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1. 发明授权

KR100461570B1 키랄 3,4-디하이드록시부티르산의 제조방법 失效
标题翻译：生产手性3,4-二羟基丁酸的方法
公开(公告)号：KR100461570B1
公开(公告)日：2005-04-06
申请号：KR1019980049703
申请日：1998-11-19
申请人： 롯데정밀화학 주식회사
发明人： 변일석 , 김영일 , 류상욱 , 하승범 , 최윤환
IPC分类号： C07C59/10
摘要： 본 발명은 키랄 3,4-디하이드록시부티르산의 제조방법에 관한 것으로서, 더욱 상세하게는 키랄 3-활성화된 하이드록시부티로락톤을 원료물질로하여 키랄센터가 역전화된 다음 화학식 1로 표시되는 키랄 3,4-디하이드록시부티르산을 경제적으로 제조하는 방법에 관한 것이다.

2. 发明授权

KR100461569B1 광학적으로 순수한 3-히드록시-피롤리딘의 제조방법 失效
标题翻译： 광학적으로순수한3-히드록시 - 피롤리딘의제조방광
公开(公告)号：KR100461569B1
公开(公告)日：2004-12-14
申请号：KR1020020027878
申请日：2002-05-20
申请人： 롯데정밀화학 주식회사
发明人： 천종필 , 황재광 , 하승범 , 조익행 , 유지욱
IPC分类号： C07D207/04
CPC分类号： C07D207/12
摘要： The present invention relates to a method for preparing optically pure 3-hydroxy-pyrrolidine, more particularly to a novel method for preparing 3-hydroxy-pyrrolidine economically, conveniently and efficiently, by reacting optically active 3,4-epoxy-1-butanol with ammonia and an aldehyde compound to prepare 4-protected-imino-butane-1,3-diol, selectively activating a hydroxy group at C-1 and then converting an imino group to an amine group by acid simultaneously or consecutively and performing intramolecular cyclization in the presence of a base.
摘要翻译：本发明涉及一种制备光学纯的3-羟基 - 吡咯烷的方法，更具体地涉及经济，方便和有效地制备3-羟基 - 吡咯烷的新方法，其通过使光学活性的3,4-环氧-1-丁醇与氨和醛化合物反应，制备4-保护的亚氨基丁烷-1,3-二醇，选择性活化C-1处的羟基，然后同时或连续地通过酸将亚氨基转化为胺基，并在其中进行分子内环化基地的存在。

3. 发明公开

KR1020010106791A 고순도 (Ｓ)-1,2,4-부탄트리올의 제조방법 失效
标题翻译：用于生产高纯度（S）-1,2,4-丁二酸的方法
公开(公告)号：KR1020010106791A
公开(公告)日：2001-12-07
申请号：KR1020000027754
申请日：2000-05-23
申请人： 롯데정밀화학 주식회사
发明人： 하승범 , 김건일 , 유호성
IPC分类号： C07C29/143
摘要： 본 발명은 고순도 (S)-1,2,4-부탄트리올의 제조방법에 관한 것으로서, 더욱 상세하게는 (S)-3-아세톡시-γ-부티로락톤을 출발물질로 사용하고 이를 수소화붕소 나트륨으로 환원한 후에 생성된 부반응물을 효과적으로 제거하여 다음 화학식 1로 표시되는 (S)-1,2,4-부탄트리올을 고순도로 제조하는 방법에 관한 것이다.

