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1. 发明授权

US07005292B2 Device and method for the detection of an analyte utilizing mesoscale flow systems 失效
公开(公告)号：US07005292B2
公开(公告)日：2006-02-28
申请号：US10646678
申请日：2003-08-22
申请人： Peter Wilding , Larry J. Kricka , Jay N. Zemel
发明人： Peter Wilding , Larry J. Kricka , Jay N. Zemel
IPC分类号： C12M3/00
CPC分类号： B01L3/5027 , B01F5/0601 , B01F15/0264 , B01J19/0093 , B01J2219/0059 , B01J2219/00722 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L7/52 , B01L7/525 , B01L9/527 , B01L2200/027 , B01L2200/0647 , B01L2200/0689 , B01L2200/10 , B01L2200/146 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2300/0822 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0883 , B01L2300/0887 , B01L2300/1827 , B01L2300/1861 , B01L2400/0406 , B01L2400/043 , B01L2400/0487 , B01L2400/086 , C12Q1/686 , C12Q2565/629 , C40B40/06 , Y10S366/03 , Y10S435/81 , Y10S435/97 , Y10S436/805 , Y10S436/806 , Y10S436/807 , Y10S436/809 , Y10S977/923 , Y10S977/953
摘要： Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow system that includes a sample flow channel extending from the inlet port. The mesoscale flow system further includes an analyte detection region in fluid communication with the flow channel comprised of a binding moiety for specifically binding the analyte. The detection region is constructed with a mesoscale dimension sufficiently small to enhance binding of the binding moiety and the analyte. The binding moiety may be immobilized in the detection region. The mesoscale detection systems of the invention may be used in a wide range of applications, including the detection of cells or macromolecules, or for monitoring reactions or cell culture growth.

2. 发明授权

US06290388B1 Multi-purpose integrated intensive variable sensor 失效
标题翻译：多用途集成密集变量传感器
公开(公告)号：US06290388B1
公开(公告)日：2001-09-18
申请号：US09263145
申请日：1999-03-05
申请人： Cyro K. Saul , Jay N. Zemel
发明人： Cyro K. Saul , Jay N. Zemel
IPC分类号： G01N2518
CPC分类号： G01K7/01
摘要： An integrated environment temperature sensor device provides improved temperature sensitivity by using a diode as the sensing element. The integrated sensor device comprises a heater element for creating a fixed quantity of heat energy. The sensor device also comprises an integrated circuit diode which receives the fixed quantity of heat energy from the heater element. The integrated circuit diode has a constant forward bias current applied thereto and a change in environment temperature is reflected in a voltage change across the integrated circuit diode. The integrated circuit diode further comprises an electrically insulating layer positioned substantially between the heater element and the integrated circuit diode for electrically insulating the two from each other.
摘要翻译：集成环境温度传感器装置通过使用二极管作为感测元件来提供改善的温度灵敏度。集成传感器装置包括用于产生固定量的热能的加热器元件。传感器装置还包括从加热器元件接收固定量的热能的集成电路二极管。集成电路二极管具有施加到其上的恒定的正向偏置电流，并且环境温度的变化反映在集成电路二极管两端的电压变化中。集成电路二极管还包括基本上位于加热器元件和集成电路二极管之间的电绝缘层，用于将两者彼此电绝缘。

3. 发明授权

US5463899A Simultaneous measurement of gas thermal conductivity and mass flow 失效
标题翻译：同时测量气体导热系数和质量流量
公开(公告)号：US5463899A
公开(公告)日：1995-11-07
申请号：US290026
申请日：1994-08-12
申请人： Jay N. Zemel , Hsin-Yi Hsieh
发明人： Jay N. Zemel , Hsin-Yi Hsieh
IPC分类号： G01F1/68 , G01F1/684 , G01P5/12
CPC分类号： G01F1/684 , G01F1/68 , G01P5/12 , G01N30/66
摘要： A system and method for simultaneous measurement of thermal conductivity and the mass flow of a fluid comprising two conduits arranged in a concentric or bypass arrangement through which the fluid is flowing, a pyroelectric anemometer disposed within each of the two conduits, and a differential amplifier connected to each of the pyroelectric anemometers which generate a signal based upon flow of fluid through the conduits.
摘要翻译：一种用于同时测量流体的热导率和质量流量的系统和方法，该流体包括以流体流过的同心或旁路装置布置的两个管道，布置在两个管道中的每一个内的热电风速计和连接的差分放大器到基于通过导管的流体流产生信号的每个热电风速计。

