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1. 发明公开

KR1020030018354A 간단하고 빠른 바이러스에 대한 항체의 간접면역효소측정법 有权
标题翻译：简单快速的间接酶联免疫免疫法检测抗病毒抗体
公开(公告)号：KR1020030018354A
公开(公告)日：2003-03-06
申请号：KR1020010052053
申请日：2001-08-28
申请人： 녹십자수의약품(주) , 박봉균
发明人： 박봉균 , 오진식 , 송대섭
IPC分类号： G01N33/569
摘要： PURPOSE: Provided is a simple and rapid indirect enzyme linked immunoassay for detecting an anti-virus antibody by using a simply purified antigen, thereby simply assaying the anti-virus antibody within a short time, and detecting virus infection rapidly. CONSTITUTION: The indirect enzyme linked immunoassay for detecting an anti-virus antibody is characterized by the step of coating a microplate with virus antigens and control antigens, wherein the virus is Corona virus, particularly a porcine epidemic diarrhea virus.
摘要翻译：目的：提供一种简单快速的间接酶联免疫分析法，通过使用简单纯化的抗原检测抗病毒抗体，从而在短时间内简单地测定抗病毒抗体，并快速检测病毒感染。构成：用于检测抗病毒抗体的间接酶联免疫测定的特征在于用病毒抗原和对照抗原包被微孔板的步骤，其中病毒是Corona病毒，特别是猪流行性腹泻病毒。

2. 发明公开

KR1020020081756A 돼지 아미노펩티다제 엔을 이용한 돼지 유행성 설사병바이러스의 배양방법 및 그 생독 백신 有权
标题翻译：使用磷酸氨基转移酶N和其灭活疫苗培养磷酸二乙酯病毒（PEDV）的方法
公开(公告)号：KR1020020081756A
公开(公告)日：2002-10-30
申请号：KR1020010021113
申请日：2001-04-19
申请人： 녹십자수의약품(주) , 박봉균
发明人： 박봉균 , 오진식 , 송대섭
IPC分类号： C12N7/01
CPC分类号： C12N7/00 , A61K39/215 , A61K2039/552 , C12N2770/20034 , C12Y304/11002
摘要： PURPOSE: Provided are a method for culturing porcine epidemic diarrhea virus(PEDV) using porcine aminopeptidase N and an attenuated vaccine thereof, thereby the PEDV can be cultured in higher concentration and the attenuated vaccine having improved immunogenecity can be produced. CONSTITUTION: The method for culturing porcine epidemic diarrhea virus(PEDV) using porcine aminopeptidase N comprises the steps of: culturing animal cells used for proliferation of PEDV; and inoculating PEDV into the cultured animal cell in a medium containing a cell receptor of PEDV and culturing it, wherein the animal cell is a vero cell; the cell receptor of PEDV is a receptor of porcine enterocyte or porcine aminopeptidase N; the medium for proliferation of PEDV contains α-MEM, 3% tryptose, phosphate broth, 0.3% yeast extract and antibiotics-antimycotic mixture, and has pH 7.2; and the attenuated vaccine for PEDV contains PEDV and the cell receptor of PEDV.
摘要翻译：目的：提供使用猪氨基肽酶N及其减毒疫苗培养猪流行性腹泻病毒（PEDV）的方法，从而可以以更高浓度培养PEDV，并且可以产生具有改善的免疫原性的减毒疫苗。构成：使用猪氨基肽酶N培养猪流行性腹泻病毒（PEDV）的方法包括以下步骤：培养用于PEDV增殖的动物细胞; 并在含有PEDV的细胞受体的培养基中将PEDV接种到培养的动物细胞中并进行培养，其中动物细胞是vero细胞; PEDV的细胞受体是猪肠细胞或猪氨基肽酶N的受体; PEDV增殖培养基含有α-MEM，3％柠檬酸，磷酸肉汤，0.3％酵母提取物和抗生素 - 抗真菌混合物，pH值为7.2; 而PEDV的减毒疫苗含有PEDV和PEDV的细胞受体。

