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1. 发明授权

KR101635782B1 폴리머 층을 구비하는 바이오 물질 운반체 포획 구조물 및 이를 이용한 바이오 물질 운반체 선택적 수집 장치와 방법 有权
标题翻译：具有聚合物层的生物材料捕获结构和装置以及使用该聚合物层收集生物材料载体的方法
公开(公告)号：KR101635782B1
公开(公告)日：2016-07-04
申请号：KR1020140071952
申请日：2014-06-13
申请人： 한국과학기술원
发明人： 서태석 , 최종섭
IPC分类号： C12Q1/24 , C12M1/00
摘要： 본발명은다수의단일세포또는바이오물질을운반하는캐리어인마이크로비드(microbead)를개별적으로포획하고원하는단일세포또는마이크로비드만을선택적으로방출하여수집하는기술에관한것이다. 본발명에의하면, 주입구멍과제1 배출구멍사이에연장되는제1 유체채널과, 제2 배출구멍과연결되고상기제1 유체채널과대향하는제2 유체채널과, 일면은상기제1 유체채널을향하고타면은상기제2 유체채널을향하도록상기제1 유체채널과상기제2 유체채널사이에설치되는포획구조물을구비하는포획칩; 및가열수단을포함하며, 상기포획구조물은, 상기제1 유체채널을향하는일면에다수의포획홈이형성되고상기제2 유체채널을향하는타면에상기포획홈 각각의바닥과연결되는다수의제1 관통홀이형성되는기판과, 상기제2 유체채널을향하는타면에형성되고상기제1 관통홀과연결되는제2 관통홀이마련된폴리머층을구비하며, 상기가열수단은상기포획홈을개별적으로가열하는것을특징으로하는바이오물질운반체선택적수집장치가제공된다.

2. 发明授权

KR101605947B1 미세 액적 내 단일 세포 배양 시스템 및 방법 有权
标题翻译：用于在精细滴漏中培养单细胞的系统和方法
公开(公告)号：KR101605947B1
公开(公告)日：2016-03-23
申请号：KR1020140025784
申请日：2014-03-05
申请人： 한국과학기술원
发明人： 서태석 , 배선웅
IPC分类号： C12M3/00
摘要： 본발명은세포배양시스템및 방법에관한것으로서, 더욱상세하게는단일세포기반세포배양환경을제공하는세포배양시스템및 방법에관한것이다. 본발명에의하면, 대량의단일세포를포함하는제1 액체가흐르도록형성된제1 유로; 제2 액체가흐르고중간에상기제1 액체가상기제2 액체와합류하도록상기제1 유로와연결되는제2 유로; 상기제1 유로의상류쪽 끝단에연결되고상기단일세포각각에특정유전자를전달하여형질전환을유도하는유전자전달부; 및상기제2 유로의하류쪽 끝단에연결되는세포배양부를포함하며, 상기제1 액체는상기제1 유로에서상기제2 유로로유입되면서제2 액체와상호작용하여내부에하나의단일세포를포함하는미세액적을연속적으로형성하며, 세포배양부는상기제2 유로로부터공급된상기다수의미세액적을수용하여단일세포를배양하며, 전기영동법등을이용하여성공적으로배양된미세조류가존재하는미세액적만을선별하는것을특징으로하는미세액적내 단일세포배양시스템및 이를이용하는미세액적내 단일세포배양방법이제공된다.

