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1. 发明公开

KR1020140117214A 나노 버블이 혼입된 장기 보존용 조성물 审中-实审
标题翻译： NANOBUBBLE液体用于组织保存
公开(公告)号：KR1020140117214A
公开(公告)日：2014-10-07
申请号：KR1020130032384
申请日：2013-03-26
申请人： (주) 지이오플랜트 , 건국대학교 산학협력단
发明人： 손종화 , 박종석 , 홍민 , 유한철 , 정광욱 , 이정익
IPC分类号： A01N1/00 , A01N1/02
CPC分类号： A01N1/021 , A01N1/0226
摘要： The present invention relates to a composition for long-term organ preservation having nanobubbles of an active gas composed of oxygen and carbon dioxide in ratio of 2:1. The composition for long-term organ preservation according to the present invention significantly increases effects of compositions with a ischemia-reperfused damage preventing effect used before for preserving an organ for clinical transplantation before, making supply of organs for transplantation to be useful in medical industries relating to organ transplantation and preservation.
摘要翻译：本发明涉及一种用于长期器官保存的组合物，其具有由氧和二氧化碳组成的活性气体的纳秒气泡比为2:1。根据本发明的用于长期器官保存的组合物显着增加了在用于保存临床移植器官之前使用的缺血再灌注损伤预防作用的组合物的作用，使得用于移植的器官的供应可用于涉及医疗行业器官移植和保存。

2. 发明授权

KR101493771B1 실험동물용 보정기 有权
标题翻译：实验动物保持器具
公开(公告)号：KR101493771B1
公开(公告)日：2015-02-17
申请号：KR1020117005182
申请日：2008-09-04
申请人： 건국대학교 산학협력단
发明人： 이정익
IPC分类号： A61D3/00 , A61D1/02
CPC分类号： A61D3/00
摘要： 본 발명의 실시예에 따르면, 실험동물을 보정하기 위한 실험동물용 보정기로서, 판 형상의 본체를 포함하고, 상기 본체의 중심을 지나는 중심 선상에서의 좌측 또는 우측으로 소정 거리 떨어진 위치에는, 상기 실험동물의 뒷다리 중 적어도 무릎까지의 통과가 가능한 지름을 갖는 뒷다리용 구멍이 형성되는 것을 특징으로 하는 실험동물용 보정기가 제공된다.

3. 发明公开

KR1020130100070A 세포 배양액 有权
标题翻译：基于流体的文化中介
公开(公告)号：KR1020130100070A
公开(公告)日：2013-09-09
申请号：KR1020130021590
申请日：2013-02-27
申请人： 건국대학교 산학협력단
发明人： 이정익 , 이수정
IPC分类号： C12N5/02 , C12N5/071 , A61L27/54
CPC分类号： C12N5/0018 , C12N2500/05 , C12N2500/14 , C12N2500/16 , C12N2500/24 , C12N2500/32 , C12N2500/34 , C12N2500/38
摘要： PURPOSE: A cell culture medium is provided to replace a commercial culture medium using an infusion solution and an injection solution which are approved as a pharmaceutical product. CONSTITUTION: A method for manufacturing a cell culture medium comprises the step of mixing an infusion solution or an injection solution for supplying vitamin; an infusion solution or an injection solution for supplying amino acids; and an infusion solution or an injection solution for supplying inorganic salts. The cell culture medium has the similar composition as a commercial cell culture medium. The method further comprises the step of adding glucose, inorganic salts supplements, antibiotics, and antifungal agents.
摘要翻译：目的：提供细胞培养基以使用批准为药物产品的输注溶液和注射溶液代替商业培养基。构成：细胞培养基的制造方法包括混合输液或供给维生素的注射液的工序; 用于供应氨基酸的输注溶液或注射溶液; 以及用于供给无机盐的输液或注射溶液。细胞培养基具有与商业细胞培养基相似的组成。该方法还包括加入葡萄糖，无机盐补充剂，抗生素和抗真菌剂的步骤。

4. 发明公开

KR1020110032433A 세포이식술을 위한 혼합세포복합체인 세포스페로이드의 제조방법 및 이의 이용방법 有权
标题翻译：用于细胞移植和混合细胞培养的混合细胞复合物的可移植颗粒的制备方法
公开(公告)号：KR1020110032433A
公开(公告)日：2011-03-30
申请号：KR1020090089912
申请日：2009-09-23
申请人： 건국대학교 산학협력단
发明人： 이정익
IPC分类号： C12N5/07 , A61L27/38 , A61K35/12
CPC分类号： C12N5/0062 , A61K35/12 , A61L27/3834 , C12N5/0662 , A61L27/38 , C12N5/0607
摘要： PURPOSE: A method for preparing spheroid which is cell complex for cell transplantation is provided to replace various tissues. CONSTITUTION: A cell spheroid for transplantation therapy is a mixed cell complex which is able to replace various tissues. The mixed cell complex comprises cells derived from auto, homo, or hetero tissues or cell derived the cells. The size of the mixed cell complex is 10-1500 um. A method for preparing cell spheroid for transplantation comprises: a step of isolating each cell material forming the mixed cell complex; a step of sub-culturing the cells and proliferating; a step of preparing cell suspension; and a step of isolating the cell spheroid.
摘要翻译：目的：提供细胞移植细胞复合物制备球状体的方法，以代替各种组织。构成：用于移植治疗的细胞球体是能够替代各种组织的混合细胞复合物。混合细胞复合物包含衍生自自体，同源或异质组织的细胞或衍生自细胞的细胞。混合细胞复合体的大小为10-1500um。一种制备用于移植的细胞球体的方法，包括：分离形成混合细胞复合物的每种细胞材料的步骤; 细胞分化培养和增殖的步骤; 制备细胞悬浮液的步骤; 以及分离细胞球体的步骤。

