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1. 发明公开

KR1020110122984A 조골세포 분화를 증가시키는 작용을 갖는 니코틴아미드 유도체 및 이를 함유하는 골형성 촉진용 조성물 无效
标题翻译：增强骨质疏松的骨质疏松症和促进骨形成的组合物的NICOTINAMIDE DORIVATION
公开(公告)号：KR1020110122984A
公开(公告)日：2011-11-14
申请号：KR1020100042378
申请日：2010-05-06
申请人： (주) 비엔씨바이오팜
发明人： 김종우 , 이상욱 , 이근형 , 박을용 , 임종환 , 이연임
IPC分类号： C07D213/82 , A61K31/455 , A61K31/4406 , A61P19/00
摘要： PURPOSE: A nicotiamide derivative having an action of enhancing osteoblast differentiation is provided to induce osteogenesis with less toxicity. CONSTITUTION: A nicotiamide derivative having an action of enhancing osteoblast differentiation or pharmaceutically acceptable salt thereof is denoted by chemical formula 1. A composition for promoting bone formation contains the derivatives or pharmaceutically acceptable salt thereof as an active ingredient. The composition is used for preventing and treating bone diseases such as metabolic bone diseases or orthopedic bone diseases. The composition is used for artificial bone, artificial joint, bone fixture, bone substitute, bone filling material, or bond implant. The composition is also used for preventing and treating periodontal disease.
摘要翻译：目的：提供具有增强成骨细胞分化作用的烟酰胺衍生物，诱导成骨细胞毒性较小。构成：具有增强成骨细胞分化作用的烟酰胺衍生物或其药学上可接受的盐由化学式1表示。用于促进骨形成的组合物含有作为活性成分的衍生物或其药学上可接受的盐。该组合物用于预防和治疗骨骼疾病如代谢性骨病或骨科疾病。该组合物用于人造骨，人造关节，骨固定，骨替代物，骨填充材料或粘合植入物。该组合物也用于预防和治疗牙周病。

2. 发明公开

KR1020110116356A Ｒｕｎｘ２의 활성을 증가시키는 작용을 갖는 3-아미노-2,6-디클로로피리딘 유도체 및 이를 함유하는 골형성 촉진용 조성물 无效
标题翻译：增加RUNX2活性的3-氨基-2,6-二氯吡啶衍生物及其促进骨形成的组合物
公开(公告)号：KR1020110116356A
公开(公告)日：2011-10-26
申请号：KR1020100035732
申请日：2010-04-19
申请人： (주) 비엔씨바이오팜
发明人： 김종우 , 이상욱 , 이근형 , 박을용 , 임종환 , 이연임 , 최영근 , 방현배 , 주현희 , 정미소
IPC分类号： A61K31/44 , C07D211/02 , A61P19/08
CPC分类号： A61K31/4406 , A61K31/16 , C07D211/02 , C07K14/49 , C07K14/495 , C07K14/503 , C07K14/51
摘要： 본 발명은 Runx2의 활성을 증가시키는 작용을 갖는 3-아미노-2,6-디클로로피리딘 유도체에 관한 것으로, 보다 상세하게는 골 형성을 담당하는 조골세포에서 골 형성에 반드시 필요한 전사인자인 Runx2의 활성을 증가시킴으로 골 형성을 촉진하는 활성이 뛰어난 하기 화학식 1로 표시되는 3-아미노-2,6-디클로로피리딘 유도체 또는 그의 약학적으로 허용되는 염과 이의 용도에 관한 것이다. 본 발명에 의한 화학식 1로 표시되는 3-아미노-2,6-디클로로피리딘 유도체는, 골 형성에 반드시 필요한 전사인자인 Runx2의 활성을 증가시켜 골 형성을 유도함으로 골 형성 촉진제로서 효과가 우수하고 독성도 적으므로, 골다공증, 골절, 골이식, 치주질환, 및 골 형성 부전증 등의 골 질환의 예방과 치료에 유용하게 사용될 수 있다.
[화학식 1]

