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    • 3. 发明授权
    • 페노피브레이트를 함유하는 경구용 약제 조성물 및 그의제조방법
    • 用于口服包含芬太尼的药物组合物及其制备方法
    • KR100767349B1
    • 2007-10-17
    • KR1020060072550
    • 2006-08-01
    • 삼천당제약주식회사
    • 백승희한성균신은종이우영박준석
    • A61K9/10A61K9/14A61P3/06
    • A61K9/146A61K9/1617A61K9/1635A61K9/1652A61K31/216
    • An oral pharmaceutical composition comprising fenofibrate and a preparation method thereof are provided to improve bioavailability of fenofibrate by increasing its solubility and reduce preparation time by rapidly drying effective ingredients through spray drying. An oral pharmaceutical composition for treating hyperlipidemia comprises solid dispersion containing amorphous fenofibrate which is prepared by dispersing 1 part by weight of amorphous fenofibrate in 0.2-2.0 parts by weight of water-soluble polymer and 0.1-0.5 parts by weight of surfactant, wherein the water-soluble polymer is selected from hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxybutylcellulose, hydroxypentylcellulose, hydroxypropylbutylcellulose, hydroxypropylalkylcellulose, polyvinylpyrrolidone and polyvinylalcohol; and the surfactant is monooleic acid ester, monolaurylic acid ester, monopalmitic acid ester, monostearic acid ester, polyoxyethylene sorbitan ester, sodium dioctylsulfosuccinic acid, lecithin, stearylalcohol, cetostearylalcohol, cholesterol, polyoxyethylene lysine oil, polyoxyethylene fatty acid glyceride, poloxamer and cremophor.
    • 提供包含非诺贝特的口服药物组合物及其制备方法,以通过通过喷雾干燥快速干燥有效成分来提高非诺贝特的溶解度并缩短制备时间来提高非诺贝特的生物利用度。 一种用于治疗高脂血症的口服药物组合物,包括含非晶非诺贝特的固体分散体,其通过将1重量份无定形非诺贝特分散在0.2-2.0重量份水溶性聚合物和0.1-0.5重量份表面活性剂中制备,其中水 可溶性聚合物选自羟丙基纤维素,羟丙基甲基纤维素,羟甲基纤维素,羟乙基纤维素,羟丁基纤维素,羟戊基纤维素,羟丙基丁基纤维素,羟丙基烷基纤维素,聚乙烯吡咯烷酮和聚乙烯醇; 表面活性剂为单油酸酯,单月桂酸酯,单棕榈酸酯,单硬脂酸酯,聚氧乙烯脱水山梨糖醇酯,二辛基磺基琥珀酸钠,卵磷脂,硬脂醇,十六醇十八醇,胆固醇,聚氧乙烯赖氨酸油,聚氧乙烯脂肪酸甘油酯,泊洛沙姆和cremophor。
    • 4. 发明公开
    • 타크로리무스를 함유하는 경구용 조성물 및 그의 제조방법
    • 包含TARCROLIMUS的口服药物组合物及其方法
    • KR1020060131028A
    • 2006-12-20
    • KR1020050050864
    • 2005-06-14
    • 삼천당제약주식회사
    • 정형준백승희이우영박준석
    • A61K31/44A61K9/00
    • A61K31/44A61K9/0053
    • An oral pharmaceutical composition comprising tacrolimus and a preparation method thereof are provided to improve the convenience, industrialization of the preparation and bioavailability of the oral composition by rapidly drying the drug and water-soluble carrier. The oral pharmaceutical composition comprises 0.1-50.0 wt.% of amorphous type solid dispersion which is prepared by mixing 1-10 parts by weight of tacrolimus, 0.1-50 parts by weight of copolymer or acid-soluble polymer, and the remaining amount of organic solvent, and spray-drying or speed-coprecipitating the mixture, and 50.0-99.9 wt.% of an additive selected from excipient, binder, disintegrant and lubricant, wherein the copolymer is copovidon, carbomer or poloxamer; the acid-soluble polymer is eudragit E or polyvinylacetal diethylaminoacetate; and the composition is formulated as tablet, capsule, granule, powder, pill or dried syrup.
