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1. 发明公开

KR1020040092968A 유자로부터 나린제닌을 정제하는 방법 및 그 용도 有权
标题翻译：用于将硝苯地宁作为白藜芦醇进行纯化的方法及其用于抑制组合物的用途
公开(公告)号：KR1020040092968A
公开(公告)日：2004-11-04
申请号：KR1020030027670
申请日：2003-04-30
申请人： 학교법인고려중앙학원
发明人： 신동훈 , 조홍연 , 홍범식 , 허호진 , 이정민 , 김미정 , 최수정 , 김혜경
IPC分类号： A61K31/35 , A61P25/28
CPC分类号： A61K31/353 , A23L33/105 , A61K36/77 , A61K2236/33 , A61K2236/51 , B01D15/20
摘要： PURPOSE: Provided are a method for purifying naringenin, as a flavonoid from a citron and the use thereof for an AChE inhibiting composition. The AChE inhibiting composition containing the naringenin as an active ingredient is useful for drugs or functional foods which improve age-associated memory impairment and senile dementia. CONSTITUTION: The method for purifying naringenin is characterized by the steps of: extracting a citron with methanol, followed by distillation under reduced pressure; subjecting the methanol extract to solvent-fraction to give a water layer and an ethyl acetate layer; and performing open silicagel column chromatography and TLC with the ethylacetate layer using chloroform and methanol to give naringenin as an AChE inhibitor.
摘要翻译：目的：提供柚子素作为柚子的黄酮类化合物的纯化方法及其用于抑制AChE的组合物。含有柚皮苷作为活性成分的AChE抑制组合物可用于改善年龄相关记忆障碍和老年痴呆症的药物或功能性食品。构成：柚皮苷纯化方法的特征在于：用甲醇萃取柚子，减压蒸馏; 甲醇提取液经溶剂馏分得到水层和乙酸乙酯层; 并使用氯仿和甲醇进行开放硅胶柱色谱和TLC，用乙酸乙酯层，得到柚皮苷作为AChE抑制剂。

2. 发明公开

KR1020040094081A 아세틸콜린에스테라제 저해용 약쑥 추출물 및 이의 정제방법 无效
标题翻译：从阿霉菌素中提取的低分子量的氟虫腈抑制乙酰胆碱酯酶活性和保护神经细胞及其提取过程
公开(公告)号：KR1020040094081A
公开(公告)日：2004-11-09
申请号：KR1020030028020
申请日：2003-05-01
申请人： 학교법인고려중앙학원
发明人： 신동훈 , 조홍연 , 홍범식 , 허호진 , 김미정 , 최수정 , 김혜경
IPC分类号： A61K31/352 , A61P31/18
CPC分类号： A61K31/352 , A23L33/105 , A61K36/282 , B01D15/20
摘要： PURPOSE: Provided are low-molecular weight flavonoids extracted from Artemisia absinthium which inhibits acetylcholinesterase(AChE) activity and protecting neuronal cells and an extracting process thereof from the methanol extract of Artemisia absinthium. Therefore, the flavonoids are used for treatment of a degenerative brain disorder, Alzheimer's disease, and improvement of one's memory. CONSTITUTION: The method for extracting 4',5-dihydroxy-3',6,7-trimethoxyflavone from Artemisia absinthium comprises the steps of: fractioning the methanol extract of Artemisia absinthium using organic solvents having different polarities to give fractions; subjecting the fractions to open column chromatography using silica gel to give acetylcholinesterase(AChE) inhibitors; fractioning the acetylcholinesterase(AChE) inhibitors by thin layer chromatography(TLC) to give fractions; separating the fractions by high pressure liquid chromatography using reverse phase column to give 4',5-dihydroxy-3',6,7-trimethoxyflavone.
摘要翻译：目的：提供从艾蒿中提取的低分子量类黄酮，其从艾蒿的甲醇提取物中抑制乙酰胆碱酯酶（AChE）活性并保护神经元细胞及其提取方法。因此，黄酮类化合物用于治疗退行性脑病，阿尔茨海默病和改善记忆。构成：从艾蒿提取4'，5-二羟基-3'，6,7-三甲氧基黄酮的方法包括以下步骤：使用具有不同极性的有机溶剂对蒿蒿的甲醇提取物进行分级，得到级分; 使用硅胶对馏分进行柱层析，得到乙酰胆碱酯酶（AChE）抑制剂; 通过薄层色谱法（TLC）对乙酰胆碱酯酶（AChE）抑制剂进行分级，得到级分; 通过使用反相柱的高压液相色谱法分离级分，得到4'，5-二羟基-3'，6,7-三甲氧基黄酮。

