专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明公开

KR1020000022106A β-락탐 항생물질의 제조방법 无效
标题翻译：用于制备BETA-LACTAM抗生素的方法
公开(公告)号：KR1020000022106A
公开(公告)日：2000-04-25
申请号：KR1019980710516
申请日：1998-04-22
申请人： 코닌클리즈케 디에스엠 엔.브이.
发明人： 판데어되스토마스 , 데프롬에릭 , 카푸르야그디쉬챈더
IPC分类号： C12P37/04
CPC分类号： C12P37/04 , C12P35/02 , C12P35/04 , C12P37/06
摘要： PURPOSE: A method for preparing a beta-lactam antibiotic is provided. The class of beta-lactam antibiotics, such as penicillin and cephalosporin antibiotics comprises a great variety of compounds, all having their own activity profile. In general, beta-lactam antibiotics consist of a nucleus, the so-called p- lactam nucleus, which is linked through its primary amino group to the so-called side chain via a linear amide bond. CONSTITUTION: Provided is a method for preparing a beta -lactam antibiotic, wherein an N-substituted beta -lactam, having general formula (I), wherein R0 is hydrogen or C1-3 alkoxy; Y is CH2, oxygen, sulfur, or an oxidized form of sulfur; Z is (a), (b), (c) or (d), wherein R1 is hydrogen, hydroxy, halogen, C1-3 alkoxy, optionally substituted, optionally containing one or more heteroatoms, saturated or unsaturated, branched or straight C1-5 alkyl, preferably methyl, optionally substituted, optionally containing one or more heteroatoms C5-8 cycloalkyl, optionally substituted aryl or heteroaryl, or optionally substituted benzyl; and X is (CH2)m-A-(CH2)n, wherein m and n are the same or different and are chosen from the group of integers 0, 1, 2, 3 or 4, and A is CH=CH, CC, CHB, C=O, optionally substituted nitrogen, oxygen, sulfur or an optionally oxidized form of sulfur, and B is hydrogen, halogen, hydroxy, C1-3 alkoxy, or optionally substituted methyl, or a salt thereof, is contacted with at least one dicarboxylate acylase, or a functional equivalent thereof, and reacted with a precursor for a side chain of the beta -lactam antibiotic in the presence of at least one penicillin acylase, or a functional equivalent thereof
摘要翻译：目的：提供一种制备β-内酰胺抗生素的方法。 β-内酰胺类抗生素类，如青霉素和头孢菌素类抗生素包括各种各样的化合物，均具有自己的活性。一般来说，β-内酰胺抗生素由细胞核组成，即所谓的β-内酰胺核，其通过其伯氨基与所谓的侧链通过线性酰胺键连接。构成：提供制备β-内酰胺抗生素的方法，其中具有通式（I）的N-取代的β-内酰胺，其中R 0是氢或C 1-3烷氧基; Y是CH 2，氧，硫或硫的氧化形式; Z是（a），（b），（c）或（d），其中R 1是氢，羟基，卤素，C 1-3烷氧基，任选地被取代，任选地含有一个或多个杂原子，饱和或不饱和的，支链或直链C1 -5烷基，优选甲基，任选地被取代，任选地含有一个或多个杂原子C5-8环烷基，任选取代的芳基或杂芳基，或任选取代的苄基; 并且X是（CH 2）mA-（CH 2）n，其中m和n相同或不同，并且选自整数0,1,2,3或4，并且A是CH = CH，CC，CHB ，C = O，任选取代的氮，氧，硫或任选氧化形式的硫，B是氢，卤素，羟基，C 1-3烷氧基或任选取代的甲基或其盐与至少一种二羧酸酰基转移酶或其功能等同物，并在至少一种青霉素酰基转移酶或其功能等同物的存在下与β-内酰胺抗生素的侧链前体反应

IPRDB

热门服务

关于我们

友情链接

联系方式