3. 发明公开

KR1020150139355A 중금속 이온 샘플 전처리용 미세 유체 칩 및 이를 이용하는 중금속 이온 샘플 전처리 장치와 방법 有权
标题翻译：用于重金属离子样品预处理的微流化芯片，以及使用该方法预处理重金属离子样品的装置和方法
公开(公告)号：KR1020150139355A
公开(公告)日：2015-12-11
申请号：KR1020140067853
申请日：2014-06-03
申请人： 한국과학기술원
发明人： 서태석 , 박민수
IPC分类号： G01N1/28 , G01N27/62 , H01J49/26 , B81B3/00 , B81C1/00
摘要： 본발명은중금속이온샘플의분석기술에관한것으로서, 더욱상세하게는중금속이온샘플을전처리하기위한미세유체칩 및이를이용하는중금속이온샘플전처리장치와방법에관한것이다. 본발명에의하면, 양이온교환수지가채워지는포획체임버와중금속이온을함유하는액상샘플을상기포획체임버로안내하는유로채널이형성되는몸체부; 상기유로채널의상부를덮어서막는멤브레인부; 및상기멤브레인부를덮는커버부를포함하며, 상기유로채널에는액체의흐름을막는차단벽이마련되며, 상기커버부에서상기멤브레인부와접하는면에는상기차단벽에대응하여위치하는압력작용홈이마련되는중금속이온샘플전처리용미세유체칩이제공된다.
摘要翻译：本发明涉及重金属离子样品的分析技术，更具体地，涉及用于重金属离子样品预处理的微流控芯片，以及使用该重金属离子样品预处理重金属离子样品的装置和方法。根据本发明，用于重金属离子样品预处理的微流体芯片包括：具有填充有阳离子交换树脂的捕获室的主体部分和将含有重金属离子的液体样品引导到捕获室的流动通道; 膜部分，以覆盖和阻挡流动通道的上部; 以及覆盖膜部的盖部。在流动通道中，制备阻挡流体流动的阻挡壁。此外，在与盖部的膜部接触的表面上制备与阻挡壁对应的位置的压力作用槽，从而提供用于重金属离子样品预处理的微流控芯片。

4. 发明公开

KR1020150117945A 환원 그래핀 산화물 기반 바이오 센서 및 이를 이용한 바이오 물질 검출 방법 无效
标题翻译：基于减少氧化石墨的生物传感器以及使用该方法感测生物材料的方法
公开(公告)号：KR1020150117945A
公开(公告)日：2015-10-21
申请号：KR1020140043769
申请日：2014-04-11
申请人： 한국과학기술원
发明人： 서태석 , 류페이 , 김요한
IPC分类号： G01N27/26 , G01N33/53 , C12Q1/68 , H01L29/786
CPC分类号： G01N27/26 , C12Q1/68 , G01N27/414 , G01N33/53 , H01L29/786
摘要： 기판; 상기기판상에구비되며, 서로이격된소스및 드레인전극; 상기소스및 드레인전극과각각접촉하는환원된그래핀산화물층; 및상기환원된그래핀산화물층상에고정되며, 검출하고자하는바이오물질과특이적으로결합하는프로브를포함하는전계효과트랜지스터소자를포함하는것을특징으로하는, 환원그래핀산화물기반바이오센서가제공된다.
摘要翻译：提供了一种基于还原型石墨烯氧化物的生物传感器，其包括：基底; 源极和漏极，其形成在衬底上并彼此间隔开; 单独连接到源电极和漏电极的还原石墨烯氧化物层; 以及固定在还原型石墨烯氧化物层上的场效应晶体管，并且包括单独耦合到想要检测的生物材料的探针。

