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11. 发明公开

KR1020120034927A 피부투과성 인간 상피세포 성장인자 및 그 생산방법 无效
标题翻译：皮肤转移人体生长因子及其生产方法
公开(公告)号：KR1020120034927A
公开(公告)日：2012-04-13
申请号：KR1020100096321
申请日：2010-10-04
申请人： 주식회사 바이오셀트란
发明人： 장상호 , 안재진 , 정진하 , 최수영 , 음원식 , 박진서
IPC分类号： C07K19/00 , A61K38/18 , A61P17/00 , A61P27/02
CPC分类号： C07K14/485 , A61K8/64 , A61K38/1808 , A61K47/64 , A61Q19/00 , C07K2319/01 , C12P21/00
摘要： PURPOSE: A skin permeability human epidermal growth factor and a method for preparing the same are provided to naturally produce rhEGF fusion protein and to regenerate tissue and skin cells. CONSTITUTION: A skin permeability human epidermal growth factor fusion protein contains non-hydrophilic domain containing 5 or more tryptophane, hydrophilic domain containing 4 or more of lysine, and protein transport domain having a spacer which is bound to rhEGF terminal by covalent bond. The fusion protein has an amino acid sequence of sequence number 9, 11, or 13. A composition for treating and preventing aging, atopy, dermatitis, or ulcer contains the fusion protein as an active ingredient. The cosmetic composition contains the fusion protein as an active ingredient.
摘要翻译：目的：提供皮肤渗透性人表皮生长因子及其制备方法，以天然产生rhEGF融合蛋白并再生组织和皮肤细胞。构成：皮肤渗透性人表皮生长因子融合蛋白含有含有5个或更多个色氨酸的非亲水结构域，含有4个或更多赖氨酸的亲水结构域，以及具有通过共价键与rhEGF末端结合的间隔基的蛋白质转运结构域。融合蛋白具有序列号9,11,11的氨基酸序列。用于治疗和预防衰老，特应性，皮炎或溃疡的组合物含有融合蛋白作为活性成分。化妆品组合物含有作为活性成分的融合蛋白质。

12. 发明公开

KR1020110138258A 압전 세라믹 식별 장치용의 개량된 멀티플렉서 审中-实审
标题翻译：改进的用于PIEZO陶瓷识别装置的多路复用器
公开(公告)号：KR1020110138258A
公开(公告)日：2011-12-26
申请号：KR1020117025136
申请日：2010-03-23
申请人： 소나베이션, 인크.
发明人： 리아우타우드크리스티안 , 슈미트라이너엠
IPC分类号： G06K9/00 , H01L27/20 , A61K38/18
CPC分类号： A61K38/1808 , G06K9/0002 , H01L27/20
摘要： 음향 임페디오그래피를 이용한 지문 센서가 제공된다. 센서는 주문형 집적 회로(ASIC 또는IC) 및 감지 요소로서 사용되는 기계적 공진기 어레이를 포함한다. 감지 요소의 어레이는 행과 열로 배열된 복수의 감지 요소를 포함한다.

13. 发明公开

KR1020090043510A 펩타이드의 지속 방출 전달을 위한 의약 조성물 有权
标题翻译：用于持续释放肽的药物组合物
公开(公告)号：KR1020090043510A
公开(公告)日：2009-05-06
申请号：KR1020097002817
申请日：2007-07-11
申请人： 큐피에스 엘엘씨
发明人： 리유후아 , 치엔벤자민
IPC分类号： A61K9/08 , A61K38/00 , A61K47/34 , A61K47/44
CPC分类号： A61K38/1808 , A61K9/0019 , A61K9/0024 , A61K9/19 , A61K38/2278 , A61K38/25 , A61K38/26 , A61K38/29 , A61K38/47 , A61K47/542 , A61K47/543 , A61K47/60
摘要： 본 발명은 생체적합성이며, 비수용성이고, 생체분해성을 갖는 폴리머의 유효량과 하나 이상의 친지성 또는 양친성 모이어티에 의해 공유적으로 변형된 치료용 펩타이드의 유효량이 생체적합성이고 수용성인 유기 용매 중에 용해 또는 분산되어 있는 형태로 포함된 액상의 약학적 조성물을 투여함으로써, 체내에서 현장(
in situ )로 고상의 생체분해성 임플란트를 형성하는 방법을 제공하다.
펩타이드, 생체적합성, 생체분해성, 전달

