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1. 发明申请

US20070269555A1 Enzyme Formulations 审中-公开
标题翻译：酶配方
公开(公告)号：US20070269555A1
公开(公告)日：2007-11-22
申请号：US11791669
申请日：2005-11-26
申请人： Jesper Jensen , Markus Lohscheidt , Andreas Habich
发明人： Jesper Jensen , Markus Lohscheidt , Andreas Habich
IPC分类号： A23K1/165 , A23L1/305 , C12N11/00 , C12N9/16 , C12N9/24 , C12N9/96
CPC分类号： C12Y302/01008 , A23K10/16 , A23K20/147 , A23K20/189 , A23K50/00 , A23K50/30 , A23K50/75 , A23L29/06 , A23L33/195 , A23P10/25 , C12Y301/03008 , C12Y302/01004 , C12Y302/01006 , C12Y302/01015 , C12Y302/01022 , C12Y302/01032 , C12Y302/01039 , C12Y302/01059 , C12Y302/01071 , C12Y302/01075 , C12Y302/01091
摘要： The present invention concerns stabilized solid or liquid enzyme formulation comprising at least one enzyme and at least one single-cell protein.
摘要翻译：本发明涉及包含至少一种酶和至少一种单细胞蛋白质的稳定的固体或液体酶制剂。

2. 发明授权

US08741599B2 Fermentative production of organic compounds 失效
标题翻译：发酵生产有机化合物
公开(公告)号：US08741599B2
公开(公告)日：2014-06-03
申请号：US12094626
申请日：2006-11-27
申请人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
发明人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
IPC分类号： C12P23/00 , C12P19/14 , C12P19/02 , C12P13/04 , C12P13/08 , C12P13/00 , C12P7/66 , C12P1/00 , C12P19/38 , C12P7/14 , C12N1/00 , C12N1/20
CPC分类号： C12P13/08 , C12N1/20 , C12N1/22
摘要： A process for the fermentative production of at least one organic compound having at least 3 C atoms or having at least 2 C atoms and at least one 1 N atom, comprising the following steps: a1) milling a starch feedstock, thus obtaining a millbase which comprises at least part of the nonstarchy solid constituents of the starch feedstock; a2) suspending the millbase in an aqueous liquid and hydrolysis of the starch portion in the millbase by enzymatic liquefaction and, if appropriate, subsequent saccharification, whereby a first liquid (1) which comprises mono- or oligosaccharides is obtained; and b) addition of the liquid (1) which comprises mono- or oligosaccharides together with metabolizable mono-, di- or oligosaccharides or together with a composition which comprises metabolizable mono-, di- or oligosaccharide in a concentration of at least 50% by weight and which is essentially free from solids which are insoluble in water to a fermentation medium comprising a microorganism which is capable of overproducing the organic compound under fermentation conditions.
摘要翻译：一种用于发酵生产至少一种具有至少3个C原子或具有至少2个C原子和至少一个1 N原子的有机化合物的方法，包括以下步骤：a1）研磨淀粉原料，从而获得一种包括淀粉原料的至少部分非淀粉样固体成分; a2）将研磨料悬浮在含水液体中，并通过酶液化和适当的后续糖化水解淀粉部分，由此获得包含单糖或寡糖的第一液体（1）; 和b）添加包含单糖或寡糖以及可代谢的单糖，二糖或寡糖的液体（1），或与包含至少50％浓度的可代谢的单糖，二糖或寡糖的组合物一起加入并且其基本上不含不溶于包含微生物的发酵培养基的固体，所述微生物能够在发酵条件下过量产生有机化合物。