상기 화학식 1에서,
R
1 은 C
3 -C
6 헤테로사이클릭 고리, -NR
2 R
3 기, , 를 나타내며, 상기 R
1 을 나타내는 치환기에서, R
2 , R
3 는 각각 수소, C
1 -C
6 직쇄 또는 분쇄상 알킬기, -(CH
2 )
n -R
6 를 나타내고, R
4 는 수소, C
1 -C
4 직쇄 또는 분쇄상 알킬기, -(CH
2 )
n -R
7 을 나타내고, R
5 는 수소, C
1 -C
4 직쇄 또는 분쇄상 알킬기, 하이드록시기, 할로겐, 카바모일기, 아세트아미도기, C
3 -C
6 헤테로사이클릭 고리를 나타낸다. 또한, 상기 R
2 , R
3 를 나타내는 치환기에서, R
6 는 하이드록시기, 할로겐, 시아노기, C
3 -C
6 사이클릭 알킬기, 카바모일기, 아세트아미도기, C
1 -C
4 직쇄 또는 분쇄상 알콕시기, C
1 -C
4 직쇄 또는 분쇄상 알킬티오기, C
2 -C
6 직쇄 또는 분쇄상 디알킬아미노기, C
3 -C
6 헤테로사이클릭 고리, 를 나타내며, R
4 를 나타내는 치환기에서, R
7 은 하이드록시기, C
1 -C
4 직쇄상 알콕시기, C
1 -C
4 알킬카바모일기, C
3 -C
6 헤테로사이클릭 고리, 를 나타낸다. 상기 R
6 를 나타내는 치환기에서, R
8 은 수소, 할로겐, 하이드록시기, C
1 -C
4 직쇄상 알킬기, C
1 -C
4 직쇄상 알콕시기, 트리플루오로메틸기를 나타내고, R
7 을 나타내는 치환기에서, R
9 는 수소, 할로겐, 하이드록시기, C
1 -C
4 직쇄상 알킬기, C
1 -C
4 직쇄상 알콕시기, 시아노기, 아세틸기, 트리플루오로메틸기, 니트로기를 나타내며, n은 0 내지 6의 정수를 나타낸다.

3. 发明公开

KR1020090066410A 바실러스 서브틸리스 ＢＣ1212 균주를 포함하는 사료첨가용 조성물 无效
标题翻译：包含BACILLUS SUBTILIS BC1212的添加剂的组合物
公开(公告)号：KR1020090066410A
公开(公告)日：2009-06-24
申请号：KR1020070133915
申请日：2007-12-20
申请人： (주) 비엔씨바이오팜
发明人： 김종우 , 한재진 , 임종환 , 박상진 , 박을용 , 신중철
IPC分类号： A23K1/17 , A23K1/16 , A23K1/14 , A23K1/00
CPC分类号： A23K10/18 , A23K20/142 , A23K20/189 , C12N1/20 , C12R1/125
摘要： A composition for feed additives comprising Bacillus subtilis BC1212 is provided to produce antibiotic with antibacterial activity in order to improve feed efficiency and weight increase. A composition for feed additives contains Bacillus subtilis BC1212(KACC 91141). The strain produces surfactin C. The composition for feed additives comprises 2.8wt% of wheat bran, 4.9wt% of rice bran, 5.1wt% of soybean cake, 0.02wt% of FeSO4, 0.5wt% of MnSO4 and 87.13wt% of water. The composition for feed additives additionally contains one or more enzyme products. The enzyme products are selected from the group consisting of lipase, phytase, amylase, phosphatase, carboxymethylcellulas, xylanase, maltase and converting enzyme. The composition for feed additives additionally contains non-pathogenic microorganisms. The non-pathogenic microorganisms are selected from the group consisting of microorganisms belonging to Lactobacillus, Aspergillus oryzae and Saccharomyces cerevisiae.
摘要翻译：提供了包含枯草芽孢杆菌BC1212的饲料添加剂组合物以产生具有抗菌活性的抗生素以提高饲料效率和重量增加。饲料添加剂组合物含有枯草芽孢杆菌BC1212（KACC 91141）。该菌株产生枯草芽孢杆菌C.用于饲料添加剂的组合物包括2.8wt％的麦麸，4.9wt％的米糠，5.1wt％的大豆饼，0.02wt％的FeSO 4，0.5wt％的MnSO 4和87.13wt％的水。饲料添加剂的组合物还含有一种或多种酶产物。酶产物选自脂肪酶，植酸酶，淀粉酶，磷酸酶，羧甲基纤维素，木聚糖酶，麦芽糖酶和转化酶。饲料添加剂的组合物还含有非致病微生物。非病原微生物选自属于乳杆菌属，米曲霉属和酿酒酵母的微生物。

