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1. 发明授权

KR100322240B1 페니실리움 속(Ｐｅｎｉｃｉｌｌｉｕｍｓｐ.)Ｆ70614(ＫＣＴＣ 8918Ｐ)와 α-글루코시다제 저해제 失效
标题翻译：。 706148918 - 从真菌青霉属菌种中发现新的葡糖苷酶抑制剂 F70614KCTC 8918P
公开(公告)号：KR100322240B1
公开(公告)日：2002-02-07
申请号：KR1019990036927
申请日：1999-09-01
申请人： 한국생명공학연구원
发明人： 김창진 , 권오성 , 박상호 , 박동진 , 윤봉식 , 김환묵 , 한상배
IPC分类号： A01N63/00
摘要： 본발명은신균주페니실리움속(sp.) F70614(KCTC 8918P)와α-글루코시다제저해작용을갖는다음화학식 1로표시되는디케토피페라진유도체에관한것이다.

2. 发明授权

KR100411186B1 아미노글리코시드계 항생제를 이용한 식물병 방제제 有权
标题翻译： 아미노글리코시드계항생제를이용한식물병방제제
公开(公告)号：KR100411186B1
公开(公告)日：2003-12-18
申请号：KR1020000079924
申请日：2000-12-21
申请人： 한국생명공학연구원
发明人： 김창진 , 박상호 , 이향범 , 박동진
IPC分类号： A01N63/02
摘要： PURPOSE: A plant disease controlling agent using aminoglycoside, in particular paromomycin having a skeletal structure of 2-deoxystreptamine and streptomycin having a skeletal structure of streptamine is provided which can be used as an environmentally friendly biocontrol agent for crop pests. CONSTITUTION: The agent for controlling plant disease such phytophthora or Pythium sp. contains aminoglycoside-based antibiotics and an agriculturally acceptable carrier, wherein the aminoglycoside-based antibiotics are 2-deoxystreptamine or streptamine.
摘要翻译：目的：提供了一种使用氨基糖苷类的植物病害防治剂，特别是具有2-脱氧链霉胺骨架结构的巴龙霉素和具有链球菌骨架结构的链霉素，可用作对环境友好的农作物害虫生物防治剂。组成：用于防治植物病害的药剂，如疫霉或腐霉菌。含有基于氨基糖苷类的抗生素和农业上可接受的载体，其中基于氨基糖苷类的抗生素是2-脱氧链霉胺或链霉胺。

3. 发明授权

KR100411185B1 신균주 스트렙토마이세스 속 ＡＧ－Ｐ（ＫＣＴＣ８９６５Ｐ）및 이를 이용한 식물병 방제제 有权
标题翻译： AG-P（KCTC8965P）를를이병방방제제
公开(公告)号：KR100411185B1
公开(公告)日：2003-12-18
申请号：KR1020000079923
申请日：2000-12-21
申请人： 한국생명공학연구원
发明人： 김창진 , 박상호 , 이향범 , 박동진 , 김흥태 , 조광연
IPC分类号： A01N63/00
摘要： PURPOSE: A plant disease controlling agent using Streptomyces sp. AG-P(KCTC8965P) having selective antimicrobial activity against Oomycete such as Phytophthora sp. and Pythium sp. is provided which can be used as an environmentally friendly biocontrol agent for crop pests. CONSTITUTION: The agent for controlling plant disease contains Streptomyces sp. AG-P(KCTC8965P) having controlling activity against phytophthora or Pythium sp. by Oomycete and an agriculturally acceptable carrier.
摘要翻译：目的：使用链霉菌（Streptomyces sp。）的植物疾病控制剂。 AG-P（KCTC8965P）具有选择性的抗Oomycete抗菌活性，如Phytophthora sp。和Pythium sp。可用作农作物害虫的环保生物防治剂。组成：用于防治植物病害的药剂包含链霉菌属（Streptomyces sp。）。 AG-P（KCTC8965P）具有防治疫霉或腐霉菌的活性。由Oomycete和农业上可接受的载体。

