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    • 6. 发明公开
    • PEPTIDES HAVING ACTIVITIES OF TRANSFORMING GROWTH FACTOR-BETA AND THEIR USES
    • 具有转化生长因子-β的活性及其用途的肽
    • KR20090133068A
    • 2009-12-31
    • KR20090032052
    • 2009-04-14
    • CAREGEN CO LTD
    • CHUNG YOUNG JIKIM YOUNG DEUGKIM EUN MICHOI JEONG JINCHOI JUN YOUNG
    • C07K14/71C07K7/08
    • A61K8/64A61K38/00A61Q19/02A61Q19/08C07K14/495
    • PURPOSE: A composition containing TGF-β-mimicking peptide for preventing or treating TGF-β effective diseases or conditions is provided to ensure high stability and improve skin permeability. CONSTITUTION: A TGF-β[transforming growth factor-beta]-mimicking peptide contains an amino acid of sequence number 1. The N-terminal or C-terminal of TGF-β-mimicking peptide additionally binds to cell adhesion amino acid sequence. The amino acid sequence is RGD(Arg-Gly-Asp). At the N-terminal or C-terminal of the peptide additionally bind with a protection group. The protection group is acetyl group, fluorenyl methloxy carbonyl group, formyl group, palmitoyl, myristyl group, stearyl group, polyethylene glycol (PEG) or amino acid. A composition for preventing or treating TGF-β-effective diseaes or conditions as an active ingredient.
    • 目的:提供含有用于预防或治疗TGF-β有效疾病或病症的TGF-β模拟肽的组合物,以确保高稳定性和改善皮肤渗透性。 构成:TGF-β[转化生长因子-β]模拟肽含有序列号1的氨基酸.TGF-β-模拟肽的N-末端或C-末端另外结合细胞粘附氨基酸序列。 氨基酸序列是RGD(Arg-Gly-Asp)。 在肽的N-末端或C末端另外与保护基结合。 保护基团是乙酰基,芴基甲氧基羰基,甲酰基,棕榈酰基,肉豆蔻基,硬脂基,聚乙二醇(PEG)或氨基酸。 用于预防或治疗TGF-β有效的疾病或病症作为活性成分的组合物。