4. 发明公开

KR1020120061701A 탈로신 Ａ를 함유하는 골다공증 예방 및 치료용 조성물 无效
标题翻译：用于预防或治疗骨质疏松症的组合物，包括托洛糖A
公开(公告)号：KR1020120061701A
公开(公告)日：2012-06-13
申请号：KR1020100123091
申请日：2010-12-03
申请人： (주) 비엔씨바이오팜
发明人： 김종우 , 이상욱 , 박상진 , 이근형 , 박을용 , 신중철 , 임종환 , 양재원
IPC分类号： A61K31/352 , A61K31/351 , A61K31/7048 , A61P19/10
摘要： PURPOSE: A composition containing talosin A is provided to enhance osteoblast generation activation and to reduce toxicity. CONSTITUTION: A composition for promoting osteoporosis and suppressing bone loss contains talosin A of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The composition is used for preventing and treating bone diseases and periodontal diseases. The composition is used in artificial bone, artificial joint, bone fixture, bone substitute, bone filler, or bone implant material. The composition is used by replacing osteogenesis growth factor.
摘要翻译：目的：提供含有托洛糖A的组合物，以增强成骨细胞的产生活化和降低毒性。构成：用于促进骨质疏松症和抑制骨丢失的组合物含有化学式1的托洛沙星A或其药学上可接受的盐作为活性成分。该组合物用于预防和治疗骨疾病和牙周病。该组合物用于人造骨，人造关节，骨固定，骨替代物，骨填充物或骨植入材料中。该组合物用于替代成骨生长因子。

5. 发明公开

KR1020080061613A 2-(메틸티오)피리미딘 유도체, 그 제조방법 및 이를포함하는 항바이러스용 약학적 조성물 无效
标题翻译： 2-（甲基）吡啶衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：KR1020080061613A
公开(公告)日：2008-07-03
申请号：KR1020060136537
申请日：2006-12-28
申请人： (주) 비엔씨바이오팜
发明人： 김종우 , 이상욱 , 이근형 , 한재진 , 박상진 , 박을용 , 신중철 , 임종환
IPC分类号： C07D413/14 , A61K31/5355
摘要： 2-(Methylthio)pyrimidine derivatives are provided to inhibit growth of hepatitis C virus and minimize toxicity and side effects, so that the compounds are useful for prevention and treatment of hepatitis C. The 2-(methylthio)pyrimidine derivatives represented by the formula(1) and pharmaceutically acceptable salts thereof inhibit growth of hepatitis C virus, wherein R1 is hydrogen, hydroxyl group, -N(R2)-(CH2)-R3 group, 4-(R4)-(Het)-1-yl group or -(CH2)n-R5 group; R2 is hydrogen or C1-C4 linear or branched alkyl group; R3 is hydrogen, halogen atom, hydroxyl group, isopropyl group, C2-C6 linear or branched dialkylamino group, C1-C4 linear or branched alkoxy group, C3-C6 cycloalkyl group or C3-C6 heterocyclic ring optionally substituted by C1-C4 linear or branched alkyl group; (Het) is piperidine or piperazine; R4 is hydrogen, hydroxyl group, carbamoyl group, acetyl group, acetamido group, C1-C4 linear or branched alkyl group, C1-C4 linear or branched hydroxyalkyl group, C1-C4 alkyl group substituted by C1-C4 alkoxy group, C1-C4 alkyl group substituted by morpholino group, phenyl group substituted by hydroxyl group, or C3-C6 heterocyclic ring containing nitrogen atom; R5 is C3-C6 heterocyclic group; and n is an integer from 0 to 4.
摘要翻译：提供2-（甲硫基）嘧啶衍生物以抑制丙型肝炎病毒的生长并使毒性和副作用最小化，使得该化合物可用于丙型肝炎的预防和治疗。由式（ 1）及其药学上可接受的盐抑制丙型肝炎病毒的生长，其中R1是氢，羟基，-N（R2） - （CH2）-R3基团，4-（R4） - （Het）-1-基或 - （CH 2）n -R 5基; R2是氢或C1-C4直链或支链烷基; R3是氢，卤素原子，羟基，异丙基，C2-C6直链或支链二烷基氨基，C1-C4直链或支链烷氧基，C3-C6环烷基或C3-C6杂环，任选地被C1-C4直链或支链烷基; （Het）是哌啶或哌嗪; R4是氢，羟基，氨基甲酰基，乙酰基，乙酰氨基，C1-C4直链或支链烷基，C1-C4直链或支链羟烷基，被C1-C4烷氧基取代的C1-C4烷基，C1-C4 被吗啉代基取代的烷基，被羟基取代的苯基或含有氮原子的C3-C6杂环; R5为C3-C6杂环基; n为0〜4的整数。

