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21. 发明公开

KR1020110017313A 발효 또는 효소처리된 복분자 추출물을 함유하는 혈당 상승 억제용 조성물 有权
标题翻译：用于抑制含有发酵或酶处理的RUBUS COREANUS MIQUEL的血液中的葡萄糖水平增加的组合物
公开(公告)号：KR1020110017313A
公开(公告)日：2011-02-21
申请号：KR1020090074913
申请日：2009-08-13
申请人： 연성대학교 산학협력단 , 주식회사 비피도
发明人： 김정성 , 전우진 , 박명수 , 지근억
IPC分类号： A61K35/744 , A61K36/73
CPC分类号： A61K35/744 , A61K36/73
摘要： PURPOSE: A composition containing Rubus coreanus Miquel fermentation for suppressing blood glucose increase is provided to maintain a function of suppressing blood glucose increase and to produce various food products for a patient with diabetes. CONSTITUTION: A composition for suppressing blood glucose increase contains Rubus coreanus Miquel fermentation. A method for preparing the Rubus coreanus Miquel fermentation comprises: a step of culturing and sonicating lactobacillusm and centrifuging for collecting supernatant; and a step of adding the supernatant to hot water extract for reaction at least three hours. The lactobacillus is Lactobacillus rhamnosus GG, Bifidobacterium bifidum BGN4, Bifidobacterium sp. SH5, Bifidobacterium breve, Leuconostoc paramescenteroides, Bifidobacterium adolescentis Int-57, Aspergillus usamii, Bifidobacterium infanti, or Aspergillus niger. The Rubus coreanus Miquel extract is obtained by mixing 1 weight part of Rubus coreanus Miquel and 8-12 weight parts of water, and performing double-boiling at 80-100°C for 2-4 hours.
摘要翻译：目的：提供含有用于抑制血糖升高的悬浮木霉发酵的组合物，以保持抑制血糖升高的功能，并为糖尿病患者生产各种食品。构成：用于抑制血糖升高的组合物含有Rubus coreanus Miquel发酵。一种制备芦苇发酵的方法包括：培养和超声乳化芽孢杆菌并离心收集上清液的步骤; 将上清液加入到热水提取物中反应至少3小时的步骤。乳酸杆菌是鼠李糖乳杆菌GG，双歧双歧杆菌BGN4，双歧杆菌属（Bifidobacterium sp。 SH5，短双歧杆菌，明串珠菌，青春双歧杆菌Int-57，美洲曲霉，婴儿双歧杆菌或黑曲霉。通过混合1重量份的Rubus coreanus Miquel和8-12重量份的水来获得Rubus coreanus Miquel提取物，并在80-100℃下进行双沸腾2-4小时。

22. 发明公开

KR1020090094491A 신규한 ＢｉｆｉｄｏｂａｃｔｅｒｉｕｍｌｏｎｇｕｍＡＬ０３１无效
标题翻译：新颖的MICROBE BIFIDOBACTERIUM LONGUM AL031
公开(公告)号：KR1020090094491A
公开(公告)日：2009-09-08
申请号：KR1020080019462
申请日：2008-03-03
申请人： 주식회사 비피도
发明人： 지근억 , 박명수
IPC分类号： C12N1/20 , C12N1/00
摘要： A novel bifidobacterium longum A031 which is derived from Korean, which provides bacteriocin is provided to ensure productivity of bacteriocin having antibacterial activity against Listeria monocytogenes and use in food or medicinal and pharmaceutical produce for preventing food poisoning. A Bifidobacterium longum AL031(KFCC11390P) which is derived from human body has productivity of bacteriocin. A method for isolating Bifidobacterium longum A031 (KFCC11390P) comprises: a step of putting gaspack in a anaerobic culture jar, removing inner air of the culture jar and substituting mixture gas of 10% of CO2, 5% of H2 and N2; a step of culturing culture medium in which human derivative is smeared at 37°C to form colony; and a step of isolating strain from the colony and maintaining at -80°C using 50% glycerol.
摘要翻译：提供了一种源自韩国人的提供细菌素的新型双歧杆菌长叶A031，以确保对单核细胞增生利斯特氏菌具有抗菌活性的细菌素的生产力，并用于食品或医药和药品以预防食物中毒。源自人体的双歧杆菌AL031（KFCC11390P）具有细菌素的生产力。用于分离长双歧杆菌A031（KFCC11390P）的方法包括：将气体包装在厌氧培养罐中，除去培养罐的内部空气并且替换10％的二氧化碳，5％的H 2和N 2的混合气体的步骤; 培养人体衍生物在37℃下涂抹以形成菌落的培养基的步骤; 以及从菌落中分离菌株并使用50％甘油维持在-80℃的步骤。

