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    • 5. 发明公开
    • 측백 추출물, 분획물 또는 이로부터 분리한 화합물을포함하는 당뇨병 합병증 예방 및 치료용 조성물
    • 包含用于预防或治疗糖尿病并发症的THUJA ORIENTALIS的提取物,部分和分离化合物的组合物
    • KR1020080085358A
    • 2008-09-24
    • KR1020070026744
    • 2007-03-19
    • 한국과학기술연구원
    • 정상훈이은하이정민김철영판철호이동언엄병헌
    • A61K36/14A61P3/10
    • A composition comprising the extract, a fraction or an isolated compound of Thuja orientalis is provided to inhibit sorbitol accumulation and non-enzymatic saccharification causing neurological disorder and neurological damage by inhibiting aldose reductase, so that the composition is useful for prevention or treatment of diabetic complications. A composition for prevention or treatment of diabetic complications comprises the extract, a fraction or an isolated compound of Thuja orientalis such as quercitrin which is isolated by (1) extracting Thuja orientalis with water, C1-C4 lower alcohol or a mixture thereof, (2) fractionating the extract of Thuja orientalis with ethyl acetate, and (3) adding CH2Cl2-MeOH or hexane-ethylacetate into the fraction of Thuja orientalis, and is a pharmaceutical or health food composition.
    • 提供包含提取物,部分或分离的东方蓟马化合物的组合物以抑制山梨醇积累和非酶促糖化,通过抑制醛糖还原酶引起神经障碍和神经损伤,使得该组合物可用于预防或治疗糖尿病并发症 。 用于预防或治疗糖尿病并发症的组合物包括通过(1)用水,C1-C4低级醇或其混合物(2)提取东方蓟马分离的提取物,部分或分离的东方桦木的化合物,例如槲皮素 )用乙酸乙酯对东方蓟马的提取物进行分馏,和(3)将甲基叔丁基甲醇或己烷 - 乙酸乙酯加入到东方蓟马馏分中,是一种药物或保健食品组合物。