3. 发明授权

US07727748B2 Method for producing D-pantothenic acid and/or salts thereof via purification by anion exchange as an additive for animal feed 失效
标题翻译：通过阴离子交换作为动物饲料添加剂的纯化生产D-泛酸和/或其盐的方法
公开(公告)号：US07727748B2
公开(公告)日：2010-06-01
申请号：US10468562
申请日：2002-02-20
申请人： Christine Beck , Hans-Peter Harz , Daniela Klein , Martin Leemann , Markus Lohscheidt
发明人： Christine Beck , Hans-Peter Harz , Daniela Klein , Martin Leemann , Markus Lohscheidt
IPC分类号： C12P13/04 , C12P21/02 , B01D15/04 , B01J41/00
CPC分类号： C12P13/02 , A23K10/12 , A23K20/174
摘要： The invention relates to an improved method for producing D-pantothenic acid and/or the salts thereof and to the use thereof as an additive for animal feed.
摘要翻译：本发明涉及一种生产D-泛酸和/或其盐的改进方法及其用作动物饲料添加剂的用途。

4. 发明申请

US20090317515A1 SOLID ENZYME FORMULATIONS AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：固体酶制剂及其制备方法
公开(公告)号：US20090317515A1
公开(公告)日：2009-12-24
申请号：US12282254
申请日：2007-03-09
申请人： Markus Lohscheidt , Roland Betz , Jörg Braun , Wolf Pelletier
发明人： Markus Lohscheidt , Roland Betz , Jörg Braun , Wolf Pelletier
IPC分类号： A23K1/165 , C12N9/96 , C12N9/98
CPC分类号： C12N9/98 , A23K20/189 , A23L29/06 , C12N9/96
摘要： The present invention relates to novel solid enzyme formulations comprising mixtures of at least one salt-stabilized enzyme composition, at least one particulate support and at least one hydrophobic liquid. In addition, the invention relates to methods for producing such solid enzyme formulations and also animal feed, foods and food supplements which comprise such enzyme formulations.
摘要翻译：本发明涉及包含至少一种盐稳定的酶组合物，至少一种颗粒载体和至少一种疏水性液体的混合物的新型固体酶制剂。此外，本发明涉及生产这种固体酶制剂的方法，还涉及包含这些酶制剂的动物饲料，食品和食品添加剂的方法。

5. 发明申请

US20090226571A1 Fermentative Production of Non-Volatile Microbial Metabolism Products in Solid Form 审中-公开
标题翻译：固体形式的非挥发性微生物代谢产物的发酵生产
公开(公告)号：US20090226571A1
公开(公告)日：2009-09-10
申请号：US11991515
申请日：2006-09-06
申请人： Stephan Freyer , Markus Pompejus , Oskar Zelder , Markus Lohscheidt , Matthias Boy , Edzard Scholten
发明人： Stephan Freyer , Markus Pompejus , Oskar Zelder , Markus Lohscheidt , Matthias Boy , Edzard Scholten
IPC分类号： A23K1/16 , C12P1/00 , C12P7/46 , C12P7/48 , C12P13/04 , C12P19/38 , C12P19/30 , C12P7/64 , C12P7/02 , C12P19/00 , C12P21/04 , C12P7/26 , C12P19/04 , C12P19/12 , C12P7/42 , C12P7/18 , C07C53/00 , C07C205/00 , C07H19/00 , C07C35/00 , C07H1/00 , C07K2/00 , C07C49/00 , C08B37/16 , C13K13/00 , C07C31/18 , D06M13/224 , D06M13/00 , A23L1/48 , D21H23/22
CPC分类号： C12P13/08 , A23K10/12 , A23L7/104 , C12P7/46 , C12P13/02 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/24 , C12P19/14
摘要： The present invention relates to a method for the production of at least one nonvolatile microbial metabolite in solid form by sugar-based microbial fermentation, in which process a microorganism strain which produces the desired metabolites is grown using a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight based on the total weight of the liquid medium, and the volatile constituents of the fermentation liquor are subsequently largely removed, the sugar-containing liquid medium being prepared by: a1) milling selected starch feedstock from cereal grains; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where, for liquefaction purposes, at least a portion of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid. Furthermore, the invention relates to a solid formulation, of a nonvolatile microbial metabolite, obtainable by the method according to the invention; and to the use of such a solid formulation as additive or supplement for human or animal nutrition or for the treatment of textiles, leather, cellulose, paper or surfaces.
摘要翻译：本发明涉及一种通过糖基微生物发酵生产固体形式的至少一种非挥发性微生物代谢物的方法，其中使用含糖单体的含糖液体培养基生产所需代谢物的微生物菌株含量超过基于液体介质总重量的20重量％，随后大量除去发酵液的挥发性成分，所述含糖液体介质通过以下步骤制备：a1）从谷物中研磨选定的淀粉原料 ; 和a2）在至少一种淀粉 - 液化酶的存在下在水性液体中液化所述研磨料，然后使用至少一种糖化酶进行糖化，其中为了液化目的，至少部分所述研磨料液体通过连续或分批加入水性液体。此外，本发明涉及通过本发明的方法获得的非挥发性微生物代谢物的固体制剂; 以及使用这种固体制剂作为人或动物营养的添加剂或补充剂或用于处理纺织品，皮革，纤维素，纸或表面的固体制剂。

