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1. 发明申请

US20140248282A1 NOVEL ANTI-DDR1 ANTIBODY HAVING ANTI-TUMOR ACTIVITY 有权
标题翻译：具有抗肿瘤活性的新型抗DDR1抗体
公开(公告)号：US20140248282A1
公开(公告)日：2014-09-04
申请号：US14240057
申请日：2012-08-23
申请人： Mei Ono , Yuji Sano , Tsukasa Suzuki
发明人： Mei Ono , Yuji Sano , Tsukasa Suzuki
IPC分类号： C07K16/40 , A61K39/395 , A61K47/48
CPC分类号： C07K16/40 , A61K39/3955 , A61K2039/505 , C07K16/2851 , C07K16/3023 , C07K2317/34 , C07K2317/76 , C07K2317/77
摘要： As a result of producing anti-DDR1 antibodies and conducting extensive studies on the antitumor activity thereof, antibodies that bind to the stalk domain in the amino acid sequence of human DDR1 were found to have a potent activity even when used alone compared to antibodies that bind to other domains. It was also found that the antibodies have one or more activities selected from the group consisting of: (i) an activity to suppress cell proliferation, (ii) an activity to inhibit cell migration, (iii) an activity to inhibit phosphorylation of DDR1 in cells, (iv) an activity to be taken up into cells, (v) an activity to decrease the expression level of DDR1 in cells, and (vi) an activity to decrease the expression level of TGF-β in cells.
摘要翻译：作为产生抗DDR1抗体并对其抗肿瘤活性进行广泛研究的结果，发现结合人DDR1的氨基酸序列中的茎结构域的抗体即使在单独使用时与具有结合力的抗体相比也具有有效活性到其他域。还发现抗体具有选自以下的一种或多种活性：（i）抑制细胞增殖的活性，（ii）抑制细胞迁移的活性，（iii）抑制DDR1磷酸化的活性细胞，（iv）被摄入细胞的活性，（v）降低细胞中DDR1表达水平的活性，和（vi）降低TGF-β1的表达水平的活性; 在细胞中。

2. 发明授权

US09550835B2 Anti-DDR1 antibody having anti-tumor activity 有权
标题翻译：抗DDR1抗体具有抗肿瘤活性
公开(公告)号：US09550835B2
公开(公告)日：2017-01-24
申请号：US14240057
申请日：2012-08-23
申请人： Mei Ono , Yuji Sano , Tsukasa Suzuki
发明人： Mei Ono , Yuji Sano , Tsukasa Suzuki
IPC分类号： C07K16/40 , C07K16/28 , C07K16/30 , A61K39/395 , A61K47/48 , A61K39/00
CPC分类号： C07K16/40 , A61K39/3955 , A61K2039/505 , C07K16/2851 , C07K16/3023 , C07K2317/34 , C07K2317/76 , C07K2317/77
摘要： As a result of producing anti-DDR1 antibodies and conducting extensive studies on the antitumor activity thereof, antibodies that bind to the stalk domain in the amino acid sequence of human DDR1 were found to have a potent activity even when used alone compared to antibodies that bind to other domains. It was also found that the antibodies have one or more activities selected from the group consisting of: (i) an activity to suppress cell proliferation, (ii) an activity to inhibit cell migration, (iii) an activity to inhibit phosphorylation of DDR1 in cells, (iv) an activity to be taken up into cells, (v) an activity to decrease the expression level of DDR1 in cells, and (vi) an activity to decrease the expression level of TGF-β in cells.
摘要翻译：作为产生抗DDR1抗体并对其抗肿瘤活性进行广泛研究的结果，发现结合人DDR1的氨基酸序列中的茎结构域的抗体即使在单独使用时与具有结合力的抗体相比也具有有效活性到其他域。还发现抗体具有选自以下的一种或多种活性：（i）抑制细胞增殖的活性，（ii）抑制细胞迁移的活性，（iii）抑制DDR1磷酸化的活性细胞，（iv）被摄入细胞的活性，（v）降低细胞中DDR1表达水平的活性，和（vi）降低细胞中TGF-β表达水平的活性。