4. 发明公开

KR1020020091905A 주쇄 2-아미노에틸글리신의 1차 아미노기가 알킬 또는아릴설포닐에톡시카르 보닐기로 보호된 펩타이드 핵산단량체와 그 제조방법 无效
标题翻译：作为亚氨基保护基团的亚氨基或芳基甲酰氧基甲酰胺保护的PNA单体，2-氨基乙酰胆碱及其制备方法
公开(公告)号：KR1020020091905A
公开(公告)日：2002-12-11
申请号：KR1020010030712
申请日：2001-06-01
申请人： 롯데정밀화학 주식회사
发明人： 하승범 , 황대일 , 안지수
IPC分类号： C07H21/00
摘要： PURPOSE: Provided are alkyl or arylsulfonylethoxycarbonyl protected PNA(peptide nucleic acid) monomer as the amino protected group of backbone, 2-aminoethylglycine and a preparation method of thereof, thereby easily manufacturing PNA oligomers which are useful as detection probes. CONSTITUTION: The PAN monomer is represented by the formula(1), wherein R1 represents C1-C6 alkyl group or substituted phenyl group(wherein the substituent of the phenyl group represents NO2, C1-C3 alkyl group and halogen atom); B represents adenine, guanine, cytosine; and R2 represents 4-methoxyphenyldiphenylmethyl group.
摘要翻译：目的：提供烷基或芳基磺酰基乙氧基羰基保护的PNA（肽核酸）单体作为主要氨基保护基团，2-氨基乙基甘氨酸及其制备方法，从而容易制备可用作检测探针的PNA寡聚体。构成：PAN单体由式（1）表示，其中R1表示C1-C6烷基或取代苯基（其中苯基的取代基表示NO2，C1-C3烷基和卤素原子）; B代表腺嘌呤，鸟嘌呤，胞嘧啶; R2表示4-甲氧基苯基二苯基甲基。

5. 发明授权

KR100267502B1 키랄 4-치환된-3-하이드록시부티르산과 이의 염의 제조방법 失效
标题翻译：制备四取代的3-羟基丁酸及其盐的方法
公开(公告)号：KR100267502B1
公开(公告)日：2000-10-16
申请号：KR1019980035653
申请日：1998-08-31
申请人： 롯데정밀화학 주식회사
发明人： 변일석 , 김경일 , 하승범
IPC分类号： C07C59/01
摘要： 본 발명은 키랄 4-치환된-3-하이드록시부티르산과 이의 염의 제조방법에 관한 것으로서, 더욱 상세하게는 원료물질으로서의 (S)-3-활성화된 하이드록시부티로락톤의 키랄센터가 역전화된 다음 화학식 1로 표시되는 키랄 4-치환된-3-하이드록시부티르산과 이의 염을 경제적으로 제조하는 방법에 관한 것이다.

상기 화학식 1에서 :
X는 수소원자, 할로겐원자, -OH, -SR', -CN, -N
3 , -NR
a R
b R
c 또는 -OAr를 나타내고, 이때 R'은 지방족 또는 방향족 탄화수소를 나타내고, R
a , R
b 및 R
c 는 서로 같거나 다른 것으로서 수소원자, 탄소원자수 2 내지 5의 알킬기 또는 벤질기를 나타내고, Ar은 페닐기, 알콕시페닐기, 나프틸기를 나타낸다.

6. 发明公开

KR1020000033043A 키랄 3,4-디하이드록시부티르산의 제조방법 失效
标题翻译：生产3,4代二氢吡啶酸的方法
公开(公告)号：KR1020000033043A
公开(公告)日：2000-06-15
申请号：KR1019980049703
申请日：1998-11-19
申请人： 롯데정밀화학 주식회사
发明人： 변일석 , 김영일 , 류상욱 , 하승범 , 최윤환
IPC分类号： C07C59/10
摘要： PURPOSE: A method for economically producing charily 3,4-dihydroxybutyric acid having an inverted charily center from charily 3-activated hydroxybutyrolactone is provided. CONSTITUTION: The method for producing charily 3,4-dihydroxybutyric acid comprises the steps: forming charily 4-hydroxy-3-activated hydroxybutyric acid of formula 3 by ring-opening reaction of charily 3-activated hydroxybutyrolactone of formula 2 in the presence of acid catalysts in water solvent; preparing charily 3,4-epoxybutyrate of formula 4 by inversion of a charily center in charily 4-hydroxy-3-activated hydroxybutyric acid in the presence of bases; producing charily 3,4-dihydroxybutyric acid of formula 1 by water substitution of charily 3,4-epoxybutyrate in the presence of acids.
摘要翻译：目的：提供一种从富含3-活化的羟基丁内酯经济地生产具有倒置的焦心中心的富含3,4-二羟基丁酸的方法。构成：生产富含3,4-二羟基丁酸的方法包括以下步骤：通过在酸存在下，将式2的三元羧酸的3-活化羟基丁内酯的开环反应形成式3的4-羟基-3-活化的羟基丁酸水溶剂中的催化剂; 通过在碱的存在下在富含4-羟基-3-活化的羟基丁酸中的一个富含中心的反应来制备式4的芳香的3,4-环氧丁酸酯; 通过在酸的存在下，用惰性3,4-环氧丁酸的水置换生成式1的芳香的3,4-二羟基丁酸。

