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    • 6. 发明公开
    • (-)에피갈로카테킨 갈레이트를 포함하는 식품 및 사료
    • 食品和饲料产品包含( - )EPIGOCOCATECHIN GALLATE
    • KR1020050033570A
    • 2005-04-12
    • KR1020050015011
    • 2005-02-23
    • 주식회사 두산가부시키 가이샤 파마푸즈김혜경최강덕정주호임강현
    • 정주호최강덕임강현김일수김순애이희제유영민박히준이향숙인창식김혜경서정철김종우
    • A23L1/29
    • A23L33/00A23V2200/322
    • A food and feed composition containing (-)epigallocatechin gallate(EGCG) useful as an inhibitor to treat and prevent various diseases associated with the acetylcholine concentration in the body by effectively inhibiting the activity of acetylcholinesterase is provided. Therefore, the composition is useful in treatment and prevention of senile dementia, myasthenia gravis, gastroparesis and glaucoma without toxicity or adverse side effect. The food and feed composition contains (-)epigallocatechin gallate obtained from extraction of green tea. The pharmaceutical preparation containing the EGCG as an effective ingredient is orally administered at a daily dose of 1 to 500mg(preferably 50 to 100mg)/kg body weight one to several times per day. The IC50 value of the EGCG is about 0.13mg/ml(about 0.34mM). For an example, 100mg EGCG is mixed with 68mg corn starch, 90mg lactose, 40mg microcrystalline cellulose and 2mg magnesium stearate to give a tablet containing EGCG.
    • 提供了含有( - )表没食子儿茶素没食子酸酯(EGCG)的食品和饲料组合物,其可用作抑制剂,通过有效抑制乙酰胆碱酯酶的活性来治疗和预防与体内乙酰胆碱浓度相关的各种疾病。 因此,该组合物可用于治疗和预防老年痴呆,重症肌无力,胃轻瘫和青光眼,无毒副作用。 食物和饲料组合物含有从提取绿茶获得的( - )表没食子儿茶素没食子酸酯。 含有EGCG作为有效成分的药物以1〜500mg(优选50〜100mg)/ kg体重每天1〜数次的口服给药。 EGCG的IC50值约为0.13mg / ml(约0.34mM)。 例如,将100mg EGCG与68mg玉米淀粉,90mg乳糖,40mg微晶纤维素和2mg硬脂酸镁混合,得到含有EGCG的片剂。