3. 发明授权

US08304686B2 Laser shock hardening method and apparatus 有权
标题翻译：激光冲击硬化方法和装置
公开(公告)号：US08304686B2
公开(公告)日：2012-11-06
申请号：US12724953
申请日：2010-03-16
申请人： Yuji Sano , Naruhiko Mukai , Masaki Yoda , Yoshiaki Ono , Ryoichi Saeki , Hideki Naito
发明人： Yuji Sano , Naruhiko Mukai , Masaki Yoda , Yoshiaki Ono , Ryoichi Saeki , Hideki Naito
IPC分类号： B23K26/00 , B23K26/12 , C21D7/06 , B23K26/18
CPC分类号： B23K26/356 , B23K26/00 , B23K26/0006 , B23K26/0622 , B23K26/067 , B23K26/0676 , B23K26/0876 , B23K26/106 , B23K26/1224 , B23K26/352 , B23K2103/04 , B23K2103/05 , B23K2103/50 , B23K2103/52
摘要： There is provided an improved laser shock hardening method and apparatus which can eliminate spattering of a liquid and waving of the liquid surface upon laser irradiation, and can stably irradiate a workpiece with a laser beam. Thus, the present invention provides in a laser shock hardening method for carrying out surface processing of a workpiece in contact with a liquid by irradiating through the liquid the surface of the workpiece with a pulsed laser beam intermittently emitted from a laser irradiation device, the improvement comprising: providing a solid transparent to the wavelength of the laser, serving as an entrance window to the surface of the liquid; allowing the liquid to be present in the light path of the laser beam between the solid and the surface of the workpiece; and allowing the laser beam to enter through the solid and irradiating through the liquid the surface of the workpiece with the laser beam, thereby shock-hardening the surface of the workpiece.
摘要翻译：提供了一种改进的激光冲击硬化方法和装置，其可以在激光照射时消除液体的飞溅和液面的挥动，并且可以用激光束稳定地照射工件。因此，本发明提供了一种激光冲击硬化方法，用于通过从激光照射装置间歇地发射的脉冲激光束照射通过液体的工件的表面来进行与液体接触的工件的表面处理，改进包括：提供对激光波长透明的固体，用作到液体表面的入口窗口; 允许液体存在于固体和工件表面之间的激光束的光路中; 并允许激光束通过固体进入并用激光束照射通过液体的工件的表面，从而对工件的表面进行冲击硬化。

4. 发明授权

US07710351B2 Load drive circuit and display device using the same 失效
标题翻译：负载驱动电路和使用其的显示装置
公开(公告)号：US07710351B2
公开(公告)日：2010-05-04
申请号：US10948300
申请日：2004-09-24
申请人： Yuji Sano , Toyoshi Kawada , Yoshinori Okada
发明人： Yuji Sano , Toyoshi Kawada , Yoshinori Okada
IPC分类号： G09G3/28
CPC分类号： G09G3/296 , G09G2320/0223 , G09G2330/06
摘要： A load drive circuit, successfully suppressed in unnecessary electromagnetic wave generation through suppressing transition time in the drive voltage waveform even under a reduced effective load, and a display device using this circuit are provided, wherein the circuit comprises a drive circuit inversively amplifying a signal, used for driving a load, input through an input terminal, and output from an output terminal; a first current source connected to the input terminal of the drive circuit and being capable of controlling current output; and a first switch circuit connected between the input terminal of the drive circuit and a first reference potential point.
摘要翻译：一种负载驱动电路，即使在降低的有效负载的情况下，通过抑制驱动电压波形中的转换时间也成功地抑制了不必要的电磁波生成，并且提供了使用该电路的显示装置，其中，该电路包括反向放大信号的驱动电路，用于驱动负载，通过输入端输入，并从输出端输出; 连接到驱动电路的输入端并能够控制电流输出的第一电流源; 以及连接在驱动电路的输入端和第一参考电位之间的第一开关电路。

5. 发明授权

US06781564B2 Display apparatus 失效
标题翻译：显示装置
公开(公告)号：US06781564B2
公开(公告)日：2004-08-24
申请号：US10320550
申请日：2002-12-17
申请人： Makoto Onozawa , Yuji Sano , Michitaka Ohsawa , Takashi Sasaki , Noboru Akiyama , Fumitaka Asami , Kazuo Yoshiikawa , Hitoshi Hirakawa , Tomokatsu Kishi , Toyoshi Kawada
发明人： Makoto Onozawa , Yuji Sano , Michitaka Ohsawa , Takashi Sasaki , Noboru Akiyama , Fumitaka Asami , Kazuo Yoshiikawa , Hitoshi Hirakawa , Tomokatsu Kishi , Toyoshi Kawada
IPC分类号： G09G328
CPC分类号： G09G3/2965 , G09G3/2927 , G09G3/293 , G09G3/294 , G09G3/296
摘要： A display apparatus includes a display panel including address electrodes and sustain electrodes crossing the address electrodes, with pixels being sandwiched between the address electrodes and the sustain electrodes. A sustain-electrode drive circuit selectively generates both sustain pulses and scan pulses and supplies them to the sustain electrodes. An address-electrode drive circuit generates address pulses based on a video signal and supplies the address pulses to the address electrodes. A control-signal generation circuit generates a control signal for controlling the sustain-electrode drive circuit to generate a selected one of the sustain pulses and the scan pulses and supplies the control signal to the sustain-electrode drive circuit. In order to display an image on the display panel, the sustain-electrode drive circuit both specifies addresses of pixels to be turned on and turns on the pixels at the specified addresses.
摘要翻译：显示装置包括显示面板，包括寻址电极和与寻址电极交叉的维持电极，像素被夹在寻址电极和维持电极之间。维持电极驱动电路选择性地产生维持脉冲和扫描脉冲，并将它们提供给维持电极。地址电极驱动电路基于视频信号产生寻址脉冲，并将地址脉冲提供给地址电极。控制信号生成电路生成用于控制维持电极驱动电路以产生维持脉冲和扫描脉冲中选择的一个的控制信号，并将控制信号提供给维持电极驱动电路。为了在显示面板上显示图像，维持电极驱动电路都指定要打开的像素的地址，并打开指定地址处的像素。

