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1. 发明授权

US09314615B2 Method of making a flexible circuit electrode array 有权
标题翻译：制造柔性电路电极阵列的方法
公开(公告)号：US09314615B2
公开(公告)日：2016-04-19
申请号：US13422892
申请日：2012-03-16
申请人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
发明人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
IPC分类号： H05K3/02 , H05K3/10 , A61N1/05 , A61N1/36 , H05K1/11 , H05K3/00 , H05K3/38 , H05K3/46
CPC分类号： A61N1/0543 , A61N1/0541 , A61N1/36046 , H05K1/028 , H05K1/0353 , H05K1/09 , H05K1/111 , H05K1/115 , H05K1/118 , H05K3/0014 , H05K3/0017 , H05K3/0041 , H05K3/06 , H05K3/188 , H05K3/22 , H05K3/388 , H05K3/4644 , H05K2201/0129 , H05K2201/0133 , H05K2201/0141 , H05K2201/0154 , Y10T29/49156 , Y10T29/49158
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
摘要翻译：一种具有多于一层金属迹线的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的多于一层由聚合物层隔开的金属痕迹层，包括适合于刺激神经组织的电极; 以及沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层。聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。

2. 发明授权

US08874239B2 Cochlear stimulation device 有权
标题翻译：人工耳蜗刺激装置
公开(公告)号：US08874239B2
公开(公告)日：2014-10-28
申请号：US12267489
申请日：2008-11-07
申请人： Robert J. Greenberg , David Daomin Zhou , Jordan Matthew Neysmith , Kelly H. McClure , Jianing Wei , Neil Hamilton Talbot , James Singleton Little
发明人： Robert J. Greenberg , David Daomin Zhou , Jordan Matthew Neysmith , Kelly H. McClure , Jianing Wei , Neil Hamilton Talbot , James Singleton Little
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/0541 , A61N1/0472
摘要： A cochlear stimulation device comprising an electrode array designed to provide enhanced charge injection capacity necessary for neural stimulation. The electrode array comprises electrodes with high surface area or a fractal geometry and correspondingly high electrode capacitance and low electrical impedance. The resultant electrodes have a robust surface and sufficient mechanical strength to withstand physical stress vital for long term stability. The device further comprises wire traces having a multilayer structure which provides a reduced width for the conducting part of the electrode array. The cochlear prosthesis is attached by a grommet to the cochleostomy that is made from a single piece of biocompatible polymer. The device, designed to achieve optimum neural stimulation by appropriate electrode design, is a significant improvement over commercially available hand-built devices.
摘要翻译：耳蜗刺激装置包括设计成提供神经刺激所需的增强的电荷注入能力的电极阵列。电极阵列包括具有高表面积或分形几何形状的电极以及相当高的电极电容和低的电阻抗。所得电极具有坚固的表面和足够的机械强度以抵抗对于长期稳定性至关重要的物理应力。该装置还包括具有多层结构的导线迹线，其为电极阵列的导电部分提供减小的宽度。耳蜗假体通过索环连接到由单一生物相容性聚合物制成的耳蜗切开术。该设备旨在通过适当的电极设计实现最佳神经刺激，这是相对于市售的手工设备的显着改进。

