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71. 发明公开

KR1020140015956A 스테레오카울론 알피넘 유래 슈도뎁시돈을 함유하는 항균 및 항산화 조성물 有权
标题翻译：含有来自立体异构体原子的脱磷酸酯或PSEUDODEPSIDONE化合物的抗微生物和抗氧化组合物
公开(公告)号：KR1020140015956A
公开(公告)日：2014-02-07
申请号：KR1020120082486
申请日：2012-07-27
申请人： 한국해양과학기술원
发明人： 임정한 , 김일찬 , 한세종 , 김덕규 , 이형석 , 김한우 , 하리다타바타라이 , 바비타파우델바타라이 , 김태경
IPC分类号： A61K36/09 , A23L29/206 , A61P31/04 , A61P17/18
摘要： The present invention relates to a compound having excellent antibiotic activity, isolated from Stereocaulon alpinum, which is a kind of antarctic lichen, and more particularly, to an antibiotic and antioxidative composition containing, as an active ingredient, lobaric acid (Compound 1) as a depsidone type natural compound and lobarstin as a pseudodepsidone type natural compound, which are isolated from an extract of Stereocaulon alpinum, or salts thereof. The composition according to the present invention exhibits an effective antibiotic ability, and thus can be used for an antibiotic composition, and a pharmaceutical composition and a functional food for preventing or treating infectious diseases. Further, the composition of the present invention exhibits an effective antioxidative effect, and thus can be prepared and applied as an antioxidative composition.
摘要翻译：本发明涉及一种具有优异的抗生素活性的化合物，它是一种南极地衣，是一种南极地衣，特别是一种抗生素和抗氧化组合物，其含有作为活性成分的洛叶酸（化合物1）作为取代吡啶酮型天然化合物和洛尔斯坦作为假食蜂星酮型天然化合物，其从Stereocaulon alpinum的提取物中分离，或其盐。根据本发明的组合物显示出有效的抗生素能力，因此可用于抗生素组合物，以及用于预防或治疗感染性疾病的药物组合物和功能性食品。此外，本发明的组合物显示出有效的抗氧化作用，因此可以制备和应用为抗氧化组合物。

72. 发明公开

KR1020130106045A 다공성 매트릭스를 이용한 라말린의 안정화 방법 및 안정화된 라말린 용액 有权
标题翻译：使用多孔矩阵和稳定的RAMALIN解决方案的RAMALIN的稳定方法
公开(公告)号：KR1020130106045A
公开(公告)日：2013-09-27
申请号：KR1020120027649
申请日：2012-03-19
申请人： 한국해양과학기술원
发明人： 임정한 , 김일찬 , 김덕규 , 한세종 , 이형석 , 하리다타바타라이 , 박수진
IPC分类号： C07C241/04 , C07C243/22 , A61K31/135 , A61Q19/02
CPC分类号： A61K31/198 , A61K8/0287 , A61K8/442 , A61K8/585 , A61K2800/52 , A61Q19/02 , A61Q19/08
摘要： PURPOSE: A stabilizing method of ramalin is provided to maintain titer in high level and to store ramalin with excellent anti-oxidation and anti-inflammation effect. CONSTITUTION: A stabilizing method of ramalin represented by chemical formula 1 comprises a step of absorbing the ramalin to a hydrophilic porous matrix; a step of reforming the surface of a porous matrix on which the ramalin is absorbed to a hydrophilic surface; and a step of dispersing the porous matrix into an organic solvent. The hydrophilic porous matrix consists of hydrophilic aerogel. The organic solvent is selected from caprylic/capric triglyceride, squalane, silicone oil, mineral oil, vegetable oil, and a mixture thereof.
摘要翻译：目的：提供拉马林的稳定化方法，以保持高水平的效价，并具有极好的抗氧化和抗炎作用。构成：用化学式1表示的马来林蛋白的稳定化方法包括将马马林吸收到亲水性多孔基质的步骤; 将马来酸盐吸收到其上的多孔基质的表面改性为亲水性表面的步骤; 以及将多孔基质分散到有机溶剂中的步骤。亲水性多孔基质由亲水性气凝胶组成。有机溶剂选自辛酸/癸酸甘油三酯，角鲨烷，硅油，矿物油，植物油及其混合物。