4. 发明授权

US4332157A Pyroelectric anemometer 失效
标题翻译：热电风速计
公开(公告)号：US4332157A
公开(公告)日：1982-06-01
申请号：US182683
申请日：1980-08-29
申请人： Jay N. Zemel , Hamid Rahnamai
发明人： Jay N. Zemel , Hamid Rahnamai
IPC分类号： G01F1/68 , G01F1/688 , G01F1/692 , G01F1/696 , G01P5/10 , G01N25/18
CPC分类号： G01F1/6886 , G01F1/68
摘要： Disclosed is a pyroelectric anemometer capable of providing an accurate indication of fluid flow rate. A pyroelectric substrate has a heater element located essentially transverse to the fluid flow direction. Sensor electrodes also transverse to the fluid flow direction are located upstream and downstream of the heater electrode. A fluctuating power supply is connected to the heater electrode which results in a fluctuating voltage at each sensor electrode. The amplitude of the fluctuations at the electrodes are compared and the difference in amplitude of fluctuations is indicative of the flow rate of fluid flowing thereover. Preferred embodiments utilize a differential amplifier to compare the fluctuating amplitudes and provides an output to a lock-in-amplifier which provides a fluid flow rate indicator output.
摘要翻译：公开了一种能够提供流体流速的精确指示的热释电风速计。热电基材具有基本上横向于流体流动方向定位的加热元件。也横向于流体流动方向的传感器电极位于加热器电极的上游和下游。波动的电源连接到加热器电极，导致每个传感器电极处的电压波动。比较电极的波动幅度，波动幅度的差异表示流过其的流体的流量。优选实施例利用差分放大器来比较波动幅度，并向提供流体流量指示器输出的锁定放大器提供输出。

5. 发明授权

US4302530A Method for making substance-sensitive electrical structures by processing substance-sensitive photoresist material 失效
标题翻译：通过处理物质敏感的光致抗蚀剂材料制造物质敏感的电气结构的方法
公开(公告)号：US4302530A
公开(公告)日：1981-11-24
申请号：US858906
申请日：1977-12-08
申请人： Jay N. Zemel
发明人： Jay N. Zemel
IPC分类号： G01N27/00 , G01N27/403 , G01N27/414 , H01L29/78 , G01N31/06
CPC分类号： G01N27/403 , Y10S438/948
摘要： Disclosed is a substance-sensitive semiconductor and a method for making the same, wherein a substance-sensitive material is combined with photoresist material and applied to an electronic device structure. The substance-sensitive material may be applied before or after the photoresist material, or even may be combined with the photoresist material to form a substance-sensitive layer of photoresist material on the semiconductor. The photoresist material is then processed, such that unwanted, or undesirable areas are free from the photoresist material and the areas of desired substance sensitivity have a fully processed photoresist layer. A further embodiment of the present disclosure provides multiple layers sensitive to different ions on a single sheet of semiconductor or electromagnetically active material.
摘要翻译：公开了一种物质敏感半导体及其制造方法，其中将物质敏感材料与光致抗蚀剂材料组合并应用于电子器件结构。物质敏感材料可以施加在光致抗蚀剂材料之前或之后，或者甚至可以与光致抗蚀剂材料组合以在半导体上形成光敏材料的物质敏感层。然后处理光致抗蚀剂材料，使得不需要的或不期望的区域不含光致抗蚀剂材料，并且所需物质敏感性的区域具有完全处理的光致抗蚀剂层。本公开的另一实施例提供对单片半导体或电磁活性材料上的不同离子敏感的多个层。

