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1. 发明授权

US09616179B2 Resetting mechanism for a drug delivery device 有权
公开(公告)号：US09616179B2
公开(公告)日：2017-04-11
申请号：US13375183
申请日：2010-05-28
申请人： David Plumptre , Christopher Jones
发明人： David Plumptre , Christopher Jones
IPC分类号： A61M5/315 , A61M5/24
CPC分类号： A61M5/31543 , A61M5/31511 , A61M5/31541 , A61M5/31551 , A61M5/31558 , A61M5/31575 , A61M5/31585 , A61M2005/2407 , A61M2005/2488 , A61M2005/2492 , A61M2005/3152
摘要： A driver for driving a spindle of a drug delivery device is provided. Said driver comprises a first component and a second component rotationally coupled to said first component. During resetting of said drug delivery device, said first component is rotationally decoupled from said second component.

2. 发明授权

US09566390B2 Medication delivery device 有权
标题翻译：药物输送装置
公开(公告)号：US09566390B2
公开(公告)日：2017-02-14
申请号：US13139693
申请日：2009-12-21
申请人： Malcolm Stanley Boyd , Robert Veasey , David Plumptre
发明人： Malcolm Stanley Boyd , Robert Veasey , David Plumptre
IPC分类号： A61M5/32 , A61M5/50 , A61M5/24 , A61M5/315
CPC分类号： A61M5/3202 , A61M5/24 , A61M5/31511 , A61M5/31525 , A61M5/31541 , A61M5/3158 , A61M5/3213 , A61M5/50 , A61M2205/27
摘要： A medication delivery device comprises a housing (1), a cap (2) configured to be attached to the housing (1) and a locking means (16, 17) configured to lock the cap (2). In a first state the cap (2) is detachable and in a second state the locking means (16, 17) locks the cap (2) if the cap (2) is attached.
摘要翻译：药物输送装置包括壳体（1），构造成附接到壳体（1）的盖（2）和被配置为锁定盖（2）的锁定装置（16,17）。在第一状态下，盖（2）是可拆卸的，并且在第二状态下，如果盖（2）被附接，则锁定装置（16,17）锁定盖（2）。

3. 发明授权

US09511193B2 Assembly and indicator for a drug delivery device 有权
标题翻译：药物输送装置的装配和指示器
公开(公告)号：US09511193B2
公开(公告)日：2016-12-06
申请号：US13392882
申请日：2010-09-21
申请人： David Plumptre , Warren Terry , Robert Veasey , Matthew Jones , Timothy Giles Claughton
发明人： David Plumptre , Warren Terry , Robert Veasey , Matthew Jones , Timothy Giles Claughton
IPC分类号： A61M5/315 , A61M5/31
CPC分类号： A61M5/31585 , A61M5/3146 , A61M5/31555 , A61M5/31593 , A61M2005/3125 , A61M2205/584
摘要： An assembly for a drug delivery device, comprising a housing having a proximal end and a distal end, a piston rod and an indicator. The piston rod is adapted to be displaced distally with respect to the housing away from a proximal start position and towards a distal end position for delivering a drug. The indicator is adapted for indicating at least two different operation conditions of the assembly, the indicator being movable with respect to the housing from a first indication position for a first condition of the assembly into a second indication position for a second condition of the assembly. The piston rod and the indicator are configured to mechanically interact for converting movement of the piston rod into movement of the indicator. A first detent is provided which is configured to releasably secure the indicator in the first indication position such that movement into the second indication position is allowed. A second detent is provided which is configured to secure the indicator in the second indication position such that movement into the first indication position is prevented.
摘要翻译：一种用于药物递送装置的组件，包括具有近端和远端的壳体，活塞杆和指示器。活塞杆适于相对于壳体向远侧远离近端起始位置并朝向用于输送药物的远端位置移位。指示器适于指示组件的至少两个不同的操作条件，所述指示器可以相对于壳体从第一指示位置移动，用于组件的第一状态到用于组件的第二状态的第二指示位置。活塞杆和指示器构造成机械相互作用，以将活塞杆的运动转换为指示器的运动。提供了第一制动器，其构造成将指示器可释放地固定在第一指示位置，使得允许进入第二指示位置的移动。提供了第二制动器，其构造成将指示器固定在第二指示位置，使得防止进入第一指示位置的移动。