4. 发明公开

KR1020020050673A 아미노글리코시드계 항생제를 이용한 식물병 방제제 有权
标题翻译：使用氨基磺酸的植物病害控制剂
公开(公告)号：KR1020020050673A
公开(公告)日：2002-06-27
申请号：KR1020000079924
申请日：2000-12-21
申请人： 한국생명공학연구원
发明人： 김창진 , 박상호 , 이향범 , 박동진
IPC分类号： A01N63/02
CPC分类号： A01N63/02 , A01N43/08 , A01N43/16 , C07H15/232
摘要： PURPOSE: A plant disease controlling agent using aminoglycoside, in particular paromomycin having a skeletal structure of 2-deoxystreptamine and streptomycin having a skeletal structure of streptamine is provided which can be used as an environmentally friendly biocontrol agent for crop pests. CONSTITUTION: The agent for controlling plant disease such phytophthora or Pythium sp. contains aminoglycoside-based antibiotics and an agriculturally acceptable carrier, wherein the aminoglycoside-based antibiotics are 2-deoxystreptamine or streptamine.
摘要翻译：目的：提供使用氨基糖苷类的植物病害防治剂，特别是具有2-脱氧链霉菌骨架结构的巴龙霉素和具有链霉胺骨架结构的链霉素，其可用作作物害虫的环境友好的生物防治剂。构成：用于控制植物病害的药剂如疫霉或腐霉属含有氨基糖苷类抗生素和农业上可接受的载体，其中氨基糖苷类抗生素为2-脱氧链霉胺或链霉胺。

5. 发明公开

KR1020020050672A 신균주 스트렙토마이세스 속 ＡＧ－Ｐ（ＫＣＴＣ８９６５Ｐ）및 이를 이용한 식물병 방제제 有权
标题翻译：新菌株STR。 AG-P（KCTC8965P）和使用相同的植物病害控制剂
公开(公告)号：KR1020020050672A
公开(公告)日：2002-06-27
申请号：KR1020000079923
申请日：2000-12-21
申请人： 한국생명공학연구원
发明人： 김창진 , 박상호 , 이향범 , 박동진 , 김흥태 , 조광연
IPC分类号： A01N63/00
CPC分类号： A01N63/02 , C12N1/20 , C12R1/465
摘要： PURPOSE: A plant disease controlling agent using Streptomyces sp. AG-P(KCTC8965P) having selective antimicrobial activity against Oomycete such as Phytophthora sp. and Pythium sp. is provided which can be used as an environmentally friendly biocontrol agent for crop pests. CONSTITUTION: The agent for controlling plant disease contains Streptomyces sp. AG-P(KCTC8965P) having controlling activity against phytophthora or Pythium sp. by Oomycete and an agriculturally acceptable carrier.
摘要翻译：目的：使用链霉菌属的植物病害防治剂对卵菌例如疫霉属（Phytophthora sp。）具有选择性抗微生物活性的AG-P（KCTC8965P）和腐霉属可用作农作物害虫的环保生物防治剂。规定：防治植物病害的药物含有链霉菌属（Streptomyces sp。）。 AG-P（KCTC8965P）具有对植物疫病或腐霉菌属的控制活性。由大肠杆菌和农业上可接受的载体。

