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    • 83. 发明授权
    • 게닌화합물 및 그 염의 제조방법과 그를 포함한 조성물의용도
    • 게닌화합물및그염의제조방법과그를포함한조성물의용도
    • KR100644764B1
    • 2006-11-14
    • KR1020050074956
    • 2005-08-16
    • 에스케이바이오랜드 주식회사
    • 김기호김기수김영희김진국이남호
    • C07H3/00
    • Novel genin compounds and their salts, a preparation method thereof and use of the composition containing the same compounds are provided to inhibit and improve wrinkles by inhibiting matrix metalloproteinase(MMP) in fibroblasts and elastase and collagenase, and treat wounds by inhibiting iNOS(inducible nitric oxide synthase) activity, COX-2(cyclooxygenase -2) expression and interleukin-Ia. The method for preparing the genin compounds represented by the formula(I) comprises the steps of: hydrolyzing glycoside of the formula(II) with ion exchange resin and recrystallizing it to obtain aglycons such as tomentosolic acid; and dissolving the aglycons in organic solvent, adding base into the solution, removing solvent, and recrystallizing the resulting product in polar solvent, wherein R is hydrogen atom or alkali metal, alkali earth metal, amine, lysine or oxalate.
    • 提供了新颖的化合物及其盐,其制备方法和含有相同化合物的组合物的用途,以通过抑制成纤维细胞和弹性蛋白酶和胶原酶中的基质金属蛋白酶(MMP)来抑制和改善皱纹,并通过抑制iNOS(诱导型一氧化氮 氧化酶合酶)活性,COX-2(环氧合酶-2)表达和白细胞介素-Ia。 制备由式(I)表示的基因化合物的方法包括以下步骤:用离子交换树脂水解式(II)的糖苷并将其重结晶以获得糖苷配基如倍他司酸; 并将糖苷元溶于有机溶剂中,将碱加入溶液中,除去溶剂,并将所得产物在极性溶剂中重结晶,其中R是氢原子或碱金属,碱土金属,胺,赖氨酸或草酸盐。
    • 84. 发明授权
    • 벌나무 및 후박나무 추출물을 함유하는 당뇨병 또는 당뇨합병증 예방 및 치료용 조성물
    • 用于预防和治疗糖尿病或糖尿病并发症的组合物,包含五加科和百合科的提取物
    • KR101808808B1
    • 2017-12-14
    • KR1020110122604
    • 2011-11-23
    • 에스케이바이오랜드 주식회사
    • 김기호김영희김진국이상일박수진정은영
    • A61K36/20A61K36/57A61P3/10A61P3/00
    • 본발명은벌나무및 후박나무추출물을함유하는당뇨병또는당뇨합병증치료용조성물에관한것으로, 더욱구체적으로벌나무및 후박나무혼합추출물을유효성분으로함유하는당뇨병또는당뇨합병증예방및 치료용약학적조성물또는식품조성물에관한것이다. 본발명에따르면, 벌나무단독추출물또는후박나무단독추출물과비교하여벌나무및 후박나무혼합추출물이현저히상승된항산화효능을갖는것으로나타났으며, 당뇨병동물모델마우스에서도상승된당뇨병및 당뇨합병증치료효과를나타내었다. 따라서본 발명에따른벌나무및 후박나무혼합추출물은당뇨병또는당뇨합병증의치료및 예방에유용한기능성식품또는약학적조성물에이용될수 있다.
    • 本发明beolnamu和厚朴涉及一种用于糖尿病或糖尿病并发症治疗含木的提取物的组合物,更具体地beolnamu和木兰糖尿病或含有混合物提取物作为用于预防和治疗物质的药物组合物或食品组合物的有效成分的糖尿病并发症 Lt。 根据本发明,beolnamu独家提取物或与厚朴木鞋底提取相比被发现具有beolnamu和木兰合并的萃取液显著升高的抗氧化作用,糖尿病动物模型表明,糖尿病和糖尿病并发症,治疗在小鼠升高 这是。 因此beolnamu和木兰根据可在功能性食品或用于治疗糖尿病或糖尿病并发症的治疗和预防有用的药物组合物可以使用本发明提取混合物。