3. 发明授权

KR100438006B1 간단하고 빠른 바이러스에 대한 항체의 간접면역효소측정법 有权
标题翻译： 간단하고빠른바이러스에대한항체의간접역역역측소측정
公开(公告)号：KR100438006B1
公开(公告)日：2004-07-02
申请号：KR1020010052053
申请日：2001-08-28
申请人： 녹십자수의약품(주) , 박봉균
发明人： 박봉균 , 오진식 , 송대섭
IPC分类号： G01N33/569
摘要： PURPOSE: Provided is a simple and rapid indirect enzyme linked immunoassay for detecting an anti-virus antibody by using a simply purified antigen, thereby simply assaying the anti-virus antibody within a short time, and detecting virus infection rapidly. CONSTITUTION: The indirect enzyme linked immunoassay for detecting an anti-virus antibody is characterized by the step of coating a microplate with virus antigens and control antigens, wherein the virus is Corona virus, particularly a porcine epidemic diarrhea virus.
摘要翻译：目的：本发明提供了一种简单快速的间接酶联免疫测定法，通过使用简单纯化的抗原来检测抗病毒抗体，从而简单地在短时间内分析抗病毒抗体，并迅速检测病毒感染。组成：用于检测抗病毒抗体的间接酶联免疫测定法的特征在于用病毒抗原和对照抗原包被微孔板的步骤，其中病毒是冠状病毒，特别是猪流行性腹泻病毒。

4. 发明授权

KR100502008B1 약독화된 돼지 유행성설사병 바이러스, 그를 포함하는면역원성 조성물 및 상기 바이러스를 검출하는 방법 有权
标题翻译：减毒猪流行性腹泻病毒，包含其的免疫原性组合物和检测病毒的方法
公开(公告)号：KR100502008B1
公开(公告)日：2005-07-18
申请号：KR1020030027069
申请日：2003-04-29
申请人： 박봉균 , 녹십자수의약품(주)
发明人： 박봉균 , 오진식 , 송대섭
IPC分类号： C12N7/04
摘要： 본 발명은 돼지 유행성설사병 바이러스 약독화주 (수탁번호 KCCM-10474) 및 치료학적으로 유효한 양의 상기 바이러스와 약리학적으로 허용가능한 담체를 포함하는 돼지 유행성 설사병의 예방 또는 치료용 조성물에 관한 것이다. 본 발명의 돼지 유행성설사병 바이러스 약독화주는 백신으로 사용하는 경우, 안전성, 안정성 및 면역원성이 우수하고, 용이하게 검출할 수 있으며, 경구투여에 의하여도 면역을 유발할 수 있다는 장점이 있다.

5. 发明公开

KR1020040092760A 약독화된 돼지 유행성설사병 바이러스, 그를 포함하는면역원성 조성물 및 상기 바이러스를 검출하는 방법 有权
标题翻译：灭活的PORCINE EPIDEMIC DIARRHEA病毒，包含其的免疫组合物和检测其的方法
公开(公告)号：KR1020040092760A
公开(公告)日：2004-11-04
申请号：KR1020030027069
申请日：2003-04-29
申请人： 박봉균 , 녹십자수의약품(주)
发明人： 박봉균 , 오진식 , 송대섭
IPC分类号： C12N7/04
CPC分类号： C12N7/04 , A61K35/76 , C12N2770/20032 , C12Q1/683 , C12Q1/70 , C12Q2600/156
摘要： PURPOSE: An attenuated porcine epidemic diarrhea virus, an immunogenic composition comprising the same and a method for detecting the same virus are provided. The virus has improved safety, stability, immunogenicity and protection efficiency for a pig. The porcine epidemic diarrhea can be prevented and treated by oral administration of the composition. CONSTITUTION: The attenuated porcine epidemic diarrhea virus(KCCM-10474) is provided. The immunogenic composition comprises the attenuated porcine epidemic diarrhea virus(KCCM-10474) and pharmaceutically acceptable carriers. The method for detecting the same attenuated porcine epidemic diarrhea virus(KCCM-10474) comprises the steps of: (a) providing a sample containing ORF3 DNA derived from the attenuated porcine epidemic diarrhea virus(KCCM-10474); (b) digesting the sample with one or more restriction enzymes selected from Hind III and Xho II, and detecting DNA fragments to obtain RFLP pattern; and (c) comparing the RFLP pattern of the step (b) with the standard RFLP pattern of ORF3 DNA which is obtained by treating the standard sample with the same restriction enzyme and detecting DNA fragments.
摘要翻译：目的：提供减毒的猪流行性腹泻病毒，包含其的免疫原性组合物和检测相同病毒的方法。该病毒改善了猪的安全性，稳定性，免疫原性和保护效率。可以通过口服施用组合物来预防和治疗猪流行性腹泻。构成：提供了减毒猪流行性腹泻病毒（KCCM-10474）。免疫原性组合物包含减毒猪流行性腹泻病毒（KCCM-10474）和药学上可接受的载体。检测相同的减毒猪流行性腹泻病毒（KCCM-10474）的方法包括以下步骤：（a）提供含有来自减毒猪流行性腹泻病毒（KCCM-10474）的ORF3 DNA的样品; （b）用一种或多种选自Hind III和Xho II的限制酶消化样品，检测DNA片段以获得RFLP图谱; 和（c）比较步骤（b）的RFLP模式与用相同的限制酶处理标准样品并检测DNA片段获得的ORF3 DNA的标准RFLP模式。

