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1. 发明申请

US20130273137A1 DRUG DELIVERY COATING AND DEVICES 审中-公开
标题翻译：药物输送涂料和装置
公开(公告)号：US20130273137A1
公开(公告)日：2013-10-17
申请号：US13695836
申请日：2011-05-03
申请人： Kenneth J. Mandell , Paula T. Hammond , Renee C. Fuller , Joseph F. Rizzo, III , Anita Shukla
发明人： Kenneth J. Mandell , Paula T. Hammond , Renee C. Fuller , Joseph F. Rizzo, III , Anita Shukla
IPC分类号： A61L27/28 , A61F2/16 , A61L27/54
CPC分类号： A61L27/28 , A61F2002/169053 , A61K9/0051 , A61K9/703 , A61K31/196 , A61K31/7052 , A61K45/06 , A61L27/34 , A61L27/54 , A61L2300/608 , A61L2420/08 , A61L2430/16 , A61K2300/00
摘要： In various embodiments, the present invention provides certain systems comprising a multi-layer decomposable film coating composition on a substrate, where the coating composition includes one or more releasable agents in at least one of its layers, and decomposes layer-by-layer to release such agent(s) over time. In some embodiments, an intra-ocular lens (IOL) system comprising an IOL coated with a multi-layer decomposable film coating composition is disclosed.
摘要翻译：在各种实施方案中，本发明提供了一些系统，其包括在基底上的多层可分解膜涂料组合物，其中涂料组合物在其至少一层中包含一种或多种可释放的试剂，并逐层分解以释放这种代理人随着时间的推移。在一些实施方案中，公开了包含涂覆有多层可分解膜涂料组合物的IOL的眼内透镜（IOL）系统。

2. 发明授权

US4278848A Automatically adjustable bidirectional-to-unidirectional transmission network 失效
标题翻译：自动调节双向单向传输网络
公开(公告)号：US4278848A
公开(公告)日：1981-07-14
申请号：US64041
申请日：1979-08-06
申请人： Joseph F. Rizzo , John A. Rudisill, Jr.
发明人： Joseph F. Rizzo , John A. Rudisill, Jr.
IPC分类号： H04B1/58
CPC分类号： H04B1/582
摘要： Transhybrid loss is maximized in a transmission network (FIG. 1, 101) of the type for coupling a bidirectional transmission facility (102, 2-wire) to receive (103) and transmit (104) unidirectional transmission facilities (4-wire) by automatically adjusting impedance elements (RKN, RZN, etc.) of an impedance network (202, FIG. 3, FIG. 4) to obtain an optimum match to the impedance of the bidirectional facility (102). To this end, individual ones of a plurality of tones (107) are supplied to a receive port (111) of the transmission network (101) and the impedance elements (RKN, RZN, etc.) are controllably adjusted in a prescribed sequence (FIGS. 8-16) to obtain amplitude nulls at a transmit port (112) of the transmission network (101). In one embodiment, predetermined ones of the impedance adjustments (RKN, RZN, etc., 820-823, 828-831) are iterated with predetermined ones of the tone signals being supplied to the receive port (111) further to optimize the impedance match.
摘要翻译：在用于将双向传输设备（102,2线）耦合到接收（103）和传输（104）单向传输设施（4线）的类型的传输网络（图1,101）中，混合损耗最大化由自动调整阻抗网络（图3中的202，图4）的阻抗元件（RKN，RZN等）以获得与双向设备（102）的阻抗的最佳匹配。为此，多个音调（107）中的各个音调（107）被提供给传输网络（101）的接收端口（111），并且阻抗元件（RKN，RZN等）以规定的顺序可控地调整（图8-16）以在传输网络（101）的发送端口（112）处获得幅度零点。在一个实施例中，预定的阻抗调整（RKN，RZN等，820-823,828-831）被迭代，其中预定的一个音调信号被提供给接收端口（111），以优化阻抗匹配。