6. 发明公开

KR1020030079396A 4-(4-치환된-아닐리노)피리미딘 유도체, 그 제조방법 및이를 포함하는 항바이러스용 약학적 조성물 失效
标题翻译： 4-（4-取代的苯胺基）吡嗪衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：KR1020030079396A
公开(公告)日：2003-10-10
申请号：KR1020020018396
申请日：2002-04-04
申请人： (주) 비엔씨바이오팜
发明人： 김종우 , 이상욱 , 이근형 , 한재진 , 박상진 , 박을용 , 신중철 , 임종환
IPC分类号： C07D413/14
摘要： PURPOSE: 4-(4-Substituted-anilino)pyrimidine derivatives, a preparation process thereof and an antiviral pharmaceutical composition comprising the same are provided. The compounds can effectively inhibit the growth of hepatitis C virus. CONSTITUTION: 4-(4-substituted-anilino)pyrimidine derivatives represented by the formula 1 and pharmaceutically acceptable salts are provided, wherein R is pyridyl-alkylamino or 4-substituted-piperazine-1-yl. A process for preparing 4-(4-substituted-anilino)pyrimidine derivatives of the formula 1 comprises the steps of: reacting 4-chloro-2-methylthio-5-pyrimidinecarboxylate of the formula 2 with 4-(4-morpholino) aniline of the formula 3 to prepare 2-methylthio-4-£4-(4-morpholino) anilino|-5-pyrimidinecarboxylic acid ethyl ester of the formula 4; hydrolysis of the compound of the formula 4 with inorganic base to prepare 2-methylthio-4-£4-(4-morpholino)anilino|-5-pyrimidine carboxylic acid of the formula 5; reacting the compound of the formula 5 with a halogen compound such as thionyl chloride to prepare a carboxylic acid chloride derivative of the formula 6; and reacting the compound of the formula 6 with an amine compound.
摘要翻译：目的：提供4-（4-取代的苯胺基）嘧啶衍生物，其制备方法和包含其的抗病毒药物组合物。该化合物可有效抑制丙型肝炎病毒的生长。构成：提供由式1表示的4-（4-取代 - 苯胺基）嘧啶衍生物及其药学上可接受的盐，其中R是吡啶基 - 烷基氨基或4-取代 - 哌嗪-1-基。制备式1的4-（4-取代 - 苯胺基）嘧啶衍生物的方法包括以下步骤：使式2的4-氯-2-甲硫基-5-嘧啶羧酸酯与4-（4-吗啉代）苯胺式3制备式4的2-甲硫基-4-（4-吗啉代）苯胺基-5-嘧啶羧酸乙酯; 用无机碱水解式4的化合物，制备式5的2-甲硫基-4-（4-吗啉代）苯胺基-5-嘧啶羧酸; 使式5的化合物与卤代化合物如亚硫酰氯反应制备式6的羧酰氯衍生物; 并使式6的化合物与胺化合物反应。

