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1. 发明授权

US07005292B2 Device and method for the detection of an analyte utilizing mesoscale flow systems 失效
公开(公告)号：US07005292B2
公开(公告)日：2006-02-28
申请号：US10646678
申请日：2003-08-22
申请人： Peter Wilding , Larry J. Kricka , Jay N. Zemel
发明人： Peter Wilding , Larry J. Kricka , Jay N. Zemel
IPC分类号： C12M3/00
CPC分类号： B01L3/5027 , B01F5/0601 , B01F15/0264 , B01J19/0093 , B01J2219/0059 , B01J2219/00722 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/027 , B01L2200/0647 , B01L2200/0689 , B01L2200/10 , B01L2200/146 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0822 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2300/0887 , B01L2300/1827 , B01L2300/1861 , B01L2400/0406 , B01L2400/043 , B01L2400/0487 , B01L2400/086 , C12Q1/686 , C12Q2565/629 , C40B40/06 , Y10S366/03 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809 , Y10S977/923 , Y10S977/953
摘要： Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system further includes an analyte detection region in fluid communication with the flow channel comprised of a binding moiety for specifically binding the analyte. The detection region is constructed with a mesoscale dimension sufficiently small to enhance binding of the binding moiety and the analyte. The binding moiety may be immobilized in the detection region. The mesoscale detection systems of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, or for monitoring reactions or cell culture growth.

2. 发明授权

US06290388B1 Multi-purpose integrated intensive variable sensor 失效
标题翻译：多用途集成密集变量传感器
公开(公告)号：US06290388B1
公开(公告)日：2001-09-18
申请号：US09263145
申请日：1999-03-05
申请人： Cyro K. Saul , Jay N. Zemel
发明人： Cyro K. Saul , Jay N. Zemel
IPC分类号： G01N2518
CPC分类号： G01K7/01
摘要： An integrated environment temperature sensor device provides improved temperature sensitivity by using a diode as the sensing element. The integrated sensor device comprises a heater element for creating a fixed quantity of heat energy. The sensor device also comprises an integrated circuit diode which receives the fixed quantity of heat energy from the heater element. The integrated circuit diode has a constant forward bias current applied thereto and a change in environment temperature is reflected in a voltage change across the integrated circuit diode. The integrated circuit diode further comprises an electrically insulating layer positioned substantially between the heater element and the integrated circuit diode for electrically insulating the two from each other.
摘要翻译：集成环境温度传感器装置通过使用二极管作为感测元件来提供改善的温度灵敏度。集成传感器装置包括用于产生固定量的热能的加热器元件。传感器装置还包括从加热器元件接收固定量的热能的集成电路二极管。集成电路二极管具有施加到其上的恒定的正向偏置电流，并且环境温度的变化反映在集成电路二极管两端的电压变化中。集成电路二极管还包括基本上位于加热器元件和集成电路二极管之间的电绝缘层，用于将两者彼此电绝缘。

3. 发明授权

US5463899A Simultaneous measurement of gas thermal conductivity and mass flow 失效
标题翻译：同时测量气体导热系数和质量流量
公开(公告)号：US5463899A
公开(公告)日：1995-11-07
申请号：US290026
申请日：1994-08-12
申请人： Jay N. Zemel , Hsin-Yi Hsieh
发明人： Jay N. Zemel , Hsin-Yi Hsieh
IPC分类号： G01F1/68 , G01F1/684 , G01P5/12
CPC分类号： G01F1/684 , G01F1/68 , G01P5/12 , G01N30/66
摘要： A system and method for simultaneous measurement of thermal conductivity and the mass flow of a fluid comprising two conduits arranged in a concentric or bypass arrangement through which the fluid is flowing, a pyroelectric anemometer disposed within each of the two conduits, and a differential amplifier connected to each of the pyroelectric anemometers which generate a signal based upon flow of fluid through the conduits.
摘要翻译：一种用于同时测量流体的热导率和质量流量的系统和方法，该流体包括以流体流过的同心或旁路装置布置的两个管道，布置在两个管道中的每一个内的热电风速计和连接的差分放大器到基于通过导管的流体流产生信号的每个热电风速计。