23. 发明授权

KR101893803B1 비피더스균을 포함하는 지방간 질환의 예방 또는 개선용 조성물 有权
公开(公告)号：KR101893803B1
公开(公告)日：2018-08-31
申请号：KR1020160166635
申请日：2016-12-08
申请人： 주식회사 비피도
发明人： 권빈 , 박명수 , 지근억
IPC分类号： A61K35/745 , A61K35/747 , A61K9/19 , A23L33/135
摘要： 본발명의지방간질환의예방또는치료(증상완화)용조성물은, 비피도박테리움비피덤 BGN4를유효성분으로포함하여, 간세포의수종변성을억제효과가우수하다.

24. 发明公开

KR1020160051453A 오크라톡신과 푸모니신을 생산하지 않는 균주의 선별 방법 및 이를 이용하여 선별된 균주로 발효하여 제조된 무독소 된장 有权
标题翻译：筛选不生产OCHRATOXIN和FUMONISIN的菌株筛选方法和MYCOTOXIN免费大豆浆
公开(公告)号：KR1020160051453A
公开(公告)日：2016-05-11
申请号：KR1020140151542
申请日：2014-11-03
申请人： 주식회사 비피도
发明人： 박명수 , 지근억 , 김남연
IPC分类号： C12Q1/68 , C12R1/685
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2531/113
摘要： 본발명은오크라톡신과푸모니신을생산하지않는균주의선별방법및 이를이용하여선별된균주로발효하여제조된무독소된장에관한것으로, 오크라톡신과푸모니신생성여부를비교적간단한방법을통해신속하게선별할수 있다. 또한, 선별된균주를실제식품에적용시켜본 결과, 실험과동일하게무독소임이확인되었다.
摘要翻译：本发明涉及一种在不产生赭曲霉毒素和伏马菌素的情况下选择菌株的方法，以及使用该方法发酵所选择的菌株制造的无毒素大豆酱。赭曲霉毒素和伏马菌素的生产可以通过相对简单的方法快速选择。此外，作为将所选菌株施用于实际食品的结果，与实验相同，确认大豆酱无毒。提供了用于检测产生霉菌毒素的菌株的引物组，其包含SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：4，SEQ ID NO：5，SEQ ID NO：6 ，SEQ ID NO：7和SEQ ID NO：8。

25. 发明公开

KR1020110115426A 홍삼 발효액을 함유하는 알레르기성 비염의 완화용 식품 조성물 有权
标题翻译：食品组合物对含有红霉素液体的过敏性成分
公开(公告)号：KR1020110115426A
公开(公告)日：2011-10-21
申请号：KR1020100034920
申请日：2010-04-15
申请人： 주식회사 비피도
发明人： 박명수 , 권빈 , 김자영 , 강혜련 , 지근억
IPC分类号： A23L19/00 , A61P37/08
CPC分类号： A23L19/10 , A23L3/00 , A23L29/065
摘要： 본 발명은 홍삼액에 비피도박테리움 비피둠(
Bifidobacterium

bifidum ) 균체 파쇄액 및 아스퍼질러스 나이거(
Aspergillus

niger ) 균체 파쇄액을 첨가한 후 발효시켜 수득한 홍삼 발효액을 유효성분으로 함유하는 것을 특징으로 하는 알레르기성 비염 완화용 식품 조성물에 관한 것으로, 코 가려움 증상 및 코막힘 증상을 호전시키면서 재채기 및 수양성 콧물의 증상지속시간이 감소시켜 실질적으로 알레르기성 비염에 대한 완화 효과를 발휘한다.

