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    • 3. 发明公开
    • 효소 처리 여정자 추출물을 함유하는 피부 미백용 조성물
    • 用于皮肤白化的组合物包含木瓜皂苷的酶处理提取物
    • KR1020140144057A
    • 2014-12-18
    • KR1020130066036
    • 2013-06-10
    • 에스케이바이오랜드 주식회사
    • 김기호김기수김영희김진국김경태한창성이강혁
    • A61K8/97A61Q19/02A61Q19/00
    • 본 발명은 효소처리 여정자 추출물을 유효성분으로 함유하는 것을 특징으로 하는 피부 미백용 화장료 조성물 및 색소침착 질환의 치료 또는 예방용 약학 조성물 관한 것이다.
      본 발명에 따르면, 효소 처리한 여정자 추출물을 함유하는 피부 미백용 조성물은 티로시나아제 활성을 저해하고 멜라닌 생합성을 억제함으로써 뛰어난 미백효과를 나타내며 천연물에서 유래하여 세포독성도 나타내지 않아 피부에 대한 부작용 없이 안전하다. 따라서 본 발명의 혼합 추출물은 피부에 안전하고 뛰어난 미백효과를 나타내는 미백용 화장료 조성물 및 색소 침착 질환의 치료 또는 예방용 약학 조성물로 이용될 수 있다.
    • 本发明涉及皮肤美白用化妆品组合物和用于治疗或预防皮肤色素沉着疾病的药物组合物,其含有经酶处理的柠檬提取物作为活性成分。 根据本发明,通过抑制酪氨酸酶活性和抑制黑色素生物合成,含有经酶处理的柠檬提取物的皮肤美白组合物表现出优异的皮肤美白效果,并且不显示细胞毒性,因此是安全的,没有副作用 因为它是从天然材料衍生的。 因此,本发明的混合提取物可以用作皮肤美白用化妆品组合物和用于治疗或预防皮肤色素沉着疾病的药物组合物,其中所述组合物对皮肤是安全的并且具有优异的皮肤美白效果。
    • 6. 发明授权
    • 타이모퀴논류 화합물을 함유하는 피부 미백용 조성물
    • 包含具有皮肤白化活性的三茂铁化合物的组合物
    • KR101094306B1
    • 2011-12-19
    • KR1020110052442
    • 2011-05-31
    • 에스케이바이오랜드 주식회사
    • 김기호김영희고강일김진국허우범박선희이수연
    • A61K8/35A61Q19/02A61Q19/00
    • PURPOSE: A pharmaceutical composition containing thymoquinone compounds for treating skin pigmentary disorders and to suppress tyrosinase activity and melanogenesis. CONSTITUTION: A cosmetic composition for skin whitening contains 0.0001-50 wt% of thymoquinone compounds of structural formula 1, 2, or 3 as an active ingredient. The composition is manufactured in the form of a skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, massage cream, foundation, hand cream, pack, soap, cleansing foam, or body cleanser. A pharmaceutical composition for treating and preventing skin pigmentary disorder contains the thymoquinone compounds as an active ingredient. The pharmaceutical composition is manufactured in the form of a cream, patch, spray, ointment, liniment, paste, or cataplasma.
    • 目的:含有用于治疗皮肤色素障碍并抑制酪氨酸酶活性和黑素生成的胸腺醌化合物的药物组合物。 构成:皮肤美白用化妆品组合物含有0.0001-50重量%的结构式1,2或3的胸腺醌化合物作为活性成分。 该组合物以皮肤洗剂,皮肤柔肤剂,皮肤调色剂,收敛剂,洗剂,乳液,按摩霜,粉底,护手霜,包装,肥皂,清洁泡沫或身体清洁剂的形式制成。 用于治疗和预防皮肤色素障碍的药物组合物含有作为活性成分的胸腺醌化合物。 药物组合物以奶油,贴剂,喷雾剂,软膏剂,搽剂,糊剂或粘膜剂的形式制备。
    • 8. 发明授权
    • 항염 및 항자극 활성을 갖는 백량금 추출물을 함유하는피부외용 조성물
    • 항염및항극극극을갖갖백백량추추추
    • KR100748851B1
    • 2007-08-13
    • KR1020060037359
    • 2006-04-25
    • 에스케이바이오랜드 주식회사
    • 김기호김영희한창성박선희고수연김진국
    • A61K36/185A61P29/00
    • A topical composition comprising the extract of Ardisia crenata showing anti-inflammatory and anti-irritation effects is provided to inhibit side effects caused by essential ingredients of cosmetics including inflammation and skin irritation by inhibiting iNOS(inducible nitric oxide synthase) activity, expression of iNOS and COX-2(cyclooxygenase-2) genes, and production of PGE2(prosta-glandin E2), IL-6(interleukin 6) and IL-8. The topical composition comprises 0.001-90 wt.%, preferably 0.01-10 wt.% of the extract of Ardisia crenata showing anti-inflammatory and anti-irritation effects which is prepared by extracting Ardisia crenata with at least one solvent selected from water, ethanol, methanol, propanol, butanol, acetone, ethylacetate, hexane, butyleneglycol, propyleneglycol, hydrous butyleneglycol, hydrous propyleneglycol and hydrous glycerin at 50-100 deg.C for 2-5 hours, wherein the composition is a pharmaceutical composition formulated as cream, gel, patch, spray, ointment, lotion, liniment, pasta or cataplasma or a cosmetic composition formulated as skin lotion, nutrition lotion, nutrition cream, massage cream, essence or pack. A daily dosage of the composition is 0.0001-100 mg/kg, preferably 0.001-10 mg/kg.