3. 发明公开

KR1020040094041A 마조람으로부터 우르솔릭산을 추출하는 방법 및 그 용도 无效
标题翻译：从马可兰提取尿酸的方法及其作为乙酰胆碱酯酶抑制组合物活性成分的用途
公开(公告)号：KR1020040094041A
公开(公告)日：2004-11-09
申请号：KR1020030027969
申请日：2003-05-01
申请人： 학교법인고려중앙학원
发明人： 신동훈 , 허호진 , 김미정 , 최수정 , 김은기 , 김병용 , 함영태 , 김혜경
IPC分类号： A61K31/19
CPC分类号： A61K31/19 , A23L33/105 , A61K36/53 , A61K2236/33 , A61K2236/51 , B01D15/20
摘要： PURPOSE: Provided are a method for extracting ursolic acid from marjoram and the use thereof as an active ingredient of an acetylcholinesterase(AChE) inhibiting composition. The ursolic acid inhibits the activity of AChE, and improves one's memory, and is thus used for functional foods or remedies for improvement of one's memory. CONSTITUTION: The method for extracting ursolic acid from marjoram comprises the steps of: extracting marjoram with ethanol, followed by distillation under reduced pressure; fractioning the ethanol extract into a chloroform layer and a water layer by adding chloroform; subjecting the chloroform layer to column chromatography using silicagel and a mixed solvent of chloroform and methanol in a ratio of 94:6 to give fractions; subjecting the fractions to column chromatography using silicagel and a mixed solvent of chloroform and methanol in a ratio of 98:2 and collecting the second fraction; subjecting the second fraction to thin layer chromatography(TLC) using a mixed solvent of chloroform and methanol in a ratio of 95:5; and analyzing the acetylcholinesterase(AChE) activity of each band and collecting a fraction having the highest AChE activity.
摘要翻译：目的：提供从黄褐霉素提取熊果酸的方法及其作为乙酰胆碱酯酶（AChE）抑制组合物的活性成分的用途。熊果酸可抑制AChE的活性，改善记忆力，因此可用于功能性食品或改善记忆的补救措施。构成：从水杨醛提取熊果酸的方法包括以下步骤：用乙醇萃取黄曲霉素，然后减压蒸馏; 通过加入氯仿将乙醇提取物分馏成氯仿层和水层; 使用硅胶和氯仿和甲醇的混合溶剂，比例为94:6，使氯仿层进行柱色谱，得到级分; 使用硅胶和氯仿和甲醇的混合溶剂，比例为98:2，对馏分进行柱层析，并收集第二级分; 使用氯仿和甲醇的混合溶剂比例为95:5对第二部分进行薄层色谱（TLC）; 并分析每个条带的乙酰胆碱酯酶（AChE）活性，并收集具有最高AChE活性的级分。

4. 发明公开

KR1020040092967A 대추로부터 올레아미드를 정제하는 방법 및 그 용도 无效
标题翻译：用于从JUJUBE净化OLEAMIDE的方法及其用于ChAT激活组合物的用途，其中OLEAMIDE具有预防和治疗对年龄相关的记忆损伤和良性发作的影响
公开(公告)号：KR1020040092967A
公开(公告)日：2004-11-04
申请号：KR1020030027669
申请日：2003-04-30
申请人： 학교법인고려중앙학원
发明人： 신동훈 , 조홍연 , 홍범식 , 허호진 , 박영준 , 김미정 , 최수정 , 김혜경
IPC分类号： A61K31/16
CPC分类号： A61K31/16 , A23L33/105 , A61K36/725 , A61K2236/33 , A61K2236/51 , B01D15/20
摘要： PURPOSE: Provided are a method for purifying oleamide from jujube and the use thereof for ChAT-activating composition. The oleamide as a ChAT activator has prevention and treatment effects on age-associated memory impairment and senile dementia. CONSTITUTION: The method for purifying oleamide from jujube comprises the steps of: extracting jujube with methanol, followed by distillation under reduced pressure; adding chloroform to the methanol extract powder to fraction a water layer and a chloroform layer; subjecting the chloroform layer to open silicagel column chromatography with the mixed solvent of chloroform and methanol in a mixing ratio of 90:10 to give a third fraction; subjecting the chloroform layer to open silicagel column chromatography with the mixed solvent of chloroform and methanol in a mixing ratio of 80:20 to give a first fraction; subjecting the mixture of the first and second fractions to open silicagel column chromatography with the mixed solvent of chloroform and methanol in a mixing ratio of 90:10 to give a third fraction; and performing TLC with the third fraction and measuring the ChAT activity of each band and recovering a band having highest ChAT activity.
摘要翻译：目的：提供从枣中提取油酰胺的方法及其用于ChAT活化组合物的方法。作为ChAT激活剂的油酰胺具有对年龄相关记忆障碍和老年痴呆的预防和治疗效果。构成：从枣中提纯油酰胺的方法包括以下步骤：用甲醇萃取枣，然后减压蒸馏; 向甲醇提取物粉末中加入氯仿以分级水层和氯仿层; 用氯仿和甲醇的混合溶剂以90:10的混合比进行氯仿层打开硅胶柱色谱，得到第三级分; 用氯仿和甲醇的混合溶剂以80:20的混合比进行氯仿层打开硅胶柱色谱，得到第一级分; 使第一和第二部分的混合物用氯仿和甲醇的混合溶剂以90:10的混合比打开硅胶柱色谱，得到第三级分; 并用第三部分进行TLC，并测量每个条带的ChAT活性，并回收具有最高ChAT活性的条带。