3. 发明授权

US08374698B2 Package for an implantable neural stimulation device 有权
标题翻译：可植入神经刺激装置的包装
公开(公告)号：US08374698B2
公开(公告)日：2013-02-12
申请号：US11893939
申请日：2007-08-18
申请人： Jerry Ok , Robert J. Greenberg , Neil Hamilton Talbot , James Singleton Little , Rongqing Dai , Jordan Matthew Neysmith , Kelly H. McClure
发明人： Jerry Ok , Robert J. Greenberg , Neil Hamilton Talbot , James Singleton Little , Rongqing Dai , Jordan Matthew Neysmith , Kelly H. McClure
IPC分类号： A61N1/375
CPC分类号： A61N1/36046 , A61F15/001 , A61N1/0529 , A61N1/0543 , A61N1/36125 , A61N1/375 , H01L23/055 , H01L23/06 , H01L23/08 , H01L23/10 , H01L24/16 , H01L24/48 , H01L25/18 , H01L2224/16225 , H01L2224/45144 , H01L2224/48091 , H01L2224/48106 , H01L2224/48225 , H01L2924/00011 , H01L2924/00014 , H01L2924/00 , H01L2224/0401
摘要： The present invention is an improved hermetic package for implantation in the human body. The implantable device includes an electrically non-conductive substrate with electrically conductive vias. A flip-chip circuit is attached to the substrate using conductive bumps and electrically connected to a first subset of the vias. The flip-chip circuit can contain one or more stacks or a folded stack. A wire-bonded circuit is also attached to the substrate and electrically connected to a second subset of the vias. A cover is bonded to the substrate. The cover, substrate, and vias form an improved hermetic package for implantation.
摘要翻译：本发明是用于植入人体的改进的密封包装。可植入装置包括具有导电通孔的非导电基底。使用导电凸块将倒装芯片电路连接到基板，并电连接到通孔的第一子集。倒装芯片电路可以包含一个或多个堆叠或折叠堆叠。引线键合电路也附接到基板并电连接到通孔的第二子集。盖子粘合到基底上。盖，衬底和通孔形成改进的用于植入的密封包装。

4. 发明授权

US07991478B2 Flexible circuit electrode array with at least one tack opening 有权
标题翻译：具有至少一个定位开口的柔性电路电极阵列
公开(公告)号：US07991478B2
公开(公告)日：2011-08-02
申请号：US11821328
申请日：2007-06-21
申请人： Robert J. Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech
发明人： Robert J. Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , James Singleton Little , Brian V. Mech
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/36046 , H05K1/036 , H05K1/0393 , H05K1/118 , H05K3/0014 , H05K2201/05 , H05K2201/053 , H05K2201/09063 , H05K2201/09409 , Y10T29/49002 , Y10T29/49117 , Y10T29/49155 , Y10T29/49156 , Y10T29/49158 , Y10T29/49174 , Y10T29/49176
摘要： The present invention provides a flexible circuit electrode array adapted for neural stimulation, comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces at least one tack opening; wherein said polymer base layer, said metal traces and said polymer top layer are thermoformed in a three dimensional shape.The present invention provides further a method of making a flexible circuit electrode array comprising depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; preparing at least one tack opening; and heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array.
摘要翻译：本发明提供一种适用于神经刺激的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基层上的聚合物顶层和所述金属迹线至少一个粘性开口; 其中所述聚合物基层，所述金属迹线和所述聚合物顶层被热成型为三维形状。本发明还提供一种制造柔性电路电极阵列的方法，包括沉积聚合物基层; 在所述聚合物基层上沉积金属; 图案化所述金属以形成金属痕迹; 在所述聚合物基底层和所述金属迹线上沉积聚合物顶层; 准备至少一个开口; 并将所述柔性电路电极阵列加热到模具中，以在所述柔性电路电极阵列中形成三维形状。

5. 发明授权

US07912556B2 Electrode array for even neural pressure 有权
标题翻译：电极阵列甚至神经压力
公开(公告)号：US07912556B2
公开(公告)日：2011-03-22
申请号：US12397974
申请日：2009-03-04
申请人： Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Jordan Matthew Neysmith
发明人： Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Jordan Matthew Neysmith
IPC分类号： A61N1/00
CPC分类号： A61N1/0543 , A61N1/0558
摘要： An electrode array attached to neural tissue, such as the retina, necessarily has graded pressure exerted on the tissue, with higher pressure near the attachment point. Greater pressure improves contact between the electrodes and neural tissue while too much pressure may damage neural tissue. Hence it is advantageous to obtain equal pressure across the array field. In the present invention multiple and selective attachment points are provided on an electrode array allowing a surgeon to select the attachment points providing the best electrode tissue contact.
摘要翻译：附着到神经组织（例如视网膜）上的电极阵列必须具有施加在组织上的分级压力，附近点附近具有更高的压力。更大的压力改善了电极和神经组织之间的接触，而太多的压力可能损伤神经组织。因此，有利的是在阵列场上获得相等的压力。在本发明中，在电极阵列上提供多个选择性附着点，允许外科医生选择提供最佳电极组织接触的附着点。