26. 发明授权

KR100721140B1 류코노스톡과 대장균에서 상호복제가 가능한 셔틀벡터 有权
标题翻译：穿梭导线为明串珠菌和大肠杆菌
公开(公告)号：KR100721140B1
公开(公告)日：2007-05-25
申请号：KR1020030060288
申请日：2003-08-29
申请人： 충북대학교 산학협력단 , 주식회사 비피도
发明人： 지근억 , 박명수 , 한남수 , 엄현주
IPC分类号： C12N15/70
摘要： 본 발명은 김치에서 분리한 류코노스톡 시트럼(
Leuconostoc citreum )으로부터 유래된 플라스미드 pNS75에 관한 것이다. 또한 새롭게 분리한 pNS75의 복제원점을 이용하여 대장균과 류코노스톡에서 상호 복제가 가능한 새로운 셔틀벡터(shuttle vector)를 구축하는 것이다.

27. 发明授权

KR100483934B1 비피도박테리움 롱검 ＭＧ1 유래 신규 플라스미드를 함유하는 셔틀벡터 失效
标题翻译：穿梭载体，其包含源自长双歧杆菌MG1的新型质粒
公开(公告)号：KR100483934B1
公开(公告)日：2005-04-19
申请号：KR1020040057847
申请日：2004-07-23
申请人： 주식회사 비피도
发明人： 지근억 , 박명수 , 강윤희 , 서정민
IPC分类号： C12N15/74

28. 发明公开

KR1020040087056A 비피도박테리움에서 외래 유전자 발현 및 분비 시스템 失效
标题翻译：外源基因表达和分泌系统在基因双歧杆菌中生产功能性乳酸菌产品生产有用的蛋白质
公开(公告)号：KR1020040087056A
公开(公告)日：2004-10-13
申请号：KR1020030021296
申请日：2003-04-04
申请人： 주식회사 비피도
发明人： 지근억 , 박명수
IPC分类号： C12N15/56
CPC分类号： C12N9/2417 , C12N9/16 , C12N15/70 , C12N15/746 , C12Y302/01001
摘要： PURPOSE: A foreign gene expression and secretion system in the genus Bifidobacterium is provided, thereby producing functional lactic acid bacteria product producing useful protein, and applying the expression cassette system containing alpha-amylase signal sequence from Bifidobacterium into industrial system. CONSTITUTION: A alpha-amylase gene from Bifidobacterium having the nucleotide sequence set forth in SEQ ID NO:1 is provided. A signal sequence of the alpha-amylase gene from Bifidobacterium having the nucleotide sequence set forth in SEQ ID NO:2 is provided. A cassette system for secretion of foreign gene contains the signal sequence of the alpha-amylase gene from Bifidobacterium. A promoter gene of alpha-amylase gene from Bifidobacterium has the nucleotide sequence of SEQ ID NO:3. An expression vector of pBESAF1 or pBESAF2(KCCM-10452) comprises the promoter gene of alpha-amylase gene from Bifidobacterium having the nucleotide sequence of SEQ ID NO:3, ribosome binding site and the signal sequence of the alpha-amylase gene from Bifidobacterium having the nucleotide sequence of SEQ ID NO:2. A phytase expression vector of pBESAF1-PHY or pBESAF2-appA comprises phytase gene from Bacillus and Escherichia coli. A E. coli or Bifidobacterium transformant is produced by transforming E. coli or Bifidobacterium with the expression vector of pBESAF1 or pBESAF2(KCCM-10452), or the phytase expression vector of pBESAF1-PHY or pBESAF2-appA.
摘要翻译：目的：提供双歧杆菌属的外源基因表达和分泌系统，从而产生产生有用蛋白质的功能性乳酸菌产品，并将含有双歧杆菌的α-淀粉酶信号序列的表达盒系统应用于工业系统。构成：提供具有SEQ ID NO：1所示的核苷酸序列的来自双歧杆菌的α-淀粉酶基因。提供了具有SEQ ID NO：2所示核苷酸序列的双歧杆菌的α-淀粉酶基因的信号序列。用于分泌外源基因的盒系统含有来自双歧杆菌的α-淀粉酶基因的信号序列。来自双歧杆菌的α-淀粉酶基因的启动子基因具有SEQ ID NO：3的核苷酸序列。 pBESAF1或pBESAF2（KCCM-10452）的表达载体包含具有SEQ ID NO：3的核苷酸序列，核糖体结合位点和来自双歧杆菌的α-淀粉酶基因的信号序列的来自双歧杆菌的α-淀粉酶基因的启动子基因， SEQ ID NO：2的核苷酸序列。 pBESAF1-PHY或pBESAF2-appA的植酸酶表达载体包含来自芽孢杆菌和大肠杆菌的植酸酶基因。通过用pBESAF1或pBESAF2（KCCM-10452）的表达载体或pBESAF1-PHY或pBESAF2-appA的植酸酶表达载体转化大肠杆菌或双歧杆菌来产生大肠杆菌或双歧杆菌转化体。

