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    • 2. 发明授权
    • 인슐린-분비세포주,그의제조방법및용도
    • 인슐린 - 분비세포주,그의제조방법및용도
    • KR100432851B1
    • 2004-11-06
    • KR1019960701650
    • 1994-09-27
    • 메르크 파텐트 게엠베하
    • 체르니코우,폴아스파리,마이랑
    • C12N5/10A61F2/02
    • C12N5/0676A61K2035/126C12N5/0677C12N2510/02
    • PCT No. PCT/FR94/01129 Sec. 371 Date Jun. 4, 1996 Sec. 102(e) Date Jun. 4, 1996 PCT Filed Sep. 27, 1994 PCT Pub. No. WO95/09231 PCT Pub. Date Apr. 6, 1995The invention relates to the field of biology and, in particular, to the field of cellular biology. The invention concerns a novel glucose-sensitive cell line designated beta cell line (INS-I) expressing glucokinase and the glucose carrier Glut 2 at levels comparable with those of normal beta cells but which is, in addition, incapable of IGF-II expression-dependent proliferation because of genetic manipulation. The invention also concerns a method for the production of said novel cell line, its aggregation in the form of a pseudoislet, its immobilization in a biocompatible hydrogel and its hardening by means of a hardening solution. Application in insulin-secreting beta -cell transplants.
    • PCT No.PCT / FR94 / 01129 Sec。 371日期1996年6月4日Sec。 102(e)日期1996年6月4日PCT提交日期1994年9月27日PCT Pub。 WO95 / 09231 PCT Pub。 日期1995年4月6日本发明涉及生物学领域,特别涉及细胞生物学领域。 本发明涉及一种新的葡萄糖敏感性细胞系,其表达葡萄糖激酶和葡萄糖载体Glut2的β细胞系(INS-1)的水平与正常β细胞的水平相当,并且另外不能表达IGF- 由于遗传操作而导致的依赖增殖 本发明还涉及生产所述新细胞系的方法,其以假小室形式聚集,其固定在生物相容性水凝胶中并通过硬化溶液硬化。 应用于胰岛素分泌型β细胞移植。
    • 5. 发明授权
    • 인슐린 분비 세포주 및 이를 포함하는 이식물
    • 인슐린분비세포주및이를포함하는이식물
    • KR100463366B1
    • 2004-12-29
    • KR1020047001293
    • 1994-09-27
    • 메르크 파텐트 게엠베하
    • 체르니코우폴아스파리마리앙
    • C12N5/10C12N5/16C07K14/62
    • C12N5/0676A61K2035/126C12N5/0677C12N2510/02
    • PCT No. PCT/FR94/01129 Sec. 371 Date Jun. 4, 1996 Sec. 102(e) Date Jun. 4, 1996 PCT Filed Sep. 27, 1994 PCT Pub. No. WO95/09231 PCT Pub. Date Apr. 6, 1995The invention relates to the field of biology and, in particular, to the field of cellular biology. The invention concerns a novel glucose-sensitive cell line designated beta cell line (INS-I) expressing glucokinase and the glucose carrier Glut 2 at levels comparable with those of normal beta cells but which is, in addition, incapable of IGF-II expression-dependent proliferation because of genetic manipulation. The invention also concerns a method for the production of said novel cell line, its aggregation in the form of a pseudoislet, its immobilization in a biocompatible hydrogel and its hardening by means of a hardening solution. Application in insulin-secreting beta -cell transplants.
    • PCT No.PCT / FR94 / 01129 Sec。 371日期1996年6月4日Sec。 102(e)日期1996年6月4日PCT提交日期1994年9月27日PCT Pub。 WO95 / 09231 PCT Pub。 日期1995年4月6日本发明涉及生物学领域,特别涉及细胞生物学领域。 本发明涉及一种新的葡萄糖敏感性细胞系,其表达葡萄糖激酶和葡萄糖载体Glut2的β细胞系(INS-1)的水平与正常β细胞的水平相当,并且另外不能表达IGF- 由于遗传操作而导致的依赖增殖 本发明还涉及生产所述新细胞系的方法,其以假小室形式聚集,其固定在生物相容性水凝胶中并通过硬化溶液硬化。 应用于胰岛素分泌型β细胞移植。
    • 9. 发明公开
    • 질병 치료를 위한 캡슐화 생물학적 물질의 이식
    • 用于治疗疾病的包埋生物材料的植入
    • KR1020050055760A
    • 2005-06-13
    • KR1020057006208
    • 2003-10-14
    • 노보셀, 인크
    • 샤프데이비드라타폴유샤오지에유에쳉윤허벨제페리
    • A61K9/50A61K35/12
    • C12N11/08A61K9/0024A61K9/5031A61K9/5036A61K2035/126C12N5/0012C12N5/0677C12N11/04C12N2533/30C12N2533/74
    • The present invention relates to compositions for treating a disease, such as diabetes, by implanting encapsulated biological material into a patient in need of treatment. Several methods are presented for coating several different types of biological materials. The coatings can be placed directly onto the surface of the biological materials or onto the surface of other coating materials that hold the biological materials. The components of the polymerization reactions that produce the coatings can include natural and synthetic polymers, macromers, accelerants, cocatalysts, photoinitiators, and radiation. These encapsulated biological materials are used to treat a variety of different human and animal diseases or disorders by implanting them into several areas in the body including the subcutaneous site. The coating materials can be manipulated to provide different degrees of biocompatibility, protein diffusivity characteristics, strength, and biodegradability to optimize the delivery of biological materials from the encapsulated implant to the host recipient while protecting the encapsulated biological materials from destruction by the host inflammatory and immune protective mechanisms without requiring long-term anti-inflammatory or anti-immune treatment of the host.
    • 本发明涉及通过将包封的生物材料植入需要治疗的患者中来治疗疾病如糖尿病的组合物。 介绍了几种不同类型的生物材料的方法。 涂层可以直接放置在生物材料的表面上或其它涂覆材料的表面上。 产生涂层的聚合反应的组分可以包括天然和合成聚合物,大分子单体,促进剂,助催化剂,光引发剂和辐射。 这些包封的生物材料用于通过将它们植入人体的包括皮下部位的几个区域来治疗各种不同的人和动物疾病或病症。 可以操作涂层材料以提供不同程度的生物相容性,蛋白质扩散性特征,强度和生物降解性,以优化从包封的植入物到宿主受体的生物材料递送,同时保护包封的生物材料免受宿主炎症和免疫的破坏 不需要对宿主进行长期抗炎或抗免疫治疗的保护机制。