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1. 发明公开

KR1020020057313A 부포린 유도체를 포함하는 항균조성물 有权
标题翻译：含有BUFFIN衍生物的抗微生物组合物
公开(公告)号：KR1020020057313A
公开(公告)日：2002-07-11
申请号：KR1020010000285
申请日：2001-01-04
申请人： 주식회사 삼양제넥스
发明人： 이재현 , 이재흥 , 이연희 , 강영임 , 조진숙 , 홍승서 , 이현수
IPC分类号： A61K38/00
摘要： PURPOSE: An antimicrobial composition containing buforin derivatives as an antimicrobial peptide is provided which can be used as medicine, animal medicine, living article, biopesticide, feed additives, etc. because it exhibits almost no toxicity while retaining wide antimicrobial activity against aerobic and anaerobic bacteria and bacteria. CONSTITUTION: This composition contains one or more peptides selected from the group consisting of peptides containing an amino acid sequence of SEQ ID NO: 1, an amino acid sequence of SEQ ID NO: 2 and sequences thereof and also treats diseases caused by bacteria. Buforin IIb as buforin derivatives exhibits an excellent antimicrobial activity against aerobic Gram-positive bacteria and Gram-negative bacteria, anaerobic bacteria and fungus containing a variety of drug-resistant bacteria.
摘要翻译：目的：提供含有作为抗微生物肽的布林素衍生物的抗微生物组合物，其可用作药物，动物医药，生物制品，生物农药，饲料添加剂等，因为它表现出几乎没有毒性，同时保持对有氧和厌氧细菌的广泛的抗微生物活性和细菌。构成：该组合物含有选自包含SEQ ID NO：1的氨基酸序列，SEQ ID NO：2的氨基酸序列及其序列的肽的一种或多种肽，并且还治疗由细菌引起的疾病。 Buforin IIb作为buforin衍生物表现出对需氧革兰氏阳性菌和革兰氏阴性细菌，厌氧细菌和含有多种耐药性细菌的真菌的抗菌活性。

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