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    • 3. 发明授权
    • 시알6 단백질과 결합하는 단백질의 유전자 및 그것의아미노산 서열
    • 시알6단백질과하는단백질의유전자및그것의아미노산서
    • KR100439489B1
    • 2004-07-09
    • KR1020000008972
    • 2000-02-24
    • 주식회사 삼양제넥스
    • 이용원정년철김대건배인수홍승서이현수
    • C12N15/00
    • PURPOSE: Provided are a gene coding protein CR1F1 bound with protein CR6 and cDNA base sequence thereof and amino acid sequence thereof, the protein CR1F1 can be used as a tracer for diagnosing cancer. CONSTITUTION: Provided are the protein CR1F1, a fragment thereof, a variant thereof, a derivative thereof, or an allelic variant thereof. Also, provided are peptides coded from the protein CR1F1, the fragment thereof, the variant thereof, the derivative thereof, or the allelic variant thereof. The method for diagnosing cancer comprises the steps of: separating a target cell tissue, expressing the CR1F1 or the protein coded by the CR1F1, from an individual; contacting the separated tissue with a reagent reacted with the CR1F1 or the protein coded by the CR1F1; measuring whether the CR1F1 or the protein coded by the CR1F1 is detected or not.
    • 目的:提供与蛋白质CR6结合的基因编码蛋白质CR1F1及其cDNA碱基序列及其氨基酸序列,该蛋白质CR1F1可作为诊断癌症的示踪剂。 构成:提供了蛋白质CR1F1,其片段,其变体,其衍生物或其等位基因变体。 此外,提供了由蛋白CR1F1编码的肽,其片段,其变体,其衍生物或其等位变体。 诊断癌症的方法包括以下步骤:从个体中分离表达CR1F1或由CR1F1编码的蛋白质的靶细胞组织; 使分离的组织与与CR1F1或由CR1F1编码的蛋白质反应的试剂接触; 测量是否检测到CR1F1或由CR1F1编码的蛋白质。
    • 4. 发明授权
    • 융합단백질로부터 염기성 펩타이드 또는 단백질을분리하는 방법
    • 융합단백질로부기염기성펩타이드또는단백질을분리하는방
    • KR100373863B1
    • 2003-02-26
    • KR1019990056378
    • 1999-12-10
    • 주식회사 삼양제넥스
    • 박흥복표상현황성욱소진언김진현김정현홍승서이현수
    • C07K14/00C07K1/14
    • PURPOSE: A method for separating basic peptides or basic proteins in high yield from a fusion protein having hydroxylamine restriction site between basic peptides or basic proteins and fusion partners. CONSTITUTION: An example of basic peptides is mergainin, buporin, dipensin, and their derivatives, and the example of basic protein is histone. The separating method comprises the steps of: harvesting the cells from a fermented culture medium; collecting fusion proteins from the crushed cell solution; reacting a fusion protein having hydroxylamine restriction site between basic peptides or basic proteins and fusion partners with hydroxylamine under condition of pH 7.5 to 8.5; and separating basic peptide from the reacting solution, in which 70% to 90% of basic peptides or basic proteins are separated.
    • 目的:从碱性肽或碱性蛋白质与融合配偶体之间具有羟胺限制性位点的融合蛋白中以高产率分离碱性肽或碱性蛋白质的方法。 构成:碱性肽的一个例子是mergainin,buporin,dipensin及其衍生物,碱性蛋白质的例子是组蛋白。 分离方法包括以下步骤:从发酵培养基中收获细胞; 从破碎的细胞溶液中收集融合蛋白; 使碱性肽或碱性蛋白质与融合配偶体之间具有羟胺限制性位点的融合蛋白与羟胺在pH7.5-8.5的条件下反应; 并从反应溶液中分离碱性肽,其中分离70%至90%的碱性肽或碱性蛋白质。
    • 8. 发明公开
    • 부포린 유도체를 포함하는 항균조성물
    • 含有BUFFIN衍生物的抗微生物组合物
    • KR1020020057313A
    • 2002-07-11
    • KR1020010000285
    • 2001-01-04
    • 주식회사 삼양제넥스
    • 이재현이재흥이연희강영임조진숙홍승서이현수
    • A61K38/00
    • PURPOSE: An antimicrobial composition containing buforin derivatives as an antimicrobial peptide is provided which can be used as medicine, animal medicine, living article, biopesticide, feed additives, etc. because it exhibits almost no toxicity while retaining wide antimicrobial activity against aerobic and anaerobic bacteria and bacteria. CONSTITUTION: This composition contains one or more peptides selected from the group consisting of peptides containing an amino acid sequence of SEQ ID NO: 1, an amino acid sequence of SEQ ID NO: 2 and sequences thereof and also treats diseases caused by bacteria. Buforin IIb as buforin derivatives exhibits an excellent antimicrobial activity against aerobic Gram-positive bacteria and Gram-negative bacteria, anaerobic bacteria and fungus containing a variety of drug-resistant bacteria.
    • 目的:提供含有作为抗微生物肽的布林素衍生物的抗微生物组合物,其可用作药物,动物医药,生物制品,生物农药,饲料添加剂等,因为它表现出几乎没有毒性,同时保持对有氧和厌氧细菌的广泛的抗微生物活性 和细菌。 构成:该组合物含有选自包含SEQ ID NO:1的氨基酸序列,SEQ ID NO:2的氨基酸序列及其序列的肽的一种或多种肽,并且还治疗由细菌引起的疾病。 Buforin IIb作为buforin衍生物表现出对需氧革兰氏阳性菌和革兰氏阴性细菌,厌氧细菌和含有多种耐药性细菌的真菌的抗菌活性。