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    • 24. 发明公开
    • 플라보노이드 계열 화합물 또는 이를 포함하는 강진향추출물을 함유한 매트릭스 메탈로프로테이나제 활성저해제 및 기능성 식품
    • 基质金属蛋白酶抑制剂和含有FLAVONOID衍生物的功能性食品或含有黄酮衍生物的DALBERGIA ODORIFERA的提取物
    • KR1020030075396A
    • 2003-09-26
    • KR1020020014588
    • 2002-03-18
    • 동화약품주식회사이승택
    • 이승택장진욱김주현장윤정정용호임문정성희진노양국신동혁장환봉
    • C07D311/40
    • PURPOSE: A matrix metalloproteinase inhibitor and functional food containing flavonoid derivatives or extracts of Dalbergia odorifera containing the flavonoid derivatives are provided, thereby effectively treating diseases associated with matrix metalloproteinase. CONSTITUTION: Extracts of Dalbergia odorifera containing fisetin of formula 1 and 3'-hydroxydidzein of formula 2 are prepared by dissolving pulverized Dalbergia odorifera in a solvent selected from methanol, a mixed solvent of methanol and water and ethylacetate, filtering the solution, and concentrating the filtered solution under reduced pressure. A fraction of Dalbergia odorifera containing fisetin and 3'-hydroxydidzein is prepared by dissolving Dalbergia odorifera in methanol or a mixed solvent of water and methanol, filtering the solution, adding ethylacetate or butanol into the filtered solution, filtering the solution, and concentrating the filtered solution under reduced pressure.
    • 目的:提供一种基质金属蛋白酶抑制剂和含有黄酮类衍生物的黄酮类衍生物或含有黄酮衍生物的提取物的功能性食品,从而有效治疗与基质金属蛋白酶相关的疾病。 构成:通过将粉碎的Dalbergia odorifera溶解在选自甲醇,甲醇和水与乙酸乙酯的混合溶剂的溶剂中,过滤该溶液并浓缩,得到含有式1的非瑟酮和式2的3'-氢氧根霉素的Dalbergia odorifera的提取物 在减压下过滤溶液。 通过将Dalbergia odorifera在甲醇或水和甲醇的混合溶剂中溶解,过滤该溶液,向过滤的溶液中加入乙酸乙酯或丁醇,过滤溶液,浓缩过滤的溶液,制备含有非丝氨酸和3'-羟基溶解素的Dalbergia odorifera的一小部分 溶液在减压下。