4. 发明授权

US09149583B2 Drug delivery dose setting mechanism with variable maximum dose 有权
标题翻译：具有可变最大剂量的药物递送剂量设定机制
公开(公告)号：US09149583B2
公开(公告)日：2015-10-06
申请号：US13320634
申请日：2010-05-28
申请人： David Plumptre
发明人： David Plumptre
IPC分类号： A61M5/31 , A61M5/315
CPC分类号： A61M5/31536 , A61M2005/3154
摘要： A method and system for proving a drug delivery device having a variable maximum dose. The drug delivery device comprising a first tubular member and a second tubular member rotatably coupled to the first tubular member. A maximum stop component is operatively coupled to the first tubular member and the second tubular member such that the maximum stop component is movable from a first position to a second position. The first position defines a first maximum dose that may be set by a user of said drug delivery device and the second position defines a second maximum dose that may be set by the user of said drug delivery device.
摘要翻译：用于证明具有可变最大剂量的药物递送装置的方法和系统。药物递送装置包括第一管状构件和可旋转地联接到第一管状构件的第二管状构件。最大限制部件可操作地联接到第一管状部件和第二管状部件，使得最大止挡部件可从第一位置移动到第二位置。第一位置定义可由所述药物递送装置的使用者设定的第一最大剂量，而第二位置限定可由所述药物递送装置的使用者设定的第二最大剂量。

5. 发明授权

US09089656B2 Spindle and bearing combination and drug delivery device 有权
标题翻译：主轴和轴承组合和药物输送装置
公开(公告)号：US09089656B2
公开(公告)日：2015-07-28
申请号：US13322813
申请日：2010-05-28
申请人： David Plumptre
发明人： David Plumptre
IPC分类号： A61M5/50 , A61M5/315
CPC分类号： A61M5/5066 , A61M5/31511 , A61M5/31515 , A61M5/3158 , A61M5/5086 , Y10T29/49826
摘要： An improved spindle and bearing combination for a drug delivery device is provided that has a first connection between the spindle (1) and bearing (4) comprising a web (5) and a second connection that replaces the first connection when the web (5) is severed that allows the spindle (1) to rotate relative to the bearing (4).
摘要翻译：提供了用于药物输送装置的改进的主轴和轴承组合，其具有在所述心轴（1）和包括腹板（5）的轴承（4）之间的第一连接和当所述腹板（5））替代所述第一连接时的第二连接，被切断，允许主轴（1）相对于轴承（4）旋转。

6. 发明授权

US08790315B2 Dose setting mechanism for a drug delivery device 有权
标题翻译：用于药物输送装置的剂量设定机构
公开(公告)号：US08790315B2
公开(公告)日：2014-07-29
申请号：US13375185
申请日：2010-05-28
申请人： David Plumptre
发明人： David Plumptre
IPC分类号： A61M5/00 , A61M5/315
CPC分类号： A61M5/31551 , A61M5/31511 , A61M5/31541
摘要： The invention relates to a dose setting mechanism, which is operable to be coupled to a medication cartridge and which comprises means that prevent the user from setting a dose greater than the remaining medication in the cartridge. The dose setting mechanism comprises a shaft. A helical groove having a first pitch is provided along a first portion of the shaft. The dose setting mechanism further comprises a nut member disposed on the helical groove of said shaft. During dose setting, the shaft is rotated relative to the nut member while the nut member traverses along the groove from a distal end of the shaft towards a proximal end of the shaft. The mechanism further comprises means preventing a user of said dose setting mechanism from setting a dose of said medication that is greater than said remaining medication in said cartridge, said means comprising a second pitch provided along a second portion of said shaft, wherein said first pitch is different from said second pitch, wherein said second pitch is preferably greater than said first pitch.
摘要翻译：本发明涉及一种剂量设定机构，其可操作以联接到药物盒，并且其包括防止使用者设定大于药筒中剩余药物的剂量的装置。剂量设定机构包括轴。具有第一间距的螺旋槽沿轴的第一部分设置。剂量设定机构还包括设置在所述轴的螺旋槽上的螺母构件。在剂量设定期间，轴相对于螺母构件旋转，同时螺母构件沿着凹槽从轴的远端朝向轴的近端横向移动。该机构还包括防止所述剂量设定机构的使用者在所述药筒中设定大于所述剩余药物的剂量的装置，所述装置包括沿所述轴的第二部分设置的第二间距，其中所述第一间距与所述第二间距不同，其中所述第二间距优选大于所述第一间距。