5. 发明公开

KR1020140049772A 근골격계 질환의 예방 또는 치료용 조성물 无效
标题翻译：用于预防或治疗肌肉松弛症的组合物
公开(公告)号：KR1020140049772A
公开(公告)日：2014-04-28
申请号：KR1020120115990
申请日：2012-10-18
申请人： 건국대학교 산학협력단
发明人： 이정익 , 이수정 , 조용화 , 김대현
IPC分类号： A61K31/727 , A61K38/17 , A61K9/16 , A61P19/00
CPC分类号： A61K31/727 , A61K9/0019 , A61K35/28 , A61K35/51 , A61K38/005 , A61K38/179 , A61K38/212 , C07K14/71
摘要： The present invention provides a composition for preventing or treating diseases related to the musculoskeletal orthopedic field including osteoarthritis and rotator cuff tearing of shoulders, which is produced based on a fact which a medicine with an unrevealed direct effect for preventing and treating musculoskeletal diseases among existing medicines with license can be used by targeting the regeneration and recovery of degenerated tissues in joints by the drug repositioning strategy if the medicine is applied with an ideal composition and mixing ratio.
摘要翻译：本发明提供了一种用于预防或治疗与肌肉骨骼整形外科领域有关的疾病的组合物，包括骨关节炎和肩袖撕裂，这是根据现有药物中具有预防和治疗肌肉骨骼疾病的直接作用的药物如果药物以理想的组成和混合比施用，可以通过药物重新定位策略来瞄准关节中的退化组织的再生和恢复。

6. 发明公开

KR1020140049771A 윤활주머니 유래 간엽계 줄기세포의 분리 배양방법 및 이를 포함하는 이식치료용 조성물 无效
标题翻译：从亚细菌分离培养和培养中等细胞干细胞的方法和用于移植包含其的组合物
公开(公告)号：KR1020140049771A
公开(公告)日：2014-04-28
申请号：KR1020120115989
申请日：2012-10-18
申请人： 건국대학교 산학협력단
发明人： 이정익 , 이상훈 , 김대현 , 이수정 , 조용화
IPC分类号： C12N5/0775 , C12N1/02 , A61K35/12 , A61P19/02
摘要： The present invention relates to a method for isolating and culturing mesenchymal stem cells derived from Subacromial bursa, and a composition for preventing and treating musculoskeletal diseases comprising the same. The method for isolating the mesenchymal stem cells derived from Subacromial bursa comprises: a step of cutting Subacromial bursa before inserting into a collagenase solution for melting tissues, and a step of obtaining the cells by passing the melted tissues through a cell strainer.
摘要翻译：本发明涉及一种用于分离和培养衍生自肩峰下囊的间充质干细胞的方法，以及用于预防和治疗包含其的肌肉骨骼疾病的组合物。分离衍生自子宫颈囊的间充质干细胞的方法包括：在插入用于熔化组织的胶原酶溶液之前切割子宫颈粘液囊的步骤，以及通过使熔融的组织通过细胞过滤器获得细胞的步骤。