3. 发明授权

US4878240A Multi-service telephone switching system 失效
标题翻译：多业务电话交换系统
公开(公告)号：US4878240A
公开(公告)日：1989-10-31
申请号：US148331
申请日：1988-01-25
申请人： Steve M. Lin , Joseph F. Rizzo
发明人： Steve M. Lin , Joseph F. Rizzo
IPC分类号： H04M3/38 , H04M3/42 , H04M3/428 , H04M3/44 , H04M3/48 , H04M3/487 , H04M3/533 , H04M3/54 , H04M3/56 , H04M11/02 , H04Q3/72 , H04Q11/04
CPC分类号： H04Q11/0407 , H04M3/42 , H04M3/533 , H04M3/54 , H04M11/022 , H04M2201/40 , H04M2203/5009 , H04M2203/5018 , H04M2203/5027 , H04M2203/5063 , H04M2242/22 , H04M3/382 , H04M3/42059 , H04M3/42102 , H04M3/428 , H04M3/44 , H04M3/48 , H04M3/487 , H04M3/56 , H04Q11/0428 , H04Q3/72
摘要： Enhanced telephone services are provided through a multi-service telephone switching system that contains a programmable adjunct connected to a telephone switching system. Specifically, this system includes a telephone switch that serves at least one subscriber and an adjunct connected both through one or more distinct paths, such as a number of hunt group lines, and through a datalink, such as a simplified message desk datalink, to the telephone switch. The telephone switch routes a telephone call involving this subscriber to the adjunct through an available hunt group line and provides a message to the adjunct over the datalink specifying a condition under which the call was routed. In response to this message, the adjunct takes complete control of the call substantially throughout the remainder of its duration and provides a desired enhanced service that has been pre-defined by a service script stored within the adjunct. Different service scripts can be invoked to provide correspondingly different enhanced services to the subscriber depending upon the specific condition for which the call was routed to the adjunct and/or a specific event occurring during the call.
摘要翻译：通过包含连接到电话交换系统的可编程附件的多业务电话交换系统来提供增强的电话服务。具体地说，该系统包括一个电话交换机，其服务于至少一个用户，以及通过一个或多个不同路径连接的辅助装置，例如多个寻线组线路，以及通过诸如简化的消息台数据链路的数据链路连接到电话开关电话交换机将涉及该用户的电话通过可用的寻线组路由到附件，并通过数据链路向附件提供消息，指定呼叫路由的条件。响应于该消息，附件在其持续时间的整个剩余时间内完全控制呼叫，并且提供已经由存储在附件内的服务脚本预先定义的期望的增强服务。可以调用不同的服务脚本以根据呼叫被路由到附件的特定条件和/或在呼叫期间发生的特定事件来向用户提供相应不同的增强服务。

4. 发明授权

US4275276A Automatically adjustable bidirectional-to-unidirectional transmission network 失效
标题翻译：自动调节双向单向传输网络
公开(公告)号：US4275276A
公开(公告)日：1981-06-23
申请号：US64042
申请日：1979-08-06
申请人： Joseph F. Rizzo
发明人： Joseph F. Rizzo
IPC分类号： H04B1/58
CPC分类号： H04B1/582
摘要： Transhybrid loss is maximized in a transmission network (FIG. 1, 101) of the type for coupling a bidirectional transmission facility (102, 2-wire) to receive (103) and transmit (104) unidirectional transmission facilities (4-wire) by automatically adjusting impedance elements (RKL and RZL) of an impedance network (202, FIG. 3) to obtain an optimum match to the impedance of the bidirectional facility (102). To this end, a plurality of tones (107) are individually supplied to a receive port (111) of the transmission network (101) and the impedance elements (RKL and RZL) are controllably adjusted in a prescribed sequence (FIGS. 7-10) to obtain amplitude nulls at a transmit port (112) of the transmission network (101). Then, an additional signal having a plurality of predetermined frequency components which repeat periodically is supplied to the receive port (111) and a predetermined one of the impedance elements (RKL) is again adjusted to obtain an average value amplitude null at the transmit port (112). In one embodiment of the invention, the additional signal is a pseudo-random noise signal having frequency components at a fixed spacing in a predetermined frequency band.
摘要翻译：在用于将双向传输设备（102,2线）耦合到接收（103）和传输（104）单向传输设施（4线）的类型的传输网络（图1,101）中，混合损耗最大化由自动调整阻抗网络（图3中的202）的阻抗元件（RKL和RZL）以获得与双向设施（102）的阻抗的最佳匹配。为此，将多个音调（107）分别提供给传输网络（101）的接收端口（111），并且以规定的顺序可控地调整阻抗元件（RKL和RZL）（图7-10 ）以在传输网络（101）的传输端口（112）处获得幅度零点。然后，将具有周期性重复的多个预定频率分量的附加信号提供给接收端口（111），并且再次调整预定的一个阻抗元件（RKL），以获得在发送端口处的平均值幅值零（ 112）。在本发明的一个实施例中，附加信号是在预定频带中具有固定间隔的频率分量的伪随机噪声信号。

