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1. 发明公开

KR1020080022108A 방사성 화상 진단제 无效
标题翻译：放射性诊断成像剂
公开(公告)号：KR1020080022108A
公开(公告)日：2008-03-10
申请号：KR1020077029369
申请日：2006-06-08
申请人： 니혼 메디피직스 가부시키가이샤
发明人： 시마다타카유키 , 나카타니아키라 , 타카하시케이에츠
IPC分类号： A61K51/00 , G01T1/161
CPC分类号： A61K51/0491 , C07H5/02
摘要： [PROBLEMS] In a radioactive diagnostic imaging agent comprising a radioactive halogen-labeled compound as an active ingredient, to prevent the radiation degradation of the active ingredient to increase the stability of the radioactive diagnostic imaging agent. [MEANS FOR SOLVING PROBLEMS] A biologically acceptable saccharide or sugar alcohol is added to the radioactive diagnostic imaging agent in an amount effective for the prevention of the radiation degradation. The amount of the saccharide or sugar alcohol to be added is preferably 10 (mmol/L)/GBq/mL or more, more preferably 50 (mmol/L)/GBq/mL or more. The saccharide is preferably selected from the group consisting of erythrose, threose, ribose, arabinose, xylose, lyxose, allose, altrose, glucose, mannose, gulose, idose, galactose, talose, erythrulose, ribulose, xylulose, psicose, fructose, sorbose and tagatose. The sugar alcohol is preferably selected from the group consisting of erythritol, xylitol, sorbitol and mannitol. ® KIPO & WIPO 2008
摘要翻译： [问题]在包含放射性卤素标记的化合物作为活性成分的放射性诊断显像剂中，为了防止活性成分的辐射降解以增加放射性诊断显像剂的稳定性。用于解决问题的手段将生物学上可接受的糖或糖醇以有效防止辐射降解的量加入到放射性诊断显像剂中。糖或糖醇的添加量优选为10（mmol / L）/ GBq / mL以上，更优选为50（mmol / L）/ GBq / mL以上。糖类优选选自赤藓糖，苏糖，核糖，阿拉伯糖，木糖，莱索糖，阿洛糖，阿卓糖，葡萄糖，甘露糖，古洛糖，艾多糖，半乳糖，托洛糖，赤藓糖，核酮糖，木酮糖，木糖，果糖，山梨糖和塔格糖。糖醇优选选自赤藓糖醇，木糖醇，山梨糖醇和甘露糖醇。 ®KIPO＆WIPO 2008

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