6. 发明授权

KR100432977B1 돼지 아미노펩티다제 엔을 이용한 돼지 유행성 설사병바이러스의 배양방법 및 그 생독 백신 有权
标题翻译： 돼지아미노펩티다제엔을이용한지유행성설사병바이러스의배양방법및그생독백신
公开(公告)号：KR100432977B1
公开(公告)日：2004-05-28
申请号：KR1020010021113
申请日：2001-04-19
申请人： 녹십자수의약품(주) , 박봉균
发明人： 박봉균 , 오진식 , 송대섭
IPC分类号： C12N7/01
摘要： PURPOSE: Provided are a method for culturing porcine epidemic diarrhea virus(PEDV) using porcine aminopeptidase N and an attenuated vaccine thereof, thereby the PEDV can be cultured in higher concentration and the attenuated vaccine having improved immunogenecity can be produced. CONSTITUTION: The method for culturing porcine epidemic diarrhea virus(PEDV) using porcine aminopeptidase N comprises the steps of: culturing animal cells used for proliferation of PEDV; and inoculating PEDV into the cultured animal cell in a medium containing a cell receptor of PEDV and culturing it, wherein the animal cell is a vero cell; the cell receptor of PEDV is a receptor of porcine enterocyte or porcine aminopeptidase N; the medium for proliferation of PEDV contains α-MEM, 3% tryptose, phosphate broth, 0.3% yeast extract and antibiotics-antimycotic mixture, and has pH 7.2; and the attenuated vaccine for PEDV contains PEDV and the cell receptor of PEDV.
摘要翻译：目的：提供一种利用猪氨肽酶N及其减毒疫苗培养猪流行性腹泻病毒（PEDV）的方法，从而可以以更高的浓度培养PEDV，并且可以产生具有改善的免疫原性的减毒疫苗。组成：用猪氨肽酶N培养猪流行性腹泻病毒（PEDV）的方法包括以下步骤：培养用于PEDV增殖的动物细胞; 并在含有PEDV细胞受体的培养基中将PEDV接种到培养的动物细胞中并培养，其中动物细胞是vero细胞; PEDV的细胞受体是猪肠细胞或猪氨肽酶N的受体; 用于PEDV增殖的培养基含有-MEM，3％胰蛋白胨，磷酸盐肉汤，0.3％酵母提取物和抗生素 - 抗真菌混合物，并且具有pH7.2; 而PEDV的减毒疫苗含有PEDV和PEDV的细胞受体。

7. 发明授权

KR101393287B1 신규한 돼지생식기호흡기증후군 바이러스 및 그의 용도 有权
公开(公告)号：KR101393287B1
公开(公告)日：2014-05-09
申请号：KR1020130070501
申请日：2013-06-19
申请人： 녹십자수의약품(주)
发明人： 송대섭 , 강보규 , 문형준 , 김혜권 , 박봉균 , 김종만
IPC分类号： C12N7/01 , A61K39/12 , A61P31/14
摘要： 신규한돼지생식기호흡기증후군바이러스(PRRSV), 불활성화된돼지생식기호흡기증후군바이러스(PRRSV)를포함하는돼지생식기호흡기증후군의예방또는치료용면역원성조성물및 그를이용한포유동물의돼지생식기호흡기증후군을예방또는치료하는방법을제공한다.