5. 发明授权

US4368362A Automatic telephone loaded/nonloaded facility type identification circuit 失效
标题翻译：自动电话装载/无负载设备类型识别电路
公开(公告)号：US4368362A
公开(公告)日：1983-01-11
申请号：US173020
申请日：1980-07-28
申请人： Li-Jin W. Chung , Ernest P. Moore , Glendon R. Porter , Joseph F. Rizzo
发明人： Li-Jin W. Chung , Ernest P. Moore , Glendon R. Porter , Joseph F. Rizzo
IPC分类号： H04B1/58 , H04B3/23 , H04B3/26 , H04B3/20
CPC分类号： H04B3/23 , H04B1/586 , H04B3/26
摘要： A bidirectional transmission path is typically coupled to unidirectional receive and transmit paths to effect amplification in repeaters or the like. A determination of whether the bidirectional path includes either loaded or nonloaded type 2-wire cable is made by inserting a test signal having a predetermined frequency and a predetermined amplitude into the receive path and measuring the peak amplitude of a transmit signal developed on the transmit path. If the transmit signal peak amplitude is greater than a predetermined threshold value, the 2-wire cable is considered loaded type, and if the transmit signal peak amplitude is less than the threshold value, the 2-wire cable is considered nonloaded type.
摘要翻译：双向传输路径通常耦合到单向接收和发送路径以在中继器等中实现放大。通过将具有预定频率和预定幅度的测试信号插入接收路径并测量在发送路径上产生的发送信号的峰值幅度来确定双向路径是否包括加载型或无负载型2线电缆。如果发射信号峰值幅度大于预定阈值，则2线电缆被认为是加载类型，如果发射信号的峰值幅度小于阈值，则2线电缆被认为是无负载型。

6. 发明授权

US06976998B2 Minimally invasive retinal prosthesis 失效
标题翻译：微创视网膜假体
公开(公告)号：US06976998B2
公开(公告)日：2005-12-20
申请号：US10346701
申请日：2003-01-17
申请人： Joseph F. Rizzo , John L. Wyatt, Jr. , Luke Theogarajan
发明人： Joseph F. Rizzo , John L. Wyatt, Jr. , Luke Theogarajan
IPC分类号： A61F2/14 , A61F9/08 , A61N1/05 , A61N1/36 , A61F2/16
CPC分类号： A61N1/0543 , A61F2/14 , A61F9/08 , A61N1/36 , A61N1/36046 , A61N1/3787
摘要： An ocular device that can more safely and effectively perform all functions needed of a retinal prosthesis with electronic components that are placed outside the wall of an eye, are powered wirelessly provided by an external power source, and which provide a patient with a view determined by natural motion of the eye and triggered by natural incident light converging at the retina. In one aspect, the invention is an externally powered, light-activated, sub-retinal prosthesis in which natural light entering the eye conveys visual details to the sub-retinal prosthesis, while wireless radiofrequency transmission provides the power needed to stimulate the retina, which would be insufficient if it were obtained from the intensity of incoming light alone.
摘要翻译：可以更安全和有效地执行放置在眼睛壁外部的电子部件的视网膜假体所需的所有功能的眼睛装置由外部电源无线提供，并且由患者提供由眼睛自然运动并由自然光线会聚在视网膜上触发。一方面，本发明是一种外部供电的光活化的次视网膜假体，其中进入眼睛的自然光将视觉细节传达到视网膜假体，而无线射频传输提供刺激视网膜所需的功率，其中如果从独自的入射光强度获得的话将不足够。

