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    • 3. 发明授权
    • 구제역 백신 조성물 및 이의 제조 방법
    • 一种疫苗组合物及其制备方法
    • KR101313159B1
    • 2013-09-30
    • KR1020117011664
    • 2009-10-23
    • 주식회사 파로스백신
    • 왕유
    • A61K39/135A61P31/14A61P31/00
    • A61K39/135A61K39/12A61K2039/552A61K2039/6056A61K2039/64C12N2770/32134
    • PURPOSE: A vaccine composition is provided to derive antibody reaction against FMDV, to be safely prepared and used, and to facilitate the handling, storage, and transportation thereof. CONSTITUTION: A vaccine composition for deriving a specific immune reaction against FMDV in animals comprises the tandem repeat of the antigen epitope of FMDV capsid proteins; and a recombinant protein including FMDV 3d protein or N-terminal to C-terminal of immunogen fragment thereof. The antigen epitope of the recombinant protein is repeated 2, 3, 4, or 5 times. [Reference numerals] (AA,FF,JJ) N-terminal; (BB,GG) Tandem repeat of the antigen epieope of FMDV VP1; (CC,HH) Unchanging area of heavy chain of immune globulin; (DD,KK) FMDV 3D protein; (EE,II,LL) C-terminal
    • 目的:提供疫苗组合物以获得抗FMDV的抗体反应,以便安全地制备和使用,并且便于其处理,储存和运输。 构成:用于在动物中获得针对FMDV的特异性免疫反应的疫苗组合物包括FMDV衣壳蛋白的抗原表位的串联重复; 以及包含FMDV 3d蛋白或其免疫原片段的C-末端的N-末端的重组蛋白质。 重组蛋白的抗原表位重复2,3,4或5次。 (标号)(AA,FF,JJ)N-末端; (BB,GG)FMDV VP1的抗原表位串联重复; (CC,HH)免疫球蛋白重链不变区; (DD,KK)FMDV 3D蛋白; (EE,II,LL)C-末端