7. 发明公开

KR1020130115455A 미백 및 주름 개선용 조성물 无效
标题翻译：皮肤白化和皱纹改善的组合物
公开(公告)号：KR1020130115455A
公开(公告)日：2013-10-22
申请号：KR1020120037741
申请日：2012-04-12
申请人： (주) 비엔씨바이오팜
发明人： 김종우 , 이상욱 , 박상진 , 박을용 , 신중철 , 임종환
IPC分类号： A61K8/63 , A61K8/60 , A61Q19/02 , A61Q19/08
摘要： PURPOSE: A composition for improving whitening and anti-wrinkling effects is provided to show anti-wrinkling effect by promoting collagen generation in human fibroblast and to have skin whitening effect by suppressing melanogenesis in melanoma cells. CONSTITUTION: A cosmetic composition contains 0.0001-10 wt% of ginsenoside F2 as an active ingredient. The composition is a cosmetic material for improving anti-wrinkling and whitening effects. The composition is manufactured in the form of a solution, a suspension, an emulsion, a paste, a gel, a cream, a lotion, powder, soap, a surfactant-containing cleansing agent, oil, a powder foundation, an emulsion foundation, a wax foundation, and a spray.
摘要翻译：目的：提供一种用于改善美白和抗皱效果的组合物，以通过促进人成纤维细胞中的胶原蛋白产生来显示抗起皱效果，并通过抑制黑素瘤细胞中的黑素生成而具有皮肤美白效果。构成：化妆品组合物含有0.0001-10重量％的人参皂苷F2作为活性成分。该组合物是用于改善抗起皱和美白效果的化妆品。该组合物以溶液，悬浮液，乳液，糊剂，凝胶，霜剂，洗剂，粉末，肥皂，含表面活性剂的清洁剂，油，粉底，乳液粉底，蜡基和喷雾。

8. 发明授权

KR101162710B1 도라지 추출물 또는 도라지 사포닌 화합물을 함유하는 Ｃ형 간염의 예방 또는 치료용 약학적 조성물 有权
标题翻译：用于预防或治疗丙型肝炎的药物组合物，包括桔梗或桔梗皂甙化合物的提取物
公开(公告)号：KR101162710B1
公开(公告)日：2012-07-05
申请号：KR1020090100092
申请日：2009-10-21
申请人： (주) 비엔씨바이오팜
发明人： 김종우 , 이상욱 , 박상진 , 신중철 , 임종환 , 양재원
IPC分类号： C01G23/047 , B82B3/00 , H01L31/04
CPC分类号： A61K36/346 , A23L33/105
摘要： 본 발명은 항바이러스제로 유용한 도라지 사포닌 및/또는 이를 포함하는 도라지 추출물을 유효성분으로 함유하는 C형 간염의 예방 또는 치료용 약학적 조성물에 관한 것으로, 본 발명의 조성물은 인체에 무해하고 C형 간염 바이러스의 증식을 억제하므로 C형 간염의 예방 또는 치료제로서 유용하게 사용될 수 있다.