7. 发明授权

US4365119A Automatically adjustable bidirectional-to-unidirectional transmission network 失效
标题翻译：自动调节双向单向传输网络
公开(公告)号：US4365119A
公开(公告)日：1982-12-21
申请号：US173014
申请日：1980-07-28
申请人： Li-Jin W. Chung , Ernest P. Moore , Glendon R. Porter , Joseph F. Rizzo
发明人： Li-Jin W. Chung , Ernest P. Moore , Glendon R. Porter , Joseph F. Rizzo
IPC分类号： H04B3/23 , H04B3/20
CPC分类号： H04B3/238
摘要： "Transhybrid" loss is maximized in a transmission network of the active canceler type employed to couple receive and transmit unidirectional transmission paths to a bidirectional transmission path including 2-wire nonloaded type cable by controllably adjusting impedance elements of the canceler circuit in a prescribed sequence to obtain amplitude nulls of signals detected on the transmit path while supplying individual ones of a plurality of single frequency test signals to the receive path. The adjustment sequence comprises a first procedure including a plurality of iterative adjustments of predetermined impedance elements in predetermined groups until no changes in the impedance settings occur and multiple iterative adjustment of predetermined groups until no changes in the impedance settings occur. If frequencies become equal at which poles and zeros occur associated with predetermined ones of the impedance elements, the impedance values of those elements are fixed in prescribed relationship and a second procedure is employed to adjust others of the canceler elements. The impedance elements to be adjusted and the adjustment sequence are selected to rapidly converge the canceler circuit to an optimum transfer function for generating a correction signal which is substantially a replica of an error signal to be canceled from the transmit path.
摘要翻译：用于将接收和发送单向传输路径耦合到包括2线无负载型电缆的双向传输路径的有源消除器类型的传输网络中，“跨混合”损耗最大化，可以通过以规定的顺序可控地调节消除器电路的阻抗元件，获得在发送路径上检测到的信号的振幅零点，同时向接收路径提供多个单频测试信号中的单个频率测试信号。调整序列包括第一程序，其包括预定组中预定阻抗元件的多次迭代调整，直到发生阻抗设置的变化和预定组的多次迭代调整，直到发生阻抗设置的变化为止。如果与预定的阻抗元件相关联的极点和零点发生频率变得相等，则这些元件的阻抗值以规定的关系固定，并且采用第二过程来调节其它的加速器元件。要调整的阻抗元件和调整序列被选择以将抵消器电路快速收敛到最佳传递函数，用于产生校正信号，校正信号基本上是要从发送路径消除的误差信号的复制品。

