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1. 发明公开

KR1020100051678A 글루타메이트성 시냅스 반응을 향상시키기 위한 비시클릭 아미드 无效
标题翻译： 글루타메이트성시냅스반응을향상시키기위한비시클릭아미드
公开(公告)号：KR1020100051678A
公开(公告)日：2010-05-17
申请号：KR1020107004015
申请日：2008-08-08
申请人： 코텍스 파마슈티칼스, 인크.
发明人： 뮐러,루돌프 , 스트릿,레슬리
IPC分类号： C07D498/04 , C07D265/24 , A61K31/519 , A61K31/535
CPC分类号： A61K31/46 , A61K31/4245 , A61K31/439 , A61K31/519 , A61K31/53 , A61K45/06 , C07D209/52 , C07D451/02 , C07D451/04 , C07D451/06 , C07D453/06 , C07D471/08 , C07D487/08 , C07D491/08
摘要： This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning, hi a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及用于预防和治疗脑功能不全的化合物，药物组合物和方法，包括增强负责基本和更高级行为的脑网络中的突触中的受体功能。这些参与调节呼吸的脑网络以及与记忆障碍有关的认知能力，诸如在各种痴呆症中观察到的，在不同大脑区域之间的神经元活动的不平衡中，如帕金森病，精神分裂症，呼吸抑制，睡眠呼吸暂停，注意力缺陷多动障碍和情感或情绪障碍，以及涉及神经营养因子缺乏的障碍，以及呼吸障碍如过量饮酒，阿片制剂，阿片类药物，巴比妥类药物，麻醉剂或神经毒素，或其中呼吸抑制导致形成诸如中枢性睡眠呼吸暂停，中风性睡眠呼吸暂停，阻塞性睡眠呼吸暂停，先天性通气不足综合征，肥胖低通气综合征，婴儿猝死综合征，Rett综合征，脊髓损伤，创伤性脑损伤，Cheney-Stokes呼吸，Ondines诅咒 Prader-Willi综合征和溺水。在一个特定的方面，本发明涉及可用于治疗这些病症的双环酰胺化合物，以及使用这些化合物进行这种治疗的方法。

2. 发明公开

KR1020100045507A 글루타메이트성 시냅스 반응을 향상시키기 위한 비시클릭 아미드 无效
标题翻译：用于增强谷氨酸反应性的双酚A
公开(公告)号：KR1020100045507A
公开(公告)日：2010-05-03
申请号：KR1020107005366
申请日：2008-08-08
申请人： 코텍스 파마슈티칼스, 인크.
发明人： 뮐러,루돌프 , 스트릿,레슬리
IPC分类号： A61K31/53 , A61K31/5025 , A61K31/4985 , A61P25/00
CPC分类号： A61K31/46 , A61K31/4245 , A61K31/439 , A61K31/519 , A61K31/53 , A61K45/06 , C07D209/52 , C07D451/02 , C07D451/04 , C07D451/06 , C07D453/06 , C07D471/08 , C07D487/08 , C07D491/08
摘要： This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning, hi a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及用于预防和治疗脑功能不全的化合物，药物组合物和方法，包括在负责基本和高级行为的脑网络中的突触中增强受体功能。涉及呼吸调节的这些脑网络，以及与记忆障碍有关的认知能力，例如在各种痴呆症中观察到的，在不同脑区域之间的神经元活动不均衡中，如在帕金森病，精神分裂症，呼吸抑制，睡眠呼吸暂停，注意缺陷多动障碍和情感或情绪障碍，以及涉及神经营养因子缺乏的疾病，以及呼吸障碍，例如过量的酒精，阿片剂，阿片样物质，巴比妥酸盐，麻醉剂或神经毒素，或呼吸抑制结果形成中枢性睡眠呼吸暂停，中风引起的中枢性睡眠呼吸暂停，阻塞性睡眠呼吸暂停，先天性通气不足综合征，肥胖低通气综合征，婴儿猝死综合征，Rett综合征，脊髓损伤，创伤性脑损伤，Cheney-Stokes呼吸，Ondines诅咒，Prader-Willi综合征和溺水。在一个特定方面，本发明涉及可用于治疗这些病症的双环酰胺化合物，以及使用这些化合物进行这种治疗的方法。

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