7. 发明授权

KR100461572B1 Ｌ-카르니틴 칼슘 염과 이의 제조방법 失效
标题翻译： L-카르니틴칼슘염과이의제조방법
公开(公告)号：KR100461572B1
公开(公告)日：2004-12-14
申请号：KR1019990010672
申请日：1999-03-27
申请人： 롯데정밀화학 주식회사
发明人： 하승범 , 변일석 , 최윤환 , 류상욱 , 김경일
IPC分类号： C07C229/00
摘要： PURPOSE: A calcium salt of L-carnitine is provided which can be used for a healthy food, a food additive, and medical supplies. CONSTITUTION: The calcium salt of L-carnitine (formula 1) is produced by a method comprising the steps of: concentrating L-carnitine and a calcium halide preferably calcium chloride in the equivalent ratio of 1-1.5:1 to obtain the L-carnitine and the calcium in the ratio of 1:1 or concentrating the L-carnitine and the calcium chloride in the equivalent ratio of 2-2.5:1 to obtain the L-carnitine and the calcium in the ratio of 2:1; adding an alcohol as a main solvent to the concentrated liquid; heating and then cooling and crystallizing the resultant. In the formula, X is a halogen, L is an integer of 1-4, n is 1 when m is 1, n is 2 when m is 0.
摘要翻译：目的：提供L-肉碱钙盐，可用于健康食品，食品添加剂和医疗用品。构成：L-肉碱钙盐（式1）通过包括以下步骤的方法生产：以1-1.5:1的当量比浓缩L-肉毒碱和卤化钙，优选氯化钙，得到L-肉毒碱与钙的比例为1：1，或者将L-肉碱和氯化钙以2-2.5：1的当量比进行浓缩，得到L-肉碱和钙的比例为2：1; 向浓缩液中加入醇作为主要溶剂; 加热，然后冷却并结晶所得物。在该式中，X是卤素，L是1-4的整数，当m是1时n是1，当m是0时n是2。

8. 发明公开

KR1020000065995A 키랄 3-히드록시-γ-부티로락톤의 제조방법 无效
标题翻译： 3-羟基 - 吲哚的制备方法
公开(公告)号：KR1020000065995A
公开(公告)日：2000-11-15
申请号：KR1019990012806
申请日：1999-04-12
申请人： 롯데정밀화학 주식회사
发明人： 변일석 , 김경일 , 류상욱 , 하승범 , 최윤환
IPC分类号： C07D307/32
摘要： PURPOSE: A process for producing 3-hydroxy-γ-butyrolactones by halogenating chiral 3,4-epoxybutyric acid or its salt using water in place of an expensive solvent and cyclization without any special purification processes in one reactor is provided which produces 3-hydroxy-γ-butyrolactones in high yield and any low cost. CONSTITUTION: Chiral 3,4-epoxybutyric acid or its salt of formula 2 is halogenated and cycled in the presence of a water solvent to give 3-hydroxy-γ-butyrolactones of formula 1. In the halogenation, a halogenating agent alone or a mixture of the halogenating agent and acid are used in which the halogenating agent is halogen acid selected from chloric acid, bromic acid, or halogenated alkali metal salt selected from sodium chloride, sodium bromide, sodium iodide, potassium chloride and potassium bromide. In formula, a chiral center (*) represents (R)- or (S)-; M is hydrogen ion, metal ion or organic amine; X is a halogen atom.
摘要翻译：目的：提供一种通过使用水代替昂贵的溶剂卤化手性3,4-环氧丁酸或其盐而生产3-羟基-γ-丁内酯的方法，并且在一个反应器中没有任何特殊的纯化方法进行环化，其产生3-羟基 γ-丁内酯，产率高，成本低。构成：手性3,4-环氧丁酸或式2的盐在水溶剂存在下被卤化和循环，得到式1的3-羟基-γ-丁内酯。在卤化反应中，单独使用卤化剂或混合物的卤化剂和酸，其中卤化剂为选自氯化钠，溴化钠，碘化钠，氯化钾和溴化钾的氯酸，溴酸或卤代碱金属盐中的卤素酸。在式中，手性中心（*）表示（R） - 或（S） - ; M是氢离子，金属离子或有机胺; X是卤原子。

