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1. 发明授权

KR101032814B1 탄저균 치사독소에 의한 대식세포 반응 유전자 분석방법 失效
标题翻译：炭疽杆菌致死毒素分析
公开(公告)号：KR101032814B1
公开(公告)日：2011-05-04
申请号：KR1020030045320
申请日：2003-07-04
申请人： 주식회사 쎌앤젠 , 채영규
发明人： 채영규 , 서귀문 , 남정아 , 오광근
IPC分类号： C12Q1/68
摘要： 본 발명은 탄저균의 치사독소에 의하여 특이적으로 대식세포에서 발현이 증가 또는 감소되는 유전자를 마이크로 어레이에 의하여 분석하는 방법에 관한 것으로, 구체적으로는 탄저균의 치사독소에 의하여 대식세포에서 특이적으로 증가 또는 감소되는 유전자를 마이크로 어레이 기술을 이용하여 탐색한 후 발현의 차이를 측정함으로써, 탄저균 치사독소에 의하여 반응하는 유전자를 바이오마커로서 활용할 수 있다.
Bacillus anthracis, 탄저치사독소, cDNA microarray, 마우스 대식세포

2. 发明公开

KR1020050003815A 탄저균 치사독소에 의한 대식세포 반응 유전자 분석방법 失效
标题翻译：通过BACILLUS ANTHRACIS LETHAL TOXIN检测BACILLUS ANTHRACIS感染的MACROPHAGE反应基因的分析方法
公开(公告)号：KR1020050003815A
公开(公告)日：2005-01-12
申请号：KR1020030045320
申请日：2003-07-04
申请人： 주식회사 쎌앤젠 , 채영규
发明人： 채영규 , 서귀문 , 남정아 , 오광근
IPC分类号： C12Q1/68
摘要： PURPOSE: An analysis method of macrophage reaction gene by Bacillus anthracis lethal toxin is provided, which macrophage reaction gene is useful as a biomarker, so that the presence of Bacillus anthracis lethal toxin can be easily detected by using the biomarker. CONSTITUTION: The analysis method of macrophage reaction gene by Bacillus anthracis lethal toxin comprises the steps of: treating genes with Bacillus anthracis lethal toxin; measuring and comparing the expressions of the genes treated with and without the Bacillus anthracis lethal toxin in macrophage; and selecting genes of which expression in macrophage is significantly changed by the Bacillus anthracis lethal toxin, wherein the genes of which expression is significantly changed by the Bacillus anthracis lethal toxin are RPL10A, ARBP, RPL30, RPS3, RPL3, RPS16 and MPRS17.
摘要翻译：目的：提供炭疽杆菌致死毒素对巨噬细胞反应基因的分析方法，该巨噬细胞反应基因可用作生物标志物，因此通过使用生物标志物可以很容易地检测到炭疽杆菌致死毒素的存在。构成：炭疽芽孢杆菌致死毒素对巨噬细胞反应基因的分析方法包括以下步骤：用炭疽杆菌致死毒素处理基因; 测量和比较巨噬细胞处理和不使用炭疽芽孢杆菌致死毒素的基因的表达; 并且选择其中巨噬细胞表达的基因被炭疽芽孢杆菌致死毒素显着改变，其中由炭疽芽孢杆菌致死毒素显着改变的基因是RPL10A，ARBP，RPL30，RPS3，RPL3，RPS16和MPRS17。