4. 发明授权

US4332157A Pyroelectric anemometer 失效
标题翻译：热电风速计
公开(公告)号：US4332157A
公开(公告)日：1982-06-01
申请号：US182683
申请日：1980-08-29
申请人： Jay N. Zemel , Hamid Rahnamai
发明人： Jay N. Zemel , Hamid Rahnamai
IPC分类号： G01F1/68 , G01F1/688 , G01F1/692 , G01F1/696 , G01P5/10 , G01N25/18
CPC分类号： G01F1/6886 , G01F1/68
摘要： Disclosed is a pyroelectric anemometer capable of providing an accurate indication of fluid flow rate. A pyroelectric substrate has a heater element located essentially transverse to the fluid flow direction. Sensor electrodes also transverse to the fluid flow direction are located upstream and downstream of the heater electrode. A fluctuating power supply is connected to the heater electrode which results in a fluctuating voltage at each sensor electrode. The amplitude of the fluctuations at the electrodes are compared and the difference in amplitude of fluctuations is indicative of the flow rate of fluid flowing thereover. Preferred embodiments utilize a differential amplifier to compare the fluctuating amplitudes and provides an output to a lock-in-amplifier which provides a fluid flow rate indicator output.
摘要翻译：公开了一种能够提供流体流速的精确指示的热释电风速计。热电基材具有基本上横向于流体流动方向定位的加热元件。也横向于流体流动方向的传感器电极位于加热器电极的上游和下游。波动的电源连接到加热器电极，导致每个传感器电极处的电压波动。比较电极的波动幅度，波动幅度的差异表示流过其的流体的流量。优选实施例利用差分放大器来比较波动幅度，并向提供流体流量指示器输出的锁定放大器提供输出。

5. 发明授权

US4302530A Method for making substance-sensitive electrical structures by processing substance-sensitive photoresist material 失效
标题翻译：通过处理物质敏感的光致抗蚀剂材料制造物质敏感的电气结构的方法
公开(公告)号：US4302530A
公开(公告)日：1981-11-24
申请号：US858906
申请日：1977-12-08
申请人： Jay N. Zemel
发明人： Jay N. Zemel
IPC分类号： G01N27/00 , G01N27/403 , G01N27/414 , H01L29/78 , G01N31/06
CPC分类号： G01N27/403 , Y10S438/948
摘要： Disclosed is a substance-sensitive semiconductor and a method for making the same, wherein a substance-sensitive material is combined with photoresist material and applied to an electronic device structure. The substance-sensitive material may be applied before or after the photoresist material, or even may be combined with the photoresist material to form a substance-sensitive layer of photoresist material on the semiconductor. The photoresist material is then processed, such that unwanted, or undesirable areas are free from the photoresist material and the areas of desired substance sensitivity have a fully processed photoresist layer. A further embodiment of the present disclosure provides multiple layers sensitive to different ions on a single sheet of semiconductor or electromagnetically active material.
摘要翻译：公开了一种物质敏感半导体及其制造方法，其中将物质敏感材料与光致抗蚀剂材料组合并应用于电子器件结构。物质敏感材料可以施加在光致抗蚀剂材料之前或之后，或者甚至可以与光致抗蚀剂材料组合以在半导体上形成光敏材料的物质敏感层。然后处理光致抗蚀剂材料，使得不需要的或不期望的区域不含光致抗蚀剂材料，并且所需物质敏感性的区域具有完全处理的光致抗蚀剂层。本公开的另一实施例提供对单片半导体或电磁活性材料上的不同离子敏感的多个层。