5. 发明授权

KR101440997B1 샘플 전처리ＰＣＲ검출 통합 마이크로칩 및 이를 이용한 분석 방법 有权
标题翻译：集成样品预处理 - 聚合酶链反应检测微孔和分析方法
公开(公告)号：KR101440997B1
公开(公告)日：2014-09-17
申请号：KR1020130039334
申请日：2013-04-10
申请人： 한국과학기술원
发明人： 서태석 , 김용태
IPC分类号： G01N33/53 , C12Q1/68 , G01N35/08
CPC分类号： G01N33/5308 , B01L3/5027 , C12Q1/6837 , C12Q1/6844 , C12Q1/686 , G01N35/085
摘要： The present invention relates to a gene analyzing technique and, more specifically, to a micro-device by which a sample pretreatment process, a PCR process, and a detection process such as capillary electrophoresis can integrally be performed; and to an analyzing method using the same. By means of the present invention, provided is a sample pretreatment-PCR-detection integrated microchip comprising: a channel wafer including a feeding channel, a discharging channel, and a micro channel equipped with a detecting domain formed to be separated from each other; and a slide plate coupled with one surface of the channel wafer to be able to slide, and has a moving chamber formed to be connected with one surface of the channel wafer. On one surface of the channel wafer, a discharging hole connected with the feeding channel and a feeding hole connected with the discharging channel are formed. The discharging hole and feeding hole are separated to be connected together with the moving chamber in accordance to the position of the moving chamber.
摘要翻译：本发明涉及一种基因分析技术，更具体地，涉及可以一体地进行样品预处理过程，PCR过程和检测过程如毛细管电泳的微装置; 以及使用该方法的分析方法。通过本发明，提供了一种样品预处理PCR检测集成微芯片，其包括：通道晶片，其包括馈送通道，放电通道和配备有形成为彼此分离的检测区域的微通道; 以及与通道晶片的一个表面耦合以能够滑动的滑板，并且具有形成为与通道晶片的一个表面连接的移动室。在通道晶片的一个表面上形成有与供给通道连接的排出孔和与排出通道连接的供给孔。排放孔和进料孔根据移动室的位置被分离成与移动室连接在一起。

6. 发明公开

KR1020140093084A 회전 ＰＣＲ 공정용 시료 처리 칩, 이를 구비하는 회전 ＰＣＲ 장치 및 이를 이용한 회전 ＰＣＲ 방법 有权
标题翻译：用于旋转PCR处理的样品处理芯片，具有该旋转PCR处理的旋转PCR装置和使用其的旋转PCR方法
公开(公告)号：KR1020140093084A
公开(公告)日：2014-07-25
申请号：KR1020130005438
申请日：2013-01-17
申请人： 한국과학기술원
发明人： 서태석 , 정재환 , 박병현
IPC分类号： C12Q1/68 , C12M1/38 , C12M1/00
CPC分类号： C12Q1/6837 , C12M1/38 , C12Q1/686
摘要： The present invention includes a unit sample processing unit which is positioned by being separated from the center of a rotation in a radial direction. The unit sample processing unit includes: a target material capturing unit which includes a capturing path having an inlet hole and an outlet hole and a capturing means filling the capturing path; a sample chamber which is positioned to be inner than the target material capturing unit in a radial direction, is connected to the inlet hole of the capturing path, and provides a space which stores a sample inside; a washing buffer solution chamber which is positioned to be inner than the target material capturing unit in a radial direction and provides a space which stores washing buffer solution inside; washing buffer solution which is positioned between the washing buffer solution chamber and the inlet of the capturing path; an elution buffer solution chamber which is positioned to be inner than the target material capturing unit in a radial direction and provides a space which stores elution buffer solution inside; and an elution buffer solution introduction path which is positioned between the elution buffer solution chamber and the inlet of the capturing path. The washing buffer solution introduction path includes inner transition curve sections which change the flow of the washing buffer solution from the inside to the outside. The elution buffer solution introduction path changes the flow of the elution buffer solution from the inside of the radial direction to the outside and includes a first inner transition curve section and a second inner transition curve section which are arranged in order in a flow direction.
摘要翻译：本发明包括通过沿径向从旋转中心分离而定位的单元样品处理单元。单元样品处理单元包括：目标材料捕获单元，其包括具有入口孔和出口孔的捕获路径和填充捕获路径的捕获装置; 在径向方向上位于目标材料捕获单元的内部的样品室连接到捕获路径的入口孔，并且提供将样品储存在其中的空间; 洗涤缓冲溶液室，其沿径向位于所述目标材料捕获单元的内部，并且提供在其中存储洗涤缓冲溶液的空间; 位于洗涤缓冲溶液室和捕获路径入口之间的洗涤缓冲溶液; 洗脱缓冲溶液室，其位于径向方向上位于靶材捕获单元的内部，并提供将洗脱缓冲溶液存储在其中的空间; 以及位于洗脱缓冲溶液室与捕获路径的入口之间的洗脱缓冲液引入路径。洗涤缓冲液引入路径包括将洗涤缓冲溶液从内向外流动的内部过渡曲线部分。洗脱缓冲溶液导入路径将洗脱缓冲溶液从径向内侧的流动改变到外部，并且包括在流动方向上依次排列的第一内部过渡曲线部分和第二内部过渡曲线部分。