6. 发明申请

US20090228086A1 Electrode Array for Even Neural Pressure 有权
标题翻译：用于均匀神经压力的电极阵列
公开(公告)号：US20090228086A1
公开(公告)日：2009-09-10
申请号：US12397974
申请日：2009-03-04
申请人： Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Jordan Matthew Neysmith
发明人： Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Jordan Matthew Neysmith
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/0558
摘要： An electrode array attached to neural tissue, such as the retina, necessarily has graded pressure exerted on the tissue, with higher pressure near the attachment point. Greater pressure improves contact between the electrodes and neural tissue while too much pressure may damage neural tissue. Hence it is advantageous to obtain equal pressure across the array field. In the present invention multiple and selective attachment points are provided on an electrode array allowing a surgeon to select the attachment points providing the best electrode tissue contact.
摘要翻译：附着到神经组织（例如视网膜）上的电极阵列必须具有施加在组织上的分级压力，附近点附近具有更高的压力。更大的压力改善了电极和神经组织之间的接触，而太多的压力可能损伤神经组织。因此，有利的是在阵列场上获得相等的压力。在本发明中，在电极阵列上提供多个选择性附着点，允许外科医生选择提供最佳电极组织接触的附着点。

7. 发明申请

US20080288037A1 Flexible Circuit Electrode Array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US20080288037A1
公开(公告)日：2008-11-20
申请号：US11934627
申请日：2007-11-02
申请人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
发明人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/0541 , A61N1/36046 , H05K1/028 , H05K1/0353 , H05K1/09 , H05K1/111 , H05K1/115 , H05K1/118 , H05K3/0014 , H05K3/0017 , H05K3/0041 , H05K3/06 , H05K3/188 , H05K3/22 , H05K3/388 , H05K3/4644 , H05K2201/0129 , H05K2201/0133 , H05K2201/0141 , H05K2201/0154 , Y10T29/49156 , Y10T29/49158
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
摘要翻译：一种具有多于一层金属迹线的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的多于一层由聚合物层隔开的金属痕迹层，包括适于刺激神经组织的电极; 以及沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层。聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。

8. 发明授权

US10188853B2 Flexible circuit electrode array with a drum stress relief 有权
公开(公告)号：US10188853B2
公开(公告)日：2019-01-29
申请号：US12044830
申请日：2008-03-07
申请人： Rajat Agrawal , Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Brian V. Mech , Jordan Matthew Neysmith , Neil Hamilton Talbot , Dao Min Zhou
发明人： Rajat Agrawal , Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Brian V. Mech , Jordan Matthew Neysmith , Neil Hamilton Talbot , Dao Min Zhou
IPC分类号： A61N1/05 , A61N1/36
摘要： The present invention is a flexible circuit electrode array with a polymer base layer, metal traces deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue, a polymer top layer deposited on the polymer base layer and the metal traces, and a soft polymer filling a void through both the polymer base layer and polymer top layer, the soft polymer forming drum stress relief around an attachment point.