6. 发明授权

US06703702B2 IC chip mounting structure and display device 失效
标题翻译： IC芯片安装结构和显示装置
公开(公告)号：US06703702B2
公开(公告)日：2004-03-09
申请号：US10202831
申请日：2002-07-26
申请人： Hirokazu Inoue , Toyoshi Kawada , Yuji Sano
发明人： Hirokazu Inoue , Toyoshi Kawada , Yuji Sano
IPC分类号： H01L2306
CPC分类号： H01L23/552 , G02F1/13452 , H01L23/057 , H01L23/36 , H01L23/5387 , H01L24/97 , H01L2224/16225 , H01L2224/32225 , H01L2224/73204 , H01L2924/01079 , H01L2924/01322 , H01L2924/14 , H01L2924/16152 , H01L2924/3011 , H05K1/147 , H05K1/189 , H01L2924/00
摘要： IC CHIP MOUNTING STRUCTURE has IC chips having protruding electrodes, a flexible printed circuit board having conductors connected to the protruding electrodes of the IC chips, and a protective plate attached to the flexible printed circuit board. The protective plate has openings to accommodate the driver IC chips. A resin member having a high heat conductivity is arranged in the opening in contact with the surface of the IC chip. The IC chip mounting structure can be attached to a chassis of a plasma display device so that heat generated by the driver IC chip is transferred to the chassis via the heat conductive resin member.
摘要翻译： IC芯片安装结构具有具有突出电极的IC芯片，具有连接到IC芯片的突出电极的导体的柔性印刷电路板以及附接到柔性印刷电路板的保护板。保护板具有容纳驱动器IC芯片的开口。具有高导热性的树脂构件布置在与IC芯片的表面接触的开口中。 IC芯片安装结构可以安装到等离子体显示装置的底盘上，使得由驱动IC芯片产生的热量经由导热树脂部件传送到底架。

7. 发明授权

US06686895B2 Display unit for displaying an image based on a video signal received from a personal computer which is connected to an input device 失效
公开(公告)号：US06686895B2
公开(公告)日：2004-02-03
申请号：US09863261
申请日：2001-05-24
申请人： Ikuya Arai , Kouji Kitou , Yuji Sano
发明人： Ikuya Arai , Kouji Kitou , Yuji Sano
IPC分类号： G09G106
CPC分类号： G09G1/167 , G06F3/14 , G09G1/165 , G09G5/006 , G09G2320/08 , G09G2330/021 , G09G2340/02 , G09G2340/125 , G09G2360/18 , G09G2370/04 , G09G2370/045
摘要： An image display apparatus capable of adjusting a display picture by an input unit through a computer body is disclosed. When the user inputs a control instruction for adjusting the display picture of the display unit by the input unit connected to the computer body, a control signal addition circuit prepares a control signal Sc corresponding to the control instruction and adds the control signal to a video signal R, G or B or a synchronizing signal Hs or Vs produced by a display control circuit during a vertical retrace period. A control signal separation circuit separates the added control signal Sc from the video signal R, G or B or the synchronizing signal Hs or Vs produced by the control signal addition circuit. A display control circuit produces adjustment signals Sa and Sb on the basis of the control signal from the control signal separation circuit to adjust a video circuit and a deflection circuit. Thus, the user can adjust the display picture by the input unit near at hand without extending the hands to adjustment switches of the display unit.

