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1. 发明公开

KR1020080007765A 실라스타틴의 정제 방법 无效
标题翻译：辛伐他汀的净化过程
公开(公告)号：KR1020080007765A
公开(公告)日：2008-01-23
申请号：KR1020060066813
申请日：2006-07-18
申请人： 영진약품 주식회사
发明人： 박의석 , 안성일 , 이동걸 , 김형민 , 허준
IPC分类号： C07C233/48 , C07C233/68 , C07F1/04 , C07C233/47
摘要： A method for purifying cilastatin is provided to obtain highly pure cilastatin within a short time with reducing the generation of waste solution by using nanofiltration. A method for purifying cilastatin comprises the steps of filtering a crude cilastatin solution by nanofiltration; and optionally filtered the nanofiltration cilastatin by nanofiltration concentration. Preferably the crude cilastatin solution comprises cilastatin dissolved in water or a mixture solvent of water and an organic solvent. Preferably the organic solvent is an alcohol, acetone, acetonitrile, or tetrahydrofuran. Preferably the nanofiltration is carried out at a pressure of 100-200 g/cm^2 r and at a temperature of 10-25 deg.C with a concentration coefficient k of 0-2.
摘要翻译：提供了一种纯化西司他丁的方法，以在短时间内获得高纯度西司他丁，通过使用纳滤法减少废溶液的产生。纯化西司他丁的方法包括通过纳滤过滤粗制西司他丁溶液的步骤; 并且任选地通过纳滤浓缩过滤了纳滤法西司他丁。优选地，粗西司他丁溶液包含溶于水的西司他丁或水和有机溶剂的混合溶剂。有机溶剂优选为醇，丙酮，乙腈或四氢呋喃。优选地，在100-200g / cm 2 r的压力和10-25℃的温度下进行纳滤，浓度系数k为0-2。

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