6. 发明申请

US20130059332A1 METHOD FOR THE PRODUCTION OF AN AQUEOUS GLUCOSE SOLUTION 审中-公开
标题翻译：生产水性葡萄糖溶液的方法
公开(公告)号：US20130059332A1
公开(公告)日：2013-03-07
申请号：US13615929
申请日：2012-09-14
申请人： Matthias Boy , Jong-Kyu Choi , Jin Won Chung , Markus Lohscheidt , Jong In Choi , Jae Yeol Seo , Jörg Braun , Mo Se Kim , Sung Hyun Kim , Arno Kochner
发明人： Matthias Boy , Jong-Kyu Choi , Jin Won Chung , Markus Lohscheidt , Jong In Choi , Jae Yeol Seo , Jörg Braun , Mo Se Kim , Sung Hyun Kim , Arno Kochner
IPC分类号： C12P19/14 , C12P7/40 , C12P7/46 , C12P7/44 , C12P7/48 , C12P7/42 , C12P13/04 , C12P21/04 , C12P19/38 , C12P19/30 , C12P19/40 , C12P7/64 , C12P7/18 , C12P7/02 , C12P19/00 , C12P23/00 , C12P7/26 , C12P17/02 , C12P7/62 , C12P5/02 , C12P19/18 , C12P13/08 , C12P13/12 , C12P13/14 , C12P13/00 , C12P19/12 , C09K3/00 , C07K14/415 , A23K1/00
CPC分类号： C13K1/06 , A23J1/125 , A23K10/37 , C12P19/02 , Y02P60/877
摘要： The present invention relates to a process for the production of an aqueous glucose solution from maize or maize kernels. The invention also relates to a glucose solution obtainable by this process, and to its use for the production of organic compounds. The process according to the invention comprises: a) fractionating dry milling of maize kernels, where the maize kernels are separated into a maize-starch-comprising endosperm fraction and a high-oil germ fraction and, if appropriate, a bran fraction; b) enzymatic liquefaction and saccharification of the maize starch in an aqueous suspension of the endosperm fraction, which gives an aqueous glucose solution comprising maize gluten; and c) depletion of the maize gluten and, if appropriate, any bran present from the aqueous glucose solution.
摘要翻译：本发明涉及从玉米或玉米粒生产葡萄糖水溶液的方法。本发明还涉及通过该方法获得的葡萄糖溶液及其用于生产有机化合物的用途。根据本发明的方法包括：a）分级玉米粒的干磨，其中将玉米粒分离成包含玉米淀粉的胚乳部分和高油胚芽部分，以及如果合适的话，分离成麸皮部分; b）在胚乳部分的水性悬浮液中酶促液化和糖化玉米淀粉，其产生包含玉米麸质的葡萄糖水溶液; 和c）从葡萄糖水溶液中除去玉米面筋和（如果适用）的任何麸皮。