14. 发明公开

KR1020090027809A 액정상의 친수성 입방형 상 제조방법, 이로부터 제조된액정상의 친수성 입방형 상 및 액정상으로부터 친수성 약물방출의 측정방법 失效
标题翻译：生产液晶相液相液相色谱的方法，生产的液晶相的液相色谱和测定从液晶相中释放水解药物的方法
公开(公告)号：KR1020090027809A
公开(公告)日：2009-03-18
申请号：KR1020070092901
申请日：2007-09-13
申请人： 재단법인서울대학교산학협력재단 , 중앙대학교 산학협력단
发明人： 이재휘
IPC分类号： A61K9/107 , A61K38/16
CPC分类号： A61K9/006 , A61K9/08 , A61K38/1808 , A61K38/28
摘要： A method of manufacturing hydrophile property cubic of liquid-crystalline phase is provided to continue effect of medicine of the hydrophile property drug and to delay or control emission of the hydrophile property drug. A method of manufacturing hydrophile property cubic of liquid-crystalline phase comprises steps of: manufacturing polymer water solution by dissolving drug of hydrophile property and water soluble polymer in water; manufacturing glyceryl monoolate liquid-crystalline phase; and homogenizing it by adding olymer water solution to GMO liquid-crystalline phase and manufacturing the cubic phase by cooling the homogenized solution. A rate of water : GMO is 1 : 0.5~ 6(w/w).
摘要翻译：提供制造液晶相的亲水性立方体的方法，以继续使用亲水性药物的药物，延迟或控制亲水性药物的发射。制备液晶相的亲水性立方体的方法包括以下步骤：通过将亲水性药物和水溶性聚合物溶解在水中来制造聚合物水溶液; 制备甘油单油酸酯液晶相; 并通过向GMO液晶相中加入低温水溶液均质化，并通过冷却均质溶液制备立方相。水分率：GMO为1：0.5〜6（w / w）。

15. 发明公开

KR1020090022873A 고농축 염화 염천수를 포함하는 화장품의 성분 및 제조방법 无效
标题翻译：化妆品制造工艺
公开(公告)号：KR1020090022873A
公开(公告)日：2009-03-04
申请号：KR1020070088537
申请日：2007-08-31
申请人： 박청하
发明人： 박청하
IPC分类号： A61K8/19 , A61Q19/00
CPC分类号： A61K8/965 , A61K8/19 , A61K35/08 , A61K38/1808 , A61K38/1825 , A61Q19/00
摘要： A cosmetic composition having high concentrated chloride brine is provided to improve skin penetration of functional materials by binding the functional materials for recovering cells with natural mineral included in the concentration chloride brine. A cosmetic composition having high concentrated chloride brine comprises the following steps of: preparing a cosmetic base; mixing and maturing a mixture of the high concentrated chloride brine, EGF(Epidermal Growth Factor), and bFGF(basic Fibroblastic Growth Factor) with mineral water to preparing a cosmetic additive; mixing the cosmetic base with the cosmetic additive; and maturing the cosmetic base with the cosmetic additive.
摘要翻译：提供了具有高浓度氯化物盐水的化妆品组合物，以通过结合用于回收细胞的功能材料来改善功能材料的皮肤渗透，所述功能材料用于浓缩氯化物盐水中包含的天然矿物。具有高浓度氯化物盐水的化妆品组合物包括以下步骤：制备化妆品基料; 将高浓度氯化物盐水，EGF（表皮生长因子）和bFGF（碱性成纤维细胞生长因子）的混合物与矿泉水混合并熟化以制备化妆品添加剂; 将化妆品基料与化妆品添加剂混合; 并用化妆品添加剂熟化化妆品基质。

16. 发明公开

KR1020050111346A 분비 단백질 계통 无效
标题翻译：分泌蛋白家族
公开(公告)号：KR1020050111346A
公开(公告)日：2005-11-24
申请号：KR1020057016659
申请日：2004-03-24
申请人： 아레스 트레이딩 에스.에이.
发明人： 파워,크리스틴 , 요르케,멜라니에 , 파간,리차드조셉 , 미칼로비크,데이비드 , 멕켄드릭,이안
IPC分类号： C07K14/47
CPC分类号： C07K14/475 , A61K38/1808 , C07K14/47 , G06F19/22
摘要： This invention relates to a new family of secreted proteins, termed the SECFAMI family, its family members including the novel proteins INSP113, INSP114, INSP115, INSP116 and INSP117, herein identified as secreted proteins containing epidermal growth factor (EGF) fold- containing domains, ranging from 125-153 amino acids in length and containing eight conserved cysteine residues and to the use of these proteins and nucleic acid sequences from the encoding genes in the diagnosis, prevention and treatment of disease.
摘要翻译：本发明涉及一种称为SECFAMI家族的新型分泌蛋白家族，其家族成员包括新型蛋白质INSP113，INSP114，INSP115，INSP116和INSP117，其鉴定为含有表皮生长因子（EGF）折叠结构域的分泌蛋白质，长度为125-153个氨基酸，含有8个保守的半胱氨酸残基，以及来自编码基因的这些蛋白质和核酸序列在诊断，预防和治疗疾病中的应用。