6. 发明授权

US08413502B2 Device for measuring infant feeding performance 有权
标题翻译：用于测量婴儿喂养性能的装置
公开(公告)号：US08413502B2
公开(公告)日：2013-04-09
申请号：US12920178
申请日：2009-04-27
申请人： Jay N. Zemel , Barbara Medoff-Cooper
发明人： Jay N. Zemel , Barbara Medoff-Cooper
IPC分类号： G01F15/02
CPC分类号： A61B5/4312 , A61B5/4288 , A61J9/00 , Y10T29/49002
摘要： Devices, systems and methods for measuring infant feeding performance. The device includes a body portion, a pressure sensor and an integrated circuit. The body portion includes a first end for receiving a fluid, a second end mateable with a feeding nipple, and a conduit in fluid communication with the first and second ends. The pressure sensor is disposed in the body portion, is in contact with the fluid in the conduit, and generates a signal representing a pressure of the fluid passing through the conduit during a feeding session. The integrated circuit is disposed in the body portion and is electrically connected to the pressure sensor. The integrated circuit receives the pressure signal and determines a feeding factor over the feeding session indicative of the infant feeding performance.
摘要翻译：用于测量婴儿喂养性能的装置，系统和方法。该装置包括主体部分，压力传感器和集成电路。主体部分包括用于接收流体的第一端，可与进料乳头配合的第二端和与第一和第二端流体连通的导管。压力传感器设置在主体部分中，与导管中的流体接触，并且在进给会话期间产生表示通过导管的流体的压力的信号。集成电路设置在主体部分中并且电连接到压力传感器。集成电路接收压力信号并且确定在馈送会话上表示婴儿喂养性能的馈送因子。

7. 发明申请

US20110087078A1 DEVICE FOR MEASURING INFANT FEEDING PERFORMANCE 有权
标题翻译：用于测量婴儿饲养性能的装置
公开(公告)号：US20110087078A1
公开(公告)日：2011-04-14
申请号：US12920178
申请日：2009-04-27
申请人： Jay N. Zemel , Barbara Medoff-Cooper , Joel Kaplan
发明人： Jay N. Zemel , Barbara Medoff-Cooper , Joel Kaplan
IPC分类号： A61B5/00 , H01S4/00
CPC分类号： A61B5/4312 , A61B5/4288 , A61J9/00 , Y10T29/49002
摘要： Devices, systems and methods for measuring infant feeding performance. The device includes a body portion, a pressure sensor and an integrated circuit. The body portion includes a first end for receiving a fluid, a second end mateable with a feeding nipple, and a conduit In fluid communication with the first and second ends. The pressure sensor is disposed in the body portion, is in contact with the fluid in the conduit, and generates a signal representing a pressure of the fluid passing through the conduit during a feeding session. The integrated circuit is disposed in the body portion and is electrically connected to the pressure sensor. The integrated circuit receives the pressure signal and determines a feeding factor over the feeding session indicative of the infant feeding performance.
摘要翻译：用于测量婴儿喂养性能的装置，系统和方法。该装置包括主体部分，压力传感器和集成电路。主体部分包括用于接收流体的第一端，可与进料接头配合的第二端和与第一端和第二端流体连通的导管。压力传感器设置在主体部分中，与导管中的流体接触，并且在进给会话期间产生表示通过导管的流体的压力的信号。集成电路设置在主体部分中并且电连接到压力传感器。集成电路接收压力信号并且确定在馈送会话上表示婴儿喂养性能的馈送因子。

