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1. 发明公开

KR1020000014628A 디아릴벤조피란유도체및이를함유하는시클로옥시게네이즈-2저해제조성물 有权
标题翻译： DIARYL BENZOPYRAN衍生物和CYCLOOXYGENASE-2抑制剂
公开(公告)号：KR1020000014628A
公开(公告)日：2000-03-15
申请号：KR1019980034131
申请日：1998-08-22
申请人： 주식회사 아모레퍼시픽그룹
发明人： 강선화 , 노민수 , 이창훈 , 주영협 , 하준용 , 최진규 , 임경민 , 김진관
IPC分类号： C07D335/06 , C07D311/28 , C07D215/06
CPC分类号： C07D405/04 , C07D311/26 , C07D409/04
摘要： PURPOSE: Title compound is provided which has a good COX-2 inhibition effect. CONSTITUTION: The diarylbenzopyran derivatives(formula I; X is O, NR5 or S(O)n; R5 is hydrogen, C1- C6 lower alkyl pr NR6R7; R6 and R7 are same or not, hydrogen or C1- C6 lower alkyl group; n is integer of 0- 2; Y is O, S, H2 or N(OR6); R1 and R2 are same or not, H, halogen, C1- C6 lower alkyl, trifluoromethyl, alkoxy, hydroxy, nitro, S(O)nR5 or NR8R9; R8 and R9 are same or not H, C1- C6 lower alkyl or methylsulfonyl group; R4 is oxazolyl, benzo£b|thienyl, benzodioxanyl, naphthyl, thiazolyl, indanyl, indolyl, etc. and formula II; R10- R14 are same or not, H, halogen, C1- C6 lower alkyl, phenyl, alkoxy, hydroxy, nitro, S(O)nR5, NR6R7, etc.) and their pharmaceutical salt and cyclooxygenase-2 inhibitor containing formula I. are provided.
摘要翻译：目的：提供具有良好COX-2抑制作用的标题化合物。构型：二芳基苯并吡喃衍生物（式I; X为O，NR 5或S（O）n; R 5为氢，C 1 -C 6低级烷基，NR 6 R 7; R 6和R 7相同或不同，为氢或C 1 -C 6低级烷基; n是0-2的整数; Y是O，S，H 2或N（OR 6）; R 1和R 2相同或不同，H，卤素，C 1 -C 6低级烷基，三氟甲基，烷氧基，羟基，硝基，）nR 5或NR 8 R 9; R 8和R 9相同或不相同，C 1 -C 6低级烷基或甲基磺酰基; R 4是恶唑基，苯并[b]噻吩基，苯并二恶烷基，萘基，噻唑基，茚满基，吲哚基等和式II; R 10 - R 14相同或不同，其中，H，卤素，C 1 -C 6低级烷基，苯基，烷氧基，羟基，硝基，S（O）nR 5，NR 6 R 7等）及其药物盐和环氧合酶-2抑制剂提供。

2. 发明公开

KR20100090737A Method for preparing high bioactive flavonoid compound and method for rapid isolating quercetin therefrom 有权
标题翻译：用于制备高活性荧光体化合物的方法和用于快速分离蛋白质的方法
公开(公告)号：KR20100090737A
公开(公告)日：2010-08-17
申请号：KR20090009988
申请日：2009-02-07
申请人： KYUNGPOOK NAT UNIV IND ACAD
发明人： JEONG SIN KYO , KWON SUN YOUNG , KIM SUK KYUNG , ZHENG HU ZHE , HWANG IN UK
IPC分类号： C12P17/06 , A61K36/78
CPC分类号： C12P17/06 , A61K36/78 , C07D311/26 , C12Y302/01004 , C12Y302/01006 , C12Y302/01008
摘要： PURPOSE: A method for preparing active flavonoid compound of high content is provided to prevent various diseases by suppressing radical generation. CONSTITUTION: A method for preparing active flavonoid compound of high content comprises: a step of adding saccharolytic enzyme to Saururus Chinensis Baill. to convert non-active flavonoid compound to active flavonoid compound. The saccharolytic enzyme is viscozyme containing cellulase, betaglucanase, and xylase. The flavonoid compound contains quercetin.
摘要翻译：目的：提供一种制备高含量的活性类黄酮化合物的方法，以通过抑制自由基产生来预防各种疾病。构成：高含量的活性类黄酮化合物的制备方法包括：向Saururus Chinensis Baill中加入糖分解酶的步骤。将非活性类黄酮化合物转化成活性类黄酮化合物。蔗糖酶是含酶的纤维素酶，β-葡聚糖酶和淀粉酶。类黄酮化合物含有槲皮素。