9. 发明公开

KR1020030089948A (Ｒ)-3,4-에폭시-1-부탄올의 제조방법 无效
标题翻译：制备（R）-3,4-环氧-1-丁醇的方法
公开(公告)号：KR1020030089948A
公开(公告)日：2003-11-28
申请号：KR1020020027877
申请日：2002-05-20
申请人： 롯데정밀화학 주식회사
发明人： 천종필 , 황재광 , 하승범 , 조익행 , 유지욱
IPC分类号： C07D303/14
CPC分类号： C07D301/02
摘要： PURPOSE: A process for preparing (R)-3,4-epoxy-1-butanol is provided, thereby cheaply preparing (R)-3,4-epoxy-1-butanol in higher yield. CONSTITUTION: A process for preparing (R)-3,4-epoxy-1-butanol represented by the formula 1 comprises the steps of: reduction of (S)-3-alkyl or arylsulfonyloxy-butyrolactone of the formula 2 to prepare 2-sulfonyloxy-1,4-butanediol of the formula 3; and epoxidation of the compound of the formula 3 in the presence of base, wherein R is C1-C12 alkyl, aryl or substituted aryl; the reduction is carried out by using a boron metal compound as a reducing agent; the boron metal compound is selected from NaBH4 and Ca(BH4)2; the reduction temperature is -10 to 40 deg. C; and the epoxidation temperature is 0 to 50 deg. C.
摘要翻译：目的：提供（R）-3,4-环氧-1-丁醇的制备方法，从而以更高的收率廉价地制备（R）-3,4-环氧-1-丁醇。构成：制备式（1）所示的（R）-3,4-环氧-1-丁醇的方法包括以下步骤：还原式2的（S）-3-烷基或芳基磺酰氧基 - 丁内酯以制备2- 式3的磺酰氧基-1,4-丁二醇; 在碱的存在下环氧化式3的化合物，其中R是C1-C12烷基，芳基或取代的芳基; 通过使用硼金属化合物作为还原剂进行还原; 硼化合物选自NaBH 4和Ca（BH 4）2; 还原温度为-10〜40℃。 C; 环氧化温度为0〜50℃。 C。

10. 发明公开

KR1020030009903A 주쇄 ２－아미노에틸글리신의 １차 아미노기가ｐ－니트로페닐설포닐에톡시카르보닐기로 보호된 펩타이드핵산 단량체의 제조방법 无效
标题翻译：具有氨基保护基的2-氨基乙酰氨基苯酚的N-硝基甲硅烷氧基甲酰胺保护的PNA单体的制备方法
公开(公告)号：KR1020030009903A
公开(公告)日：2003-02-05
申请号：KR1020010044570
申请日：2001-07-24
申请人： 롯데정밀화학 주식회사
发明人： 하승범 , 황대일 , 안지수
IPC分类号： C07K1/06
CPC分类号： C07K1/061 , C07K14/003
摘要： PURPOSE: Provided is a preparation method of a p-nitrophenylsulfonylethoxycarbonyl protected PNA monomer with the amino protected group of 2-aminoethylglycine backbone, thereby easily producing a PNA oligomer by effectively deprotecting the PNA monomer under mild condition. CONSTITUTION: The peptide nucleic acid(PNA) monomer is represented by the formula(1) or (2). In the formula(1), B is adenine, guanine and cytosine and R1 is a 4-methoxyphenyldiphenylmethyl group, and in the formula(2) B is adenine, guanine, cytosine, R1 is a 4-methoxyphenyldiphenylmethyl group and R' is a C1-C6 alkyl group. The preparation method of the PNA monomer employs an intermediate represented by the formula(3), wherein R' is a methyl group or an ethyl group.
摘要翻译：目的：提供具有氨基保护基的2-氨基乙基甘氨酸骨架的对硝基苯磺酰基乙氧基羰基保护的PNA单体的制备方法，从而通过在温和条件下有效地脱保护PNA单体，容易地制备PNA低聚物。构成：肽核酸（PNA）单体由式（1）或（2）表示。在式（1）中，B是腺嘌呤，鸟嘌呤和胞嘧啶，R1是4-甲氧基苯基二苯基甲基，在式（2）中，B是腺嘌呤，鸟嘌呤，胞嘧啶，R1是4-甲氧基苯基二苯基甲基，R' C1-C6烷基。 PNA单体的制备方法使用由式（3）表示的中间体，其中R'为甲基或乙基。

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