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    • 1. 发明公开
    • 근위축성측삭경화증에 대한 진단 마커로서의 돌연변이 유전자 및 이를 이용한 진단방법
    • 突变基因作为肌萎缩侧索硬化的诊断标记和使用它们的诊断方法
    • KR1020170041955A
    • 2017-04-18
    • KR1020150141113
    • 2015-10-07
    • 사회복지법인 삼성생명공익재단한양대학교 산학협력단서울대학교산학협력단
    • 기창석김영은김승현이승복
    • C12Q1/68G01N33/53G01N33/68
    • C12Q1/68G01N33/53G01N33/68
    • 본발명은근위축성측삭경화증에대한마커로서,,,,,,,,,돌연변이유전자및 돌연변이단백질과이를이용한근위축성측삭경화증의진단방법을제공한다. 본발명의근위축성측삭경화증마커는한국인 ALS 환자로부터발견한새로운변이로서종전에보고된데이터베이스에서 0.1% 미만의빈도로나타난매우드문변이이거나보고된바 없는변이이며, 정상대조군에서는발견되지않는변이이다. 본발명에서발견한돌연변이유전자및/또는이로부터코딩되는돌연변이단백질은 ALS의유전학적원인을밝히고 ALS를진단하는데매우유용하게사용될수 있다. 본발명에서발견한돌연변이유전자및/또는이로부터코딩되는돌연변이단백질에대하여유전자또는단백질검사를실시함으로써근위축성측삭경화증을조기진단할수 있으며, 적절한치료방법을조기에적용하여치료효과를극대화할수 있고, 나아가정확한병인에따른맞춤치료를가능하게할 수있다.
    • COY本发明作为用于萎缩性侧索硬化的标记物提供的,,,,,,,,,突变体基因和突变蛋白,并使用相同的肌萎缩侧索硬化的诊断方法。 本发明的肌萎缩性侧索硬化标记是变异并不少见突变或报告为韩语ALS患者中发现了新的变化出现在小于0.1%的在数据库中的频率作为在先前报道的,未在对照组中发现的突变 。 突变基因和/或由此发现在本发明中编码的突变蛋白可以是揭示ALS的遗传原因诊断ALS非常有用的。 通过进行基因或突变基因和/或突变的蛋白通过这个发现,本发明中的编码可以是肌萎缩性侧索硬化的早期诊断测试的蛋白质,并且可以在早期阶段最大化通过施加适当的治疗的治疗效果, 此外,根据精确病理的定制治疗可能成为可能。
    • 5. 发明授权
    • 탄소나노튜브가 함유된 폴리술폰 지지체를 이용한 폴리아미드 역삼투막 및 그 제조방법
    • 使用含有碳纳米管的聚砜支撑材料的聚酰亚胺反渗透膜及其制造方法
    • KR101250310B1
    • 2013-04-03
    • KR1020120095296
    • 2012-08-30
    • 한국수자원공사경남대학교 산학협력단한양대학교 산학협력단
    • 배상식이상철김영철김지웅정창희임재림이경혁이영주김승현민충식김치성박호범
    • B01D69/12B01D61/02B01D71/56B01D71/02
    • Y02A20/131B01D69/12B01D61/025B01D69/141B01D71/021B01D71/56C02F1/441C02F2103/08
    • PURPOSE: A polyamide reverse osmosis membrane and a manufacturing method thereof using a polysulfone support having a multi-walled carbon nanotube are provided to use a polysulfone support with a polysulfone membrane containing a carbon nanotube and maintaining a chemical tolerance and mechanical properties identical to the properties of an existing membrane, thereby maintaining a salt rejection rate and improving permeable behaviors compared with an existing reverse osmosis membrane using the polysulfone support. CONSTITUTION: A manufacturing method for a polyamide reverse osmosis membrane includes: a step(S100) of opening the terminal portion of a multi-walled carbon nanotube with heat treatment in order to improve an unstable terminal portion structure of the multi-walled carbon nanotube such as a pentagonal ring or a heptagonal ring; a step(S200) of surface-treating the multi-walled carbon nanotube, of which the terminal portion is open, with a nonionic surfactant in order to increase the dispersive properties of the multi-walled carbon nanotube against an organic solvent; a step(S300) of manufacturing a polysulfone solution added with the surface-treated multi-walled carbon nanotube into a polysulfone membrane containing the multi-walled carbon nanotube using a nonsolvent-induced phase separation method; and a step(S400) of impregnating an M-phenylenediamine aqueous solution and a trimesoyl chloride organic solution using the polysulfone membrane as a support, and drying the polysulfone membrane to manufacture the polyamide reverse osmosis membrane. [Reference numerals] (AA) Start; (BB) End; (S100) Step of opening the terminal portion of a MWCNT(Multi-walled Carbon Nanotube) with heat treatment in order to improve the unstable terminal portion structure of the multi-walled carbon nanotube such as a pentagonal ring or a heptagonal ring, where the MWCNT is used as a flow path for reducing the resistance of a polysulfone support in a reverse osmosis membrane; (S200) Step of surface-treating the MWCNT of which the terminal portion is opened using a nonionic surfactant in order to increase the dispersive property of the MWCNT against an organic solvent; (S300) Step of manufacturing a polysulfone solution added with the surface-treated MWCNT into a polysulfone membrane containing the MWCNT using a nonsolvent-induced phase separation method; (S400) Step of impregnating the polysulfone membrane containing the MWCNT as a support in an MPD aqueous solution and a TMC organic solution, and then drying to manufacture the polyamide reverse osmosis membrane;
    • 目的:提供聚酰胺反渗透膜及其使用具有多壁碳纳米管的聚砜载体的制造方法,以使用具有含有碳纳米管的聚砜膜的聚砜载体,并保持与性能相同的化学耐受性和机械性能 的现有膜,从而与使用聚砜载体的现有反渗透膜相比,保持了脱盐率和改善渗透性能。 构成:聚酰胺反渗透膜的制造方法包括:通过热处理打开多壁碳纳米管的末端部分的步骤(S100),以改善多壁碳纳米管的不稳定的末端部分结构,如 作为五角环或七角环; 为了提高多壁碳纳米管相对于有机溶剂的分散性,用非离子表面活性剂表面处理末端部分开放的多壁碳纳米管的步骤(S200) 使用非溶剂诱导相分离方法将表面处理的多壁碳纳米管加入到含有多壁碳纳米管的聚砜膜中的聚砜溶液的步骤(S300) 和使用聚砜膜作为载体浸渍间苯二胺水溶液和均苯三酰氯有机溶液的步骤(S400),并干燥聚砜膜以制造聚酰胺反渗透膜。 (附图标记)(AA)开始; (BB)结束; (S100)通过热处理来打开MWCNT(多壁碳纳米管)的端子部分的步骤,以改善五壁环或七角环等多壁碳纳米管的不稳定末端部分结构,其中 MWCNT用作用于降低反渗透膜中聚砜载体的电阻的流动路径; (S200)为了提高MWCNT相对于有机溶剂的分散性,使用非离子表面活性剂对末端部分开孔的MWCNT进行表面处理的步骤; (S300)使用非溶剂诱导相分离方法将加成表面处理的MWCNT的聚砜溶液制造成含有MWCNT的聚砜膜的工序; (S400)将含有MWCNT的聚砜膜作为载体浸渍在MPD水溶液和TMC有机溶液中,然后干燥以制造聚酰胺反渗透膜;