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    • 3. 发明公开
    • 하전된 격자결함 함유형 다중이온 동시치환 인회석 세라믹스 및 그 제조방법
    • 带有电荷缺陷的多离子共同取代的磷酸钙陶瓷及其制造方法
    • KR1020160043807A
    • 2016-04-22
    • KR1020140138495
    • 2014-10-14
    • 서울대학교산학협력단
    • 이상훈
    • C04B35/447C04B35/64
    • C04B35/447C04B35/64
    • 본발명은알칼리족금속이온과할로겐족이온이수산화인회석의칼슘과수산화이온자리에동시에부분치환되며, 탄산이온자리와수산화이온의수소이온자리에각각양과음으로공공(vacancy)이부분적으로형성되고, 일부수산화이온중 수소이온의소실에의해형성된비가교산소와수산화이온일부자리에치환된할로겐족이온이주위수산화이온과수소결합을형성, 수산화이온이대칭배열된구조(tail-to-tail structure)를갖는수산화인회석(hydroxyapatite)과이런수산화인회석과삼인산칼슘(tricalcium phosphate)이균일하게혼합된이상인회석(biphasic calcium phosphate) 및이의제조방법에관한것이다. 본발명에따르면, 다중이온동시치환에의해수산화인회석구조의불안정성이높아져수산화인회석의용해도가증가하며, 이는이러한수산화인회석을포함하는인회석세라믹스의생체활성및 골전도도를향상시키는결과를가져올수 있다.
    • 本发明涉及羟基磷灰石羟基磷灰石中的羟基磷酸钙和羟基离子部分被碱金属离子和卤素离子部分共取代的羟基磷酸酯,分别在碳酸根离子和氢离子位置上分别形成正,负空位 的羟基离子和由羟基离子的一部分中的氢离子的损失引起的非交联氧和被羟基离子的一些位置取代的卤素基离子与周围的羟基离子一起形成氢键,使得 羟基离子具有尾 - 尾结构; 其中上述羟基磷酸酯和磷酸三钙均匀混合的双相磷酸钙; 及其制造方法。 根据本发明,通过多离子共取代,羟基磷灰石的结构变得更加不稳定,以增加羟基磷灰石的溶解度,并且可以改善含有上述羟基磷灰石的磷酸钙陶瓷的生物活性和骨传导性。
    • 6. 发明公开
    • 인산 칼슘 시멘트의 다공성 스캐폴드 제조방법
    • 磷酸钙水泥多孔溶液的制备方法
    • KR1020130009477A
    • 2013-01-23
    • KR1020110070630
    • 2011-07-15
    • 단국대학교 산학협력단
    • 김해원이길수
    • A61L27/56A61L27/12A61L27/14A61L27/54C04B35/447
    • A61L27/46A61L27/54A61L27/56A61L27/12A61L27/14A61L2430/00A61L2430/02C04B35/447C08L5/04
    • PURPOSE: A manufacturing method of porous scaffolds is provided to manufacture porous scaffolds of calcium phosphate cement by injecting a suspension of the calcium phosphate cement and alginate into a mold filled with calcium ion aqueous solution, and to provide the effect of delivering biological molecules for stimulating bone reproduction by loading biological molecules for stimulating bone reproduction together in manufacturing the scaffolds. CONSTITUTION: A manufacturing method of porous scaffolds of calcium phosphate cement comprises the first step of making a suspension of calcium phosphate cement and alginate; and the second step of solidifying by injecting the suspension into a mold filled with calcium ion aqueous solution. The manufacturing method further includes a step of compressing the scaffolds mechanically after the second step. The mixing ratio of calcium phosphate cement to alginate is 20:1-500:1 based on the weight. The concentration of the calcium ion is 10-200 mM.