8. 发明授权

US4242636A Digital operate/release timer 失效
标题翻译：数字操作/释放定时器
公开(公告)号：US4242636A
公开(公告)日：1980-12-30
申请号：US954179
申请日：1978-10-24
申请人： John L. Gilmer , Joseph F. Rizzo
发明人： John L. Gilmer , Joseph F. Rizzo
IPC分类号： H03K5/13 , H03K5/135 , H03K17/28 , H03K5/20
CPC分类号： H03K5/135
摘要： Operate/release timing circuits are employed to generate time delayed pulse signals, for example, dial pulses, wink signals and other supervisory signals employed in telecommunications signaling systems. Pulse position and pulse width errors and other problems found in prior operate/release timers are resolved by employing a single digital counter and associated control logic elements. The timing circuit is controllably configured into several timer circuit arrangements including an integrating timer, AM timer, integrating timer including coast option, and AM timer including coast option. With the coast option enabled, initial noise immunity in the pulse signal is realized by resetting the counter to an initial state in response to any discontinuity in the input pulse signal until the input pulse signal is continuously present for a predetermined interval. Pulse break, gap and the like immunity is achieved by controlling the counter to count up for a predetermined interval regardless of the presence or absence of the input pulse signal. Once a valid input pulse has been detected and is terminated a timer output change of state is delayed for a so-called release delay interval. Once the pulse signal has terminated for a predetermined integrated interval the counter is controlled to continue counting down until the initial condition is reached regardless of the presence or absence of the input pulse signal. When the AM timer option is enabled the release interval is shortened by controllably resetting the counter to the initial condition upon the counter reaching the predetermined integrated interval.
摘要翻译：采用操作/释放定时电路来生成时间延迟的脉冲信号，例如拨号脉冲，眨眼信号和在电信信令系统中采用的其它监控信号。在先前的操作/释放定时器中发现的脉冲位置和脉冲宽度误差以及其他问题通过采用单个数字计数器和相关联的控制逻辑元件来解决。定时电路被可控地配置成多个定时器电路布置，包括积分定时器，AM定时器，包括惯性选择的积分计时器和包括惯性选项的AM定时器。在使能海岸选项的情况下，脉冲信号中的初始抗噪声能力是通过将输入脉冲信号连续存在预定间隔来响应输入脉冲信号中的任何不连续性将计数器复位到初始状态来实现的。通过控制计数器对预定间隔进行计数，而不管输入脉冲信号的存在或不存在，实现脉冲间断，间隙等抗扰性。一旦检测到有效的输入脉冲并被终止，定时器输出的状态改变被延迟所谓的释放延迟时间间隔。一旦脉冲信号已经终止了预定的积分间隔，则计数器被控制以继续向下计数，直到达到初始条件，而不管存在或不存在输入脉冲信号。当AM定时器选项被使能时，通过在计数器达到预定的积分间隔时将计数器可控地复位到初始条件来缩短释放间隔。

9. 发明授权

US4223184A Minimum break/make pulse corrector 失效
标题翻译：最小断点/制动脉冲校正器
公开(公告)号：US4223184A
公开(公告)日：1980-09-16
申请号：US954180
申请日：1978-10-24
申请人： John L. Gilmer , Joseph F. Rizzo
发明人： John L. Gilmer , Joseph F. Rizzo
IPC分类号： H03K5/04 , H04Q1/36
CPC分类号： H04Q1/36
摘要： Pulse signals, for example, dial pulses, wink signals or the like, have been corrected to have minimum break and make intervals by employing at least two analog resistor/capacitor type timers, usually connected in tandem. These prior timer arrangements are not readily implemented by employing large-scale integration because of their use of analog circuit components. Indeed, it is desirable to correct pulse signals to have at least minimum break and make intervals (FIG. 2) by employing digital techniques. To this end, a control signal (ENO) for determining the minimum break and make intervals is generated by utilizing a single digital counter (35) and associated logic for controllably supplying first (Y15) and second (Y30) timing signals (from 34) to the counter (36). The frequencies of the first and the second timing signals are selected in relationship to the desired minimum break and make intervals, respectively. An output control circuit (12 or 11 and 12) is jointly responsive to the control signal (ENO) and first (OPR) and second (REL) input signals representative of first and second states, respectively, of a supplied pulse signal for generating a corrected pulse signal (H) having the desired minimum break and make intervals. The control signal inhibits (via 15 and 16) response of the output control circuit (12) to the input signals (OPR and REL) for the desired minimum break and make intervals. Additionally, the supplying (via 20) of the timing signals to the counter (36) is inhibited (by H and H) after each count cycle until there is a change in state of the output signals (H and H) from the output control circuit (12).
摘要翻译：脉冲信号，例如拨号脉冲，闪烁信号等已被校正为具有最小间隔并且通过采用通常串联连接的至少两个模拟电阻器/电容器型定时器来产生间隔。由于使用模拟电路部件，因此通过采用大规模集成不容易实现这些先前的定时器布置。实际上，期望通过采用数字技术来校正脉冲信号以具有至少最小间隔和产生间隔（图2）。为此，通过利用单个数字计数器（35）和相关联的逻辑来产生用于确定最小间隔和产生间隔的控制信号（ENO），用于可控地提供第一（Y15）和第二（Y30）定时信号（从34）到柜台（36）。第一和第二定时信号的频率分别与期望的最小间隔和制作间隔相关地选择。输出控制电路（12或11和12）分别对表示所提供的脉冲信号的第一和第二状态的控制信号（ENO）和第一（OPR）和第二（REL）输入信号进行共同响应，校正脉冲信号（H）具有所需的最小间隔并产生间隔。控制信号禁止输出控制电路（12）对输入信号（OPR和REL）（期望的最小间隔）的响应（通过15和16）并产生间隔。此外，在每个计数周期之后，禁止向定时器（36）提供定时信号（通过20）（由H和H），直到来自输出控制器的输出信号（H和H）的状态发生变化电路（12）。

