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1. 发明授权

KR100772895B1 BIOPOLYMER SYNTHESIS APPARATUS, METHOD FOR SYNTHESIZING BIOPOLYMER AND METHOD FOR FABRICATING MICROARRAY 无效
标题翻译：生物聚合物合成设备，合成生物聚合物的方法和微波炉制备方法
公开(公告)号：KR100772895B1
公开(公告)日：2007-11-05
申请号：KR20060041035
申请日：2006-05-08
申请人： SAMSUNG ELECTRONICS CO LTD
发明人： CHI SUNG MIN , HAH JUNG HWAN , KIM KYOUNG SEON , KIM WON SUN
IPC分类号： C12Q1/68
CPC分类号： C40B60/14 , B01J19/0046 , B01J2219/00286 , B01J2219/00389 , B01J2219/00432 , B01J2219/00527 , B01J2219/00533 , B01J2219/00536 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00659 , B01J2219/00675 , B01J2219/00689 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , B01J2219/00583
摘要： A biopolymer synthesizing device is provided to allow all steps of the polymer synthesis to be continuously done in a closely sealed chamber, thereby increasing the process efficiency and preventing the contamination by the foreign materials flowing in. A biopolymer synthesizing device(600) comprises at least one chamber(200) including a chamber body and a chamber cover covering the chamber body and having at least one through hole on the upper side; a fluid supplying pipe(320) connected to the chamber through the through hole; and a drain part(400) connected to a drain hole formed on the lower side of the chamber to which a nucleotide phosphoramidite monomer of which a photodegradable protecting group is coupled is supplied through the fluid supplying pipe, wherein the nucleotide is a nucleotide having one base selected from the group consisting of adenine, guanine, thymine and cytosine. A method for preparing a microarray comprises the steps of: (a) providing a substrate having a functional group able to react with a nucleotide phosphoramidite monomer; (b) providing a nucleotide phosphoramidite monomer of which a photodegradable monomer is coupled to the substrate to be coupled to the functional group; (c) capping the functional group not reacting with the monomer; and (d) oxidizing the monomer coupled to the functional group, wherein the coupling, capping and oxidizing are performed in a closely sealed single chamber.
摘要翻译：提供生物聚合物合成装置，以使聚合物合成的所有步骤在紧密密封的室中连续进行，从而提高工艺效率并防止异物流入的污染。生物聚合物合成装置（600）至少包括一个室（200），其包括室主体和覆盖所述室主体并且在上侧具有至少一个通孔的室盖; 通过所述通孔连接到所述室的流体供给管（320）以及排出部（400），其连接到形成在所述室的下侧的排水孔，所述排出孔通过所述流体供给管供给所述排出孔，所述排泄孔与可光降解保护基团连接的核苷酸亚磷酰胺单体被供给，其中所述核苷酸是具有一个碱基选自腺嘌呤，鸟嘌呤，胸腺嘧啶和胞嘧啶。制备微阵列的方法包括以下步骤：（a）提供具有能够与核苷酸亚磷酰胺单体反应的官能团的底物; （b）提供其可光降解性单体与待连接到所述官能团的所述基材偶联的核苷酸亚磷酰胺单体; （c）封端不与单体反应的官能团; 和（d）氧化与官能团偶联的单体，其中偶联，封端和氧化在紧密密封的单室中进行。

2. 发明公开

KR20070106886A MICROARRAY AND METHOD FOR MANUFACTURING THE SAME 审中-公开
标题翻译：微波炉及其制造方法
公开(公告)号：KR20070106886A
公开(公告)日：2007-11-06
申请号：KR20060039291
申请日：2006-05-01
申请人： SAMSUNG ELECTRONICS CO LTD
发明人： KIM WON SUN , CHI SUNG MIN , HAH JUNG HWAN , KIM KYOUNG SEON
IPC分类号： C12Q1/68
CPC分类号： C12Q1/682 , C12Q1/6816 , C12Q1/6834 , C12Q2563/107
摘要： A microarray is provided to remove a additional signal amplification process in fluorescence analysis of hybridization results between a probe and a target material by containing a photonic crystal structure, thereby increasing detection sensitivity of the hybridization signal. A microarray comprises: a substrate(200); a photonic crystal structure(360) on the substrate for amplifying the wavelength of a light emitted from a fluorescent material attached to a target material(430) to be hybridized with a probe(400); and a probe immobilized on the photonic crystal structure, wherein the photonic crystal structure contains a first dielectric(300) and a second dielectric which are extended in a first direction in a strip type, and have different dielectric rate each other and the width having 1/4 length of wavelength of a light emitted from the fluorescent material.
摘要翻译：提供微阵列以通过包含光子晶体结构在探针和靶材料之间的杂交结果的荧光分析中除去附加信号放大过程，从而增加杂交信号的检测灵敏度。微阵列包括：基底（200）; 在所述基板上的光子晶体结构（360），用于放大从与所述探针（400）杂交的与靶材料（430）连接的荧光材料发射的光的波长; 以及固定在所述光子晶体结构上的探针，其中，所述光子晶体结构包含第一电介质（300）和第二电介质，所述第一电介质（300）和第二电介质沿带状的第一方向延伸，并且具有不同的介电率，并且所述宽度具有1 / 4从荧光材料发射的光的波长长度。