29. 发明公开

KR1020040072545A 비피도박테리움 롱검 ＭＧ1 유래 신규 플라스미드를 함유하는 셔틀벡터 失效
标题翻译：包含从双歧杆菌MG1衍生的PLASMID的切片向量
公开(公告)号：KR1020040072545A
公开(公告)日：2004-08-18
申请号：KR1020040057847
申请日：2004-07-23
申请人： 주식회사 비피도
发明人： 지근억 , 박명수 , 강윤희 , 서정민
IPC分类号： C12N15/74
摘要： PURPOSE: A shuttle vector comprising a plasmid derived from Bifidobacterium longum MG1 is provided, thereby requiring no additional purification when a target gene is expressed by using the shuttle vector, and directly adding the expressed target gene into food or oral vaccines without further processing. CONSTITUTION: The shuttle vector comprises a plasmid pMG1 derived from Bifidobacterium longum MG1(KFCC-11273) having the nucleotide sequence set forth in SEQ ID NO:1 which is linked to a transformation vector derived from Escherichia coli selected from pEK104, pUC19 and pBR322, gene Mob derived from the plasmid pMG1 having the nucleotide sequence set forth in SEQ ID NO:2, gene Rep derived from the plasmid pMG1 having the nucleotide sequence set forth in SEQ ID NO:3, and a selection gene selected from ampicillin resistance gene, kanamycin resistance gene and chloramphenicol acetyl transferase gene.
摘要翻译：目的：提供包含来源于长双歧杆菌MG1的质粒的穿梭载体，从而当通过使用穿梭载体表达目标基因时不需要额外的纯化，并且将表达的靶基因直接添加到食物或口服疫苗中而不进一步处理。构型：穿梭载体包含源自长双歧杆菌MG1（KFCC-11273）的质粒pMG1，其具有SEQ ID NO：1所示的核苷酸序列，其与衍生自选自pEK104，pUC19和pBR322的大肠杆菌的转化载体连接，衍生自具有SEQ ID NO：2所示核苷酸序列的质粒pMG1的基因Mob，以及源自具有SEQ ID NO：3所示核苷酸序列的质粒pMG1的基因Rep，以及选自氨苄青霉素抗性基因，卡那霉素抗性基因和氯霉素乙酰转移酶基因。

30. 发明公开

KR1020030010879A 비피도박테리움 아돌레센티스에서 분리된 β-갈락토시다제유전자 无效
标题翻译： - 从双歧杆菌分离的角质酶基因
公开(公告)号：KR1020030010879A
公开(公告)日：2003-02-06
申请号：KR1020010045531
申请日：2001-07-27
申请人： 주식회사 비피도
发明人： 지근억 , 박명수 , 조상희 , 윤현진
IPC分类号： C12N15/56
CPC分类号： C12N9/2471 , C12N15/70 , C12Y302/01023
摘要： PURPOSE: Provided is β-galactosidase gene which is characteristically isolated from Bifidobacterium adolescentis, particularly Bifidobacterium adolescentis Int57, and used as a selection marker for foods. Also, provided are a recombinant vector inserted with the gene and a transformant transformed with the vector. CONSTITUTION: The β-galactosidase gene characteristically isolated from Bifidobacterium adolescentis Int57 has the amino acid sequence of the SEQ ID NO:1. The recombinant vector, pBIG, includes the β-galactosidase gene. The transformant is transformed with the recombinant vector, pBIG.
摘要翻译：目的：提供从青春双歧杆菌特别是青春双歧杆菌Int57特征性分离的β-半乳糖苷酶基因，并用作食物的选择标记。此外，提供了插入该基因的重组载体和用载体转化的转化体。构成：从青春双歧杆菌Int57特征性分离的β-半乳糖苷酶基因具有SEQ ID NO：1的氨基酸序列。重组载体pBIG包括β-半乳糖苷酶基因。转化体用重组载体pBIG转化。

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