7. 发明申请

US20090274795A1 Enzyme Granulate l Containing Phytase 审中-公开
标题翻译：含有植酸酶的酶颗粒
公开(公告)号：US20090274795A1
公开(公告)日：2009-11-05
申请号：US11991837
申请日：2006-09-11
申请人： Markus Lohscheidt , Roland Betz , Jörg Braun , Wolf Pelletier , Peter Ader
发明人： Markus Lohscheidt , Roland Betz , Jörg Braun , Wolf Pelletier , Peter Ader
IPC分类号： C12N9/16 , A23L1/30
CPC分类号： C12Y301/03026 , A23K20/189 , A23K40/10 , A23K40/20 , A23K40/25 , A23K40/30
摘要： The present invention relates to novel phytase-comprising enzyme granules, those particles of which have A) a core which comprises at least one phytase and at least one solid carrier material suitable for feeds, and b) a coating arranged on the core, the cores of the particles or the entire particle, after if appropriate required grinding, on suspension or dissolution in demineralized water at 25° C. giving a pH in the range from 4.5 to 6.5, preferably in the range from 4.6 to 6.0, and particularly preferably from 4.7 to 5.5 and which are suitable as feed additives, and also a method for production thereof. The invention also relates to the use of the phytase-comprising enzyme granules in feed compositions and, in particular, pelleted feed compositions, which are obtainable using the phytase-comprising enzyme granules.
摘要翻译：本发明涉及新颖的含有植酸酶的酶颗粒，其中的颗粒具有A）包含至少一种植酸酶和至少一种适用于饲料的固体载体材料的芯，以及b）布置在芯上的涂层，芯的颗粒或整个颗粒，如果合适的话需要研磨，在25℃的软化水中悬浮或溶解，得到4.5至6.5，优选在4.6至6.0范围内，特别优选为 4.7〜5.5，适合作为饲料添加剂，也可以是其制造方法。本发明还涉及含有植酸酶的酶颗粒在饲料组合物中的用途，特别是使用含有植酸酶的酶颗粒可获得的颗粒饲料组合物。

8. 发明申请

US20090162892A1 Fermentative production of fine chemicals 有权
标题翻译：发酵精细化学品生产
公开(公告)号：US20090162892A1
公开(公告)日：2009-06-25
申请号：US11597782
申请日：2005-05-27
申请人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
发明人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
IPC分类号： C12P23/00 , C12P1/00 , C12P21/00 , C12P19/38 , C12P19/30 , C12P19/12 , C12P19/04 , C12P13/04 , C12P17/18 , C12P17/12 , C12P7/64 , C12P7/40 , C12P7/48 , C12P7/46 , C12P7/42 , C12P7/26 , C12P7/02
CPC分类号： C12P25/00 , C12P7/46 , C12P13/02 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/24 , C12P19/02 , C12P19/14 , C12P19/20 , Y02P20/582
摘要： The invention relates to a process for the production of at least one microbial metabolite having at least 3 carbon atoms or at least 2 carbon atoms and at least 1 nitrogen atom by means of sugar-based microbial fermentation, comprising: a) the preparation of a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight from a starch feedstock, the sugar-containing liquid medium also comprising non-starchy solid constituents of the starch feedstock; b) the fermentation of the sugar-containing liquid medium for the production of the metabolite(s); and c) depletion or isolation of at least one metabolite from the fermentation liquor, wherein a microorganism strain which produces the desired metabolite(s) is cultivated with the sugar-containing liquid medium, said liquid medium being obtained by: a1) milling the starch feedstock; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where at least some of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid.
摘要翻译：本发明涉及通过糖基微生物发酵生产具有至少3个碳原子或至少2个碳原子和至少1个氮原子的至少一种微生物代谢物的方法，包括：a）制备含糖液体介质，其单糖含量大于淀粉原料的20重量％以上，所述含糖液体介质还包含淀粉原料的非淀粉状固体成分; b）用于生产代谢物的含糖液体培养基的发酵; 和c）从所述发酵液中消耗或分离至少一种代谢物，其中产生所需代谢物的微生物菌株与所述含糖液体培养基一起培养，所述液体培养基通过以下步骤获得：a1）研磨所述淀粉原料; 和a2）在至少一种淀粉 - 液化酶的存在下在水性液体中液化所述研磨料，然后使用至少一种糖化酶进行糖化，其中至少一些所述絮凝液通过连续或分批添加至所述水性液体而液化。