7. 发明申请

US20130289518A1 Dose Setting Mechanism and Method of Using the Same 有权
标题翻译：剂量设定机构及其使用方法
公开(公告)号：US20130289518A1
公开(公告)日：2013-10-31
申请号：US13878113
申请日：2011-10-11
申请人： Joseph Butler , David Plumptre
发明人： Joseph Butler , David Plumptre
IPC分类号： A61M5/315
CPC分类号： A61M5/31535 , A61M5/31551 , A61M5/31561 , A61M5/31585 , A61M2205/581 , A61M2205/582 , A61M2205/584 , A61M2205/585
摘要： The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a drug delivery device housing, a dose dial component positioned in the housing and rotatable during dose setting and dose delivery, a clutch rotatable during dose setting and non-rotatable during dose delivery having, preferably located at a distal end, clutch teeth, and a clutch ring engaged with the housing in a first rotatable configuration and in a second non-rotatable configuration.
摘要翻译：本发明涉及药物输送装置的剂量设定机构及其使用方法。该机构包括药物输送装置壳体，位于壳体中并可在剂量设定和剂量递送期间旋转的剂量拨号部件，在剂量设定期间可旋转的离合器以及在剂量递送期间不可旋转的离合器，优选位于远端，离合器齿以及离合器环，其以第一可旋转构造和第二不可旋转构造与壳体接合。

8. 发明申请

US20130197479A1 Dose Setting Mechanism and Method of Setting a Dose 有权
标题翻译：剂量设定机制及设定方法
公开(公告)号：US20130197479A1
公开(公告)日：2013-08-01
申请号：US13878555
申请日：2011-10-11
申请人： Joseph Butler , David Plumptre
发明人： Joseph Butler , David Plumptre
IPC分类号： A61M5/315
CPC分类号： A61M5/31535 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M5/31585 , A61M2005/3126
摘要： A method and system for preventing delivery of less than a predetermined minimum dose of a medicament by providing a dose setting mechanism having a spindle nut and a sprung lock nut. The mechanism includes a housing and a dose dial component positioned in the housing. The dose dial component is rotatable during a dose setting step. The mechanism further includes a drive sleeve positioned within the dose dial component. The drive sleeve is configured to drive a rotatable spindle during a dose administration step. The spindle nut is coupled to the spindle and the sprung lock nut is removably coupled to the drive sleeve and rotationally fixed to the housing. In one arrangement, when the dose dial component is rotated to select a dose less than a preselected minimum dose, the sprung lock nut allows the spindle nut to rotate thereby preventing the dose from being administered.
摘要翻译：一种用于通过提供具有心轴螺母和弹簧锁定螺母的剂量设定机构来防止小于预定最小剂量的药物的递送的方法和系统。该机构包括定位在壳体中的壳体和剂量拨号部件。在剂量设定步骤期间，剂量拨号组件可旋转。该机构还包括位于剂量拨号部件内的驱动套筒。驱动套筒构造成在剂量给药步骤期间驱动可旋转的主轴。主轴螺母联接到主轴，弹簧锁定螺母可拆卸地联接到驱动套筒并旋转地固定到壳体。在一种布置中，当剂量拨号组件旋转以选择小于预选的最小剂量的剂量时，弹簧锁定螺母允许主轴螺母旋转，从而防止施用该剂量。