    • 目的:提供多孔支架的制造方法,通过将磷酸钙水泥和藻酸盐的悬浮液注入填充有钙离子水溶液的模具中来制备磷酸钙水泥的多孔支架,并提供输送生物分子刺激的作用 通过在制造支架中一起加载用于刺激骨再生的生物分子来产生骨繁殖。 构成:磷酸钙水泥多孔支架的制造方法包括制备磷酸钙水泥和藻酸盐的悬浮液的第一步骤; 以及通过将悬浮液注入填充有钙离子水溶液的模具中而固化的第二步骤。 制造方法还包括在第二步骤之后机械压缩支架的步骤。 基于重量,磷酸钙水泥与藻酸盐的混合比为20:1-500:1。 钙离子的浓度为10-200mM。
    • 7. 发明授权
    • 몰드의 엔드커버용 내구사
    • 在模具中可以耐用的砂带
    • KR101224971B1
    • 2013-01-22
    • KR1020110098050
    • 2011-09-28
    • 현대제철 주식회사
    • 최인석박준욱김선홍
    • C04B35/657C04B35/14C04B35/18C04B35/447
    • C04B35/18C04B35/447C04B35/66C04B2235/3217C04B2235/3418
    • PURPOSE: Molding sand for an end cover of a mold with low thermal conductivity and production cost is provided to replace castable refractory. CONSTITUTION: Molding sand(10) for an end cover(2) of a mold comprises 43-49% of SiO2, 34-40% of Al2O3, 4-10% of pyrophosphoric acid aluminum, 3-9% of phosphoric acid, and the residual amount of unavoidable impurities. The phosphoric acid is composed of 65-85 volume% of phosphoric acid 65-85 and 15-35 volume% of water. The molding sand is injected into the mold(1) consisting of an end cover shape. The molding sand has the heat resistance of 1,670 deg. Celsius. The thermal conductivity of the molding sand is 80% based on the thermal conductivity of 100%. [Reference numerals] (AA) Pyrophosphoric acid aluminum; (BB) Phosphoric acid
    • 目的:提供具有低导热性和生产成本的模具端盖的成型砂,以替代浇注耐火材料。 构成:用于模具端盖(2)的成型砂(10)包括43-49%的SiO 2,34-40%的Al 2 O 3,4-10%的焦磷酸铝,3-9%的磷酸和 剩余量不可避免的杂质。 磷酸由65-85体积%的磷酸65-85和15-35体积%的水组成。 将型砂注射到由端盖形状组成的模具(1)中。 型砂的耐热性为1670度。 摄氏度。 基于热导率100%,型砂的导热率为80%。 (标号)(AA)焦磷酸铝; (BB)磷酸
    • 9. 发明公开
    • 표면 다공성 티타늄-수산화인회석 복합체의 제조방법
    • 多孔钛 - 羟基磷酸酯复合物及其制备方法
    • KR1020120073647A
    • 2012-07-05
    • KR1020100135468
    • 2010-12-27
    • 전북대학교산학협력단
    • 우기도강덕수
    • C04B38/04C04B35/64A61L27/06
    • C04B38/04C04B35/447C04B35/645C04B2235/404
    • PURPOSE: A porous titanium-hydroxyapatite(ha) composite and a manufacturing method thereof are provided to prevent cell death and to enable efficient cell proliferation and cell fixation by sintering and leaching titanium and hydroxyapatite. CONSTITUTION: A manufacturing method of a porous titanium-hydroxyapatite(ha) composite comprises the following steps: mixing titanium (Ti) powder and hydroxyapatite powder; forming a composite by sintering the mixed powder; and adding the composite to a leaching solution and forming a pore by eluting the hydroxyapatite. A particle size of the titanium powder is 5-100 micro meters and the hydroxyapatite powder is 5-100 nano meters. 10-50 weight% of the hydroxyapatite powder is mixed in the titanium powder. The sintering step is processed under 10-200 MPa, at 800-1200 deg. Celsius for 2-10 minutes. The porous titanium-hydroxyapatite composite comprises micro sized pores which are connected as 3D.
    • 目的:提供多孔钛羟基磷灰石(ha)复合物及其制备方法,以防止细胞死亡,并能通过烧结和浸出钛和羟基磷灰石使细胞增殖和细胞固定。 构成:多孔钛羟基磷灰石(ha)复合材料的制造方法包括以下步骤:将钛(Ti)粉末和羟基磷灰石粉末混合; 通过烧结混合粉末形成复合材料; 并将该复合物加入到浸出溶液中并通过洗脱羟基磷灰石形成孔。 钛粉末的粒径为5-100微米,羟基磷灰石粉末为5-100纳米。 将10-50重量%的羟基磷灰石粉末混合在钛粉末中。 烧结步骤在10-200MPa,800-1200℃加工。 摄氏2-10分钟。 多孔钛羟基磷灰石复合材料包括以3D连接的微孔。