7. 发明授权

KR101391066B1 회전형 디지털 ＰＣＲ 공정용 마이크로 칩 및 이를 이용한 디지털 ＰＣＲ 방법 有权
标题翻译：用于旋转数字PCR处理的微型计算机和使用该方法的PCR方法和装置
公开(公告)号：KR101391066B1
公开(公告)日：2014-05-27
申请号：KR1020130033734
申请日：2013-03-28
申请人： 한국과학기술원
发明人： 서태석 , 박병현
IPC分类号： G01N35/00 , C12M1/00 , C12Q1/68 , G01N37/00
CPC分类号： G01N35/00 , C12M1/00 , C12Q1/6837 , C12Q1/6844 , C12Q1/686 , G01N37/00
摘要： The present invention relates to a digital PCR, and more specifically, to a microchip for a rotary digital PCR process and a digital PCR method using the same. According to an embodiment of the present invention, the microchip includes: a capturing chamber which has an entrance and an outlet facing each other; and a plurality of capturing structures which are placed inside the capturing chamber and independently captures samples, wherein the width of the entrance is greater than the width of the outlet.
摘要翻译：本发明涉及数字PCR，更具体地，涉及一种用于旋转数字PCR过程的微芯片和使用该PCR的数字PCR方法。根据本发明的一个实施例，微芯片包括：具有彼此面对的入口和出口的捕获室; 以及放置在捕获室内并独立地捕获样品的多个捕获结构，其中入口的宽度大于出口的宽度。

8. 发明授权

KR101355994B1 병원체 검출용 마이크로디바이스 有权
标题翻译：用于病原体检测的MICRODEVICE
公开(公告)号：KR101355994B1
公开(公告)日：2014-01-29
申请号：KR1020110122199
申请日：2011-11-22
申请人： 한국과학기술원
发明人： 서태석 , 정재환
IPC分类号： C12M1/34 , C12Q1/04 , C12M1/42
CPC分类号： B01F5/0647 , B01F5/0655 , B01F13/0059 , B01L3/50273 , B01L3/502753 , B01L2200/0647 , B01L2300/0806 , B01L2300/0883 , B01L2300/1827 , B01L2400/0409 , B01L2400/0421 , B01L2400/043 , B82Y5/00 , B82Y35/00 , G01N27/44726 , G01N27/44791 , G01N33/54326 , G01N33/54346 , G01N33/54366
摘要： 병원체(pathogen), 제 1 프로브(probe), 및 제 2 프로브를 믹싱하기 위한 수동식 마이크로믹서(passive micromixer); 상기 수동식 마이크로믹서에 연결된 자기적 분리(magnetic separation) 챔버; 및, 상기 자기적 분리 챔버에 연결된 모세관 전기영동(capillary electrophoresis) 채널을 포함하는, 병원체 검출용 마이크로디바이스에 관한 것이다.