8. 发明授权

US06639588B2 Image display apparatus 失效
公开(公告)号：US06639588B2
公开(公告)日：2003-10-28
申请号：US10166691
申请日：2002-06-12
申请人： Ikuya Arai , Kouji Kitou , Yuji Sano
发明人： Ikuya Arai , Kouji Kitou , Yuji Sano
IPC分类号： G09G106
CPC分类号： G09G1/167 , G06F3/14 , G09G1/165 , G09G5/006 , G09G2320/08 , G09G2330/021 , G09G2340/02 , G09G2340/125 , G09G2360/18 , G09G2370/04 , G09G2370/045
摘要： An image display apparatus capable of adjusting a display picture by an input unit through a computer body is disclosed. When the user inputs a control instruction for adjusting the display picture of the display unit by the input unit connected to the computer body, a control signal addition circuit prepares a control signal Sc corresponding to the control instruction and adds the control signal to a video signal R, G or B or a synchronizing signal Hs or Vs produced by a display control circuit during a vertical retrace period. A control signal separation circuit separates the added control signal Sc from the video signal R, G or B or the synchronizing signal Hs or Vs produced by the control signal addition circuit. A display control circuit produces adjustment signals Sa and Sb on the basis of the control signal from the control signal separation circuit to adjust a video circuit and a deflection circuit. Thus, the user can adjust the display picture by the input unit near at hand without extending the hands to adjustment switches of the display unit.

9. 发明授权

US6081254A Color correction system of imaging apparatus 失效
标题翻译：成像装置的色彩校正系统
公开(公告)号：US6081254A
公开(公告)日：2000-06-27
申请号：US288698
申请日：1994-08-12
申请人： Mariko Tanaka , Shinichi Yamada , Tomoko Ogawa , Yuji Sano , Kiyoharu Kishimoto , Takuya Imaide , Michitaka Ohsawa , Eiichi Yamazaki , Masaaki Kurosu , Hitoshi Yamadera , Takeshi Hoshino , Hiroshi Koizumi , Moritaka Taniguchi , Kouji Kitou , Ikuya Arai
发明人： Mariko Tanaka , Shinichi Yamada , Tomoko Ogawa , Yuji Sano , Kiyoharu Kishimoto , Takuya Imaide , Michitaka Ohsawa , Eiichi Yamazaki , Masaaki Kurosu , Hitoshi Yamadera , Takeshi Hoshino , Hiroshi Koizumi , Moritaka Taniguchi , Kouji Kitou , Ikuya Arai
IPC分类号： G09G5/02 , H04N1/40 , H04N1/60 , H04N17/00 , G09G5/04
CPC分类号： H04N1/40006 , G09G5/02 , H04N1/6033 , H04N17/002
摘要： The present invention is a color correction system including an imaging apparatus which inputs or outputs an image signal from a signal processor into or from an image device such as an input device such as a scanner or a camera or an output device such as a display device or a print device and which is constituted so as to correct colors by inputting or outputting image signals via a color converter, the conversion characteristic of which can be controlled according to a variation in the setting status or use environment of the imaging apparatus and faithful color reproduction can be realized between a plurality of imaging apparatuses having different characteristics.
摘要翻译：本发明是一种颜色校正系统，其包括：成像装置，其将来自信号处理器的图像信号输入或输出到诸如扫描仪或相机的输入装置的图像装置或诸如显示装置的输出装置或打印装置，其构成为通过经由颜色转换器输入或输出图像信号来校正颜色，其颜色转换器的转换特性可以根据成像设备的设置状态或使用环境的变化以及忠实的颜色来控制可以在具有不同特性的多个成像装置之间实现再现。

10. 发明授权

US06078301A Computer apparatus for sending video information to an image display apparatus and receiving information from the image display apparatus 失效
公开(公告)号：US06078301A
公开(公告)日：2000-06-20
申请号：US644292
申请日：1996-05-10
申请人： Ikuya Arai , Kouji Kitou , Yuji Sano
发明人： Ikuya Arai , Kouji Kitou , Yuji Sano
IPC分类号： G09G5/00 , G06F3/14 , G09G1/16 , G09G1/06
CPC分类号： G09G1/167 , G06F3/14 , G09G1/165 , G09G2320/08 , G09G2330/021 , G09G2340/02 , G09G2340/125 , G09G2360/18 , G09G2370/04 , G09G2370/045 , G09G5/006
摘要： An image display apparatus capable of adjusting a display picture by an input unit through a computer body is disclosed. When the user inputs a control instruction for adjusting the display picture of the display unit by the input unit connected to the computer body, a control signal addition circuit prepares a control signal Sc corresponding to the control instruction and adds the control signal to a video signal R, G or B or a synchronizing signal Hs or Vs produced by a display control circuit during a vertical retrace period. A control signal separation circuit separates the added control signal Sc from the video signal R, G or B or the synchronizing signal Hs or Vs produced by the control signal addition circuit. A display control circuit produces adjustment signals Sa and Sb on the basis of the control signal from the control signal separation circuit to adjust a video circuit and a deflection circuit. Thus, the user can adjust the display picture by the input unit near at hand without extending the hands to adjustment switches of the display unit.

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