3. 发明公开

KR1020040056725A 다이옥신의 생물학적 분석방법 无效
标题翻译：二氧化物生物分析方法
公开(公告)号：KR1020040056725A
公开(公告)日：2004-07-01
申请号：KR1020020083276
申请日：2002-12-24
申请人： 주식회사 쎌앤젠
发明人： 오광근 , 채영규 , 남덕화 , 박달문 , 백승연
IPC分类号： C12Q1/68
摘要： PURPOSE: A biological analysis method of dioxin is provided, thereby easily and cheaply analysing dioxin present in various environment samples by using gene whose expression is specifically increased or reduced by dioxin. CONSTITUTION: The biological analysis method of dioxin comprises hybridizing the nucleic acid in a sample which is anticipated to be influenced from dioxin with a DNA chip containing the genes whose expression are specifically increased or reduced by dioxin, having the nucleotide sequences set forth in SEQ ID NO: 1 to SEQ ID NO: 29, wherein the DNA chip is prepared by arraying the genes whose expression are specifically increased or reduced by dioxin, having the nucleotide sequences set forth in SEQ ID NO: 1 to SEQ ID NO: 29 on a slide glass.
摘要翻译：目的：提供二恶英的生物分析方法，通过使用二恶英特异性增加或减少的基因，容易且便宜地分析各种环境样品中存在的二恶英。构成：二恶英的生物学分析方法包括将预期受二恶英影响的样品中的核酸与包含其表达被二恶英特异性增加或降低的基因的DNA芯片杂交，其具有SEQ ID NO： NO：1〜SEQ ID NO：29，其中DNA芯片通过将具有SEQ ID NO：1至SEQ ID NO：29所示核苷酸序列的二恶英特异性增加或减少的基因排列在幻灯片

4. 发明授权

KR100370796B1 바실러스 서브틸리스 씨지-1과 락토바실러스 델브루에키씨지-2 미생물 및 이들의 혼합배양에 의한 대두발효물의제조방법 失效
标题翻译： 바실러스서브틸리스씨지-1과락토바실러스델브루에키씨지-2미생물및이들의혼합배양에의한대두발효물의제조방
公开(公告)号：KR100370796B1
公开(公告)日：2003-02-05
申请号：KR1020020021828
申请日：2002-04-20
申请人： 주식회사 쎌앤젠
发明人： 오광근 , 박달문 , 남덕화 , 인재평 , 이시경 , 채영규
IPC分类号： C12N1/20
摘要： PURPOSE: Provided are Bacillus subtilis CG-1 and Lactobacillus delbrueckii CG-2, and a preparation method of fermented soybean by mixed culture of them. Therefore, the fermented soybean has high enzyme activity, increased phytochemicals and stability in intestine. CONSTITUTION: Bacillus subtilis CG-1(KCCM 10337) producing protease and fibrinolytic enzyme, and Lactobacillus delbrueckii CG-2(KCCM 10359) having acid and bile resistance are mixed cultured to increased the content of active phytochemicals in the fermented soybean. The fermented soybean can be dry-powdered then formulated into granules, capsules, paste or tablets.
摘要翻译：用途：提供枯草芽孢杆菌CG-1和德氏乳杆菌CG-2，以及通过混合培养它们的发酵大豆的制备方法。因此，发酵大豆具有高酶活性，增加了植物化学物质和肠内稳定性。构成：将产生蛋白酶和纤维蛋白溶解酶的枯草芽孢杆菌CG-1（KCCM10337）和具有耐酸和胆汁抗性的德氏乳杆菌CG-2（KCCM10359）混合培养以增加发酵大豆中活性植物化学物质的含量。发酵大豆可以干粉状，然后配制成颗粒，胶囊，糊剂或片剂。

