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1. 发明公开

KR1020030083348A 지방세포 분화 저해 활성을 가지는 프로토베르베린알칼로이드 화합물인 베르베린을 유효성분으로 함유하는비만예방 및 치료 无效
标题翻译：用于预防和治疗含有针对ADIPOCYTE差异（3T3-L1和F442A细胞）的抑制性贝伐单抗的成分的组合物
公开(公告)号：KR1020030083348A
公开(公告)日：2003-10-30
申请号：KR1020020021844
申请日：2002-04-22
申请人： 주식회사 케이티앤지생명과학 , 김재범
发明人： 김재범 , 곽태환 , 오원근 , 안종석 , 이철호 , 김명수 , 조혜진
IPC分类号： A61K31/4375
摘要： PURPOSE: Provided is a composition for prevention and treatment of obesity containing berberine having inhibitory effects on adipocyte differentiation (3T3-L1 AND F442A cell). The berberine is of protoberberine alkaloid compounds and represented by the formula(1), and has prevention and treatment effects on obesity. CONSTITUTION: A composition for prevention and treatment of obesity is characterized by containing berberine having inhibitory effects on adipocyte differentiation (3T3-L1 AND F442A cell) as an active ingredient. The berberine is derived from a herbal plant selected from Corydalis ternata, Chelidonium major, Coptis japonica, and Phellodendron amurense. It further contains pharmaceutically acceptable diluent.
摘要翻译：目的：提供一种用于预防和治疗含有对脂肪细胞分化具有抑制作用的小檗碱（3T3-L1和F442A细胞）的肥胖症的组合物。小檗碱是原生动物生物碱化合物，由式（1）表示，具有预防和治疗对肥胖的作用。构成：用于预防和治疗肥胖症的组合物的特征在于含有对脂肪细胞分化具有抑制作用的小檗碱（3T3-L1和F442A细胞）作为活性成分。小檗碱来源于选自紫堇，天竺葵，黄连和黄柏的草本植物。它还含有药学上可接受的稀释剂。

2. 发明公开

KR1020030084026A 생약으로부터 얻은 지방세포 분화 저해용 활성분획 조성물 无效
标题翻译：含有从药用植物分离的ADIPOCYTES（NIH3T3-L1细胞）的抑制作用的活性成分组成
公开(公告)号：KR1020030084026A
公开(公告)日：2003-11-01
申请号：KR1020020022500
申请日：2002-04-24
申请人： 주식회사 케이티앤지생명과학 , 김재범
发明人： 김재범 , 곽태환 , 오원근 , 안종석 , 이철호 , 김명수 , 조혜진
IPC分类号： A61K36/73 , A61K36/36 , A61K36/234 , A61P3/04
摘要： PURPOSE: A composition containing an active fraction having inhibitory effect on adipocytes (NIH3T3-L1 cell) isolated from medicinal plants such as Agrimonia pilosa, Dianthus chinensis or the like is provided. The active fraction specifically shows inhibiting activity of obesity on a Lepr¬db/Lepr¬db mouse, as an animal model and is thus used as a therapeutic or preventing agent for obesity. CONSTITUTION: A composition contains an active fraction having inhibitory effect on adipocytes (NIH3T3-L1 cell) isolated from medicinal plants such as Agrimonia pilosa, Dianthus chinensis, Thuja orientalis and Pinelliae Rhizoma and additionally pharmaceutically acceptable carriers or excipients. One or more active fractions are obtained by extracting the herbal plants in a solvent such as purified water, C1-5 alcohols such as ethanol, methanol, propanol, butanol and ethanol or an organic solvent. The active component is administered in a range of 1 to 1,000mg/day per adult weight.
摘要翻译：目的：提供一种含有对药用植物例如Agrimonia pilosa，Dianthus chinensis等分离的脂肪细胞（NIH3T3-L1细胞）具有抑制作用的活性成分的组合物。作为动物模型，活性级分特异性地显示肥胖对Leprdb / Leprrdb小鼠的抑制活性，因此用作肥胖症的治疗或预防剂。构成：组合物含有对从药用植物例如Agrimonia pilosa，Dianthus chinensis，Thuja orientalis和Pinelliae Rhizoma分离的脂肪细胞（NIH3T3-L1细胞）具有抑制作用的活性成分和另外的药学上可接受的载体或赋形剂。通过在溶剂例如纯水，C 1-5醇如乙醇，甲醇，丙醇，丁醇和乙醇或有机溶剂中萃取草药植物来获得一种或多种活性级分。活性成分以每成人体重1至1,000mg /天的范围给药。

3. 发明授权

KR100528398B1 지방세포 분화를 저해하는 팥꽃나무 추출물 失效
标题翻译：具有对脂肪细胞NIH3T3-L1细胞具有抑制作用的达芙妮genkwa提取物
公开(公告)号：KR100528398B1
公开(公告)日：2005-11-15
申请号：KR1020020046704
申请日：2002-08-08
申请人： 주식회사 케이티앤지생명과학
发明人： 곽태환 , 김재범 , 주재훈 , 조혜진
IPC分类号： A61K36/83 , A61P3/04
摘要： 본 발명은 팥꽃나무 (
Daphne genkwa )로부터 얻은 지방세포 (NIH3T3-L1 cell) 분화 저해용 활성분획 조성물에 관한 것으로, 더욱 상세하게는 팥꽃나무과 식물인 팥꽃나무의 줄기 및 뿌리로부터 지방세포 (NIH3T3-L1 cell) 분화를 저해하여 비만의 원인이 되는 지방의 축적을 저해하며 제2형 당뇨병의 원인인 고혈당을 낮출 수 있는 추출물을 유효성분으로 함유하는 비만예방 및 치료 또는 당뇨병예방 및 치료 생약제에 관한 것이다.

4. 发明公开

KR1020040013675A 지방세포 분화를 저해하는 팥꽃나무 추출물 失效
标题翻译：具有对ADIPOCYTES（NIH3T3-L1细胞）的抑制作用的DAPHNE GENKWA的提取
公开(公告)号：KR1020040013675A
公开(公告)日：2004-02-14
申请号：KR1020020046704
申请日：2002-08-08
申请人： 주식회사 케이티앤지생명과학
发明人： 곽태환 , 김재범 , 주재훈 , 조혜진
IPC分类号： A61K36/83 , A61P3/04
摘要： PURPOSE: Provided is an extract of Daphne genkwa having inhibitory effects on adipocytes (NIH3T3-L1 cell). It inhibits the accumulation of fat and decreases high blood glucose level. Therefore, it is used for prevention and treatment of obesity and diabetes. CONSTITUTION: A composition for prevention and treatment of obesity and diabetes is characterized by containing a therapeutically or prophylactically effective amount of the extract of Daphne genkwa. It has inhibitory effect on adipocytes. A drug for prevention and treatment of obesity and diabetes contains the composition, and a pharmaceutically acceptable carrier or diluent.
摘要翻译：目的：提供对脂肪细胞（NIH3T3-L1细胞）具有抑制作用的达芙妮genkwa提取物。它可以抑制脂肪的积累，降低血糖水平。因此，它用于预防和治疗肥胖和糖尿病。构成：用于预防和治疗肥胖症和糖尿病的组合物的特征在于含有治疗或预防有效量的达芙妮genkwa提取物。它对脂肪细胞具有抑制作用。用于预防和治疗肥胖症和糖尿病的药物含有该组合物和药学上可接受的载体或稀释剂。

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