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    • 5. 发明专利
    • 製備經吡啶取代的胺基縮酮衍生物類之方法 PROCESS FOR PREPARING PYRIDINE-SUBSTITUTED AMINO KETAL DERIVATIVES
    • 制备经吡啶取代的胺基缩酮衍生物类之方法 PROCESS FOR PREPARING PYRIDINE-SUBSTITUTED AMINO KETAL DERIVATIVES
    • TWI316054B
    • 2009-10-21
    • TW093102879
    • 2004-02-09
    • 賽諾菲阿凡提斯德意志有限公司
    • 費雷米柯柏慕勒韋柏
    • C07D
    • C07D213/53C07D213/51
    • 本發明係關於一種製備式(I)之1-(吡啶基)-1,1-二烷氧基-2-胺基乙烷衍生物類的有效方法,藉此可製得高純度及產率並呈游離鹼形態之式(I)化合物,但不須分離由安全觀點來看為關鍵產物之式(XI)乙醯基吡啶肟固體。 The present invention relates to an efficient process for preparing derivatives of 1-(pyridinyl)-1,1 -dialkoxy-2-aminoethane of the formula(I), with which compounds of fomula (I) can be prepared in high purity and yield and in the form of the free base without isolating the acetylpyridine oxime of the formula (XI)which is a critical product from a safety point of view as a solid.
    • 本发明系关于一种制备式(I)之1-(吡啶基)-1,1-二烷氧基-2-胺基乙烷衍生物类的有效方法,借此可制得高纯度及产率并呈游离碱形态之式(I)化合物,但不须分离由安全观点来看为关键产物之式(XI)乙酰基吡啶肟固体。 The present invention relates to an efficient process for preparing derivatives of 1-(pyridinyl)-1,1 -dialkoxy-2-aminoethane of the formula(I), with which compounds of fomula (I) can be prepared in high purity and yield and in the form of the free base without isolating the acetylpyridine oxime of the formula (XI)which is a critical product from a safety point of view as a solid.