6. 发明申请

US20100131454A1 METHOD AND SYSTEM FOR EVALUATING FEEDING PERFORMANCE OF INDIVIDUAL NEONATES 有权
标题翻译：用于评估个体的输出性能的方法和系统
公开(公告)号：US20100131454A1
公开(公告)日：2010-05-27
申请号：US12595755
申请日：2008-04-14
申请人： Joel Kaplan , Jay N. Zemel , Barbara Medoff-Cooper
发明人： Joel Kaplan , Jay N. Zemel , Barbara Medoff-Cooper
IPC分类号： G06N5/02
CPC分类号： A23L33/40
摘要： A method and system for computing a relative score indicative of an individual infant's feeding performance based, at least in part, upon a comparison of one or more feeding factor measurements of the individual infant with a corresponding databased metric that is derived from a population-based sample of infants, where the comparison optionally provides a statistical association between normative metric values and adverse outcomes recorded for the same population-based sample and, thereby, a means for assessing the tested infant's risk for said adverse outcomes.
摘要翻译：至少部分地基于将所述个体婴儿的一个或多个进食因子测量与从基于群体的导出的相应的数据库度量进行比较来计算指示个体婴儿喂养性能的相对得分的方法和系统婴儿样本，其中比较可选地提供规范度量值与针对相同基于人群的样本记录的不良结果之间的统计学关联，从而评估所测试的婴儿对所述不良结果的风险的手段。

7. 发明授权

US4980646A Impedance tomographic tactile sensor 失效
标题翻译：阻抗层析成像触觉传感器
公开(公告)号：US4980646A
公开(公告)日：1990-12-25
申请号：US175348
申请日：1988-03-30
申请人： Jay N. Zemel
发明人： Jay N. Zemel
IPC分类号： G01D5/252
CPC分类号： G01D5/252
摘要： Disclosed is a container holding a partially conductive ionic fluid with a flexible tactile surface covering the fluid and sealing the container. Along the bottom of the container a series of parallel conductors are located with the farthest spaced apart conductors being connected to a voltage source. Measurements of changes in voltages between individual pairs of conductors will provide an indication of any localized deformation of the flexible tactile surface. Such a tactile sensor can be utilized in any device where an electrical output is desired which is indicative of the surface or surface characteristics of the object to be contacted.
摘要翻译：公开了一种容纳部分导电的离子流体的容器，其具有覆盖流体的柔性触觉表面并密封容器。沿着容器的底部，一系列平行的导体位于最远的间隔开的导体连接到电压源。单个导体对之间的电压变化的测量将提供柔性触觉表面的任何局部变形的指示。这种触觉传感器可以用于需要电输出的任何装置中，该装置指示待接触物体的表面或表面特性。

8. 发明授权

US4551425A Pyroelectric gas sensor 失效
标题翻译：热电气体传感器
公开(公告)号：US4551425A
公开(公告)日：1985-11-05
申请号：US425400
申请日：1982-09-28
申请人： Jay N. Zemel
发明人： Jay N. Zemel
IPC分类号： G01N25/14 , G01N25/48 , G01N30/00 , C12Q1/00 , G01N25/32
CPC分类号： G01N25/4873 , G01N25/14 , G01N30/00 , Y10S435/807
摘要： A pyroelectric substrate is provided with a heater and at least one set of electrodes for sensing charge redistributions due to changes in the substrate temperature. In a preferred embodiment, there are two interdigitated electrodes, one coated with an absorber/desorber material. The heater pulsatingly raises the temperature of the substrate past the desorption temperature of a fluid of interest. If the fluid was exposed to the absorber/desorber material prior to heating, a portion of the fluid will have been absorbed. When the substrate reaches the desorption temperature, additional heat pulses will not increase the substrate temperature significantly until the fluid has desorbed. Thus, heat used in changing state does not raise the substrate temperature and, lacking a temperature change, reduces the charge redistribution sensed by the electrode coated with the material. Its output is compared with the uncoated electrode (whose temperature continues to rise) and the difference is equal to the amount of fluid desorbed and the temperature is indicative of the species of fluid desorbed.
摘要翻译：热电基板设置有加热器和用于感测由于基板温度的变化引起的电荷再分布的至少一组电极。在优选实施例中，存在两个交错电极，一个涂覆有吸收器/解吸器材料。加热器脉动地升高衬底的温度超过感兴趣的流体的解吸温度。如果在加热之前将流体暴露于吸收器/解吸器材料，则一部分流体将被吸收。当衬底达到解吸温度时，额外的热脉冲将不会明显增加衬底温度直到流体解吸。因此，在改变状态下使用的热量不会升高衬底温度，并且没有温度变化会降低由涂覆材料的电极感测到的电荷再分布。将其输出与未涂覆的电极（其温度继续上升）进行比较，其差异等于解吸的流体的量，温度表示解吸的流体的种类。