8. 发明授权

US5866345A Apparatus for the detection of an analyte utilizing mesoscale flow systems 失效
标题翻译：用于使用中尺度流量系统检测分析物的装置
公开(公告)号：US5866345A
公开(公告)日：1999-02-02
申请号：US811873
申请日：1997-03-05
申请人： Peter Wilding , Larry J. Kricka , Jay N. Zemel
发明人： Peter Wilding , Larry J. Kricka , Jay N. Zemel
IPC分类号： B01F5/06 , B01J19/00 , B01L3/00 , B01L7/00 , B01L9/00 , C12M1/26 , C12M1/34 , C12M3/08 , C12Q1/68 , C40B40/06 , G01N33/558 , G01N33/569
CPC分类号： B01L3/5027 , B01F15/0264 , B01J19/0093 , B01L3/502707 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L9/527 , C12Q1/686 , B01F5/0601 , B01J2219/0059 , B01J2219/00722 , B01L2200/027 , B01L2200/0647 , B01L2200/0689 , B01L2200/10 , B01L2200/146 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0822 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2300/0887 , B01L2300/1827 , B01L2300/1861 , B01L2400/0406 , B01L2400/043 , B01L2400/0487 , B01L2400/086 , B01L3/50273 , B01L3/502746 , B01L3/502761 , C12Q2565/629 , C40B40/06 , Y10S366/03 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809 , Y10S977/923 , Y10S977/953
摘要： Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system further includes an analyte detection region in fluid communication with the flow channel comprised of a binding moiety for specifically binding the analyte. The detection region is constructed with a mesoscale dimension sufficiently small to enhance binding of the binding moiety and the analyte. The binding moiety may be immobilized in the detection region. The mesoscale detection systems of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, or for monitoring reactions or cell culture growth.
摘要翻译：公开了用于检测流体样品中预选分析物的存在的装置。这些装置包括微结构以限定样品入口的基底和包括从入口延伸的样品流动通道的中尺度流动系统。中尺度流动系统还包括与包含用于特异性结合分析物的结合部分的流动通道流体连通的分析物检测区域。检测区域的中尺度尺寸足够小以增强结合部分和分析物的结合。结合部分可以被固定在检测区域中。本发明的中尺度检测系统可用于广泛的应用，包括细胞或大分子的检测，或用于监测反应或细胞培养生长。

9. 发明授权

US4103227A Ion-controlled diode 失效
标题翻译：离子二极管
公开(公告)号：US4103227A
公开(公告)日：1978-07-25
申请号：US781474
申请日：1977-03-25
申请人： Jay N. Zemel
发明人： Jay N. Zemel
IPC分类号： G01N27/00 , G01N27/30 , G01N27/414 , G01R19/08 , G01R27/22 , G01R31/26 , H01L29/78 , G01R27/02
CPC分类号： G01R31/2621 , G01N27/414 , G01R19/08 , G01R27/22
摘要： Disclosed is an ion-controlled device for providing an electrical indication of a specific ion concentration in a fluid. An ion-sensitive membrane is placed over the junction of a gate controlled diode whose impedance is being measured. An external reference electrode is biased such that an inversion layer forms in the semiconductor material near the ion-sensitive membrane. Changes in the concentration of the unknown ion in fluid passing over the ion-sensitive membrane will affect the inversion layer in the gate controlled diode. The change in inversion layer will result in measurable changes in the diodes impedance.

10. 发明申请

US20100131454A1 METHOD AND SYSTEM FOR EVALUATING FEEDING PERFORMANCE OF INDIVIDUAL NEONATES 有权
标题翻译：用于评估个体的输出性能的方法和系统
公开(公告)号：US20100131454A1
公开(公告)日：2010-05-27
申请号：US12595755
申请日：2008-04-14
申请人： Joel Kaplan , Jay N. Zemel , Barbara Medoff-Cooper
发明人： Joel Kaplan , Jay N. Zemel , Barbara Medoff-Cooper
IPC分类号： G06N5/02
CPC分类号： A23L33/40
摘要： A method and system for computing a relative score indicative of an individual infant's feeding performance based, at least in part, upon a comparison of one or more feeding factor measurements of the individual infant with a corresponding databased metric that is derived from a population-based sample of infants, where the comparison optionally provides a statistical association between normative metric values and adverse outcomes recorded for the same population-based sample and, thereby, a means for assessing the tested infant's risk for said adverse outcomes.
摘要翻译：至少部分地基于将所述个体婴儿的一个或多个进食因子测量与从基于群体的导出的相应的数据库度量进行比较来计算指示个体婴儿喂养性能的相对得分的方法和系统婴儿样本，其中比较可选地提供规范度量值与针对相同基于人群的样本记录的不良结果之间的统计学关联，从而评估所测试的婴儿对所述不良结果的风险的手段。

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