9. 发明授权

US09131863B2 Insulated implantable electrical circuit 有权
标题翻译：绝缘可植入电路
公开(公告)号：US09131863B2
公开(公告)日：2015-09-15
申请号：US11441993
申请日：2006-05-26
申请人： Robert Greenberg , Neil Hamilton Talbot , Jerry Ok , Jordan Matthew Neysmith
发明人： Robert Greenberg , Neil Hamilton Talbot , Jerry Ok , Jordan Matthew Neysmith
IPC分类号： A61N1/05 , A61B5/04 , H05K1/03 , H05K3/00 , C23C16/01 , C23C16/56 , H05K3/04 , H05K3/06 , H05K3/28 , H05K3/46
CPC分类号： A61B5/04001 , A61B2562/125 , A61N1/0529 , A61N1/0543 , A61N1/0551 , A61N1/0553 , C23C16/01 , C23C16/56 , H05K1/032 , H05K3/007 , H05K3/048 , H05K3/06 , H05K3/28 , H05K3/4676 , H05K2201/0179 , H05K2203/016 , H05K2203/0502 , H05K2203/176 , Y10T29/49124 , Y10T29/49155
摘要： The invention is directed to an implantable insulated electrical circuit that utilizes polyparaxylylene, preferably as Parylene, a known polymer that has excellent living tissue implant characteristics, to provide for chronic implantation of conductive electrical devices, such as stimulators and sensors. The device is thin, flexible, electrically insulated, and stable after long exposure to living tissue. Layers of Parylene may be combined with layers of a polymer, such as polyimide, to yield greater design flexibility in the circuit. Multiple electrical conduction layers may be stacked in the circuit to increase packing density.
摘要翻译：本发明涉及一种可植入绝缘电路，其利用聚对二甲苯，优选作为聚对二甲苯（parylene），已知具有极好活体组织植入特征的聚合物，以提供诸如刺激剂和传感器的导电电气装置的慢性植入。该设备在长时间暴露于生物体组织之后，薄，柔性，电绝缘和稳定。聚对二甲苯层可以与诸如聚酰亚胺的聚合物层结合，以在电路中产生更大的设计灵活性。多个导电层可以堆叠在电路中以增加堆积密度。

10. 发明授权

US08524311B1 Method of manufacturing a flexible circuit electrode array 有权
标题翻译：柔性电路电极阵列的制造方法
公开(公告)号：US08524311B1
公开(公告)日：2013-09-03
申请号：US11926459
申请日：2007-10-29
申请人： Robert J. Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , Jerry Ok , Brian V. Mech
发明人： Robert J. Greenberg , Neil Hamilton Talbot , Jordan Matthew Neysmith , Jerry Ok , Brian V. Mech
IPC分类号： A61N1/04
CPC分类号： H05K3/0011 , A61N1/0543 , H05K3/0035 , H05K3/064 , H05K2203/0736 , H05K2203/095
摘要： Polymer materials make useful materials as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision. Regardless of which polymer is used, the basic construction method is the same. A layer of polymer is laid down. A layer of metal is applied to the polymer and patterned to create electrodes and leads for those electrodes. A second layer of polymer is applied over the metal layer and patterned to leave openings for the electrodes, or openings are created later by means such as laser ablation. Hence the array and its supply cable are formed of a single body. A method for manufacturing a flexible circuit electrode array, comprises: a) depositing a metal trace layer on an insulator polymer base layer; b) applying a layer of photoresist on said metal trace layer and patterning said metal trace layer and forming metal traces on said insulator polymer base layer; and c) activating said insulator polymer base layer and depositing a top insulator polymer layer and forming one single insulating polymer layer with said base insulator polymer layer; wherein the insulator polymer layers were treated at a temperature from 80-150° C. and then at a temperature from 230-350° C.
摘要翻译：聚合物材料作为电极阵列体用于神经刺激。它们对视网膜刺激特别有用，以产生人造视力。不管使用哪种聚合物，基本的施工方法是一样的。放置一层聚合物。将一层金属施加到聚合物上并图案化以产生用于那些电极的电极和引线。将第二层聚合物施加在金属层上并图案化以留下电极的开口，或稍后通过诸如激光烧蚀的手段产生开口。因此阵列及其供电电缆由单体形成。一种制造柔性电路电极阵列的方法，包括：a）在绝缘体聚合物基层上沉积金属迹线层; b）在所述金属迹线层上施加一层光致抗蚀剂，并图案化所述金属迹线层并在所述绝缘体聚合物基底层上形成金属迹线; 以及c）激活所述绝缘体聚合物基层并沉积顶绝缘体聚合物层并与所述基础绝缘体聚合物层形成一个单一绝缘聚合物层; 其中绝缘体聚合物层在80-150℃的温度下然后在230-350℃的温度下进行处理

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