    • 提供了包含他克莫司的口服药物组合物及其制备方法,以通过快速干燥药物和水溶性载体来提高口服组合物的制备方便性,工业化和生物利用度。 口服药物组合物包含0.1-50.0重量%的非晶型固体分散体,其通过混合1-10重量份他克莫司,0.1-50重量份共聚物或酸溶性聚合物和剩余量的有机物 溶剂和喷雾干燥或速度共沉淀混合物,以及50.0-99.9重量%的选自赋形剂,粘合剂,崩解剂和润滑剂的添加剂,其中共聚物是共
      聚维酮,卡波姆或泊洛沙姆; 酸溶性聚合物是Eudragit E或聚乙烯醇缩乙醛二乙基氨基乙酸酯; 并将该组合物配制成片剂,胶囊剂,颗粒剂,粉剂,丸剂或干糖浆。
    • 5. 发明授权
    • 이트라코나졸을 함유하는 경구용 조성물
    • 含伊曲康唑的口服组合物
    • KR100555794B1
    • 2006-03-03
    • KR1020050022312
    • 2005-03-17
    • 삼천당제약주식회사
    • 정형준문병관이우영박준석
    • A61K31/496A61K47/38
    • 본 발명은 항진균제인 이트라코나졸을 포함하는 경구용 조성물에 관한 것으로, 이트라코나졸 1 중량부가 히드록시프로필 메틸셀룰로오스 0.1-10 중량부 및 흡수증진제 0.01-5 중량부에 고체분산화되어 무정형으로 제조된 고체분산체 40-70 중량%, 삼투유도제 0.1-30 중량% 및 붕해제 0.1-30 중량%를 포함하는 본 발명의 경구용 조성물은 이트라코나졸을 포함하는 고체분산체가 인공위액에서 용출이 빨라져 생체이용률을 향상시킬 뿐 아니라, 습식과립 공정이 아닌 건식과립 과정을 거쳐 직타함으로써 경제성도 우수하다.
      이트라코나졸, 히드록시프로필 메틸셀룰로오스, 고체분산체, 삼투유도제, 염화칼륨, 탄산마그네슘
    • 本发明涉及含有抗真菌剂伊曲康唑,伊曲康唑1重量份的羟丙基甲基纤维素和0.1〜10重量份的吸收增强剂的口服给药的组合物是0.01-5份(重量)制成的40无定形固体分散体的固体分散的 -70%(重量),0.1-30渗透诱导剂组合物,用于口服使用的本发明的,包括(重量)的(重量)的崩解剂0.1-30%的%,以及在人工胃液体的固体分散体更快改善的生物利用率,包括伊曲康唑的溶出 在湿法造粒过程中以及在干法造粒过程中不经济。
    • 7. 发明公开
    • 이스라디핀을 포함하는 서방성 제제 및 이의 제조방법.
    • 包含伊曲肽的持续组合物及其方法
    • KR1020060131029A
    • 2006-12-20
    • KR1020050050866
    • 2005-06-14
    • 삼천당제약주식회사
    • 최명규김세연이우영박준석
    • A61K9/22A61K9/14A61K31/44
    • A61K9/2054A61K9/146A61K9/2018A61K9/2027A61K9/2031A61K9/205A61K31/4439A61K2121/00
    • A sustained releasing composition comprising isradipin and a preparation method thereof are provided to maintain the release rate of isradipin constantly for a long period, and improve the preparation convenience and economical efficiency by using conventional preparation process. The sustained releasing composition comprises 1 parts by weight of the solid dispersion in the amorphous type prepared by mixing 1 part by weight of isradipin, 0.1-10 parts by weight of water-soluble polymer or surfactant and the remaining amount of organic solvent, and drying or coprecipitating the mixture with a speed mixer, 2-90 parts by weight of excipient, and 1-30 parts by weight of sustained releasing material, wherein the water-soluble polymer is hydroxypropylcellulose, hydroxypropylmethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxybutylcellulose, hydroxypentylcellulose, hydroxypropylbutylcellulose, hydroxypropylalkylcellulose, polyvinylpyrrolidone or polyvinylalcohol; the organic solvent is ethanol, dichloromethane or methanol; and the sustained releasing material is hydroxypropylmethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose, colidone SR, eudragit RL, eudragit RS, sodium alginate or xanthan gum.
    • 本发明提供一种持续释放组合物及其制备方法,其用于长时间维持阿司匹林的释放速度,并且通过常规制备方法提高了制备方便性和经济性。 持续释放组合物包含1重量份通过混合1重量份的isradipin,0.1-10重量份的水溶性聚合物或表面活性剂和剩余量的有机溶剂制备的无定形固体分散体,并干燥 或用速度混合器,2-90重量份赋形剂和1-30重量份缓释材料共混沉淀,其中水溶性聚合物是羟丙基纤维素,羟丙基甲基纤维素,羟甲基纤维素,羟乙基纤维素,羟丁基纤维素,羟戊基纤维素,羟丙基丁基纤维素 ,羟丙基烷基纤维素,聚乙烯吡咯烷酮或聚乙烯醇; 有机溶剂为乙醇,二氯甲烷或甲醇; 缓释材料为羟丙基甲基纤维素,羟丙基纤维素,羟乙基纤维素,聚乙烯吡咯烷酮SR,eudragit RL,eudragit RS,藻酸钠或黄原胶。