10. 发明授权

US4368361A Automatically adjustable bidirectional-to-unidirectional transmission network 失效
标题翻译：自动调节双向单向传输网络
公开(公告)号：US4368361A
公开(公告)日：1983-01-11
申请号：US173011
申请日：1980-07-28
申请人： Li-Jin W. Chung , Ernest P. Moore , Glendon R. Porter , Joseph F. Rizzo
发明人： Li-Jin W. Chung , Ernest P. Moore , Glendon R. Porter , Joseph F. Rizzo
IPC分类号： H04B1/58 , H04B3/20
CPC分类号： H04B1/586
摘要： "Transhybrid" loss is maximized in a transmission network of the active canceler type employed to couple receive and transmit unidirectional transmission paths to a bidirectional transmission path including 2-wire loaded type cable by controllably adjusting impedance elements of the canceler circuit in a prescribed sequence including adjustment of a network build out capacitor to obtain amplitude nulls of signals detected on the transmit path while supplying individual ones of a plurality of test signals to the receive path. The test signals include first and second signals having a plurality of equally spaced frequency components in first and second frequency bands, respectively, and a third signal having a predetermined single frequency. The adjustment sequence includes a plurality of iterative adjustments of predetermined impedance elements in predetermined groups until no changes in the impedance settings occur and multiple iterative adjustment of predetermined groups until no changes in the impedance settings occur. The impedance elements to be adjusted and the adjustment sequence are selected to rapidly converge the canceler circuit to an optimum transfer function for generating a correction signal which is substantially a replica of an error signal to be canceled from the transmit path.
摘要翻译：用于通过以规定的顺序可控地调节消除器电路的阻抗元件将接收和发送单向传输路径耦合到包括2线负载型电缆的双向传输路径的有源消除器类型的传输网络中，“跨混合”损耗最大化，包括调整网络建立电容器以获得在发送路径上检测到的信号的振幅零点，同时向接收路径提供多个测试信号中的各个测试信号。测试信号包括分别在第一和第二频带中具有多个等间隔的频率分量的第一和第二信号，以及具有预定单个频率的第三信号。调整序列包括对预定组中的预定阻抗元件的多次迭代调整，直到发生阻抗设置的变化和预定组的多次迭代调整，直到发生阻抗设置的变化为止。要调整的阻抗元件和调整序列被选择以将抵消器电路快速收敛到最佳传递函数，用于产生校正信号，校正信号基本上是要从发送路径消除的误差信号的复制品。

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