9. 发明授权

US08475414B2 Medication delivery device and method for operating a medication delivery device 有权
标题翻译：药物输送装置和用于操作药物输送装置的方法
公开(公告)号：US08475414B2
公开(公告)日：2013-07-02
申请号：US12326133
申请日：2008-12-02
申请人： Malcolm Boyd , Robert Veasey , David Plumptre
发明人： Malcolm Boyd , Robert Veasey , David Plumptre
IPC分类号： A61M5/315
CPC分类号： A61M5/31555 , A61M5/24 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/31541 , A61M5/31558 , A61M5/3156 , A61M5/3157 , A61M5/31575 , A61M5/3158 , A61M5/347 , A61M2005/3103 , A61M2005/3104 , A61M2005/3152 , A61M2205/581 , A61M2205/582 , A61M2205/583
摘要： A medication delivery device (1) comprises a housing (4) having a proximal end (P) and a distal end (D), a cartridge (3) for holding a medication (M), the cartridge (3) having an outlet (2), a moveable piston (5) being retained within the cartridge (3), a drive member (17) moveable in a proximal direction with respect to the housing (4) for setting a dose of medication (M) to be delivered and in the distal direction with respect to the housing (4) for delivering the dose and a piston rod (10) adapted to drive the piston (5) in a distal direction with respect to the cartridge (3) for delivering the dose. The drive member (17) is releasably coupled to the piston rod (10). The medication delivery device (1) further comprises a resilient member (21) which is arranged to move the drive member (17) in the proximal direction with respect to the housing (4) after dose delivery, thereby reducing pressure of the piston rod (10) on the piston (5).
摘要翻译：药物输送装置（1）包括具有近端（P）和远端（D）的壳体（4），用于保持药物（M）的药筒（3），所述药筒（3）具有出口 2），可移动的活塞（5）保持在所述药筒（3）内;驱动构件（17）可相对于所述壳体（4）在近端方向上移动，用于设定要输送的药物（M）在相对于用于输送剂量的壳体（4）的远端方向上;以及活塞杆（10），其适于相对于药筒（3）沿远端方向驱动活塞（5），用于递送剂量。驱动构件（17）可释放地联接到活塞杆（10）。药物输送装置（1）还包括弹性构件（21），弹性构件（21）被布置成在剂量递送之后相对于壳体（4）在近端方向上移动驱动构件（17），从而减小活塞杆 10）在活塞（5）上。

10. 发明授权

US08317757B2 Drug delivery device inner housing having helical spline 有权
标题翻译：药物输送装置内壳具有螺旋花键
公开(公告)号：US08317757B2
公开(公告)日：2012-11-27
申请号：US13295658
申请日：2011-11-14
申请人： David Plumptre
发明人： David Plumptre
IPC分类号： A61M5/00
CPC分类号： A61M5/31525 , A61M5/31541 , A61M5/31543 , A61M5/31551 , A61M5/31585
摘要： A dose setting mechanism for a drug delivery device is disclosed. The mechanism comprises an outer housing and an inner housing having an external groove and a helical spline. The inner housing helical spline guides a driver to dispense a set dose. A dial sleeve is disposed between the outer and inner housing and is rotatably engaged with the inner housing. When a dose is set, the dial sleeve is rotated and translates away from both the outer housing and the inner housing.
摘要翻译：公开了用于药物输送装置的剂量设定机构。该机构包括外壳和具有外槽和螺旋花键的内壳。内壳螺旋花键引导驾驶员分配一定剂量。拨号套筒设置在外壳体和内壳体之间并且可旋转地与内壳体接合。当剂量被设定时，拨盘套筒旋转并且从外壳体和内壳体两者平移。

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