5. 发明授权

KR100500840B1 유자로부터 나린제닌을 정제하는 방법 및 그 용도 有权
标题翻译：从柚子提纯柚子碱的方法及其用途
公开(公告)号：KR100500840B1
公开(公告)日：2005-07-12
申请号：KR1020030027670
申请日：2003-04-30
申请人： 학교법인고려중앙학원
发明人： 신동훈 , 조홍연 , 홍범식 , 허호진 , 이정민 , 김미정 , 최수정 , 김혜경
IPC分类号： A61K31/35 , A61P25/28
摘要： 본 발명은 유자로부터 분리된 저분자성 플라보노이드류인 나린제닌을 유효성분으로 함유하는 아세틸콜린에스터라아제(AChE) 저해용 조성물에 관한 것이다.
유자를 메탄올로 추출한 뒤 감압증류하고, 메탄올 추출물 분말에 에틸 아세테이트를 가하여 물층과 에틸 아세테이트층으로 용매 분획하고, 에틸 아세테이트층에 대하여 전개용매를 클로로포름과 메탄올로 하여 오픈 실리카겔 컬럼 크로마토그래피 및 TLC를 실시함으로써 아세틸콜린에스터라아제(AChE) 저해활성물질인 나린제닌을 수득할 수 있다.
이러한 방법으로 제조된 저분자성 플라보노이드인 나린제닌은, AChE 저해활성능 및 기억, 학습증진 효과를 가지고 있어 노인성 치매 환자나 고령화로 인한 기억력 감퇴현상의 개선제로서 기능성 식품이나 약물에 유용하게 사용될 수 있다.

6. 发明公开

KR1020040094956A 아세틸콜린에스터라아제 저해용 상엽추출물 및 이의정제방법 无效
标题翻译：提取特别是低分子量的嘌呤衍生物，对乙酰胆碱酯酶具有抑制作用，并从其中提取其提取过程
公开(公告)号：KR1020040094956A
公开(公告)日：2004-11-12
申请号：KR1020030028524
申请日：2003-05-06
申请人： 학교법인고려중앙학원
发明人： 신동훈 , 허호진 , 김미정 , 최수정 , 김은기 , 김병용 , 함영태 , 김혜경
IPC分类号： A61K31/52
CPC分类号： A61K36/605 , A23L33/105 , A61K31/52 , A61K2236/33 , B01D15/20
摘要： PURPOSE: Provided is an extract, in particular, low molecular weight purine adenine derivative, which has inhibiting effect on acetylcholinesterase that is contained in the neuron and associated with degenerative dementia. Also, provided is an extracting process thereof from mulberry leaves. CONSTITUTION: The extract of mulberry leaf is characterized by containing as an active ingredient, 2-methyl-4-(1H-purin-6-yl amino)-2-buten-1-ol. The 2-methyl-4-(1H-purin-6-yl amino)-2-buten-1-ol is obtained by extracting mulberry leaf with methanol; fractioning the extract with polar solvents; and performing open silicagel column chromatography with the fraction, followed by HPLC.
摘要翻译：目的：提供一种提取物，特别是低分子量的嘌呤腺嘌呤衍生物，其具有对包含在神经元中并与退行性痴呆相关的乙酰胆碱酯酶的抑制作用。此外，提供了从桑叶提取过程。构成：桑叶提取物的特征在于含有2-甲基-4-（1H-嘌呤-6-基氨基）-2-丁烯-1-醇作为活性成分。通过甲醇提取桑叶获得2-甲基-4-（1H-嘌呤-6-基氨基）-2-丁烯-1-醇; 用极性溶剂对提取物进行分级; 并用级分进行开放硅胶柱色谱，然后进行HPLC。

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