73. 发明公开

KR1020120036026A 신규 화합물 로바린을 함유하는 당뇨병 또는 비만의 예방 또는 치료용 약학 조성물 有权
标题翻译：用于预防或治疗含有新型化合物LOBARIN的糖尿病或糖尿病的药物组合物
公开(公告)号：KR1020120036026A
公开(公告)日：2012-04-17
申请号：KR1020100097678
申请日：2010-10-07
申请人： 한국해양과학기술원
发明人： 임정한 , 김일찬 , 김덕규 , 한세종 , 이형석 , 오현철 , 조동규 , 박미라 , 박유경 , 김성진 , 김태경 , 강필성 , 박희용 , 박하주
IPC分类号： C07D307/88 , C07D307/87 , A61K31/343 , A61P3/04
摘要： PURPOSE: A pharmaceutical composition containing a novel compound, lobarin, is provided to suppress tyrosine phosphatase 1B and to ensure antidiabetic effect. CONSTITUTION: A novel compound, lobarin, is denoted by chemical formula 1. A method for preparing the compound of chemical formula 1 comprises: a step of extracting Stereocaulon alpinum with methanol; a step of eluting methanol solution by column chromatography; a step of eluting the eluted fraction by reverse-phase high performance liquid chromatography using a acetonitrile(CH_3CN) solution to prepare a fraction containing lobaric acid; a step of dissolving the fraction in solvent and a step of adding NaOH or KOH. A pharmaceutical composition for preventing or treating diabetes or obesity contains the compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：目的：提供含有新化合物洛尔林的药物组合物，以抑制酪氨酸磷酸酶1B并确保抗糖尿病作用。构成：化学式1表示新化合物洛比林。化学式1化合物的制备方法包括：用甲醇提取立体异黄酮的步骤; 通过柱色谱法洗脱甲醇溶液的步骤; 通过使用乙腈（CH 3 CN）溶液的反相高效液相色谱法洗脱洗脱级分以制备含有叶酸的级分的步骤; 将级分溶解在溶剂中的步骤和加入NaOH或KOH的步骤。用于预防或治疗糖尿病或肥胖症的药物组合物含有化学式1的化合物或其药学上可接受的盐作为活性成分。

74. 发明公开

KR1020120036025A 소듐 로바레이트를 함유하는 당뇨병 또는 비만의 예방 또는 치료용 약학 조성물 有权
标题翻译：用于预防或治疗含有白蛋白的糖尿病或糖尿病的药物组合物
公开(公告)号：KR1020120036025A
公开(公告)日：2012-04-17
申请号：KR1020100097677
申请日：2010-10-07
申请人： 한국해양과학기술원
发明人： 임정한 , 김일찬 , 김덕규 , 한세종 , 이형석 , 오현철 , 조동규 , 박미라 , 박유경 , 김성진 , 김태경 , 강필성 , 박희용 , 박하주
IPC分类号： A61K31/357 , A61P3/04 , A61P3/10
摘要： PURPOSE: A pharmaceutical composition containing sodium lobarate is provided to suppress tyrosine phosphatase 1B and to treat type II diabetes. CONSTITUTION: A pharmaceutical composition for preventing or treating diabetes or obesity contains sodium lobarate of chemical formula 1 as an active ingredient. A functional food for preventing or treating diabetes or obesity contains sodium lovarate of chemical formula 1. Sodium lovarate is isolated from Stereocaulon alpinum extract. A method for preparing lovaric acid comprises: a step of extracting dried Stereocaulon alpinum using methanol for 24 hours; a step of distilling the solvent; a step of loading flash column chromatography filled with silicagel(C18); and a step of injecting 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, and 100%(v/v) methanol in order to obtain each fraction.
摘要翻译：目的：提供含有洛乐碱钠的药物组合物，以抑制酪氨酸磷酸酶1B并治疗II型糖尿病。构成：用于预防或治疗糖尿病或肥胖症的药物组合物含有化学式1的挥发油作为活性成分。用于预防或治疗糖尿病或肥胖症的功能性食物含有化学式1的乐天酸钠。从立体立体异黄酮提取物中分离出乐果酸钠。一种制备洛伐克酸的方法包括：使用甲醇提取干燥的立体立体异黄酮24小时的步骤; 蒸馏溶剂的步骤; 加载填充有硅胶（C18）的快速柱色谱的步骤; 以及注入10％，20％，30％，40％，50％，60％，70％，80％，90％和100％（v / v）甲醇的步骤，以获得每个级分。

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