3. 发明授权

KR100772894B1 OLIGOMER PROBE ARRAY WITH MULTIFUNCTIONAL ASSAY AND FABRICATION METHOD THEREOF 无效
标题翻译：具有多功能测定的低分辨率探针阵列及其制造方法
公开(公告)号：KR100772894B1
公开(公告)日：2007-11-05
申请号：KR20060039717
申请日：2006-05-02
申请人： SAMSUNG ELECTRONICS CO LTD
发明人： HAH JUNG HWAN , CHI SUNG MIN , KIM KYOUNG SEON , KIM WON SUN
IPC分类号： G01N33/53 , G01N33/48 , G01N33/50
CPC分类号： C07H21/04 , B01J19/0046 , B01J2219/00608 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00662 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B50/14
摘要： A multi-functional oligomer probe array is provided to perform different kinds of analyses using only one oligomer probe array. And a method for preparing the same is also provided. A multi-functional oligomer probe array comprises a substrate(100a); a first array region including a plurality of first probe cell active regions(1120) which is separated by a probe cell separation region(1130) not including a functional group(150) coupled to an oligomer probe(160) on the surface and formed on or in the substrate and a plurality of oligomer probes of sequences different from one another coupled to each of the first probe cell active regions; a second array region including a plurality of probe cell active regions(2120) which is separated by a probe cell separation region(2130) not including a functional group coupled to an oligomer probe on the surface and formed on or in the substrate and a plurality of oligomer probes of sequences different from one another coupled to each of the second probe cell active regions; and a column lifting device(100b) for cutting off cross-talk of target samples respectively applied to the first array region and the second array region, wherein the first array region is to analyze the gene expression; the second array region is to analyze genotype; the surface of each of the first and the second probe cell active regions is a flat surface or a three-dimensional surface; the surface of the first and the second probe cell active regions includes a functional group coupled to the oligomer probe, wherein a portion of the functional group is coupled to the oligomer probe and the other functional group is inactively capped; and each of the first and the second probe cell active regions is a pattern of a film formed on the substrate, an LOCOS(local oxidation silicon) film formed by topically oxidizing the substrate or a trench-type active.
摘要翻译：提供多功能低聚物探针阵列，以仅使用一种低聚物探针阵列进行不同种类的分析。还提供了制备该方法。多功能低聚物探针阵列包括基底（100a）; 第一阵列区域，其包括多个第一探针单元活性区域（1120），所述第一探针单元活性区域由不包括与所述表面上的低聚物探针（160）耦合的官能团（150）分离的探针单元分离区域（1130）分开，并形成在或在衬底中以及与第一探针单元活性区域中的每一个彼此不同的序列的多个寡聚体探针; 第二阵列区域，包括由探针单元分离区域（2130）分离的多个探针单元活性区域（2120），所述探针单元活性区域不包括与表面上的低聚物探针连接并形成在基底上或其中的多个的不同于彼此耦合到每个第二探针细胞活性区的序列的寡聚体探针; 以及用于切断分别施加到第一阵列区域和第二阵列区域的目标样本的串扰的列提升装置（100b），其中第一阵列区域用于分析基因表达; 第二个阵列区域是分析基因型; 第一和第二探针单元活性区域中的每一个的表面是平坦表面或三维表面; 第一和第二探针单元活性区域的表面包括与低聚物探针连接的官能团，其中官能团的一部分与低聚物探针偶联，而另一个官能团被非活性地加帽; 并且第一和第二探针单元有源区中的每一个是在基板上形成的膜的图案，通过局部氧化基板或沟槽型活性物形成的LOCOS（局部氧化硅）膜。

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