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1. 发明公开

KR1020080019050A 당흡수 조절제 및 당뇨병 또는 당뇨병 합병증의 치료방법 有权
标题翻译：葡萄糖摄取调节剂和治疗糖尿病或糖尿病并发症的方法
公开(公告)号：KR1020080019050A
公开(公告)日：2008-02-29
申请号：KR1020087000284
申请日：2006-07-07
申请人： 학교법인 포항공과대학교 , 주식회사 포스코
发明人： 예경무 , 김재윤 , 김종현 , 이병대 , 이승재 , 이태훈 , 서판길 , 류성호
IPC分类号： A61K31/7032 , A61P3/08
CPC分类号： A61K31/7032 , A61K38/2228 , A61K38/28 , A61K2300/00
摘要： A glucose uptake modulator is provided to promote glucose uptake of adipocytes and reduce blood glucose without side effects by using a new ligand isolated from the serum, so that it is useful for treatment of diabetes or diabetic complications. A glucose uptake modulator comprises a serum derived compound selected from lysophosphatidylcholine(LPC), lysophosphatidylserine(LPS), lysophosphatidic acid(LPA) and urocortin(UCN), wherein the glucose uptake modulation for lysophosphatidylserine is inhibited by PKC(protein kinase C) delta inhibitor rotlerine and dominant negative expression of PKC delta and independent from PI3(Phosphoinositide 3)-kinase dependent signal transfer pathway; the lysophosphatidylcholine is myristoyl LPC or palmitoyl LPC; and the urocortin acts as insulin-sensitizer together with insulin. The diabetes or diabetic complications are treated by administering the glucose uptake modulator to a mammal.
摘要翻译：提供葡萄糖摄取调节剂以通过使用从血清分离的新配体来促进脂肪细胞的葡萄糖摄取并降低血糖而没有副作用，因此它可用于治疗糖尿病或糖尿病并发症。葡萄糖摄取调节剂包含选自溶血磷脂酰胆碱（LPC），溶血磷脂酰丝氨酸（LPS），溶血磷脂酸（LPA）和尿皮质素（UCN））的血清衍生化合物，其中溶血磷脂酰丝氨酸的葡萄糖摄取调节被PKC（蛋白激酶C）罗格列酮和PKCδ的显性负性表达，独立于PI3（磷酸肌醇3） - 激酶依赖性信号转导途径; 溶血磷脂酰胆碱是肉豆蔻酰的LPC或棕榈酰LPC; 尿激酶与胰岛素一起作为胰岛素敏化剂。通过向哺乳动物施用葡萄糖摄取调节剂来治疗糖尿病或糖尿病并发症。

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