    • 本发明提供一种局部用组合物,其包含显示出抗炎和抗刺激作用的Ardisia crenata提取物,以通过抑制iNOS(诱导型一氧化氮合酶)活性,iNOS表达和抑制炎症和皮肤刺激来抑制由化妆品的基本成分引起的副作用 COX-2(环氧合酶-2)基因,以及PGE2(前列腺素E2),IL-6(白细胞介素6)和IL-8的产生。 所述局部用组合物包含0.001-90重量%,优选0.01-10重量%的具有抗炎和抗刺激作用的紫金莲提取物,其通过用至少一种选自水,乙醇 ,甲醇,丙醇,丁醇,丙酮,乙酸乙酯,己烷,丁二醇,丙二醇,含水丁二醇,含水丙二醇和含水甘油在2-50小时内混合2-5小时,其中组合物是配制成乳膏, ,贴剂,喷雾剂,软膏剂,洗剂,擦剂,面食或巴布剂或配制成皮肤洗剂,营养洗剂,营养霜,按摩霜,香精或包装的化妆品组合物。 组合物的日剂量为0.0001-100mg / kg,优选0.001-10mg / kg。
    • 9. 发明公开
    • 신규 미백제 및 그것을 함유하는 화장료 조성물
    • 抑制酪氨酸酶活性抑制成分的新型皮肤白化剂和含有它的化妆品组合物
    • KR1020050006622A
    • 2005-01-17
    • KR1020030046500
    • 2003-07-09
    • 에스케이바이오랜드 주식회사
    • 김기호김기수김진국김경태한창성박선희
    • A61K8/34A61Q19/02
    • A61K8/60A61K2800/782A61Q1/02A61Q19/02
    • PURPOSE: Provided are a novel skin whitening agent which inhibits tyrosinase activity and melanogenesis and a cosmetic composition containing the same as an active ingredient. CONSTITUTION: The novel skin whitening agent contains a compound manufactured by binding glucose to the phenol derivative and represented by the formula(I), wherein R1 and R2 are independently hydrogen, glucose, galactose, mannose, sucrose, ribose, fructose, provided that one of R1 and is hydrogen; and R3 is one of hydrogen, hydroxy, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, pentyl, carboxy, methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl, isopropoxycarbonyl, carboxymethyl, methoxycarbonylmethyl, ethoxycarbonylmethyl, propoxycarbonylmethyl, isopropoxycarbonylmethyl and butoxycarbonylmethyl.
    • 目的:提供抑制酪氨酸酶活性和黑素生成的新型皮肤增白剂和含有活性成分的化妆品组合物。 构成:新型皮肤增白剂含有通过将葡萄糖与酚衍生物结合并由式(I)表示的化合物,其中R1和R2独立地是氢,葡萄糖,半乳糖,甘露糖,蔗糖,核糖,果糖,条件是一个 的R1是氢; 羟基,甲基,乙基,丙基,异丙基,丁基,异丁基,戊基,羧基,甲氧基羰基,乙氧基羰基,丙氧基羰基,异丙氧基羰基,羧甲基,甲氧基羰基甲基,乙氧基羰基甲基,丙氧基羰基甲基,异丙氧基羰基甲基和丁氧基羰基甲基。
    • 10. 发明公开
    • 코직산 유도체의 신규 제조방법
    • 醇酸衍生物的新型制备方法及其应用
    • KR1020040040990A
    • 2004-05-13
    • KR1020020076479
    • 2002-12-04
    • 에스케이바이오랜드 주식회사
    • 김기호김기수양은경김진국박수남
    • C07H15/26
    • PURPOSE: A novel preparation method of kojic acid derivatives and application thereof are provided, thereby easily isolating and purifying the kojic acid derivatives which inhibit tyrosinase activity and melanin formation, and preparing the kojic acid derivatives in higher yield. CONSTITUTION: A novel preparation method of kojic acid derivatives represented by the formula(I) comprises the steps of: reacting beta-D-pentaacetylglucose of the formula(III) with kojic acid of the formula(II) using organic acid or Lewis acid, or organic acid and base or Lewis acid and base to prepare kojic acid-2-O-beta-D-tetraacetylglucopyranoside of the formula(IV); hydrolysis of kojic acid-2-O-beta-D-tetraacetylglucopyranoside of the formula(IV) and recrystallizing the hydrolyzed compound, wherein Ac is acetyl group.
    • 目的:提供曲酸衍生物的新型制备方法及其应用,从而容易地分离和纯化抑制酪氨酸酶活性和黑色素形成的曲酸衍生物,并以更高的产率制备曲酸衍生物。 构成:由式(I)表示的曲酸衍生物的新型制备方法包括以下步骤:使用有机酸或路易斯酸使式(III)的β-D-五乙酰基葡萄糖与式(II)的曲酸反应, 或有机酸和碱或路易斯酸和碱,以制备式(IV)的曲酸-2-O-β-D-四乙酰基吡喃葡萄糖苷; 水解式(Ⅳ)的曲酸-2-O-β-D-四乙酰基吡喃糖苷并重结晶水解的化合物,其中Ac是乙酰基。