5. 发明公开

KR1020020057851A 바실러스 서브틸리스 씨지-1과 락토바실러스 델브루에키씨지-2 미생물 및 이들의 혼합배양에 의한 대두발효물의제조방법 失效
标题翻译： BACILLUS SUBTILIS CG-1和LACTOBACILLUS DELBRUECKII CG-2，以及其混合培养物的发酵大豆的制备方法
公开(公告)号：KR1020020057851A
公开(公告)日：2002-07-12
申请号：KR1020020021828
申请日：2002-04-20
申请人： 주식회사 쎌앤젠
发明人： 오광근 , 박달문 , 남덕화 , 인재평 , 이시경 , 채영규
IPC分类号： C12N1/20
摘要： PURPOSE: Provided are Bacillus subtilis CG-1 and Lactobacillus delbrueckii CG-2, and a preparation method of fermented soybean by mixed culture of them. Therefore, the fermented soybean has high enzyme activity, increased phytochemicals and stability in intestine. CONSTITUTION: Bacillus subtilis CG-1(KCCM 10337) producing protease and fibrinolytic enzyme, and Lactobacillus delbrueckii CG-2(KCCM 10359) having acid and bile resistance are mixed cultured to increased the content of active phytochemicals in the fermented soybean. The fermented soybean can be dry-powdered then formulated into granules, capsules, paste or tablets.
摘要翻译：目的：提供枯草芽孢杆菌CG-1和德氏乳杆菌CG-2，以及通过混合培养发酵大豆的制备方法。因此，发酵大豆具有较高的酶活性，植物化学物质的增加和肠道的稳定性。构成：将具有酸和胆汁抗性的产生蛋白酶和纤维蛋白溶解酶的枯草芽孢杆菌CG-1（KCCM 10337）和具有耐酸性和耐胆汁性的德氏乳杆菌CG-2（KCCM 10359）混合培养以增加发酵大豆中活性植物化学物质的含量。发酵的大豆可以干粉状，然后配制成颗粒，胶囊，糊剂或片剂。

6. 发明公开

KR1020040100197A 프로테옴 분석으로 초기 탄저감염 바이오마커및 백신후보물질 탐색 无效
标题翻译：通过检测通过两维电泳和MALDI-TOF质谱仪检测蛋白质表达的早期感染细胞培养物中的蛋白质表达，检测五个生物标志物作为候选药物的候选物质
公开(公告)号：KR1020040100197A
公开(公告)日：2004-12-02
申请号：KR1020030032454
申请日：2003-05-22
申请人： 채영규
发明人： 채영규 , 서귀문 , 오광근 , 김성주 , 김지천
IPC分类号： C12Q1/66
摘要： PURPOSE: A method for detecting biomarkers as the vaccine candidate in early infecting spore of bacillus anthraces with macrophage by analyzing proteome is provided to detect expression of protein from initial interaction in infecting the spore of bacillus anthraces with the macrophage with the two-dimensional electrophoresis and the MALDI(Matrix-Assisted Laser Desorption Ionization)-TOF(time of flight) mass spectrometer. CONSTITUTION: To analyze the initial interaction of the spore of bacillus anthraces and the macrophage, expression of protein increased and decreased from the initial interaction of the spore of bacillus anthraces and the macrophage is analyzed with the two-dimensional electrophoresis. Protein spots are manufactured into peptide, and the protein related to initial interaction is gained by deciding the molecular weight with the MALDI-TOF mass. The bacillus anthraces are diagnosed and investigated by detecting five kinds of biomarkers including CD18, HSPA5, GNA-13, Syndapin and CDC46 in infecting the spore of bacillus anthraces with the macrophage at the initial stage. Infection of bacillus anthraces is analyzed by using the biomarkers related to interaction to develop the vaccine.
摘要翻译：目的：提供一种通过分析蛋白质组来检测具有巨噬细胞的芽孢杆菌早期感染孢子中的生物标志物的方法，以检测蛋白质在初次相互作用中的表达，用双向电泳感染巨噬细胞的杆菌烟草孢子， MALDI（矩阵辅助激光解吸电离）-TOF（飞行时间）质谱仪。构成：为了分析芽孢杆菌和巨噬细胞的孢子的初始相互作用，用二维电泳分析了从杆状芽孢杆菌和巨噬细胞的孢子的初始相互作用中增加和减少的蛋白质的表达。蛋白质斑点被制成肽，并且通过用MALDI-TOF质量决定分子量来获得与初始相互作用相关的蛋白质。通过检测五种生物标志物（包括CD18，HSPA5，GNA-13，Syndapin和CDC46）在初始阶段感染巨噬细胞的杆菌的孢子来诊断和研究杆菌属。通过使用与相互作用相关的生物标志物来研究疫苗来分析杆菌感染。

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