17. 发明公开

KR1020020032795A 수용성 펩타이드 약물의 건조 리포좀 조성물 및 그의 제조방법 失效
标题翻译：含有水溶性，基于肽的药物的干性脂质体组合物及其制备方法
公开(公告)号：KR1020020032795A
公开(公告)日：2002-05-04
申请号：KR1020000063457
申请日：2000-10-27
申请人： 한건
发明人： 한건 , 고종호 , 김은영
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K38/1808 , A61K38/1841 , A61K47/24
摘要： PURPOSE: Provided are dry liposome composition containing water-soluble, peptide-based drugs and its preparation method. Particularly, water-soluble peptide or water-soluble drugs are formulated into solid liposome to transfer drugs stably. CONSTITUTION: The manufacturing method of dry liposome composition comprises the steps of; mixing water-soluble peptide drugs with oil and surfactant to W/O emulsion type of water-soluble peptide drugs; dispersing multi-porous powdery carrier into the W/O emulsion then including it; removing oil from the surface then evaporating water to manufacture dry carrier which includes water-soluble peptide drugs; and coating the dry carrier with mixed a mixed solution of phospholipid and organic solvent.
摘要翻译：目的：提供含有水溶性，基于肽的药物的干性脂质体组合物及其制备方法。特别地，将水溶性肽或水溶性药物配制成固体脂质体以稳定转运药物。构成：干脂质体组成的制造方法包括以下步骤：将水溶性肽药物与油和表面活性剂混合到W / O乳液型水溶性肽类药物中; 将多孔粉末载体分散到W / O乳液中，然后包括它; 从表面除去油，然后蒸发水以制造包含水溶性肽类药物的干燥载体; 并用磷脂和有机溶剂的混合溶液混合干燥的载体。

18. 发明公开

KR1020010081888A 상피세포 성장인자를 유효성분으로 하는 안정한 약제학적조성물 有权
标题翻译：含有活性成分因子的稳定的药物组合物作为有效成分
公开(公告)号：KR1020010081888A
公开(公告)日：2001-08-29
申请号：KR1020000008116
申请日：2000-02-21
申请人： 주식회사 대웅
发明人： 양정화 , 이장원 , 손미영 , 김영준
IPC分类号： A61K38/27
CPC分类号： A61K9/0014 , A61K9/0048 , A61K9/7023 , A61K9/7053 , A61K9/7061 , A61K38/1808 , A61K47/32
摘要： PURPOSE: A biologically and physically stable epidermal growth factor (EGF) composition prepared by using a carboxy vinyl polymer as base material is provided, which can be effectively used as a therapeutic agent for intractable ulcer. CONSTITUTION: The stable epidermal growth factor contains 0.01 to 1,000 microgram/g biologically active epidermal growth factor as an effective component and 0.001 to 50(w/w) carboxy vinyl polymer as base material, based on the total preparation respectively, wherein the biologically active epidermal growth factor is prepared in the shape of natural type or recombinant protein.
摘要翻译：目的：提供通过使用羧乙烯基聚合物作为基材制备的生物和物理上稳定的表皮生长因子（EGF）组合物，其可以有效地用作难治性溃疡的治疗剂。构成：稳定的表皮生长因子分别含有基于总制剂的0.01至1,000微克/ g生物活性表皮生长因子作为有效成分和0.001至50（w / w）羧基乙烯基聚合物作为基础材料，其中生物活性表皮生长因子以天然型或重组蛋白的形式制备。

19. 发明公开

KR20180021736A 세포의 항아폽토시스, 생존, 또는 증식을 유도하기 위한 조성물 및 방법 审中-公开
标题翻译：用于诱导细胞的抗凋亡，存活或增殖的组合物和方法
公开(公告)号：KR20180021736A
公开(公告)日：2018-03-05
申请号：KR20177037742
申请日：2016-06-14
申请人： VITAL THERAPIES INC
发明人： ASHLEY ROBERT A , LANDEEN LEE
IPC分类号： A61K38/18 , A61K35/407 , A61K38/17 , A61K45/06 , A61M37/00 , A61P1/16
CPC分类号： A61K35/407 , A61K38/177 , A61K38/1808 , A61K45/06 , A61M37/00 , A61K2300/00
摘要： 본발명은세포의항아폽토시스, 항피롭토시스, 항네크롭토시스, 생존, 보호, 증식및/또는표현형조정을유도할뿐만아니라개체에서질환을치료하기위한조성물및 방법을제공한다.
摘要翻译：本发明提供了用于治疗个体疾病以及诱导细胞的抗凋亡，抗凋亡，hemanechotocis，存活，保护，增殖和/或表型调节的组合物和方法。

20. 发明授权

KR101725062B1 피부 발진의 예방 또는 치료용 약학 조성물 有权
公开(公告)号：KR101725062B1
公开(公告)日：2017-04-10
申请号：KR1020150067176
申请日：2015-05-14
申请人： 주식회사 대웅제약 , 동아대학교 산학협력단
发明人： 오성용 , 민경현
IPC分类号： A61K38/18 , A61K35/36 , A61K31/505 , A61K31/517 , A61K9/06
CPC分类号： A61K38/1808 , A61K9/0014 , A61K9/06 , A61K31/517 , A61K31/7068
摘要： 본발명은상피세포성장인자를유효성분으로포함하는, 피부발진특히엘로티닙등의상피세포성장인자수용체억제제의투여에의해부작용으로발생되는피부발진의예방또는치료용약학조성물을제공한다.

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