9. 发明申请

US20080299606A1 Fermentative Production of Organic Compounds 失效
标题翻译：有机化合物的发酵生产
公开(公告)号：US20080299606A1
公开(公告)日：2008-12-04
申请号：US12094626
申请日：2006-11-27
申请人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
发明人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
IPC分类号： C12P23/00 , C12P1/00 , C12P21/04 , C12P13/00 , C12P7/64 , C12P7/18 , C12P7/40 , C12P19/38 , C12P19/40 , C12P19/30
CPC分类号： C12P13/08 , C12N1/20 , C12N1/22
摘要： A process for the fermentative production of at least one organic compound having at least 3 C atoms or having at least 2 C atoms and at least one 1 N atom, comprising the following steps: a1) milling a starch feedstock, thus obtaining a millbase which comprises at least part of the nonstarchy solid constituents of the starch feedstock; a2) suspending the millbase in an aqueous liquid and hydrolysis of the starch portion in the millbase by enzymatic liquefaction and, if appropriate, subsequent saccharification, whereby a first liquid (1) which comprises mono- or oligosaccharides is obtained; and b) addition of the liquid (1) which comprises mono- or oligosaccharides together with metabolizable mono-, di- or oligosaccharides or together with a composition which comprises metabolizable mono-, di- or oligosaccharide in a concentration of at least 50% by weight and which is essentially free from solids which are insoluble in water to a fermentation medium comprising a microorganism which is capable of overproducing the organic compound under fermentation conditions.
摘要翻译：一种用于发酵生产至少一种具有至少3个C原子或具有至少2个C原子和至少一个1 N原子的有机化合物的方法，包括以下步骤：a1）研磨淀粉原料，从而获得一种包括淀粉原料的至少部分非淀粉样固体成分; a2）将研磨料悬浮在含水液体中，并通过酶液化和适当的后续糖化水解淀粉部分，由此获得包含单糖或寡糖的第一液体（1）; 和b）添加包含单糖或寡糖以及可代谢的单糖，二糖或寡糖的液体（1），或与包含至少50％浓度的可代谢的单糖，二糖或寡糖的组合物一起加入并且其基本上不含不溶于包含微生物的发酵培养基的固体，所述微生物能够在发酵条件下过量产生有机化合物。

10. 发明授权

US09109244B2 Fermentative production of fine chemicals 有权
公开(公告)号：US09109244B2
公开(公告)日：2015-08-18
申请号：US11597782
申请日：2005-05-27
申请人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
发明人： Markus Pompejus , Stephan Freyer , Markus Lohscheidt , Oskar Zelder , Matthias Boy
IPC分类号： C12P25/00 , C12P7/46 , C12P13/12 , C12P13/02 , C12P13/08 , C12P13/10 , C12P13/14 , C12P13/24 , C12P19/02 , C12P19/14 , C12P19/20
CPC分类号： C12P25/00 , C12P7/46 , C12P13/02 , C12P13/08 , C12P13/10 , C12P13/12 , C12P13/14 , C12P13/24 , C12P19/02 , C12P19/14 , C12P19/20 , Y02P20/582
摘要： The invention relates to a process for the production of at least one microbial metabolite having at least 3 carbon atoms or at least 2 carbon atoms and at least 1 nitrogen atom by means of sugar-based microbial fermentation, comprising: a) the preparation of a sugar-containing liquid medium with a monosaccharide content of more than 20% by weight from a starch feedstock, the sugar-containing liquid medium also comprising non-starchy solid constituents of the starch feedstock; b) the fermentation of the sugar-containing liquid medium for the production of the metabolite(s); and c) depletion or isolation of at least one metabolite from the fermentation liquor, wherein a microorganism strain which produces the desired metabolite(s) is cultivated with the sugar-containing liquid medium, said liquid medium being obtained by: a1) milling the starch feedstock; and a2) liquefying the millbase in an aqueous liquid in the presence of at least one starch-liquefying enzyme, followed by saccharification using at least one saccharifying enzyme, where at least some of the millbase is liquefied by continuous or batchwise addition to the aqueous liquid.

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