9. 发明授权

US4453405A Pyroelectric vorticimeter 失效
标题翻译：热电脉搏计
公开(公告)号：US4453405A
公开(公告)日：1984-06-12
申请号：US381344
申请日：1982-05-24
申请人： Jay N. Zemel
发明人： Jay N. Zemel
IPC分类号： G01P5/12 , G01F1/68
CPC分类号： G01P5/12
摘要： Disclosed is a pyroelectric shear meter which can be utilized as a pyroelectric vorticimeter in which a pyroelectric substrate has a heater element located thereon and two conductor elements located adjacent the heater element. The conductor elements are spaced apart along the longitudinal axis of the heater element and located on the same side of the longitudinal axis. A fluctuating power supply is connected to the heater element causing a fluctuating surface charge distribution which varies as a function of the temperature of the substrate in the vicinity of each of the spaced apart conductor elements. Differences in charge redistributions sensed at each of the spaced apart conductor elements is an indication of the differences in flow velocity due to shear in the vicinity of the shear meter. The orienting of two shear meters with heating elements at 90.degree. with respect to each other provides shear flow components in the X and Y directions and electrically multiplying the two shear flow components provides an electronic indication of the vorticity of the flow in the region of the pyroelectric substrate.
摘要翻译：公开了一种热电剪切计，其可以用作热释电测力计，其中热电基底具有位于其上的加热元件和位于加热器元件附近的两个导体元件。导体元件沿着加热器元件的纵向轴线间隔开并且位于纵向轴线的同一侧上。波动的电源连接到加热器元件，导致波动的表面电荷分布随着每个间隔开的导体元件附近的基板的温度而变化。在每个间隔开的导体元件处感测到的电荷重新分布的差异是由于剪切仪附近的剪切引起的流速差异的指示。具有相对于彼此90度的加热元件的两个剪切计的取向在X和Y方向上提供剪切流分量，并且电乘法两个剪切流分量提供了在该区域中的流动的涡度的电子指示热电基片。

10. 发明授权

US08413502B2 Device for measuring infant feeding performance 有权
标题翻译：用于测量婴儿喂养性能的装置
公开(公告)号：US08413502B2
公开(公告)日：2013-04-09
申请号：US12920178
申请日：2009-04-27
申请人： Jay N. Zemel , Barbara Medoff-Cooper
发明人： Jay N. Zemel , Barbara Medoff-Cooper
IPC分类号： G01F15/02
CPC分类号： A61B5/4312 , A61B5/4288 , A61J9/00 , Y10T29/49002
摘要： Devices, systems and methods for measuring infant feeding performance. The device includes a body portion, a pressure sensor and an integrated circuit. The body portion includes a first end for receiving a fluid, a second end mateable with a feeding nipple, and a conduit in fluid communication with the first and second ends. The pressure sensor is disposed in the body portion, is in contact with the fluid in the conduit, and generates a signal representing a pressure of the fluid passing through the conduit during a feeding session. The integrated circuit is disposed in the body portion and is electrically connected to the pressure sensor. The integrated circuit receives the pressure signal and determines a feeding factor over the feeding session indicative of the infant feeding performance.
摘要翻译：用于测量婴儿喂养性能的装置，系统和方法。该装置包括主体部分，压力传感器和集成电路。主体部分包括用于接收流体的第一端，可与进料乳头配合的第二端和与第一和第二端流体连通的导管。压力传感器设置在主体部分中，与导管中的流体接触，并且在进给会话期间产生表示通过导管的流体的压力的信号。集成电路设置在主体部分中并且电连接到压力传感器。集成电路接收压力信号并且确定在馈送会话上表示婴儿喂养性能的馈送因子。

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