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    • 4. 发明公开
    • 신규 3-페녹시-4-파이론, 3-페녹시-4-피리돈 또는 4-피리돈 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 항균 조성물
    • 新型3-苯基-4-吡喃酮,3-苯氧基-4-吡啶酮或4-吡啶酮衍生物,其制备方法和含有其作为活性成分的抗生物组合物
    • KR1020110011271A
    • 2011-02-08
    • KR1020090068834
    • 2009-07-28
    • 한국과학기술연구원서울대학교산학협력단
    • 신계정노은주정민경차현주서선희
    • C07D309/34C07D213/06A61K31/351A61P31/00
    • C07D213/06A61K31/351C07D309/34
    • PURPOSE: A novel 3-phenoxy-4-pyrone, 3-penoxy-4-pyridone or 4-pyridoen derivative and an antibacterial composition are provided to effectively suppress enoyl-ACP reductase(Fabl). CONSTITUTION: A novel 3-penoxy-4-pyrone, 3-phenoxy-4-pyridone or 4-pyridone derivative is denoted by chemical formula 1. A method for preparing the novel 3-phenoxy-4-pyrone derivative of chemical formula 1 comprises: a step of performing Ullmann reaction of kojic acid compound of chemical formula 4 to obtain a compound of chemical formula 5; a step of substituting the compound of chemical formula 5 with a chloride group to prepare a compound of chemical formula 6; a step of performing Arbuzov reation of the compound of chemical formula 6 to obtain a compound of chemical formula 7; and a step of performing Horner-Emmons reaction of compound of chemical formula 7 to introduce a double bond structure to prepare a compound of chemical formula 1a. An antibacterial composition contains the novel 3-phenoxy-4-pyrone, 3-phenoxy-4-pyridone or 4-pyridone derivative or pharmaceutically acceptable salt thereof as an active ingredient.
    • 目的:提供新颖的3-苯氧基-4-吡喃酮,3-缩氧-4-吡啶酮或4-吡啶酮衍生物和抗菌组合物,以有效抑制烯酰-ACP还原酶(Fab1)。 构成:化学式1表示新的3-氧羰基-4-吡喃酮,3-苯氧基-4-吡啶酮或4-吡啶酮衍生物。制备化学式1的新型3-苯氧基-4-吡喃酮衍生物的方法包括 :进行化学式4的曲酸化合物的乌尔曼反应以获得化学式5的化合物的步骤; 用氯化物基团取代化学式5的化合物制备化学式6的化合物的步骤; 进行化学式6的化合物的Arbuzov化合以获得化学式7的化合物的步骤; 并进行化学式7化合物的霍纳 - 埃蒙斯反应以引入双键结构以制备化学式1a的化合物的步骤。 抗菌组合物含有新型3-苯氧基-4-吡喃酮,3-苯氧基-4-吡啶酮或4-吡啶酮衍生物或其药学上可接受的盐作为活性成分。