6. 发明公开

KR1020010037884A 신균주 시스토박터 속 ＭＳＬ-9(ＫＣＴＣ 8958Ｐ) 및 이로부터 생산되는 고분자 분산제 无效
标题翻译：新款CYSTOBACTER SP。 MSL-9菌株（KCTC 8958P）及其生产的聚合物分散剂
公开(公告)号：KR1020010037884A
公开(公告)日：2001-05-15
申请号：KR1019990045622
申请日：1999-10-20
申请人： 한국생명공학연구원
发明人： 김창진 , 박상호 , 박동진 , 정은예 , 박해룡 , 권오성
IPC分类号： C12N1/20
摘要： PURPOSE: A novel Cystobacter sp. MSL-9 strain(KCTC 8958P) and a polymeric dispersant produced therefrom are provided, thereby the polymeric dispersant can effectively disperse clay mineral ores such as kaoline, bentonite and calcium carbonate in a liquid solution. CONSTITUTION: The novel Cystobacter sp. MSL-9 strain (KCTC 8958P) produces the polymeric dispersant which can easily disperse clay mineral ores such as kaoline, bentonite and calcium carbonate in a liquid solution. The polymeric dispersant is produced by incubating Cystobacter sp. MSL-9(KCTC 8958P) in a medium containing casitone; centrifuging the fermented culture; collecting the supernatant; adding ethanol into the supernatant; and separating the polymeric dispersant with methanol and chloroform.
摘要翻译：目的：一种新型囊状杆菌提供MSL-9菌株（KCTC 8958P）和由其制备的聚合物分散剂，由此聚合物分散剂可有效地将粘土矿物如高岭土，膨润土和碳酸钙分散在液体溶液中。构成：新型囊状杆菌 MSL-9菌株（KCTC 8958P）生产聚合物分散剂，其可以容易地将粘土矿物如高岭土，膨润土和碳酸钙分散在液体溶液中。聚合物分散剂是通过孵育囊泡杆菌 MSL-9（KCTC 8958P）在含有中间体的培养基中; 离心发酵培养; 收集上清液; 向上清液中加入乙醇; 并用甲醇和氯仿分离聚合物分散剂。

7. 发明公开

KR1020010025876A 페니실리움 속(Ｐｅｎｉｃｉｌｌｉｕｍｓｐ.)Ｆ70614(ＫＣＴＣ 8918Ｐ)와 α-글루코시다제 저해제 失效
标题翻译： PENICILLIUM SP。 F70614（KCTC 8918P）和葡糖苷酶抑制剂
公开(公告)号：KR1020010025876A
公开(公告)日：2001-04-06
申请号：KR1019990036927
申请日：1999-09-01
申请人： 한국생명공학연구원
发明人： 김창진 , 권오성 , 박상호 , 박동진 , 윤봉식 , 김환묵 , 한상배
IPC分类号： A01N63/00
CPC分类号： A61K31/495 , A61K36/06 , C12N1/14 , C12R1/80
摘要： PURPOSE: A Penicillium sp. F70614(KCTC 8918P) and an α-glucosidase inhibitor(diketopiperazine derivaives(formula)) are provided, which inhibits α-glucosidase effectively, so can be used for treatment and prevention of diabetes and obesity. CONSTITUTION: A process for the preparation of Penicillium sp. F70614(KCTC 8918P) and α-glucosidase inhibitor comprises the steps of: inoculating Penicillium sp. F70614(KCTC 8918P) on a prepared plate, and culturing for 3days at 28deg.C; inoculating the cultured solution in a fermentor, and culturing for 7days at 28deg.C; centrifuging the final cultured solution to separate cultured supernatant and bacillus body, extracting the bacillus body with acetone and concentrating under decompression to remove acetone, and mixing with the cultured supernatant and extracting with ethylacetate; concentrating the ethylacetate extract, and processing silicagel chromatography, LH-20 column chromatography and high-pressure liquid chromatography to get pure active ingredients; removing solvent using a decompressed dryer, and freeze-drying to get the white diketopiperazine derivaives powder(which can be also prepared by chemical synthesis).
摘要翻译：目的：青霉属提供F70614（KCTC8918P）和α-葡糖苷酶抑制剂（二酮哌嗪衍生物（配方）），其有效抑制α-葡糖苷酶，因此可用于治疗和预防糖尿病和肥胖症。规定：制备青霉菌的方法 F70614（KCTC 8918P）和α-葡糖苷酶抑制剂包括以下步骤：接种青霉菌 F70614（KCTC 8918P），在28℃培养3天; 将培养液接种在发酵罐中，培养7天，培养温度为28℃; 将最终培养液离心分离培养的上清液和杆菌体，用丙酮提取芽孢杆菌体，减压浓缩除去丙酮，与培养上清液混合，用乙酸乙酯萃取; 浓缩乙酸乙酯提取物，加工硅胶色谱，LH-20柱色谱和高压液相色谱，得到纯活性成分; 使用减压干燥器除去溶剂，并冷冻干燥得到白色二酮哌嗪衍生物粉末（其也可以通过化学合成制备）。

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