby completed the present invention. The anti-AXL antibodies of the present invention are useful as angiogenesis inhibitors and agents for inducing or inhibiting phosphorylation activity.
摘要翻译：本发明人成功地制备了具有特定功能的抗AXL抗体。本发明人还发现，抗体具有血管发生抑制作用和抗肿瘤作用，从而完成了本发明。本发明的抗AXL抗体可用作血管生成抑制剂和诱导或抑制磷酸化活性的药剂。

9. 发明申请

US20110044984A1 Monoclonal Antibody Capable of Binding to Anexelekto, and Use Thereof 有权
标题翻译：能够与Anexelekto结合的单克隆抗体及其用途
公开(公告)号：US20110044984A1
公开(公告)日：2011-02-24
申请号：US12742947
申请日：2008-11-14
申请人： Takehisa Kitazawa , Tsukasa Suzuki , Shigehisa Nagahashi , Hajime Miyamoto
发明人： Takehisa Kitazawa , Tsukasa Suzuki , Shigehisa Nagahashi , Hajime Miyamoto
IPC分类号： A61K39/395 , C07K16/32 , C12N5/00 , A61P35/00
CPC分类号： C07K16/32 , A01K2267/0331 , A61K2039/505 , C07K16/40 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2319/30
摘要： The present inventors have succeeded in producing anti-AXL antibodies with specific functions. The present inventors also discovered that the antibodies have an angiogenesis-suppressive effect and an antitumor effect, and thereby completed the present invention. The anti-AXL antibodies of the present invention are useful as angiogenesis inhibitors and agents for inducing or inhibiting phosphorylation activity.
摘要翻译：本发明人成功地制备了具有特定功能的抗AXL抗体。本发明人还发现，抗体具有血管发生抑制作用和抗肿瘤作用，从而完成了本发明。本发明的抗AXL抗体可用作血管生成抑制剂和诱导或抑制磷酸化活性的药剂。

10. 发明授权

US07517965B2 Non-neutralizing anti-aPC antibodies 有权
标题翻译：非中和抗APC抗体
公开(公告)号：US07517965B2
公开(公告)日：2009-04-14
申请号：US10522086
申请日：2003-07-17
申请人： Takaki Koga , Tsukasa Suzuki , Hiroyuki Saito
发明人： Takaki Koga , Tsukasa Suzuki , Hiroyuki Saito
IPC分类号： C07K16/00
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/565 , C07K2317/76
摘要： The present invention provides anti-aPC antibodies that suppress the inactivation of activated protein C (aPC), and uses thereof. The present inventors screened anti-aPC antibodies, and succeeded in isolating anti-aPC antibodies comprising the activity of suppressing aPC inactivation in blood. The antibodies of the present invention can be used to maintain aPC activity by suppressing aPC inactivation, and can thus be used to sustain aPC bioactivities, such as the activity of suppressing activation of the blood coagulation system, and anti-inflammatory activity. In addition, the present invention provides uses of the antibodies of the present invention in aPC therapy for diseases such as thrombosis and sepsis. The therapeutic effect of aPC can be prolonged in treatment that uses aPC administration by allowing an antibody of the present invention to bind with aPC. The antibodies of the present invention can be used in the treatment and prevention of diseases such as thrombosis and sepsis.
摘要翻译：本发明提供抑制活化蛋白C（aPC）失活的抗-APC抗体及其用途。本发明人筛选了抗-APC抗体，并成功地分离了包含抑制血液中的aPC失活活性的抗-APC抗体。本发明的抗体可用于通过抑制aPC灭活来维持PCPC活性，因此可用于维持aPC生物活性，例如抑制血液凝固系统活化的活性和抗炎活性。此外，本发明提供本发明的抗体在aPC治疗中用于血栓形成和败血症等疾病的用途。通过使本发明的抗体与aPC结合，可以延长使用aPC施用的治疗中aPC的治疗效果。本发明的抗体可用于治疗和预防诸如血栓形成和败血症等疾病。

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