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    • 5. 发明公开
    • 유도체화 반응 기체 크로마토그래피 칩
    • 衍生反应气体色谱芯片
    • KR1020150071285A
    • 2015-06-26
    • KR1020130158130
    • 2013-12-18
    • 한국기초과학지원연구원
    • 김상구임성민
    • G01N30/90G01N35/08G01N30/02
    • G01N30/6095G01N30/06G01N2030/067G01N30/90
    • 본발명은유도체화반응기체크로마토그래피칩에관한것으로, 본발명에따른유도체화반응기체크로마토그래피칩은분석대상물을함유하는분석액이유입되는분석액유입구; 상기분석대상물과화학적으로반응하는유도체를함유하는반응액이유입되는유도체유입구; 상기분석액유입구및 상기유도체유입구각각과제1미세채널의일 단을연결하는가이드채널; 상기분석액유입구와상기유도체유입구로유입되는유체가흐르며인가되는에너지에의해상기유체내 상기유도체와반응한분석대상물의기화가이루어지는제1미세채널; 상기제1미세채널의다른일 단과연결되는제1배출구; 상기제1배출구와연통되는가스상유입구; 상기가스상유입구와일 단이연결되고고정상이형성된제2미세채널; 상기제2미세채널의다른일 단과연결되는제2배출구;를포함하는단일한칩 본체에의해, 분석액에함유된분석대상물의기화및 고정상에의한기화된분석대상물의분리가이루어지는특징이있다.
    • 本发明涉及一种衍生化反应气相色谱芯片。 根据本发明,衍生化反应气相色谱芯片包括:导入包含分析对象物的分析液的分析液入口; 导入含有与分析对象化学反应的衍生物的反应液的导入口; 引导通道,其将第一精细通道的端部与分析液体入口和导出入口单元中的每一个连接; 所述第一精细通道使所述分析目标与所述液体中的衍生物反应,通过使用在所述液体引入所述分析液入口和所述衍生物入口单元时施加的能量来蒸发所述分析目标; 第一出口连接到第一精细通道的另一端; 与第一出口连通的气体入口; 形成有固定相的第二细通道,其端部连接到气体入口; 以及连接到第二精细通道的另一端的第二出口。 本发明可以蒸发分析液中包含的分析对象,并将蒸发的分析对象与固定相分离。
    • 6. 发明授权
    • 가스 크로마토그래피 칩 적층체
    • 多层气相色谱芯片组件
    • KR101404041B1
    • 2014-06-10
    • KR1020120142018
    • 2012-12-07
    • 한국기초과학지원연구원
    • 김상구임성민
    • G01N30/02B01D15/08G01N35/08
    • G01N30/30G01N30/6095
    • Disclosed are a gas chromatography chip and a gas chromatography chip laminate. The gas chromatography chip is configured to comprise a substrate which consists of an upper substrate and a lower substrate; a gas supply connection unit which is formed on one side plane of one side surface of the substrate or the one side plane of the other side surface of the substrate; a gas deflation connection unit which is formed on other side plane of the one side surface thereof or the other side plane of the other side surface thereof; a micro-channel which is extended continuously from the gas supply connection unit to the gas deflation connection unit to form a micro-channels pattern unit; two or more position alignment markers which are formed on the one side surface or the other side surface of the surface opposing the substrate; and a heat transfer unit and a temperature control device for controlling the temperature of the substrate.
    • 公开了气相色谱芯片和气相色谱芯片层压体。 气相色谱芯片被构造成包括由上基板和下基板组成的基板; 气体供给连接单元,其形成在所述基板的一个侧面的一个侧面或所述基板的另一个侧面的一个侧面中; 气体排放连接单元,其形成在其一个侧表面的另一个侧面或另一个侧表面的另一个侧面上; 从气体供给连接单元连续地延伸到气体收缩连接单元以形成微通道图案单元的微通道; 两个或更多个位置对准标记,其形成在与所述基板相对的所述表面的一个侧表面或另一个侧表面上; 以及用于控制基板的温度的传热单元和温度控制装置。
    • 8. 发明公开
    • LC­MFR­MS 기반 신약후보물질 스크리닝 방법 및 신약후보물질 스크리닝 장치
    • 基于液相色谱 - 微流体反应器 - 质谱法和新型药物筛选设备的新型药物候选药物筛选方法
    • KR1020100076879A
    • 2010-07-06
    • KR1020090125277
    • 2009-12-16
    • 한국기초과학지원연구원
    • 김상구이기라정주희서정주박찬수
    • G01N30/72G01N33/15C12Q1/00G01N21/64
    • G01N30/6095B01L3/502784B01L2300/0654B01L2300/0816B01L2300/0883B01L2400/0487G01N30/7233G01N33/54366G01N33/6845Y10T436/143333
    • PURPOSE: A screening method of a potential material for a new invented drug, a LC/MSF/MS system, a splitter device, an organizing method of a library, an identification method of a reactant, and an identification device of the reactant are provided to invent the potential material for the new drug with low cost. CONSTITUTION: A screening method of a potential material for a new invented drug using a liquid chromatography(LC), a micro fluidic device(MSF), and a mass spectrograph system(MS) comprises the following steps: dividing a natural or a synthetic potential material for the new invented drug using the liquid chromatography; inserting the divided potential materials to the inlet of the micro fluidic device and the mass spectrograph system using a splitter; inserting a target material to an inlet of the target material channel; reacting the target material and the potential material inside a reaction channel forming droplets by inserting oil to the reaction channel; and detecting the droplets with the fluorescence among the droplets using the mass spectrograph.
    • 目的:提供新发明药物,LC / MSF / MS系统,分离器装置,文库的组织方法,反应物的鉴定方法和反应物的鉴定装置的筛选方法 以低成本发明新药的潜在材料。 构成:使用液相色谱(LC),微流体装置(MSF)和质谱系统(MS)的新发明药物的潜在材料的筛选方法包括以下步骤:将天然或合成潜能 使用液相色谱的新发明药物的材料; 将分割的潜在材料插入微流体装置的入口和使用分离器的质谱系统; 将目标材料插入目标材料通道的入口; 通过将油插入到反应通道中使目标材料和潜在材料在反应通道内部形成液滴; 并使用质谱仪在液滴中用荧光检测液滴。