3. 发明公开

KR1020100092808A 감초로 리퀴리티제닌을 고수율, 고순도로 제조하는 방법과 이 방법으로 제조된 리퀴리티제닌을 포함하는 기능성 화장료 조성물 有权
标题翻译：在高效液相色谱法中制备纯赖氨酸的方法和包含液体色谱的功能化妆品组合物
公开(公告)号：KR1020100092808A
公开(公告)日：2010-08-23
申请号：KR1020090012113
申请日：2009-02-13
申请人： 주식회사 콧데
发明人： 구창섭 , 하병집 , 배동준 , 정윤주 , 황규상 , 장동일
IPC分类号： C12P17/06 , A61K8/97 , C12R1/685 , C12R1/69
CPC分类号： C12P17/06 , A61K8/97 , A61K8/99 , A61K2800/85 , A61Q19/00 , C07D311/26
摘要： PURPOSE: A method for preparing liquiritigenin from Glycyrrhiza Radix is provided to ensure skin whitening and anti-wrinkle effects. CONSTITUTION: A method for preparing liquiritigenin comprises a step of adding green mold to Glycyrrhiza radix extract and culturing at 20-50°C for 1-10 days. The method comprises a step of adding enzyme liquid or mixture enzyme liquid to Glycyrrhiza Radix; and a step of reacting at 20-65°C for 1-24 hours. The green mold is Aspergillus niger, Aspergillus oryzae. A cosmetic composition for skin whitening and anti-wrinkle contains 0.0001-20 weight% liquiritigenin as an active ingredient.
摘要翻译：目的：提供甘草中甘草素的制备方法，以确保皮肤美白和抗皱效果。构成：制备甘草素的方法包括向甘草提取物中加入绿霉菌并在20-50℃下培养1-10天的步骤。该方法包括向甘草提供酶液或混合酶液的步骤; 和在20-65℃下反应1-24小时的步骤。绿色霉菌是黑曲霉（Aspergillus niger），米曲霉（Aspergillus oryzae）。用于皮肤美白和抗皱的化妆品组合物含有0.0001-20重量％的甘草素作为活性成分。