8. 发明授权

KR101013226B1 개 바이러스성 설사병 예방용 백신 有权
标题翻译：用于预防犬病毒性腹泻的疫苗
公开(公告)号：KR101013226B1
公开(公告)日：2011-02-10
申请号：KR1020080044735
申请日：2008-05-14
申请人： 녹십자수의약품(주)
发明人： 송대섭 , 강보규 , 이철승 , 박봉균
IPC分类号： A61K39/23 , A61K39/215 , A61K39/12
摘要： 본 발명은 불활화시킨 개 파보바이러스(Canine Parvovirus, CPV), 불활화시킨 개 코로나바이러스(Canine Coronavirus, CCoV) 및 불활화시킨 개 로타바이러스(Canine Rotavirus, CRV)로 이루어진 군으로부터 선택되는 하나 이상을 함유하는 개 바이러스성 설사병 예방용 백신에 관한 것이다. 본 발명의 백신은 CPV, CRV 및 CCoV로 인한 개 바이러스성 설사병을 1회의 접종으로 동시에 모두 예방할 수 있고 안전성이 우수하면서도 개에서의 설사병으로 인한 피해를 최소화시킬 수 있는 유용한 백신이다.
개, 설사병, 백신, 파보바이러스, 로타바이러스, 코로나바이러스

9. 发明公开

KR1020090118756A 개 바이러스성 설사병 예방용 백신 有权
标题翻译：用于预防犬类病毒的疫苗
公开(公告)号：KR1020090118756A
公开(公告)日：2009-11-18
申请号：KR1020080044735
申请日：2008-05-14
申请人： 녹십자수의약품(주)
发明人： 송대섭 , 강보규 , 이철승 , 박봉균
IPC分类号： A61K39/23 , A61K39/215 , A61K39/12
CPC分类号： A61K39/175 , A61K35/765
摘要： PURPOSE: A vaccine for preventing canine viral diarrhea is provided to minimize damage caused by diarrhea. CONSTITUTION: A vaccine for preventing canine viral diarrhea contains canine pavovirus CPV-2a(KCTC 11082BP) and CPV-2b(KCTC 11083BP), inactivated canine rotavirus(KCTC 11081BP) or inactivated canine corona virus(KCTC 11317BP). The vaccine further contains immunoadjuvant. The ratio of the canine pavovirus CPV-2a, CPV-2b, canine rotavirus, and canine corona virus is 40:25:25 or 30:30:30.
摘要翻译：目的：提供一种预防犬病毒性腹泻的疫苗，以减少由腹泻引起的损伤。构成：用于预防犬病毒性腹泻的疫苗包含犬疫病毒CPV-2a（KCTC 11082BP）和CPV-2b（KCTC 11083BP），灭活的犬轮状病毒（KCTC 11081BP）或灭活的犬冠状病毒（KCTC 11317BP）。该疫苗还含有免疫佐剂。犬病毒CPV-2a，CPV-2b，犬轮状病毒和犬冠状病毒的比例为40:25:25或30:30:30。

10. 发明授权

KR101393286B1 신규한 돼지생식기호흡기증후군 바이러스 및 그의 용도 有权
标题翻译：一种新型猪呼吸综合征病毒及其用途
公开(公告)号：KR101393286B1
公开(公告)日：2014-05-09
申请号：KR1020130070498
申请日：2013-06-19
申请人： 녹십자수의약품(주)
发明人： 송대섭 , 강보규 , 문형준 , 김혜권 , 박봉균 , 김종만
IPC分类号： C12N7/01 , A61K39/12 , A61P31/14
摘要： 신규한돼지생식기호흡기증후군바이러스(PRRSV), 불활성화된돼지생식기호흡기증후군바이러스(PRRSV)를포함하는돼지생식기호흡기증후군의예방또는치료용면역원성조성물및 그를이용한포유동물의돼지생식기호흡기증후군을예방또는치료하는방법을제공한다.
摘要翻译：该新型猪繁殖与呼吸综合征病毒（PRRSV），失活的哺乳动物中猪生殖和呼吸系统综合征的猪繁殖与呼吸综合征病毒（PRRSV），用于预防和治疗猪生殖与呼吸综合征，免疫原性组合物和使用相同的，包括预防或提供一种治疗方法。

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