9. 发明公开

KR1020130045995A 환원 그래핀 산화물-금속 나노입자 복합필름의 제조방법, 이에 의하여 제조된 환원 그래핀 산화물-금속 나노입자 복합필름 및 이를 이용한 바이오센서 有权
标题翻译：一种制造减少氧化亚金属纳米复合膜的方法，由其制造的还原型氧化亚金属纳米复合膜，以及包含减少的图形氧化亚金属纳米复合膜的生物传感器
公开(公告)号：KR1020130045995A
公开(公告)日：2013-05-07
申请号：KR1020110110275
申请日：2011-10-27
申请人： 한국과학기술원
发明人： 서태석 , 류페이
IPC分类号： C01B31/02 , G01N33/48 , B82B3/00 , B82Y40/00
CPC分类号： C01B32/182 , B82B3/0009 , B82Y40/00 , C01B32/15 , C01G7/00
摘要： PURPOSE: A graphene composite film, a manufacturing method thereof, and a biosensor using the same are provided to mass produce graphene composite films at a low cost without using separate chemicals for treating the surface, and to control the composition of nano-materials. CONSTITUTION: A manufacturing method of a graphene composite film comprises the following steps: a step of obtaining a mixed solution by mixing a metal nanoparticle solution to a dispersion solution in which graphene oxide sheets are dispersed; a step of obtaining a metal nanoparticle-graphene oxide composite film by centrifugally rotating said mixed solution in the vacuum condition; and a step of manufacturing a metal nanoparticle-reduced graphene composite film by reducing said metal nanoparticle-graphene oxide composite film. The surface of metal nanoparticles has the same electric charge to the surface of graphene oxides.
摘要翻译：目的：提供石墨烯复合膜及其制造方法和使用该石墨烯复合膜的生物传感器，以低成本批量生产石墨烯复合膜，而不使用用于处理表面的单独化学品，并且控制纳米材料的组成。构成：石墨烯复合膜的制造方法包括以下步骤：通过将金属纳米颗粒溶液与其中分散有石墨烯氧化物片的分散液混合来获得混合溶液的步骤; 通过在真空条件下离心旋转所述混合溶液获得金属纳米颗粒 - 石墨烯氧化物复合膜的步骤; 以及通过还原所述金属纳米颗粒 - 石墨烯氧化物复合膜来制造金属纳米颗粒还原型石墨烯复合膜的步骤。金属纳米颗粒的表面与石墨烯氧化物的表面具有相同的电荷。

10. 发明公开

KR1020130024223A 다파장 균일 조사기와 검출센서를 이용하여 형광물질을 검출 가능한 회전 실시간 ＰＣＲ장치, 이를 위한 실시간 ＰＣＲ 칩, 이를 이용한 회전 실시간 ＰＣＲ 방법 无效
标题翻译：使用具有多个波长和传感器的发光体感测荧光材料的旋转实时PCR
公开(公告)号：KR1020130024223A
公开(公告)日：2013-03-08
申请号：KR1020110087532
申请日：2011-08-31
申请人： 한국과학기술원
发明人： 서태석
IPC分类号： C12M1/38 , C12Q1/68
CPC分类号： C12M1/38 , C12M1/10 , C12Q1/686
摘要： PURPOSE: A rotary real-time PCR apparatus, a real-time PCR chip for the same, and a rotary real-time PCR method using the same are provided to ensure a stable and accurate rotation number and quantity. CONSTITUTION: A rotary real-time PCR apparatus for detecting a fluorescent substance using a multiple wavelength irradiator(300a) and a sensor(300b) comprises: a rotation device, a temperature area forming device, and a light measuring device. The rotation device is connected with a PCR chip and rotates the PCR chip. The temperature area forming device is separated from the PCR chip and applies heat energy to the PCR chip. The temperature area forming device has a plurality of heating blocks. The light measuring device has an excitation light and a measuring device. The rotation device has a shaft, and a motor which rotates the shaft.
摘要翻译：目的：提供旋转实时PCR装置，用于其的实时PCR芯片和使用其的旋转实时PCR方法，以确保稳定且准确的旋转数量和数量。构成：使用多波长照射器（300a）和传感器（300b）检测荧光物质的旋转实时PCR装置包括：旋转装置，温度区域形成装置和光测量装置。旋转装置与PCR芯片连接并旋转PCR芯片。将温度区域形成装置与PCR芯片分离，并向PCR芯片施加热能。温度区域形成装置具有多个加热块。光测量装置具有激发光和测量装置。旋转装置具有轴和使轴旋转的马达。

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