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2. 发明公开

KR1020090105309A 광학활성을 갖는 5-히드록시-3-옥소헵타노에이트 유도체의제조방법 失效
标题翻译：制备光学活性的5-羟基-3-氧代苯甲酸酯衍生物的方法
公开(公告)号：KR1020090105309A
公开(公告)日：2009-10-07
申请号：KR1020080030682
申请日：2008-04-02
申请人： 주식회사 파마코스텍
发明人： 유형철 , 박호현 , 김재원 , 민인기 , 차영권 , 김봉기 , 윤서영
IPC分类号： C07C201/06 , C07C205/51 , C07C205/15
摘要： PURPOSE: A process for preparing optically active 5-hydroxy-3-oxoheptanoate derivatives with optical activity is provided to be useful in the manufacture of a statin compound and to ensure mass production and high yield. CONSTITUTION: A process for preparing optically active 5-hydroxy-3-oxoheptanoate derivatives with optical activity comprises the steps of: ring-opening a compound of the chemical formula 2 and nitromethane sodium salt; preparing an intermediate compound of chemical formula 5 through substitution reaction with cyanide without a refining process; ring-opening a compound of the chemical formula 3 and cyanide; preparing an intermediate compound of chemical formula 5 through substitution reaction with nitromethane sodium salt; preparing an intermediate compound of chemical formula 6 through ring opening reaction of a compound of the chemical formula 4 and nitromethane sodium salt; and reacting the intermediate of chemical formula 5 or 6 with chemical formula 7 in the presence of zinc.
摘要翻译：目的：制备具有光学活性的光学活性的5-羟基-3-氧代庚酸衍生物的方法可用于制备他汀类化合物并确保大量生产和高产率。构成：用光学活性制备光学活性的5-羟基-3-氧代庚酸衍生物的方法包括以下步骤：打开化学式2的化合物和硝基甲烷钠盐; 通过与氰化物的取代反应制备化学式5的中间体化合物而不进行精制过程; 打开化学式3和氰化物的化合物; 通过与硝基甲烷钠盐的取代反应制备化学式5的中间体化合物; 通过化学式4的化合物和硝基甲烷钠盐的开环反应制备化学式6的中间体化合物; 并在锌的存在下使化学式5或6的中间体与化学式7反应。

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