7. 发明公开

KR1020130102506A 성숙 낭성 기형종 유래 세포 및 조직의 용도 无效
标题翻译：使用组织和细胞从成熟的CYSTIC TERATOMA衍生
公开(公告)号：KR1020130102506A
公开(公告)日：2013-09-17
申请号：KR1020130024510
申请日：2013-03-07
申请人： 건국대학교 산학협력단
发明人： 이정익 , 고기남 , 황한성 , 조용화
IPC分类号： C12N5/071 , C12Q1/02 , C12Q1/24 , A01K67/027
摘要： PURPOSE: A cell derived from mature cystic teratoma is provided to research diseases using a surgical specimen and to apply tissue-derived cells to a basic physiology-endocrinology study and a cell study. CONSTITUTION: A method for acquiring mature cystic teratoma-derived differentiated cells comprises the step of treating a mature cystic teratoma tissue with enzyme. A method for culturing the differentiated cells comprises the steps of: culturing mature cystic teratoma-derived cells in a culture dish; isolating a lump of cells into each single cell; and culturing the single cell on other culture dish. [Reference numerals] (AA) Mature cystic teratoma (MCT); (BB) Tissues; (CC) Cells; (DD) Use as it is; (EE) Use after proper processing; (FF) Poory differentiated cell (undifferentiated cell); (GG) Well differentiated cell (differentiated cell)
摘要翻译：目的：提供来自成熟囊性畸胎瘤的细胞用于使用手术标本研究疾病，并将组织来源的细胞应用于基础生理学 - 内分泌学研究和细胞研究。构成：获得成熟囊性畸胎瘤衍生的分化细胞的方法包括用酶处理成熟囊性畸胎瘤组织的步骤。培养分化细胞的方法包括以下步骤：在培养皿中培养成熟的囊性畸胎瘤来源的细胞; 将细胞块分离成每个单细胞; 并在其他培养皿上培养单细胞。（AA）成熟囊性畸胎瘤（MCT）; （BB）组织; （CC）细胞; （DD）原样使用; （EE）正确加工后使用; （FF）分化细胞（未分化细胞）; （GG）分化细胞（分化细胞）

8. 发明公开

KR1020170034271A 동결 절편조직을 이용한 유착방지용 조성물 및 그의 제조방법 无效
标题翻译：用于防止使用冷冻切片组织粘附的组合物及其制造方法
公开(公告)号：KR1020170034271A
公开(公告)日：2017-03-28
申请号：KR1020150132709
申请日：2015-09-18
申请人： 건국대학교 산학협력단
发明人： 이정익 , 이수정 , 이새롬 , 한유나 , 이경미
IPC分类号： A61L31/00 , A61L31/04
摘要： 본발명은탈세포화동결절편조직을이용한유착방지제및 그의제조방법에관한것으로, 더욱상세하게는수술후 수복과정중에장기및 조직이서로붙게되는현상인유착을방지하기위하여생물체에서유래된조직, 더자세하게는연골조직등을박편으로제작하여해당조직의세포외기질에서유착방지에있어서유효성분을이용하는시트형유착방지제및 그의제조방법에관한것이다.
摘要翻译：更具体地，本发明涉及源自生物体的组织，更具体地涉及来自生物体的组织，以便在术后恢复过程期间防止器官和组织相互粘附，是如产生软骨组织在片状粘连防止剂和在组织的细胞外基质中的防止粘连使用活性成分的制造方法的薄片。

9. 发明授权

KR101649375B1 세포이식술을 위한 혼합세포복합체인 세포스페로이드의 제조방법 및 이의 이용방법 有权
标题翻译：用于细胞移植的混合细胞复合物的可移植球体的制造方法及其用途
公开(公告)号：KR101649375B1
公开(公告)日：2016-08-30
申请号：KR1020090089912
申请日：2009-09-23
申请人： 건국대학교 산학협력단
发明人： 이정익
IPC分类号： C12N5/07 , A61L27/38 , A61K35/12
CPC分类号： C12N5/0062 , A61K35/12 , A61L27/3834
摘要： [과제] 본발명자는임상에효과적이면서실질적으로이용가능한이식치료용세포스페로이드를제공함으로, 정상에서벗어난질병상태에있는, 일부혹은전부의손상또는결손된환부에이식치료하기위한것으로서, 신체내정상적혹은건강한상태와유사한조직으로서형질발현된신체내를구성하는각종의조직을대신할 수있는본 발명를이용한각 질환에대한치료법그리고, 피검물질의약효및 독성을평가하기위한시스템으로서상당히유용한것이라는것을확인하고본 발명을완성하기에이르렀다. [해결수단] 본발명의한 관점에의하면, (1) 혼합세포복합체를구성하는각세포재료를분리준비하는단계 ; (2) 상기분리된세포를계대배양하여증폭하는단계 ; (3) 1 종류혹은 2 종류이상의세포를배양액내에서단독혹은혼합한세포재료혼탁액을준비하고세포를고밀도의부유상태로유지시키는배양을함으로써세포재료들을상호접착시켜혼합세포복합체를제조하는단계 ; 및 (4) 세포스페로이드를분리하여각각의목적별사용방법에따른소정의장소로이동시키는단계를포함한이식세포치료용스페로이드의제조방법및 이용방법을제공한다.

10. 发明授权

KR101508323B1 세포 배양액 有权
标题翻译：流体培养基
公开(公告)号：KR101508323B1
公开(公告)日：2015-04-14
申请号：KR1020130021590
申请日：2013-02-27
申请人： 건국대학교 산학협력단
发明人： 이정익 , 이수정
IPC分类号： C12N5/02 , C12N5/071 , A61L27/54
CPC分类号： C12N5/0018 , C12N2500/05 , C12N2500/14 , C12N2500/16 , C12N2500/24 , C12N2500/32 , C12N2500/34 , C12N2500/38
摘要： 본발명은세포배양액에관한것으로, 더욱상세하게는세포치료제등을위한안전하고, 안정되며유효한세포배양액에관한것이다.

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