9. 发明公开

KR1020040033100A 2-메톡시-1,3,5-트리아진 유도체, 그 제조방법 및 이를 포함하는 항바이러스용 약학적 조성물 失效
标题翻译： 2-甲氧基-1,3,5-三嗪衍生物，其制备方法和包含其的抗病毒药物组合物
公开(公告)号：KR1020040033100A
公开(公告)日：2004-04-21
申请号：KR1020020061995
申请日：2002-10-11
申请人： (주) 비엔씨바이오팜
发明人： 김종우 , 이상욱 , 이근형 , 한재진 , 박상진 , 박을용 , 신중철 , 윤효인 , 임종환
IPC分类号： C07D413/14
摘要： PURPOSE: 2-Methoxy-1,3,5-triazine derivatives, a preparation method thereof and an antiviral pharmaceutical composition comprising the same are provided. The 2-Methoxy-1,3,5-triazine derivatives inhibit the growth of hepatitis C virus(HCV) and have low toxicity, so that they can be useful for the treatment of hepatitis caused by hepatitis C virus. CONSTITUTION: 2-methoxy-1,3,5-triazine derivatives represented by the formula(1) and pharmaceutically acceptable salts thereof are provided, wherein R is heterocycliccarbonyl or substituted phenyl. A method for preparing the 2-methoxy-1,3,5-triazine derivatives of the formula(1) comprises the steps of: (a) reacting 2-methoxy-6-£4-(4-morpholino) anilino|-4-chloro-1,3,5-triazine of the formula(2) with piperazine of the formula(3) to prepare 2-methoxy-6-£4-(4-morpholino) anilino|-4-(piperazin-1-yl) of the formula(4); and reacting the compound of the formula(4) with heterocycliccarbonyl chloride. A pharmaceutical composition for the prevention and treatment of hepatitis C comprises the 2-methoxy-1,3,5-triazine derivatives of the formula(1) and pharmaceutically acceptable salts thereof as effective components.
摘要翻译：目的：提供2-甲氧基-1,3,5-三嗪衍生物，其制备方法和包含其的抗病毒药物组合物。 2-甲氧基-1,3,5-三嗪衍生物抑制丙型肝炎病毒（HCV）的生长，毒性低，因此可用于治疗丙型肝炎病毒引起的肝炎。构成：提供由式（1）表示的2-甲氧基-1,3,5-三嗪衍生物及其药学上可接受的盐，其中R是杂环羰基或取代的苯基。制备式（1）的2-甲氧基-1,3,5-三嗪衍生物的方法包括以下步骤：（a）使2-甲氧基-6-（4-吗啉代）苯胺基-4 （2）的氯-1,3,5-三嗪与式（3）的哌嗪反应，制备2-甲氧基-6-（4-吗啉代）苯胺基} -4-（哌嗪-1-基）（4）的化合物）。并使式（4）的化合物与杂环羰基氯反应。用于预防和治疗丙型肝炎的药物组合物包含式（1）的2-甲氧基-1,3,5-三嗪衍生物及其药学上可接受的盐作为有效成分。

10. 发明公开

KR1020120061700A 탈로신 Ａ를 함유하는 유방암 예방 및 치료용 조성물 无效
标题翻译：用于预防或治疗人乳腺癌的组合物，包括托洛糖A
公开(公告)号：KR1020120061700A
公开(公告)日：2012-06-13
申请号：KR1020100123089
申请日：2010-12-03
申请人： (주) 비엔씨바이오팜
发明人： 김종우 , 이상욱 , 박상진 , 이근형 , 박을용 , 신중철 , 임종환 , 양재원
IPC分类号： A61K31/352 , A61K31/351 , A61K31/7048 , A61P35/00
摘要： PURPOSE: A talosin A isolated from Actinomyces kitasatospora kifunensis strain and an anti-cancer agent using the same are provided to suppress breast cancer cells and to treat breast cancer with less toxicity. CONSTITUTION: A composition for suppressing breast cancer proliferation and tumor growth contains talocin A of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The composition is used for preventing and treating breast cancer. The compound of chemical formula 1 is used in the form of pharmaceutically acceptable salt. The salt is addition salt formed by pharmaceutically acceptable base. The base includes inorganic base or organic base.
摘要翻译：目的：提供从放线菌（Actinomyces kitasatospora kifunensis）菌株中分离得到的托洛沙星菌A和使用其的抗癌剂，以抑制乳腺癌细胞并以较低的毒性治疗乳腺癌。构成：用于抑制乳腺癌增殖和肿瘤生长的组合物含有化学式1的talocin A或其药学上可接受的盐作为活性成分。该组合物用于预防和治疗乳腺癌。化学式1的化合物以药学上可接受的盐的形式使用。该盐是由药学上可接受的碱形成的加成盐。碱包括无机碱或有机碱。

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