4. 发明公开

KR1020080088799A 생변환 시스템을 이용한 오르토-디하이드록시이소플라본의제조방법 有权
标题翻译：使用生物传感系统制备异羟肟酸的方法
公开(公告)号：KR1020080088799A
公开(公告)日：2008-10-06
申请号：KR1020070031552
申请日：2007-03-30
申请人： (주)아모레퍼시픽
发明人： 박준성 , 박혜윤 , 노호식 , 김덕희 , 장이섭 , 김병기 , 노창현 , 서수현 , 최권영 , 김준형 , 차민호 , 비슈누파사드판데이
IPC分类号： C12P17/06 , C12P19/04
CPC分类号： C12P17/06 , C07D311/26
摘要： A method for preparing ortho-dihydroxyisoflavones having high antioxidative and skin-whitening effects through the biotransformation system is provided to improve the preparation yield of ortho-dihydroxyisoflavones by using microorganisms. The ortho-dihydroxyisoflavones including 7,8,4Ý†-trihydroxyisoflavone, 7,6,4Ý†-trihydroxyisoflavone, 7,3Ý†,4Ý†-trihydroxyisoflavone and 7,5,3Ý†,4Ý†-tetrahydroxyisoflavone are prepared by biotransforming daidzein and genistein with a microorganism derived from Actinomyces selected from Streptomyces evermitilis, Nocardia farcinica and Streptomyces lincolnesis through site specific hydroxylation at 3Ý† site in a batch reactor to which oxygen is supplied.
摘要翻译：提供通过生物转化体系制备具有高抗氧化和皮肤美白效果的邻二羟基异黄酮的方法，以通过使用微生物来提高邻二羟基异黄酮的制备产率。通过生物转化黄豆苷原制备了包含7,8,4†-三羟基异黄酮，7,6,4†-三羟基异黄酮，7,3†，4†-三羟基异黄酮和7,5,3†，4Ý-四羟基异黄酮的邻二羟基异黄酮染料木素与来自放线菌属的微生物，所述放线菌选自Streptomyces evermitilis，诺卡氏菌（Nocardia farcinica）和链霉菌链霉菌（Streptomyces lincolnesis），通过在供给氧的间歇反应器中的3'†位点进行位点特异性羟基化。

5. 发明公开

KR1020140135840A 척수성 근위축증을 치료하기 위한 화합물 审中-实审
公开(公告)号：KR1020140135840A
公开(公告)日：2014-11-26
申请号：KR1020147029409
申请日：2013-03-14
申请人： 피티씨 테라퓨틱스, 인크.
发明人： 양티아늘 , 카르프개리미첼 , 퀴홍기안
IPC分类号： C07D491/04 , A61K31/4353 , A61P21/00
CPC分类号： C07D405/04 , A61K31/352 , C07D311/22 , C07D311/26 , C07D311/30 , C07D405/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： 본 발명은 척수성 근위축증을 치료하기 위한 화합물, 이의 조성물 및 용도에 관한 것이다.

6. 发明公开

KR1020130056020A 콩가공부산물을 미생물로 발효함으로써 이소플라본 비배당체의 함량을 증진시키는 방법 有权
标题翻译：使用微生物发酵法提高大豆的ISOFLAVON AGLUCON含量的方法
公开(公告)号：KR1020130056020A
公开(公告)日：2013-05-29
申请号：KR1020110121739
申请日：2011-11-21
申请人： 주식회사 웰빙엘에스
发明人： 이동진 , 최세영 , 이득식
IPC分类号： C12P17/06 , C07D311/36 , C12N1/20
CPC分类号： C12P17/06 , A23K10/12 , A23L11/09 , A23L33/10 , C07D311/26
摘要： PURPOSE: A method for enhancing the content of isoflavone aglycon by fermenting soybean-processed by-product with a microbe is provided to manufacture a functional food and a functional feed product. CONSTITUTION: A method for enhancing the content of isoflavone aglycon comprises a step of fermenting soybean-processed by-product with a microbe for 48 hours. The microbe is B. Licheniformis LS02(KFCC 11482P). The by-product is a soybean curd residue. The content of isoflavone extract is enhanced using 80% ethanol. [Reference numerals] (a) Soybean curd residues used for experiment; (b) Soybean extracted powder used for experiment; (c) Soybean curd residue isoflavone freeze-dried product; (d) Soybean extracted powder isoflavone freeze-dried product
摘要翻译：目的：提供通过用微生物发酵大豆加工的副产物来增强异黄酮苷元含量的方法，以制备功能性食品和功能性饲料产品。构成：提高异黄酮糖苷配基含量的方法包括用微生物发酵大豆加工副产物48小时的步骤。微生物是地衣芽孢杆菌LS02（KFCC 11482P）。副产物是大豆凝乳残渣。使用80％乙醇提高异黄酮提取物的含量。（附图标记）（a）用于实验的豆腐残渣; （b）用于实验的大豆提取粉; （c）大豆凝乳渣异黄酮冷冻干燥产品; （d）大豆提取粉状异黄酮冻干产品

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